A series of new N-azolides of 2,4,6-triisopropylbenzenesulphonic acid have been synthesized and their biological activity with respect to the processes of cell proleferation, energy metabolism, and programmed destruction (apoptosis) has been studied. Convincing evidence is obtained for pronounced immunomodulating и cytoprotecting properties of two compounds (N-imidazolide and N-triazolide of 2,4,6-triisopropylbenzenesulphonic acid), which produce directed positive influence at pathological states, in particular, favor cell proliferation and normalize the cell energy metabolism and apoptosis.
A series of new N-azolides of 2,4,6-triisopropylbenzenesulfonic acid have been synthesized. Their biological activity with respect to the processes of cell proliferation, energy expenditure, and programmed cell death (apoptosis) has been studied. Convincing evidence is obtained for pronounced immunomodulating and cytoprotecting properties of two compounds (N-imidazolide and N-triazolide of 2,4,6-triiospropylbenzenesulfonic acid), which produce a positive influence directed at pathological states, in particular, cell proliferation, cell energy expenditure, and apoptosis.
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
In recent years, nitrogen-containing heterocyclic compounds have found increasing application in the treatment of cardiovascular disorders [1, 2]. For this reason, we found it interesting to study the sulfonic acid azolides as possible vasotropic agents and immunomodulants for chemotherapy for patients suffering from disorders involving the immune inflammation of vascular walls. For this purpose, we have synthesized a series of new methanesulfonic acid azolides and studied their cytotoxicity immunomodulant activity. The new methanesulfonic acid azolides (Ia, Ib) were synthesized using the following reaction scheme:
