阶跃折射率分布光纤是光纤光学课程的重要内容,理论性强,内容抽象难懂.将抽象的理论公式转化为生动、直观的光学现象,可极大地激发学生的学习兴趣,提高课程教学效率.采用Matlab仿真软件及图形用户界面功能,模拟分析了阶跃折射率光纤的单模条件、弱导光纤的色散曲线、模式截止条件及模式分布.光纤的纤芯直径、折射率分布、入射波长等参数均对光纤内的传输模式具有一定的影响.通过可视化的图形用户界面,灵活设置实验参数,可方便地分析光束的传播特性,为工程实践提供了一定的理论指导.

A new kind of negatively charged polymer-shielded supramolecular nano-micelles with dual-responsive property was designed for tumor treatment, which was prepared on the basis of adamantane terminated linear PAsp(DIP) and disulfide-β-cyclodextrin-terminated PAsp(EDA). The supramolecular nano-micelles comprised a 2,3-dimethylmaleic anhydride (DA) protective layer to stabilize the micelles, a pH-responsive core to package hydrophobic model drugs, and a disulfide-crosslinked interlayer to shackle the core against drug leakage under normal physiological conditions. After arriving at the tumor tissue via EPR, the targeting function could be turned on by dislodging DA groups on the surface of micelles, which allowed the drug-loaded nano-micelles to be easily phagocytized by the tumor cells, and then release the drug inside the cells induced by the increased glutathione level and acidic pH. The results indicated that the charge-conversional dual-responsive supramolecular nano-micelles showed excellent antitumor activity.

The traditional treatment for bacterial infections is the use of antibiotics, but the overuse of antibiotics can lead to the formation of multidrug‐resistant bacteria, and eventually lead to the formation of biofilms, which can resist the attack of the host immune system and the penetration of antibiotics in biofilms. Although biofilm‐targeted and stimulus‐responsive antibiotic delivery nanocarriers are available, the drugs that can be delivered is extremely limited. Therefore, an amphiphilic supramolecule Arg‐CD‐AcMH is constructed via host–guest interactions between β‐CD‐terminated arginine (Arg‐CD) and ferrocene‐terminated acetal‐modified maltoheptaose. The amphiphilic supramolecule Arg‐CD‐AcMH can self‐assemble with glucoamylase and glucose oxidase in aqueous solution to form spherical nanoparticles through hydrophilic–hydrophobic and electrostatic interactions. These nanoparticles can respond to the micro‐environment in the biofilm and selectively increase the level of H 2 O 2 in the biofilm through the cascading catalytic effect of enzymes based on the self‐supply glucose, thus providing conditions for the release of anti‐biofilm active drug nitric oxide.

In this work, a positively charged chitosan-grafted-polyarginine (CS-N-PArg) as the macro-molecular NO donor, and a negatively charged acetalated starch (AcSt-O-PAsp) as a glucose donor, have been synthesized. To achieve the multi-enzymatic cascade system for local generation of self-supply glucose to increase the H2O2 concentration for the subsequent oxidization of L-Arg into NO, the designed positively charged CS-N-PArg, negatively charged AcSt-O-PAsp, glucoamylase (GA) and glucose oxidase (GOx) are absorbed and assembled in the pore of the gelatin sponge via electrostatic interaction to establish a smart antibacterial dressings (CS/St + GOx/GA). Once stimulated by Escherichia coli (E. coli)-infected wounds (a slightly acidic environment), the cascade reaction system can sequentially induce to generate glucose, H2O2 and NO, which exhibits a meaningful alternative idea for a high-performance antibacterial therapy.

光电信息科学与工程专业成功进入教育部《"新工科"研究与实践项目名单》,为该专业的建设带来了重大的机遇和挑战.本文以文华学院光电信息科学与工程专业为例,结合专业建设的措施与经验,从建设背景、专业定位、校企合作、教学改革、师资建设以及人才培养等多个角度进行了阐述与分析,提出了对光电信息科学与工程专业建设的思考和建议,为民办应用型高校同类专业的建设工作提供了参考.

The active oxygen species in the catalytic oxidation system of Fe(III)PcTs-t-BuOOH were identified, and the mechanism of the catalytic oxidation of phenolic substrates was proposed. Quinone imine molecules, the main products of catalytic oxidation reaction, can be adsorbed on the surface of CdTe QDs, resulting in their fluorescence quenching. A dual function of catalytic oxidation and fluorescence sensing was developed for the determination of dichlorophenol (DCP) based on the Fe(III)PcTs-BuOOH-CdTe QDs system. The linear detection range of DCP was 1×10−6–1.3×10−4 mol/L, and the detection limit 2.4×10−7 mol/L. This method was characterized by high selectivity, good repeatability and desirable stability, presenting promising potentials for analyzing DCP concentration in real water samples.

