Prostate diseases,male infertility,sexual dysfunction and other male diseases are highly prevalent in men and seri-ously affect their quality of life,causing significant impacts on their physical and mental health.According to the theory of"brain-heart-kidney-essence chamber(BHKE)"axis,the brain,heart,kidney and essence chamber are linked by meridians,based on es-sence and blood,and guided by spirit,which are interconnected to form an organic whole as the main axis for the pathogenesis,diag-nosis and treatment of male diseases.At present,considerable progress has been made in the application and development of the"BH-KE"axis theory in the treatment of male diseases in Chinese medicine,but the interpretation of its scientific connotation is not suffi-cient enough and its biological basis lacks further clarification.This review explores into the biological basis of the maladjusted BHKE axis in different male diseases,such as chronic prostatitis,BPH,male infertility,ED,premature ejaculation,from the perspectives of the nerves,endocrine,immune system,and micro-environment,aiming to provide some evidence for further in-depth studies of the scientific connotation and application value of the"BHKE"axis theory in the treatment of male diseases.
Background To implement the spirit of the 20th National Congress of the Communist Party of China and the Opinions on Promoting the Inheritance, Innovation, and Development of Traditional Chinese Medicine (TCM), regularly summarize the research results of TCM, present the academic progress on TCM dynamically, and fully leverage the academic leadership of academic groups, the China Association of Chinese Medicine organized the selection of the top 10 academic progress on TCM in 2022. The selection process adhered to 4 orientations, eliminated any biases, highlighted the solutions to clinical problems, answered scientific questions, and led the industry’s development. It reflected an exploratory and forward-looking approach, emphasizing innovation and breakthroughs. The selection focused on new laws, new discoveries, new methods, new products, and new theories in the field of basic research and applied basic research in TCM. Through a process of dynamic collection, preliminary examination, review, and final judgment, the top 10 academic progress of TCM in 2022 were determined.
Background: No comprehensive meta-analysis has evaluated the efficacy and safety of the protective effect of Jiedu Tongluo Therapy on the kidney of DKD until now. This meta-analysis covers this gap in knowledge. Methods: We have conducted an extensive search of databases, including CNKI, Wanfang, PubMed, and Web of Science. The selection was based on conventional treatment, including information and education on DKD, blood glucose, hypertension control methods, and lifestyle. The control group was composed of conventional western medicine or proprietary Chinese medicine, and the experimental group was composed of Jiedu Tongluo therapy controlled trials (RCTs) between 2003 and 2023. R 4.1.0 software was used to perform statistical analysis. Results: A total of 1871 patients from 19 RCTs were analyzed. Meta-analysis results showed that the Jiedu Tongluo therapy was effective in improving clinical efficacy (OR = 2.47, 95% CI [1.94, 3.15], I 2 = 0%), and these trials were more effective in reducing Scr (MD = -19.81, 95% CI [-27.64, -11.97], p < 0.01), BUN (MD = -0.70, 95% CI [-1.13, -0.27], p < 0.01), UAER (MD = -29.97, 95% CI [-37.33, -22.61], p < 0.01), FBG (MD = -0.85, 95% CI [-1.22, -0.47], p < 0.01), and certain medication safety (OR = 0.75, 95% CI [0.27, 2.11]). Conclusions: For treating diabetic kidney disease, TCM-based Jiedu Tongluo therapy showed optimal clinical efficacy and safety. However, further rational experiments are needed to validate the above conclusions.
溃疡性结肠炎(UC)主要发生于结直肠,该病病理机制复杂,与肠道的不可控性炎症反应密切相关.当前,西医主要使用糖皮质激素、免疫抑制剂等减轻肠道炎症,虽然可以在一定程度上阻遏UC的进展,但不良反应较大.越来越多研究证实,中医药防治UC具有明显的优势,可显著降低该病复发率.细胞焦亡是一种新型细胞死亡方式,可破坏细胞结构,释放胞内促炎物质,介导UC肠道免疫反应.研究人员认为中医药对细胞焦亡的干预主要表现为促进细胞焦亡(损其有余)和抑制细胞焦亡(补其不足),这与调节阴阳相一致.其中,中药主要通过抑制细胞焦亡(补其不足),减轻肠道免疫反应,起到治疗UC的作用.近年来,业界开展了大量研究探索中药通过调控NOD样受体热蛋白结构域相关蛋白3(NLRP3)焦亡通路治疗UC的作用机制,结果表明NLRP3焦亡通路是中药治疗UC的关键靶通路.但目前尚缺乏关于中药抑制NLRP3焦亡通路进而治疗UC的全面系统的总结.该文以"细胞焦亡""NLRP3""溃疡性结肠炎"及"中药"等为关键词,检索和分析近年来该领域中英文文献,发现调控NLRP3焦亡通路的中药主要包括清热燥湿类、调和气血类、行气通腑类和健脾祛湿类,这可为科研人员更为全面认识中医药对UC中NLRP3焦亡通路的机制提供帮助,以期为UC的治疗及进一步的药物开发提供理论依据.
Objective:To explore the quality differences between steamed products and raw products of Citri Reticulatae Pericarpium（CRP）.Method:The color of steamed products and raw products of CRP was determined from the perspective of appearance by electronic eye technique,and the quality differences between them was objectively characterized by the luminous value（L * ）,yellow-blue value（b * ）,red-green value（a * ） and total chromatic value(E ab * ).Based on this,ultra-high performance liquid chromatography（UPLC） was used to establish a fingerprint evaluation method with the mobile phase of acetonitrile（A）-0.1%formic acid aqueous solution（B） for gradient elution（0-5 min,5%A;5-30 min,5%-20%A;30-60 min,20%-52%A）,detection wavelength at 270 nm,flow rate of 0.3 m L·min -1 and column temperature of 30℃.The quality differences between steamed products and raw products of CRP were compared from the perspective of chemical composition,and correlation analysis was used to reveal the correlation between the difference in appearance color and the difference in internal chemical composition.Result:After being steamed,L * ,b * and E ab * of CRP showed an overall decreasing trend,indicating that the color of the steamed products darkened and deepened from yellow to blue but still tended to be yellow,while a * showed an overall increasing trend,indicating that the color of the steamed products tended to red.A total of 24 peaks were identified in the fingerprint profiles of raw products and steamed products of CRP,and 13 of the main peaks were identified.The precision,stability and repeatability studies showed that compared with the reference peak （peak 14,hesperidin）,the relative standard deviations（RSDs） of the relative peak area and relative retention time of the remaining peaks were＜3.0%.The results of chemometric statistical analysis showed that there were some differences between raw products and steamed products of CRP,and 7 main differential components were identified,among which 5-hydroxymaltol（peak 1） and 5-hydroxymethylfurfural（peak 2） were the characteristic components of steamed products.The correlation analysis results showed that,in addition to the above two characteristic components,four components of peak 4,peak 10 （vicenin-2）,peak 23 （tangeretin） and peak 24 （5-demethylnobiletin） also correlated significantly with the color change (E ab * ) of the samples （P＜0.05,P＜0.01）.Conclusion:Before and after steaming,not only the chemical composition changes,but also the color.Comparing the characteristic peaks of chemical composition difference and color difference before and after steaming of CRP,it is found that5-hydroxymaltol,5-hydroxymethylfurfural and peak 4 are common characteristic difference components,which can provide a reference for establishing the characteristic quality control method of steamed products,and quickly evaluating the quality difference between raw products and steamed products of CRP.
