Objectives: The aim of this study was to investigate the feasibility of contrast-enhanced ultrasound (CEUS)-guided microwave ablation for managing iatrogenic hepatic hemorrhage following percutaneous liver puncture. Materials and methods: This retrospective study analyzed six patients (5 males, 1 female; mean age 56.8 ± 12.3 years) with CEUS-confirmed active hepatic hemorrhage refractory to 10 min compression and Agkistrodon halflorum hemagglutinase administration after percutaneous liver puncture (2023-2024). Etiologies included portal vein cavernous transformation (n = 4) and therapeutic intervention complications (n = 2). All patients underwent CEUS-guided microwave ablation comprising three phases: bleeding site localization, real-time ultrasound-guided ablation, and immediate postprocedural verification (CEUS: n = 6; DSA: n = 2). The protocol was approved by the institutional ethics committee with written informed consent. Results: All six patients achieved immediate hemostasis (mean 2.8 min) through CEUS-guided microwave ablation with 100% technical/clinical success. Preprocedural localization combined color Doppler and CEUS, while intraoperative real-time guidance ensured precise microwave needle placement. Post-ablation verification relied on CEUS (n = 6) with DSA confirmation in two cases. No major complications occurred; one patient reported transient abdominal pain resolving spontaneously. All patients remained stable during 7-day follow-up with no delayed complications. Conclusions: This study suggests that CEUS-guided microwave ablation is a rapid, minimally invasive, and effective option for iatrogenic hepatic hemorrhage, warranting further validation in larger cohorts.

Solid solution material Li1.2Ni0.16Co0.08Mn0.56O2 (0.5Li2MnO3∙0.5LiNi0.4Co0.2Mn0.4O2) is obtained through rheological phase method and further treated in ammonium persulfate solution. The post-treatment significantly decreases the charging capacity above 4.5 V and enhances the columbic efficiency in the initial cycle. Along with the higher efficiency, the cycling stability and the rate capability both get improved. The improvement mechanism is investigated in terms of XRD, XPS, Raman spectrometry, and ICP-AES. The results confirm that (NH4)2S2O8 treatment leads to Li+ removal from Li2MnO3 component while the layered structure of the solid solution phase is well maintained. After being treated in 30% (NH4)2S2O8 solution, 95% columbic efficiency is observed on Li1.2Ni0.16Co0.08Mn0.56O2 in the first cycle and it also shows a near 200 mAh g−1 capacity at 4C current rate.

目的:探讨超声引导下经皮穿刺活检术对于周围型肺肿块及胸膜病变诊断的临床应用价值及适应证的选择和并发症的处理.方法:对628例经CT检查确诊的肺周围型肿块或明确的胸膜病变,先经常规超声检查了解病灶二维图像及血流分布情况,筛选后在超声引导下穿刺活检并送检.结果:628例中,肺周围型肿块570例,胸膜病变58例;627例穿刺成功,穿刺成功率99.8％;穿刺结果与术后病理结果诊断符合率达93.5％(587/628);并发症发生率5.09％(32/628).结论:超声引导下肺胸膜病变穿刺活检术诊断准确率高、简便易行、创伤小、并发症少、可操作性强,临床应用价值较高.

Objective To assess the value of transabdominal ultrasound-guided catheter drainage of postoperative lymphocysts in patients with pelvic malignancy. Methods 143 postoperative lymphocysts in 112 patients with pelvic malignancy were drained percutaneously using 8.5F Cook catheters under ultrasound guidance. Results The procedure was successful in all patients without complications. 142 lymphocysts were completely healed with cure rate of 99.3%. Only one recurred after three months. The duration of drainage ranged from 3 to 15 days (average:.5 days) totaling 270-3200 ml(average:.812 ml). Conclusion Transabdominal ultrasound-guided percutaneous drainage of pelvic lymphocysts is simple and safe with less pain , fewer complications , high cure rate , and low recurrence rate.

