Objective To explore autophagy-related genes(ARGs)in lung adenocarcinoma and con-struct a prognostic model for lung adenocarcinoma based on ARGs.Methods RNA high-throughput tran-scriptome data of lung adenocarcinoma were obtained from The Cancer Genome Atlas(TCGA)database and HADb database to acquire ARGs.A prognostic model for lung adenocarcinoma was constructed and validated based on differentially expressed ARGs,followed by the construction of column line graphs and calibration curves to explore the clinical application value of the model.Gene ontology and Kyoto Encyclopedia of Genes and Genomes enrichment analyses were performed on differentially expressed ARGs.Lasso regression analysis was conducted on differentially expressed ARGs with prognostic significance to construct the prognostic model for lung adenocarcinoma.Kaplan-Meier survival curves were plotted.Results A total of 31 differentially expressed ARGs were obtained,and 10 differentially expressed ARGs with prognostic signifi-cance were selected.Patients in the high-risk group were significantly associated with poorer overall survival,with statistical significance(P<0.05).T stage,N stage and risk score was an independent prognostic factor for patients with lung adenocarcinoma.The global consistency of the calibration curve column line graph was 0.710,indi-cating a high level of agreement between the model's predicted results and actual outcomes.Conclusion The risk model constructed based on differentially expressed ARGs can serve as a prognostic feature for patients with lung ade-nocarcinoma or provide a reference for individualized treatment for patients with lung adenocarcinoma.
Objective To explore the effect of health education and nursing based on information-motiva-tion-behavior(IMB)model in inpatients with cerebral hemorrhage.Methods A total of 86 inpatients with intracerebral hemorrhage treated in Department of Neurosurgery,Hanzhong Central Hospital from January 2020 to December 2022 were selected as the research objects,and they were divided into a control group and a study group according to random number table method,with 43 cases in each group.Patients in the control group received routine health education and nursing,and those in the study group received health education and nursing based on IMB model.Before discharge,the compliance of rehabilitation exercise and the scores of Fugl-Meyer Motor Function Assessment(FMA),Self-rating Anxiety Scale(SAS),and Self-rating Depression Scale(SDS)before and after nursing were compared between the two groups.Results The compliance of rehabilitation exercise in the study group was 97.67%,significantly higher than 79.07%in the control group(P<0.05).Before nursing,there were no statistically significant difference in FMA scores of upper and lower limbs between the two groups(P>0.05);after nursing,the FMA scores of upper limbs and lower limbs of the study group were(40.30±3.91)points and(20.55±2.69)points,which were significantly higher than(35.26±3.27)points and(16.71±2.67)points of the control group(P<0.05).Before nursing,there were no significant dif-ference in SAS and SDS scores between the two groups(P>0.05);after nursing,the SAS and SDS scores of the study group were(32.34±7.92)points and(33.28±6.83)points,which were significantly lower than(46.36±8.47)points and(46.36±7.54)points of the control group(P<0.05).Conclusion The application of health education and nursing based on IMB model in inpatients with cerebral hemorrhage can improve patients'compliance with rehabilitation exercise,speed up the recovery of limb function,and effectively improve their psychological state,which is worthy of clinical pro-motion and application.
