Objective To construct nomogram model for individualized prediction of esophageal stenosis risk after endoscopic submucosal dissection（ESD） for early esophageal cancer. Methods A total of 198 patients treated with ESD in the digestive surgery department of our hospital from January 2016 to June 2019 were selected as the research objects.According to whether esophageal stenosis occurred after operation, the patients were divided into stenosis group and nonstenosis group. The influencing factors of esophageal stenosis after ESD in patients with early esophageal cancer were analyzed. R4.1.1 software was used to construct nomogram model for predicting esophageal stenosis risk after ESD in patients with early esophageal cancer. The receiver operating characteristic（ROC） curve and calibration curve were drawn to evaluate the discrimination and consistency of the nomogram model in predicting esophageal stenosis risk after ESD in patients with early esophageal cancer. Results Among 198 patients with early esophageal cancer treated by ESD, 51 cases had esophageal stenosis, with an incidence of 25.76%. Univariate analysis results showed that there were statistically significant differences in age, operation time, lesion longitudinal diameter, muscle layer injury, lesion circumference and infiltration depth between the stenosis group and the non-stenosis group（P＜0.05）. Multivariate Logistic regression analysis results showed that lesion longitudinal diameter ≥5 cm, muscular layer injury, lesion circumference≥3/4 circles and M3/SM1infiltration depth were risk factors for esophageal stenosis after ESD for early esophageal cancer（P＜0.05）. The area under the curve（AUC） of the nomogram model for predicting esophageal stenosis risk after ESD in patients with early esophageal cancer was 0.838. Hosmer-Lemeshow goodness-of-fit test showed there was a good consistency between the predicted probability of the nomogram and the current value（P=0.596）. Conclusion The lesion longitudinal diameter ≥5 cm, muscular layer injury, lesion circumference≥3/4 circles and M3/SM1 infiltration depth are risk factors for esophageal stenosis after ESD in patients with early esophageal cancer. The nomogram model constructed in this study has a good predictive ability for the risk of esophageal stenosis after ESD in patients with early esophageal cancer.
目的 探讨甲状腺功能正常人群甲状腺激素水平与代谢相关脂肪性肝病(MAFLD)的相关性.方法 选取2019年1月至12月就诊于苏州市相城区太平街道社区卫生服务中心的120例健康体检者作为研究对象,根据是否患有MAFLD将其分为正常组(n=79)和MAFLD组(n=41).比较两组的一般资料;分析甲状腺激素水平与代谢相关指标的关系;用多因素Logistic回归分析探讨影响MAFLD发生的危险因素.结果 研究对象的平均年龄(46.38±9.69)岁,其中41例符合MAFLD诊断标准,患病率为34.17％.MAFLD组的促甲状腺激素(TSH)、游离三碘甲状腺原氨酸(FT3)水平均高于正常组,差异有统计学意义(P<0.05).Pearson秩相关分析结果显示:TSH与腰围(WC)、体重指数(BMI)、空腹血糖(FPG)、总胆固醇(TC)、天冬氨酸氨基转移酶(AST)、γ-谷氨酰转肽酶(GGT)呈正相关,与高密度脂蛋白胆固醇(HDL-C)呈负相关(P<0.05);FT3与WC、BMI、FPG、TG、丙氨酸氨基转移酶(ALT)、AST、GGT呈正相关,与HDL-C呈负相关(P<0.05);游离甲状腺素(FT4)与指标间无相关性(P>0.05).多因素Logistic回归分析显示,TSH、FT3水平是影响MAFLD发生的独立危险因素(P<0.05).结论 甲状腺功能正常人群中TSH、FT3水平是影响MAFLD发生的独立危险因素.