Neoadjuvant chemotherapy has been increasingly used to downstage breast cancer prior to surgery recently. However, in some cases, it was observed that despite sufficient regression of primary tumors, the metastatic lymph nodes remained nonresponsive. In this study, we applied lymphatic-targeted strategy to evaluate its efficacy and safety for patients presenting refractory nodes following systemic chemotherapy. A total of 318 breast cancer patients were demonstrated with lymph node metastasis by needle biopsy and given neoadjuvant chemotherapy. Two cycles later, 72 patients were observed with responsive tumors but stable nodes, 42 of which received a subcutaneous injection of lymphatic-targeted pegylated liposomal doxorubicin during the third cycle, while the remaining 30 patients were continued with former neoadjuvant therapeutic pattern and regarded as the control. Lymphatic-targeted treatment substantially increased both clinical and pathological node response rate [62 % (26/42) vs. 13 % (4/30) and 12 % (5/42) vs. 0 (0/30), respectively], and induced a higher apoptosis level of metastatic cells (median, 41 vs. 6 %), compared with the control. Moreover, a higher disease-free survival was observed after a median follow-up of 4 years (69 vs. 56 %). Inflammatory reaction surrounding injection sites was the most common side effect. Lymphatic chemotherapy has reliable efficacy and well-tolerated toxicity for breast cancer patients presenting refractory lymph nodes following neoadjuvant chemotherapy.

Objective:To investigate the value of high-frequency ultrasound-guided wire localization in the resection of non-palpable breast mass.Methods:Sixty-three patients with breast mass,which were diagnosed through ultrasound but non-palpable by surgeon,were selected.After ultrasound-guided wire localizations were performed,the mass were excised and sent to biopsies.Results:Sixty-three lesions were successfully localized and guide wires were located within the lesions.All lesions were accurately and completely removed without any complications such as hematoma,guide wire falling off and broken etc in all cases.The time needed for guide wire localization ranged from 3to 10min with an average of 5min. The time for surgical excision ranged from 15to 40min with an average of 25min.Conclusion:In the resection of non-palpable breast mass,ultrasound-guided wire localization can be performed simply and accurately,and can shorten the time for surgical excision and reduce gland damage in surgery.

The LiCo1-xSbxO2 (0<x<1) materials were prepared for the first time. Comparing with parent LiCoO2 sample, they show improved cycleability under higher upper limit potential, better rate capability and thermal stability. XRD, SEM and particle size analysis indicate that the introduction of Sb during preparation effectively suppress the particle growth and thus the “doping” phase shows reduced particle size. Moreover, XPS measurements tell that the added Sb is enriched in the layer near the particle surface. According to these observations, it is reasonable to believe that the mechanism of the performance improvement is attributed to some coating effect for LiCo1-xSbxO2 materials.

EDAX measurement reveals that the atomic ratio of Ti/(Ti + Co) is much higher than the mole feed ratios in the preparation for the LiCo0.99Ti0.01O2 material. XPS observation further tells that in LiCo0.998Ti0.002O2 phase with quite low Ti amount, almost no Ti can enter into the LiCoO2 lattice, it is more inclined to enrich in the particle surface. Electrochemical examinations show that the cycling stability of LiCo0.998Ti0.002O2 is as good as that of LiCoO2/LiCo0.99Ti0.01O2 composite between 3.0 and 4.3 V, and the latter has a better rate performance. It is considered that the difference of the high rate performance between the Ti-modified LiCoO2 materials is more likely to originate from the different particle characteristics, when their Ti amounts are low enough. (C) 2014 Elsevier B.V. All rights reserved.