Objective To study the application of intravoxel incoherent motion(IVIM)imaging and diffusion kurtosis imaging(DKI)in the grading of glioma.Methods The clinical data of 82 patients with brain glioma diagnosed by surgery and puncture pathology in Xianyang Hospital of Yan'an University from May 2022 to April 2023 were ana-lyzed retrospectively,including 12 cases of grade Ⅰ,26 cases of grade Ⅱ,25 cases of grade Ⅲ,and 19 cases of gradeⅣ.All patients underwent conventional MRI plain scan,IVIM,and DKI before operation.IVIM sequence applied 8 groups of b values:0 s/mm2,50 s/mm2,100 s/mm2,150 s/mm2,200 s/mm2,400 s/mm2,800 s/mm2,and 10 000 s/mm2.DKI adopts 30 directions,and b values were 0 s/mm2,1 000 s/mm2,and 2 000 s/mm2.The original data of IVIM and DKI are processed and analyzed by post-processing software,and combined with plain scan and enhanced images,the true dispersion coeffi-cient(D)diagram,perfusion fraction(f)diagram,and false dispersion coefficient(D*)diagram,as well as the parameters of average dispersion coefficient(MD),anisotropic fraction(FA),average dispersion kurtosis(MK),axial kurtosis(AK),and radial kurtosis(RK)are obtained.Receiver operating characteristic(ROC)curve of IVIM and DKI was drawn,and the area under the curve(AUC)was calculated.Results The D*values of tumor areas in patients with gradeⅠ,Ⅱ,Ⅲ,and Ⅳ gliomas were(2.03±0.52)×10-3 mm2/s,(3.32±0.68)×10-3 mm2/s,(4.63±0.82)×10-3 mm2/s,(7.15±0.61)×10-3 mm2/s,respec-tively;the MK values were 0.71±0.14,0.86±0.19,1.03±0.18,and 1.25±0.23,respectively;the higher the grade of glioma,the higher the level of D*and MK,with statistically significant difference(P<0.05).The AUC of D*value and MK value in differentiating high-grade gliomas were 0.840 and 0.821,respectively,indicating that both D*value and MK value had high diagnostic efficiency in differentiating high-grade gliomas.Conclusion There are significant differences in D*value and MK value of patients with different grades of glioma.The tumor of glioma can be accurately graded by IVIM and DKI scanning and related parameters,which can provide important reference for clinical diagnosis and prognosis evaluation.
Objective To investigate the incidence of primary aldosteronism(PA)in hypertensive patients with acute ischemic stroke as the first symptom in Yuhuan,Zhejiang Province,and to analyze its clinical characteristics.Methods A total of 150 hypertensive patients with acute ischemic stroke as the first symptom admitted to the Inpatient Department of the Second People's Hospital of Yuhuan from January 2018 to December 2022 were selected for PA screening.Non-recumbent position aldosterone and renin activities were detected from 8:00 to 10:00 in the morn-ing,and aldosterone renin ratio(ARR)was calculated.Patients with positive ARR were given saline load test,and patients positive in saline load test was confirmed as PA.Adrenal morphology was evaluated by CT scan in pa-tients with PA.Results Among the 150 patients,23(15.33%)were diagnosed with PA,8(34.78%)were combined with hypokalemia,4(17.39%)were diagnosed with adrenal adenoma by CT,13(56.52%)were diagnosed with bilateral adrenal hyperplasia,and 5(21.74%)were diagnosed with unilateral adrenal hyperplasia.There was no obvious adrenal CT lesion in 1 patient(4.35%).There were 20 patients(86.96%)with grade 3 hypertension and 3 patients(13.04%)with grade 2 hypertension in PA.Conclusion In Yuhuan area of Zhejiang Province,the prevalence rate of PA among hyper-tensive patients with acute ischemic stroke as the first symptom was 15.33%,the proportion of grade 3 hypertension in patients with PA was as high as 86.96%,and the proportion of hypokalemia was only 34.78%.The proportions of adeno-ma,bilateral adrenal hyperplasia and unilateral adrenal hyperplasia were 39.13%,34.78%,and 21.74%,respectively.
In recent years,many studies have found that the core antibody detection of hepatitis B virus is relat-ed to the response to antiviral drug treatment,the differentiation of different natural history periods of chronic hepatitis B,and Hepatitis B(HBV)reactivation after immunosuppressive treatment.It is expected to become an important refer-ence index for initiating antiviral therapy,predicting efficacy and judging prognosis,and has great clinical application po-tential.This paper summarizes the latest research progress and clinical significance of the detection of hepatitis B virus core antibody(anti-HBc),so as to provide some help for the early realization of accurate and individualized treatment of chronic HBV infected patients.