Objective To investigate the application effect of extracorporeal mechanical side-to-side anastomosis and end-to-side anastomosis in laparoscopic-assisted radical resection of right colon cancer.Methods A total of 100 patients who underwent laparoscopic-assisted radical resection of right colon cancer from April 2019 to April 2021 were selected as the research objects.Based on the order of admission,the patients were divided into control group(50 cases,end-to-side anastomosis)and study group(50 cases,side-to-side anastomosis).The application effects of the two groups were compared.Results The intraoperative blood loss in the study group was less than that in the control group,the first ventilation time after operation and the recovery time of intestinal function after operation were shorter than those in the control group(P<0.05).At 3 d after operation,the levels of C-reactive protein(CRP),interleukin-6(IL-6)and tumor necrosis factor-α(TNF-α)in the two groups were higher than those before operation,but those in the study group were lower than the control group(P<0.05).At 3 d after operation,the levels of CD3+,CD4+ and CD4+/CD8+ in the two groups were lower than those before operation,and CD8+ was higher than that before operation,but those in the study group were better than the control group(P<0.05).The total incidence of complications in the study group was lower than that in the control group(P<0.05).Conclusion Compared with end-to-side anastomosis,side-to-side anastomosis is more helpful to promote the recovery of gastrointestinal function in patients undergoing laparoscopic-assisted radical resection of right colon cancer,and has higher safety,which is of positive significance for improving the prognosis of patients.
Objective To explore the effect of budesonide formoterol powder inhalation combined with tiotropium bromide and salbutamol in the treatment of elderly bronchial asthma(BA).Methods A total of 120 elderly patients with BA admitted from April 2019 to June 2021 were selected as the research objects.According to different treatment schemes,the patients were divided into control group and observation group,with 60 cases in each group.The control group was treated with tiotropium bromide and salbutamol,and the observation group was treated with budesonide formoterol powder inhalation on the basis of the treatment plan of the control group.The therapeutic effects of the two groups were compared.Results The dyspnea relief time,asthma relief time,cough relief time and lung rale disappearance time in the observation group were shorter than those in the control group(P<0.05).After 4 courses of treatment,the thickness of bronchial mucosa's reticular basement membrane(TRBM)and mucosal myofibroblast count in the observation group were lower than those in the control group(P<0.05).After 4 courses of treatment,the levels of mast cell carboxypeptidase(MC-CP)and sphingosine-1-phosphate(S1P)in the observation group were lower than those in the control group(P<0.05).After 4 courses of treatment,the frequency of asthma attack in the observation group was less than that in the control group,and the duration of asthma was shorter than that in the control group(P<0.05).Conclusion Budesonide formoterol powder inhalation combined with tiotropium bromide and salbutamol has a significant effect in the treatment of elderly patients with BA,which can regulate the levels of MC-CP and S1P,promote airway remodeling,improve clinical symptoms,reduce the frequency of asthma attacks,and shorten the duration of asthma,it is worth promoting in clinic.
Objective To explore the effect of Jinkui Shenqi pill combined with modified Taohong Siwu decoction in the treatment of elderly patients with heart failure of Qi deficiency and blood stasis type.Methods A total of 90 elderly patients with heart failure of Qi deficiency and blood stasis type admitted from August 2019 to January 2022 were selected as the research objects.According to the random number table method,the patients were divided into control group and observation group,with 45 cases in each group.The control group was treated with conventional western medicine,and the observation group was treated with Jinkui Shenqi pill combined with modified Taohong Siwu decoction on the basis of the control group.The therapeutic effects of the two groups were compared.Results The total effective rate of treatment in the observation group was higher than that in the control group(P<0.05).After treatment,the interventricular septal thickness(IVST),left ventricular posterior wall thickness(LVPWT)and the left ventricular mass index(LVMI)in the observation group were lower than those in the control group(P<0.05).After treatment,the levels of superoxide dismutase(SOD)and nitric oxide(NO)in the observation group were higher than those in the control group,and the level of malondialdehyde(MDA)was lower than that in the control group(P<0.05).Conclusion Jinkui Shenqi pill combined with modified Taohong Siwu decoction has a satisfactory effect in the treatment of elderly patients with heart failure of Qi deficiency and blood stasis type.It can improve ventricular remodeling function and reduce oxidative stress injury.
