Objective To investigate the clinical characteristics of patients with tumor-like calcinosis(TC)in rare diseases and analyze the associated risk factors.Methods We collected clinical data and laboratory data on 25 patients with TC at Nanfang Hospital from January 2001 to August 2021.All the patients were diagnosed by surgical pathology.The clinical,imaging and pathological features were analyzed.Eleven hospitalized patients with complete clinical data and eleven age-and gender-matched healthy controls were enrolled into the study.The clinical and biochemical characteristics of TC patients were analyzed and summarized to explore the potential risk factors associated with the development of TC.Results X-ray of patients often showed high-density calcifications in soft tissues and MRI showed short T1 and long T2 signal shadows.The tumor exhibited uneven signal intensity,with clear boundary,and the local areas may be connected to the synovial capsule.Compared with healthy people,the serum uric acid levels were significantly increased in TC patients(P=0.038).The serum uric acid levels were positively correlated with the prevalence of TC,and the risk of TC increased by threefold(RR=3,95%CI:1.041-8.646).In addition,the product of serum phosphorus and calcium-phosphorus ratio in TC patients with hyperphosphatemia was increased significantly to the healthy population P<0.05).Hyperphosphatemia increased the risk of TC by 3.2-fold(RR=3.2,95%CI:1.547-6.619).Conclusion High serum phosphate and uric acid increased the risk of TC.Therefore,it was important to make a differential diagnosis between TC patients and patients with hyperuricemia or hyperphosphatemia.A comprehensive consideration,including age of disease onset,blood phosphorus concentration,past medical history,imaging,and pathological diagnosis could help to reduce the rate of misdiagnosis.
Objective To explore the correlation between clinical diagnosis and prognosis in patients with acute pulmonary thrombus embolism(PTE)using multi-mode imaging.Methods Fifty-five patients with PTE confirmed in Beijing Hospital of Traditional Chinese Medicine from January 2018 to January 2022 were evaluated retrospectively.Echocardiography,two-dimensional speckle tracking imaging,ultrasound,computer tomography pulmonary angiography(CTPA)and lab marker,including D-dimer,NT-pro brain natriuretic peptide(NT-proBNP)and C-reactive protein results were reviewed.55 patients with PTE were ranked 5 classes according to CTPA results.Associations and correlations between CTPA classes of D-dimer,NT-proBNP,C-reactive protein,velocity of tricuspid regurgitation(VTR),pulmonary systolic pressure(PAPS)and longitudinal strain in right ventricular free wall(RLS)were analysed.Results NT-proBNP,VTR and PAPS showed a gradually increased trend with increased CTPA class and the absolute value of RLS showed a gradually decreased trend with increased CTPA class.The statistical difference among CTPA grading groups was significant(P<0.05).Positive correlations were found between increased NT-proBNP,VTR,PAPS,decreased absolute value of RLS with higher CTPA class(r=0.25,0.24,0.32,0.28,P<0.05).Conclusion Increased NT-proBNP,VTR,PAPS and RLS are significantly associated with the severity of acute PTE patients,which has important clinical value for the diagnosis,treatment and prognosis evaluation of acute PTE patients..
Objective To analyze the current status and hot issues in the field of Obstructive sleep apnea hypopnea syndrome(OSAHS)imaging research.Methods The literature on imaging studies of OSAHS in the Web of Science core database from the establishment of the database to September 2023 was retrieved,and CiteSpace 6.1.R6 software was used for visual analysis.Results A total of 1016 articles were retrieved,and the number of publications showed a fluctuating upward trend.The research countries/regions were concentrated in the United States,China and Turkey.The main journals were Sleep,Am J Resp Crit Care and Chest.210 research institutions,represented by Univ Calif Los Angeles,Stanford Univ,Capital Med Univ,etc.There were 331 researchers,represented by Kumar R,Harper RM,Macey PM,Woo MA,Yan-go FL,etc.Keyword analysis suggested that the current research hotspots were related research on OSAHS imaging diagnostic techniques,OSAHS multi-disease coexistence,and the pathogenesis of OSAHS comorbidity.Conclusion At present,OSAHS imaging research in China has gradually become a hot spot,but the cooperation between clinical research institutions needs to be strengthened.The new technology of OSAHS imaging diagnosis needs more research and verification with larger samples and more standardized methods.The research on the reverse relationship between OSAHS and comorbidity,the study of different pathogenic mechanisms,and the combination of neuroimaging markers and negative cognitive results need to be strengthened.
Cardiovascular disease is one of the leading causes of death and disease burden worldwide.Accurate evaluation of myocardial viability is helpful for clinical decision-making and has important prognostic value for patients with cardiovascular disease.Positron-emission tomography(PET)has good image quality and high diagnostic accuracy with known or suspected coronary artery disease.The value of classical PET myocardial perfusion and metabolic imaging in evaluating myocardial viability has been recognized.At present,the image analysis of PET myocardial viability assessment mainly relies on visual assessment or semi-quantitative scoring.With the promotion and application of automatic analysis by various software,the inclusion of quantitative indicators provides more valuable reference information for clinical practice.Continuous advances in software and technical equipment have also facilitated better use of PET in assessing myocardial viability.The rise of artificial intelligence technology and the exploration and application of integrated PET/MR provide new means for PET myocardial viability imaging and image interpretation,but the opportunities of new technology are accompanied by challenges as well.This review briefly describes the common software,image display,different image analysis methods and progress in PET myocardial viability assessment.
Objective To analyze the clinical manifestations and radiographic features of desmoplastic fibroma(DF).Methods The clinical and imaging findings of 17 patients with DF were retrospectively analyzed,including 11 male patients and 6 female patients,with the age ranged from 4-64 years old and a mean age of 20.27 years old.17 patients underwent CT examination(enhanced scan for 16 cases,non-enhanced CT for 1 case).5 patients underwent enhanced MR examination.Results The main clinical manifestations were painless mandibular mass and restricted mouth opening among 17 patients.All cases were in the mandibles,mainly located in the corner of the mandibles.CT images revealed expansile osteolytic lesions and partial compression bone destruction,central or eccentric growth,with soft tissue masses.All cases had"tree root-like"bone ridges.The lesions were divided into 2 types based on the different patterns of bone destruction:osteolytic type(n=12)and parosteal type(n=5).Lesions showed moderate/marked enhancement after contrast-enhanced scanning.All cases have no calcification and periosteal reaction.MR showed isointense or hypointense on T1 weighted images,hyperintense on T2 weighted images.The mean ADC value was 1.2×10-3 mm2/s.The time-signal intensity curve type of 3 cases was type Ⅰ,and 2 cases with type Ⅱ indicating benign tumor.Conclusion DF is invasive and prone to recurrence.By combining CT,MR and functional examinations,it is possible to reflect the tissue composition of the lesions,and provide important evidence for the accurate preoperative diagnosis.
