Objective To investigate the clinical value of joint detection of six tumor markers in patients with colorectal cancer. Methods Eighty?six patients with colorectal cancer were included in the study group,86 healthy subjects were selected as the control group at the same period. The difference of tumor markers in different groups,tumor stages and prognosis were compared. Results The levels of carcinoembryonic antigen (CEA),carbohydrate antigen 19?9 (CA19?9),carbohydrate antigen 242 (CA242),carbohydrate antigen 72?4 ( CA72?4) , carbohydrate antigen 125 ( CA125 ) and carbohydrate antigen 50 ( CA50 ) in study group were significantly higher than those in the control group (CEA: (22. 5±6. 2)μg/L vs. (2. 2±1. 0)μg/L;CA19?9:(95. 7±27. 3) U/ml vs. (17. 1±9. 5) U/ml;CA242:(29. 5±8. 3) U/ml vs. (6. 0±2. 7) U/ml;CA72?4:(21. 6 ±5. 1) U/ml vs. (3. 6±1. 2) U/ml;CA125:(95. 4±32. 8) U/ml vs. (18. 9±8. 4) U/ml;CA50:(51. 8±20. 6)μg/L vs. (8. 3±3. 7)μg/L,t=29. 98,25. 22,24. 97,31. 86,20. 95,19. 27,P<0. 05). Among the single index detections,the sensitivity and negative predictive value of CA72?4 were the highest ( 61. 6%, 68. 3%) , the specificity of CA19?9 was the highest( 91. 9%) ,the positive predictive value of CEA was the highest ( 80. 4%) . The sensitivity,positive predictive value and negative predictive value of the joint detection were all higher than those in each single index detection (80. 3%,87. 3%,74. 1%). The levels of CEA,CA19?9,CA242,CA72?4, CA125 and CA50 in patients with stage III and IV were significantly higher than those in patients with stageⅠandⅡ(CEA:(32. 7±7. 1)μg/L vs. (15. 9±4. 4)μg/L;CA19?9:(127. 8±33. 7) U/ml vs. (52. 5±13. 8) U/ml;CA242:(40. 3±12. 7) U/ml vs. (23. 5±8. 6) U/ml;CA72?4:(37. 6±10. 2) U/ml vs. (13. 6±4. 1) U/ml;CA125:(128. 9±38. 4) U/ml vs. (59. 7±12. 8) U/ml;CA50:(88. 3±23. 7)μg/L vs. (41. 8±15. 6)μg/L,t=13. 04,13. 32,7. 11,14. 06,10. 99,10. 64,P<0. 05) . The levels of CEA,CA19?9,CA242,CA72?4,CA125 and CA50 in the recurrent metastasis group were significantly higher than those in the non?recurrent metastasis group ( CEA:( 37. 7 ± 8. 6 ) μg/L vs. ( 3. 8 ± 1. 7 ) μg/L;CA19?9:( 110. 5 ± 29. 4 ) U/ml vs. ( 25. 5 ± 13. 8 ) U/ml;CA242:( 33. 6 ± 10. 3 ) U/ml vs. ( 15. 5 ± 6. 6 ) U/ml;CA72?4:( 33. 1 ± 15. 3 ) U/ml vs. ( 9. 3 ± 3. 0 ) U/ml;CA125:(113. 4±31. 7) U/ml vs. (28. 7±7. 8) U/ml;CA50:(55. 4±14. 6)μg/L vs. (16. 8±9. 6)μg/L,t=29. 04,18. 31,9. 86,11. 47,19. 28,14. 65,P<0. 05) . Conclusion The joint detection of six markers can further improve the sensitivity, positive predictive value and negative predictive value of diagnosis, and can provide a more reliable basis for the auxiliary diagnosis of colorectal cancer.
临床医学实习生在实习阶段的党员教育管理工作是不可或缺的内容,为了实习生党员接受党组织的管理、教育和监督,避免实习生党员处于"脱管"状态,学校应做到全员全过程全方位育人,使实习生党员理想信念更坚定,行为举止更规范,更能守得住初心.文章分析现阶段医学院校实习生党员党性教育存在的主要问题,在互联网+时代背景下,从实习生党员党性教育出科成绩形成性评价机制入手,创建了线上、线下实习生党员科学、合理、务实的医校共管机制,增强育人实效,为医学院校培养党性坚强、信仰坚定、医德高尚、医术精湛的医务工作者提供指导作用.
目的 首先对规范化培训护士(也称规培护士)对组织的认同程度状况进行调查,并对其成就动机进行分析,找出两者之间的关系,由此得出的结论可供后续学习者和医学研究者参考使用,特别是在规培方面的教学与实践过程中能发挥应有的作用.方法 采用随机抽样法选取 2022年 6-7 月参与广西 15 所三甲医院规培的护士为研究对象,一共有 224 名护士参与研究分析,采用一般资料调查表、组织认同量表、成就动机量表进行问卷调查.结果 规培护士组织认同总均分(5.62±0.41)分,成就动机各维度均分为(0.61±0.16)分,规培护士组织认同与成就动机呈正相关(r=0.603,P＜0.05);学历、职称、组织认同的归属性认同及成功性认同是影响规培护士成就动机的主要因素.结论 在规范化培训过程中护理管理者应重视组织认同提升培训策略,以提升护士的成就动机,从而促进护士职业稳定.
目的 在内科护理实训教学中引入学生标准化病人,探讨对护士核心胜任力的影响.方法 随机选取 2021 年 9月至 2022 年 6 月江西卫生职业学院 2020 级三年制高职护理两个班护生,分别为试验组(128 名)和对照组(125名).试验组采用基于学生标准化病人的案例情景模拟教学法,对照组采用案例情景模拟教学法.实训前后对两组护生进行护士核心胜任力评定及成绩考核.结果 实训前,两组的综合成绩和护士核心胜任力评分差异无统计学意义(P＞0.05),具有可比性.实训后,试验组的核心胜任力总分、良好的个人特质、临床护理能力、支持和人际沟通能力、批判性临床思维能力以及综合成绩均高于对照组,差异有统计学意义(P＜0.05).结论 在内科护理教学中开展基于学生标准化病人的案例情景模拟教学,能够提升护士核心胜任力,改善成绩,提高教学效果.
党二十大报告强调"立德树人"是高校建设的根本任务,"双一流"建设的根本任务是建立世界一流的高素质人才方阵,而培养具有国际竞争力的创新后备军、德才兼备的师资队伍是"深入实施人才强国战略"的重要保证.文章结合医药高校的特点,从价值观偏移、缺乏敬业精神、重科研轻育人、重实操轻医德培养四个方面,分析了"双一流"建设背景下医德、师德师风建设中存在的问题.然后,文章总结其他医药高校的成功经验,针对上述问题,从发挥教师主体作用、强化敬业精神以及育人使命并有效利用名师示范工程表率效应、建立平衡教研的多元业绩考核体系、构建监督防控体系四个方面,提出符合医药高校特点的实施策略,以期为医药高校"双一流"建设助推加力.