Introduction Lithium rich layered material has attracted much attention because of its high capacity, however, the low effciency in the 1st cycle and poor rate property is a big issue for its practical use. We adopted a (NH 4 ) 2 S 2 O 8 treatment on Li 1.2 Ni 0.16 Co 0.08 Mn 0.56 O 2 material, the prodcut showed a greatly increased 1 st cycle efficinecy of above 90% and a capacity as high as 200mAh. g -1 at 4C rate. Experiment Li 1.2 Ni 0.16 Co 0.08 Mn 0.56 O 2 was prepared by a rheological method. Stoichiometric amount of Li 2 CO 3 , Ni(CH 3 COO) 2 ·4H 2 O, Co(CH 3 COO) 2 ·4H 2 O, Mn(CH 3 COO) 2 ·4H 2 O and oxalic acid were mixed. And then a proper amount of water was added. After stirring the mixture at 80-90 ºC for 4 h, it was dried at 120 ºC for 10 h, followed by annealing at 850 ºC for 20 h. (NH 4 ) 2 S 2 O 8 solution with different concerntration was used to treat the above Li 1.2 Ni 0.16 Co 0.08 Mn 0.56 O 2 sample, the product was named as 20%-RL,30%-RL, 40%-RL, 50%-RL according the different concerntration of (NH 4 ) 2 S 2 O 8 solution. Cycling test was conducted to evaluate the cyclcing stability and rate property of the products. The samples were characterized in terms of XRD, SEM, XPS and Raman measurement. Result and discussion The 1 st charge/discharge curves are compared in Fig.1. The pristine Li 1.2 Ni 0.16 Co 0.08 Mn 0.56 O 2 shows an intial caapcity of 224.0 mAh g -1 but with a low efficiency of 79%. With the increasing of the (NH 4 ) 2 S 2 O 8 concerntration, the product shows an increased effciency and reachs 99% in the “40%-RL” sample. Additionally, the (NH 4 ) 2 S 2 O 8 treatment leads to an improvement in the cycling stability. In Fig.2, untreated Li 1.2 Ni 0.16 Co 0.08 Mn 0.56 O 2 maintains 88% capacity in the 100 th cycle, while the “40%-RL” sample shows capacity retention of 97% after 100 cyles. The (NH 4 ) 2 S 2 O 8 -treated samples also present greatly improved rate performance. In Fig.3, the increase of the current rate from 0.1C to 4C causes a capacity decrease from 255mAh.g -1 to 67mAh.g -1 for the pristine Li 1.2 Ni 0.16 Co 0.08 Mn 0.56 O 2 sample. For the (NH 4 ) 2 S 2 O 8 -treated samples, they all exhibit a much better rate property than the untreated phase. Especially for the “30%-RL” and “40%-RL” sample, they both present a capcity above 200mAh.g -1 at the 4C rate. XRD measurements prove that the (NH 4 ) 2 S 2 O 8 -treatment weakens the super lattice in the Lithium rich layered material. ICP and Raman analysis furtheres reveal that the Li content in Li 2 MnO 3 decreased after the (NH 4 ) 2 S 2 O 8 -treatment, which can be the main reason of the efficiency increase in the 1 st cycle.

LiMn2O4/LiNi0.5Mn1.5O4 composite with LiMn2O4 substrate and LiNi0.5Mn1.5O4 surface layer is proposed and prepared through sol–gel method. The resulting samples have been characterized by XRD and SEM measurements, in terms of which the impurity-free phase, uniform particle morphology have been proved. Charge–discharge test, XPS measurement combining with TEM observation confirm the existence of LiNi0.5Mn1.5O4 surface layer. Comparing with the bare LiMn2O4, the LiNi0.5Mn1.5O4-coated LiMn2O4 phase presents significantly improved cycling stability, especially at 60 °C. Additionally, the rate capability and thermal safety of LiMn2O4 are greatly enhanced after being coated by LiNi0.5Mn1.5O4. ICP-AES measurement, structural analysis, and impedance experiment indicate that the improved electrochemical property of LiNi0.5Mn1.5O4-coated LiMn2O4 should be attributed to the alleviated dissolution loss of manganese, strengthened structural stability, and improved SEI property.

A simple rheological phase method has been successfully put forward to synthesize layer Li[Li0.182Ni0.182Co0.091Mn0.545]O2 under a stepped temperature. The structure and morphology of Li[Li0.182Ni0.182Co0.091Mn0.545]O2 powder were characterized. The sub-micron Li[Li0.182Ni0.182Co0.091Mn0.545]O2 sample possesses an integrated layer hexagonal structure with minimal cation disorder. The Li[Li0.182Ni0.182Co0.091Mn0.545]O2 cathodes were prepared with different binders of sodium carboxymethyl cellulose (CMC), polyvinylidene fluoride (PVDF) and sodium alginate (SA). Electrochemical performances, including cyclability, rate capacity and voltage decay, of the cathodes were investigated. Compared with the PVDF, favorable electrochemical properties are obtained by using SA or CMC as the binder. It indicates that the aqueous binder is more suitable for Li[Li0.182Ni0.182Co0.091Mn0.545]O2 cathode in Li-ion battery.

The layered LiMO2 (M = Ni, Co and Mn) materials LiNi1/3Co1/3Mn1/3O2 and LiNi0.4Co0.2Mn0.4O2 are synthesized by rheological phase method. Sb2O3-modified phases are further obtained by mechanical ball milling treatment. The structure and morphology of the bare and modified samples are characterized by X-ray diffraction, scanning electron microscopy and transmission electron microscopy. Charge/discharge tests indicate that the modified phases all improve cycling stability, rate capability and thermal safety. Careful comparison of the charge/discharge profiles reveals that the serious polarization increment in cycling is suppressed in the Sb2O3-modified LiMO2 electrodes. AC impedance shows that Sb2O3/LiNi1/3Co1/3Mn1/3O2 electrode has smaller R-ct and R-f value. Further analysis proves that Sb2O3 hinders the reaction between electrolyte and cathode during charge/discharge process and helps to stabilize the SEI. Other experiments prove that using Sb2O3-coated separator can achieve similar positive effect on layered LiMO2 cathode. (C) 2014 Elsevier B.V. All rights reserved.

We have fabricated a micron-sized LiCoO2/LiCo0.99Ti0.01O2 composite successfully by solid-phase synthesis, its core-shell structure has been proved by SEM and XPS observation. Electrochemical examinations show that comparing with LiCoO2 and LiCo0.99Ti0.01O2, the obtained LiCoO2/LiCo0.99Ti0.01O2 composite presents greatly enhanced cycling stability as well as rate capability. In addition, DSC measurement indicates that LiCoO2/LiCo0.99Ti0.01O2 has a better thermal safety than LiCoO2. It is considered that all the improvement should be explained by the particular core-shell morphology of the LiCoO2/LiCo0.99Ti0.01O2 sample.

Background Only a small percentage of patients with hepatocellular carcinoma (HCC) may benefit out of surgical resection. Thus, lots of these patients are in need of local control, such as percutaneous ethanol injection (PEI), percutaneous laser ablation (PLA), or radiofrequency thermal ablation (RF). Purpose To investigate the effects of ultrasound-guided PLA combined with PEI on rabbit VX2 liver tumors, using conventional gray-scale ultrasonography (US), color/power Doppler (CD/PD)US, contrast-enhanced (CE) US, and histologic examination. Material and Methods VX2 tumors were implanted in the livers of 80 rabbits. Fourteen days after implantation, animals were randomly separated into four groups of 20 rabbits. Treatment of the four groups was with: (i) PLA; (ii) PEI; (iii) combined therapy of PLA immediately followed by PEI; and (iv) combined therapy of PEI immediately followed by PLA. Conventional gray-scale US, CD US, PD US, and CE US were performed before and after ablation. The effects on ablated areas were assessed by histologic examination. Results Conventional gray-scale US showed a clear boundary around the ablated area in groups 1, 3, and 4. An isoechoic treated region with an irregular boundary was seen in group 2. On CE US, coagulated areas demonstrated a perfusion defect. Both conventional gray-scale US and CE US showed that the ablated volume in group 4 was larger than that in groups 1, 2, and 3. CD US and PD US demonstrated residual tumor in the periphery of ablated areas in groups 1 and 2, but not in groups 3 and 4. CE US demonstrated no residual tumor in group 4, unlike in groups 1, 2, and 3. Examination of treated tumors demonstrated necrosis in the ablated zones and increasing surrounding fibrous bands in the four treatment groups. Residual viable tissue in group 4 was less than that in groups 1, 2, and 3. Conclusion Combined therapy of PEI immediately followed by PLA can coagulate significantly larger volumes of tumor and reduce residual tumor.