Objective To explore the application effect of group nursing management in operating room nursing management and its influence on the occurrence of risk events.Methods A total of 160 patients who were treated in the operating room of our hospital from December 2021 to March 2022 were selected as the research objects.The patients were divided into control group(80 cases,routine nursing management)and observation group(80 cases,group nursing management)according to the random number table method.During the same period,20 operating room nurses were divided into control group and observation group by double-blind method,with 10 cases in each group.The application effects of the two groups were compared.Results The total incidence of nursing risk events of patients in the observation group was lower than that in the control group,and the difference was statistically significant(P<0.05).After nursing,the scores of theoretical knowledge,document nursing,equipment,disinfection and isolation,tour cooperation and equipment cooperation of nursing staff in the observation group were higher than those in the control group,and the differences were statistically significant(P<0.05).The nursing satisfaction of patients of the observation group was higher than that of the control group,and the difference was statistically significant(P<0.05).Conclusion The group nursing management in operating room nursing management has ideal effect,which can significantly reduce the incidence of nursing risk events,improve the quality and safety of nursing,and obtain high recognition from patients.
Objective To explore the application effect of lamotrigine combined with topiramate in children with epilepsy.Methods A total of 64 children with epilepsy admitted in our hospital from February 2018 to February 2022 were selected as the research objects and randomly divided into control group(32 cases,topiramate)and observation group(32 cases,lamotrigine combined with topiramate).The therapeutic effects of the two groups were compared.Results The total effective rate of treatment in the observation group was higher than that in the control group(P<0.05).The improvement rate of electroencephalogram in the observation group was higher than that in the control group(P<0.05).After treatment,the levels of interleukin-6(IL-6),tumor necrosis factor-α(TNF-α)and C-reactive protein(CRP)in the two groups significantly decreased,and those in the observation group were lower than the control group(P<0.05).After treatment,the levels of brain-derived neurotrophic factor(BDNF)and neuron-specific enolase(NSE)in the two groups significantly decreased,and those in the observation group were lower than the control group(P<0.05).After treatment,the scores of each aspect of Gesell developmental scale in the two groups significantly improved,and those in the observation group were higher than the control group(P<0.05).There was no significant difference in the total incidence of adverse reactions between the two groups(P>0.05).Conclusion Lamotrigine combined with topiramate in the treatment of children with epilepsy has a significant effect.It can improve their electroencephalogram and clinical symptoms,reduce the levels of inflammatory factors and nerve factors,and improve the cognitive function.It is worthy of promotion and application.
Objective To investigate the effects of compound Danshen dripping pills combined with ticagrelor on arterial stiffness and vascular endothelial function in patients with coronary heart disease angina pectoris.Methods Eighty patients with coronary heart disease angina pectoris admitted from February 2021 to April 2022 were selected as the study objects and divided into control group and observation group according to the admission time,with 40 cases in each group.The control group received conventional treatment and ticagrelor,and the observation group was treated with compound Danshen dripping pills on the basis of the control group.The therapeutic effects of the two groups were compared.Results After treatment,the carotid femoral pulse wave velocity(cfPWV)and brachial-ankle pulse wave velocity(baPWV)of the observation group were lower than those of the control group,and the ankle brachial index(ABI)was greater than that of the control group(P<0.05).After treatment,the levels of endothelin-1(ET-1)and vascular endothelial cell adhesion molecule-1(VCAM-1)in the observation group were lower than those in the control group,and the vascular endothelial growth factor(VEGF)level was higher than that in the control group(P<0.05).After treatment,the levels of N-terminal pro-brain natriuretic peptide(NT-proBNP)and creatine kinase isoenzyme(CK-MB)in the observation group were lower than those in the control group(P<0.05).After treatment,the duration of angina pectoris in the observation group was shorter than that in the control group,and the frequency of angina pectoris was lower than that in the control group(P<0.05).Conclusion Compound Danshen dripping pills combined with ticagrelor in the treatment of coronary heart disease angina pectoris can improve arterial stiffness and vascular endothelial function,regulate the expression of myocardial injury markers,and shorten the duration of angina pectoris,reduce the frequency,which is worthy of promotion.
Objective To analyze the clinical effect of glucocorticoid combined with early sequential hemoperfusion(HP)in the treatment of rhabdomyolysis(RM)caused by acute bee sting.Methods From January 2019 to January 2021,40 patients with RM caused by acute bee sting were selected as the research objects.According to the random number table method,the patients were divided into control group(n=20,early sequential HP treatment)and observation group(n=20,glucocorticoid combined with early sequential HP treatment).The therapeutic effects of the two groups were compared.Results After treatment,the levels of creatinine,urea nitrogen and uric acid in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).After treatment,the levels of creatine kinase(CK),lactate dehydrogenase(LDH),creatine kinase isoenzyme(CK-MB)and myoglobin(Myo)in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).After treatment,the levels of interleukin-1β(IL-1β),interleukin-6(IL-6),procalcitonin(PCT)and tumor necrosis factor-α(TNF-α)in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).The total incidence of complications in the observation group was lower than that in the control group,and the difference was statistically significant(P<0.05).Conclusion Glucocorticoid combined with early sequential HP is effective in the treatment of RM caused by acute bee sting,it can slow down the damage of heart and kidney function,reduce the levels of inflammatory factors and improve the prognosis of patients,which is worthy of clinical promotion.
Objective To investigate the application effect of hydrocolloid pull-up suture-free method combined with silver ion antibacterial dressing on wound healing after laparotomy and its influence on growth factor level.Methods A total of 150 patients undergoing laparotomy admitted in our hospital from January 2020 to January 2022 were selected as the research objects.According to different wound nursing methods,the patients were divided into control group and observation group,with 75 cases in each group.The control group was treated with routine suture and dressing change nursing,while the observation group was treated with hydrocolloid pull-up suture-free method combined with silver ion antibacterial dressing nursing.The nursing effects of the two groups were compared.Results The pain degree per unit time,wound healing rate per unit time and fresh granulation tissue formation time in the observation group were better than those in the control group(P<0.05).The wound healing time and total dressing change time in the observation group were shorter than those in the control group,and the total dressing change times was less than that in the control group(P<0.05).After nursing,the levels of vascular endothelial growth factor(VEGF),epidermal growth factor(EGF)and basic fibroblast growth factor(bFGF)in the observation group were higher than those in the control group(P<0.05).After nursing,the levels of interleukin-8(IL-8)and tumor necrosis factor-α(TNF-α)in the observation group were lower than those in the control group(P<0.05).Conclusion Hydrocolloid pull-up suture-free method combined with silver ion antibacterial dressing has a good application effect on wound healing after laparotomy,it can regulate the levels of growth factors and down-regulate the expression of inflammatory factors,which is worthy of promotion.
Objective To explore the effect of Huangkui capsules combined with saxagliptin in treatment of diabetes kidney disease(DKD)and its influences on oxidative stress indexes and renal fibrosis indexes.Methods From February 2020 to September 2022,100 patients with DKD were selected as the research objects,and the patients were divided into control group(conventional symptomatic treatment + saxagliptin)and observation group(conventional symptomatic treatment + saxagliptin + Huangkui capsules)by random number table method,with 50 cases in each group.The therapeutic effects of the two groups were compared.Results The total effective rate of treatment in the observation group was higher than that in the control group,and the difference was statistically significant(P<0.05).Before treatment,there were no significant differences in the levels of catalase(CAT),total antioxidative capacity(T-AOC)and superoxide dismutase(SOD)and lipid peroxide(LPO)between the two groups(P>0.05);after treatment,the levels of CAT,T-AOC and SOD in the observation group were higher than those in the control group,and the level of LPO was lower than that in the control group,the differences were statistically significant(P<0.05).Before treatment,there were no significant differences in the levels of cystatin C(Cys C),collage typeⅣ(CⅣ),β2-microglobulin(β2-MG)and tissue inhibitor of metalloproteinase-1(TIMP-1)between the two groups(P>0.05);after treatment,the levels of Cys C,CⅣ,β2-MG and TIMP-1 in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).Conclusion Huangkui capsules combined with saxagliptin can effectively regulate the levels of oxidative stress indexes and renal fibrosis indexes in DKD patients,and improve the overall treatment effect,which is worthy of promotion and application in clinical practice.