Objective To test the feasibility of using microwave to produce rapid hemostasis of liver active bleeding. Methods Twelve new Zealand white rabbits were anesthetized, and their livers were exposed. After heparinized, the animals were randomly divided into 80 W group, 60 W group and control group. Guided by color Doppler ultrasonography, an 18 G semi-automatic biopsy needle was inserted into the hepatic parenchyma, injuring the hepatic parenchyma and small blood vessel to create active bleeding. There were about 3-5 hepatic active bleeding sites created in one animal. Paired comparisons were performed among three groups. The microwave antenna was posed to the bleeding site worked with 80 W or 60 W. A corresponding site of active bleeding in another animal without application of microwave served as a control. Significant differences of blood loss, hemostasis time and carbonization rate were tested. Results 80 W and 60 W groups showed significantly less mean blood loss than control group [(0.09±0.12)g vs (1.83±0.52)g, χ 2=25.00, P0.05;(0.10±0.10)g vs (1.83±0.52)g, χ 2=23.00, P 0.050]. There was no significant difference of blood loss between 80 W group and 60 W group (χ 2=2.00, P0.05). 80 W group had less hemostasis time than 60 W group [(13.1±4.2)s vs (18.3±7.9)s, T+=4.5000, T-=115.5000, P=0.000], but had higher carbonization rate than 60 W group (13/16 vs 5/16, χ 2=8.127, P=0.004). Conclusions Coagulation with microwave is a rapid and effective method to arrest hepatic active bleeding. Sixty W can effectively induce hemostasis without significant carbonization, and the time of duration is 10 s to 40 s.

Objective To evaluate the value of contrast-enhanced ultrasound(CEUS) in differential diagnosis of hepatic hematoma and hepatic hemotoma with active bleeding.Methods New Zealand white rabbits(male,body weight 2.5-3.5 kg,n = 15) were heparinized and subsequently impacted with a self-made impactor to create hepatic blunt injury model.An 18 G semi-automatic biopsy needle was used to create hepatic active bleeding in 10 rabbits by injuring hepatic artery.Both unenhanced and contrast enhanced scanning were performed to evaluate the hepatic injury and search for hematomas and active bleeding sites.After that,the abdomen was opened to check if the injury of liver was identical with the results of sonographic studies.Results A total of 15 liver injury animal models were created,which included 5 cases of liver hematoma and 10 cases of liver hematoma with active bleeding.The 2-dimensional ultrasound imaging confirmed 9 cases of hematomas(9/15) but failed to suggest the presence of active bleeding(0/10),while contrast-enhanced imaging confirmed 15 hematomas(15/15) and identified 10 active bleeding(10/10).Active bleeding from contrast-enhanced imaging was displayed in the form that the contrast agent was extravasated from the injured liver parenchyma.The results of pathological examinations were basically matched with the results of sonographic studies.Conclusion It is demonstrated that CEUS is a rapid and effective diagnostic approach for differential diagnosis of hepatic hematoma and hepatic hematoma with active bleeding,wherein the existence of contrast agent active spillover is the main identification point.

Simulation methods employing continuity equations to describe particle transportation are used to examine the process of single discharge. However, it is difficult to simulate partial discharge (PD) behaviour accurately by these methods, because it will take too much computation time to simulate consecutive PD sequences. In this report, in order to save computation time, a simple three-dimensional network is used to simulate PD sequences in a small void under ac voltage. The model considers charge generation, charge transport and charge disappearance, and electrical field redistribution in three dimensions. The continuity equations for electrons, positive ions and negative ions, including the effects of ionization, attachment, recombination, electron diffusion and the transport of charge under electrical field are solved simultaneously with Poisson's equation. With this model, the phase-resolved PD pattern and the current forms of each PD are obtained. Moreover, considering the propagation process of each PD and its influence on surface charge distribution, the fall part of PD current form and the effect of previous discharge on the subsequent one are also studied.