Objective To investigate the application effect of transactional analysis(TA)theory-oriented group psychological intervention in elderly patients recovering from stroke.Methods Ninety-eight elderly patients recovering from stroke admitted in our hospital were selected and divided into control group and observation group according to different admission order,with 49 cases in each group.The control group was given routine nursing intervention,and the observation group was given TA theory-oriented group psychological intervention on the basis of the control group.The intervention effects of the two groups were compared.Results After intervention,the National Institutes of Health Stroke Scale(NIHSS)and Self-Rating Anxiety Scale(SAS)scores of the observation group were lower than those of the control group(P<0.05).After intervention,the scores of Self-Perceived Burden Scale(SPBS)and Activity of Daily Living Scale(ADL)in the observation group were lower than those in the control group,and the scores of Herth Hope Index(HHI)and Southampton Stroke Self-Management Questionnaire(SSSMQ)were higher than those in the control group(P<0.05).The satisfaction of the observation group was higher than that of the control group(P<0.05).Conclusion TA theory-oriented group psychological intervention can adjust the psychological state of patients recovering from stroke,reduce the sense of burden,enhance the level of hope,improve self-management ability,contribute to the improvement of neurological function,and then enhance satisfaction.
Objective To explore the intervention effect of high quality nursing in patients with lower extremity arteriosclerosis obliterans(ASO)treated by angioplasty combined with catheter thrombolysis.Methods A total of 56 patients with lower extremity ASO who underwent angioplasty combined with catheter thrombolysis admitted in our hospital from August 2019 to January 2022 were selected as the research objects.According to the random number table method,the patients were divided into control group and observation group,with 28 cases in each group.The control group was given routine nursing,while the observation group was given high quality nursing on the basis of the control group.The nursing effects of the two groups were compared.Results After nursing,the scores of Self-Rating Anxiety Scale(SAS),Self-Rating Depression Scale(SDS)and Surgical Fear Questionnaire(SFQ)in the observation group were lower than those in the control group(P<0.05).After nursing,the scores of vitality(VT),social functioning(SF),role emotional(RE),mental health(MH),physical functioning(PF)and bodily pain(BP)in the observation group were higher than those in the control group(P<0.05).At 7 and 10 d after nursing,the Visual Analogue Scale(VAS)score of the observation group was lower than that of the control group(P<0.05);the nursing satisfaction score of the observation group was higher than that of the control group(P<0.05).The incidences of puncture point bleeding and hematoma in the observation group were significantly lower than those in the control group(P<0.05).Conclusion The high quality nursing in patients with lower extremity ASO treated by angioplasty combined with catheter thrombolysis has significant intervention effect,which can improve the anxiety,depression and fear of patients,improve the quality of life and nursing satisfaction of patients.
Objective To explore the application effect of pursed lip-abdominal breathing training combined with early pulmonary rehabilitation nursing in acute exacerbation of chronic obstructive pulmonary disease(AECOPD)complicated with respiratory failure.Methods A total of 120 patients with AECOPD complicated with respiratory failure admitted from April 2019 to April 2021 were selected as the research objects.According to the order of admission,the patients were divided into control group(60 cases,routine nursing)and experimental group(60 cases,pursed lip-abdominal breathing training combined with early pulmonary rehabilitation nursing).The intervention effects of the two groups were compared.Results After intervention,the pH value,partial pressure of oxygen in arterial blood(PaO2),blood oxygen saturation(SaO2)and partial pressure of oxygen in arterial blood/fraction of inspired oxygen(PaO2/FiO2)in the two groups increased,and those in the experimental group were higher than the control group(P<0.05).The forced vital capacity(FVC)and forced expiratory volume in one second(FEV1)in the experimental group were higher than those in the control group,the 6 min walking distance was longer than that in the control group,and the St George's Respiratory Questionnaire(SGRQ)score was lower than that in the control group(P<0.05).After intervention,the CD4+ and CD4+/CD8+ in the two groups increased,the CD8+ decreased,and those in the experimental group were better than the control group(P<0.05).The total incidence of complications in the experimental group was lower than that in the control group(P<0.05).Conclusion Pursed lip-abdominal breathing training combined with early pulmonary rehabilitation nursing has a good application effect in patients with AECOPD complicated with respiratory failure.
Objective To study the application value of real-time tissue elastography peak strain index(PSI)combined with free prostate specific antigen/total prostate specific antigen(FPSA/TPSA)in the differential diagnosis of prostatic cancer in gray area of prostate specific antigen(PSA).Methods Ninety-five patients with suspected prostatic cancer admitted from January 2018 to May 2022 were included.According to the pathological examination results,32 patients with prostatic cancer were included in prostatic cancer group and 63 patients without prostatic cancer were included in control group.Elastic imaging score,PSI,average strain index(ASI),FPSA,TPSA and FPSA/TPSA were compared between the prostatic cancer group and the control group;binary Logistic stepwise regression was used to establish the combined prediction regression model of prostatic cancer in gray area of PSA;the receiver operating characteristic(ROC)curve was used to analyze the diagnostic value of PSI,FPSA/TPSA alone and in combination for prostatic cancer in gray area of PSA.Results The elastic imaging score,PSI and ASI in the prostatic cancer group were significantly higher than those in the control group,and the differences were statistically significant(P<0.05).The FPSA level and FPSA/TPSA in the prostatic cancer group were significantly lower than those in the control group,and the differences were statistically significant(P<0.05).In the binary Logistic stepwise regression analysis,the joint prediction regression model:Logit(P)=-3.366+0.298×PSI-17.871×FPSA/TPSA.The ROC curve showed that PSI combined with FPSA/TPSA had the highest area under curve(AUC)of 0.916 in the diagnosis of prostatic cancer in gray area of PSA.Conclusion Real-time tissue elastography PSI combined with FPSA/TPSA has a higher diagnostic value for prostatic cancer in gray area of PSA and is worthy promotion and application in clinic.
Objective To investigate the effect of non-steroidal drugs preemptive analgesia combined with continuous passive motion(CPM)treatment on functional recovery after total hip arthroplasty in patients with traumatic osteoarthritis of the hip.Methods A total of 53 patients with traumatic osteoarthritis of the hip admitted from May 2016 to June 2021 were selected as the research objects.Among them,21 patients from May 2016 to December 2017 were not given preoperative oral analgesia and postoperative CPM treatment(control group),and 32 patients from January 2018 to June 2021 were given preoperative oral analgesia and postoperative CPM treatment(observation group).The therapeutic effects of the two groups were compared.Results The postoperative hospital stay in the observation group was less than that in the control group,and the Visual Analogue Scale(VAS)score on the 1st and 3rd day after operation were lower than those in the control group(P<0.05).There was no incision infection and deep vein thrombosis in the observation group;in the control group,there were 1 case of incision infection and 2 cases of deep vein thrombosis.At 3 and 7 d after operation,the Harris Hip Score(HHS)score of the observation group was higher than that of the control group(P<0.05).At 5,7 and 14 d after operation,the score of Short Physical Performance Battery(SPPB)in the observation group was higher than that in the control group(P<0.05).At 5,7 and 14 d after operation,the timed stair climb(TSC)of the observation group was shorter than that of the control group(P<0.05).Conclusion Non-steroidal drugs preemptive analgesia combined with postoperative CPM treatment can effectively reduce early postoperative pain in patients with traumatic osteoarthritis of the hip,improve early postoperative joint function and hip muscle coordination stability.
Objective To investigate the effects of VECTOR periodontal therapy instrument combined with high-strength fiber band on periodontal condition,oral function and aesthetics in patients with severe periodontitis and tooth loosening.Methods From January 2021 to September 2022,60 patients with severe periodontitis and tooth loosening in our hospital were selected as the research objects.According to the different treatment methods,the patients were divided into control group(30 cases,curettage combined with high-strength fiber band treatment)and observation group(30 cases,VECTOR periodontal therapy instrument combined with high-strength fiber band treatment).The therapeutic effects of the two groups were compared.Results The total effective rate of treatment in the observation group was higher than that in the control group(P<0.05).After treatment,the probing depth(PD),plaque index(PLI)and gingival index(GI)scores in the two groups decreased,and those in the observation group were lower than the control group(P<0.05).After treatment,the bite force and chewing efficiency of the two groups increased,and those in the observation group were higher than the control group(P<0.05).After treatment,the scores of fixed function,chewing function,pronunciation function and comfort degree in the two groups increased,and those in the observation group were higher than the control group(P<0.05).After treatment,the scores of Pink Esthetic Score(PES)and White Esthetic Score(WES)in the two groups increased,and those in the observation group were higher than the control group(P<0.05).Conclusion VECTOR periodontal therapy instrument combined with high-strength fiber band can improve the periodontal condition and oral function of patients with severe periodontitis and tooth loosening,and improve the oral aesthetics,which has significant curative effect and is worthy of promotion.