患儿,男,4岁.因腹胀进行性加重34 d,呼吸困难、多汗24 d入院.患儿于入院前34 d因发现腹部膨降,伴有纳差,就诊于当地诊所,被诊断为消化功能紊乱,给予口服多酶片1周,腹胀无好转,并出现双下肢水肿,伴有活动后呼吸困难,面色苍白,外院检查显示少量心包积液、中等量胸腔积液和腹腔积液.胸腹腔引流液为黄色浑浊黏稠液,引流末可见血性液体.胸水检查提示为渗出液:总蛋白29.4 g/L,葡萄糖0.61 mmol/L,乳酸脱氢酶8127 U/L,浆液粘蛋白阳性,比重＞1.018,细胞总数为97.5×109/L,白细胞数为62.4×109/L,单个核细胞占35％,多核细胞占65％;胸腔积液培养(普通条件下)无细菌生长,抗酸染色阴性.胸腹水病理检查未见肿瘤细胞,仪显示大量以淋巴细胞为主的炎性细胞及少量退变间皮细胞.腹部CT示腹膜广泛增厚和肠管广泛增粗.给予患儿广谱抗生素和正规抗结核药物联合治疗3周.治疗期间,患儿腹胀和呼吸困难进行性加重,并伴有发热和消瘦,遂转来我院诊治.

Objective To explore the short-term effects of contrast-enhanced ultrasound guided hemocoagulase injection therapy in renal trauma models.Methods A total of 25 rabbits were induced as grade Ⅲ-Ⅳ renal trauma models by puncture.Mean blood pressure was monitored simultaneously and maintained at 70 mm Hg(1 mm Hg=0.133 kPa).Two groups including percutaneous hemostatic injection treatment in experiment group and percutaneous saline injection treatment in control group were guided by contrast-enhanced ultrasonography.Subcapsular hematomas were assessed by regular ultrasonography 1 h after treatment,and hemorrhage volume was recorded and the specimens of lesion were harvested for histopathology after animal executed.Results In the control group,active bleeding still be existed with blood clots,while the active bleeding was stopped completely in the experiment group.No significance was found in the areas of subcapsular hematomas between 2 groups.The hemorrhage volume in the control group was significantly greater than those in treatment group(76±11 mL versus 13±5 mL,P0.05).Conclusion As the hemocoagulase injection can effectively stop bleeding in experimental models within a short time,the hemostatic agent could be regarded as a potential clinical treatment in renal trauma.

Summary 1. The aim of the present study was to evaluate the clinical value of colour Doppler application in encircling constriction of the superficial femoral vein in deep vein insufficiency. 2. A total of 87 patients with primary deep venous insufficiency (PDVI) using ascending venography were randomly divided into group A (44 patients) and group B (43 patients). All patients underwent encircling constriction of the superficial femoral vein, high ligation and ablation of the great saphenous vein and perforator vein. The duration of venous reflux at operation was monitored with colour Doppler in group A (but not group B) to evaluate the immediate effects. Clinical grading and scoring of the clinical, etiological, anatomical, pathophysiological (CEAP) classification system were used to evaluate the follow‐up curative effect. 3. In four cases from group A, completely destroyed valves were identified at the time of operation and autografting of the vein segment with a valve was carried out. The intraoperative examination of colour Doppler in group A showed a much shorter duration of vein reflux after the encircling constriction procedure than the presurgery condition. According to the results of CEAP grading, the success rate of group A (95.0%, 38/40) was significantly higher than that of group B (76.7%, 33/43). Postoperative clinical scores were markedly lower than preoperative scores in both groups A and B. 4. In conclusion, our data suggest that application of colour Doppler in encircling constriction of superficial femoral vein might enhance surgical pertinence and improve surgical effect for PDVI.