Objective To explore the influences of edaravone combined with torasemide on antioxidant indexes and inflammatory factors levels in patients with acute cerebral hemorrhage.Methods A total of 136 patients with acute cerebral hemorrhage admitted from June 2017 to June 2020 were selected as the study objects,and randomly divided into control group(68 cases,routine treatment)and study group(68 cases,edaravone combined with torasemide on the basis of routine treatment).The therapeutic effects of the two groups were compared.Results The total effective rate of treatment in the study group was 95.6%,which was higher than 83.8%in the control group(P<0.05).After treatment,the levels of nitric oxide(NO),superoxide dismutase(SOD)and glutathione peroxidase(GSH-Px)in the two groups were higher than those before treatment,and those in the study group were higher than the control group(P<0.05).After treatment,the levels of C-reactive protein(CRP),tumor necrosis factor-α(TNF-α),interleukin-6(IL-6)and interleukin-8(IL-8)in the two groups were lower than those before treatment,and those in the study group were lower than the control group(P<0.05).After treatment,the whole blood low shear viscosity(WLV),whole blood middle shear viscosity(WMV),whole blood high shear viscosity(WHV),plasma viscosity(PV),packet cell volume(PCV)and erythrocyte sedimentation rate(ESR)in the two groups were lower than those before treatment,and those in the study group were lower than the control group(P<0.05).Conclusion The edaravone combined with torasemide in the treatment of patients with acute cerebral hemorrhage has a significant effect.
Objective To explore the effects of traditional Chinese medicine Kushen decoction wet compress combined with traditional Chinese medicine emotional intervention on wound healing and pain degree of patients with mixed hemorrhoids after procedure for prolapse and hemorrhoids(PPH).Methods A total of 80 patients with mixed hemorrhoids after PPH admitted from January 2021 to April 2022 were selected as the research objects.According to the nursing plan,the patients were divided into control group and observation group,with 40 cases in each group.The control group was given routine nursing intervention,and the observation group was given traditional Chinese medicine Kushen decoction wet compress combined with traditional Chinese medicine emotional intervention on the basis of the control group.The intervention effects of the two groups were compared.Results The grade A healing rate of the observation group was higher than that of the control group,and the wound healing time and the disappearance time of anal bulge were shorter than those of the control group,the differences were statistically significant(P<0.05).At 48 h and 7 d after intervention,the scores of Visual Analogue Score(VAS)and wound edema in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).After 7 d of intervention,the scores of Self-Rating Anxiety Scale(SAS)and Self-Rating Depression Scale(SDS)in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).Conclusion Traditional Chinese medicine Kushen decoction wet compress combined with traditional Chinese medicine emotional intervention applied in postoperative nursing of mixed hemorrhoids PPH can improve the psychological state of patients,relieve pain and wound edema,and promote wound healing,which is worthy of promotion.
Objective To investigate the application effect of double guide wire technique combined with transpancreatic papillary sphincterotomy in patients with difficult intubation of endoscopic retrograde cholangiopancreatography(ERCP)and its influences on stress response and success rate of intubation.Methods From January 2019 to January 2022,90 patients with difficult intubation of ERCP were selected as the research objects,and the patients were divided into control group(n=45)and observation group(n=45)according to the random number table method.The control group was given conventional transpancreatic papillary sphincterotomy,and the observation group was given double guide wire technique on the basis of the control group.The therapeutic effects of the two groups were compared.Results At intubation(T1)and 5 min after intubation(T2),the levels of cortisol(Cor)and epinephrine(E)in the observation group were lower than those in the control group(P<0.05).The success rate of intubation in the observation group was significantly higher than that in the control group,and the time of successful intubation was significantly shorter than that in the control group(P<0.05).The incidence of postoperative pancreatitis in the observation group was significantly lower than that in the control group(P<0.05).Conclusion The double guide wire technique combined with transpancreatic papillary sphincterotomy applied in patients with difficult intubation of ERCP is helpful to reduce the body stress response,improve the success rate of intubation,shorten the time of successful intubation,and reduce the incidence of postoperative pancreatitis,which is worthy of promotion.