偏振光学知识抽象,实验条件要求较高.加强教学内容的生动性、提交教学效率、简化实验环境等问题成为教学研究的重点.采用Matlab软件的图形用户界面(Graphic User Interface,GUI)功能,搭建偏振光转换实验仿真平台,通过可视化的图形用户界面,形象模拟偏振光的传输特性.该仿真平台拓展性强、操作便捷、可灵活设置实验参数,达到较好的演示教学目的.

In order to improve manufacture quality and machining efficiency, this paper studies the technology of rectangular flat-topped beam. Flat-topped beam can effectively reduce the region of heat affected zone. Rectangular beam can reduce overlap rate. So, it is very important to convert the circular Gaussian beam to rectangular flat-topped beam. The fiber laser has been widely used to laser manufacture Industry at this present. The fiber has better coupling capability with laser spot. We choose double-cladding fiber to acquire uniform rectangular beam. Laser beam transmission model was created up with RP fiber power soft. We also make the model of the double-cladding fiber. When the Gaussian beam is transmitting along fiber, high-order mode lights appear and mixture with each other. Because the double-cladding fiber has central-dip profile index, the energy transfers from central to edge. The results show that the double-cladding fiber can be used to improve the uniformity of transmitting beam. When the shape of fiber core is rectangular and the chamfer is circle arc work, we can get rectangular uniformity beam.

Terahertz time-domain spectroscopy was used to make experiment and investigation for the characteristics of high quality 0.3BaSrTiO3-0.7NdAlO3 ceramics in the terahertz range, which was made by the solid state reaction method. The frequency resolution of experiment system was 4.5 GHz, and all-solid-state 532nm laser was used as external optical pump, which obliquely incidence on the surface of the sample at the angle of 45°. From the experiment that when the external optical pump’s intensity increased from 0 mW to 300 mW at room temperature, the 0.3BaSrTiO3-0.7NdAlO3 ceramics’ transmission waveform time shifts could be obviously observed, and with the increasing power of pump laser, the absorption coefficient could be modulated, the modulation range varied from 21.38 cm-1 to 13.77 cm-1 and the modulation depth nearly reached up to 36% at 0.55 THz. Further analysis showed that the micro-mechanism of absorption coefficient modulation with the intensity of external optical pump was attributed to the internal space charge field in the 0.3BaSrTiO3-0.7NdAlO3 ceramics caused by the excited free carriers. The experiment and analysis proved that the 0.3BaSrTiO3-0.7NdAlO3 ceramics have higher tunability, lower dielectric loss and good temperature stability in THz range, which will have good reference value and wide application for communication in THz range.

Thrombin is a serine protease known as activated coagulation factor II and is primarily applied as an effective local hemostatic agent. However, its clinical application is hindered by drawbacks, such as high sensitivity to the surrounding environment, instability and poor storage stability, easy inactivation, and low bioavailability. The biological functions of biomacromolecules in harsh environments can be preserved through biomineralization. Despite the success of biomimetic mineralization, limited consideration has been given to the mineral-based methods and the effect of various metal ions on enzyme activity. To explore an efficient technique for biomimetic mineralized thrombin, six kinds of ion/thrombin hybrid microflowers and two kinds of thrombin/MOF were synthesized in this work. The results showed that Zn-HNFs-G exhibits good hemostatic effect and maintains high enzymatic activity when exposed to high-temperature conditions. Meanwhile, Fe-HNFs-G, Thrombin@ZIF-8-G and Thrombin@MAF-7-G possess negligible enzyme protection.

Catalytic conversion of hydrogen peroxide (H2O2) to more toxic hydroxyl radicals (•OH) is a good choice for sterilization and anti-infection, but endogenous H2O2 is insufficient to achieve satisfactory sterilization efficacy. Despite great efforts, designing and developing antimicrobial materials that specifically and effectively self-supply H2O2 at the wound site remain as tremendous challenges. Here, we report a pH-responsive copper peroxide-loaded wound dressing made from copper hydroxide and gelatin sponge and then reacted with H2O2. In vitro experiments show that the prepared wound dressing has good bactericidal properties against Escherichia coli (E. coli), Staphylococcus aureus (S. aureus), and Pseudomonas aeruginosa (P. aeruginosa). Moreover, the as-prepared wound dressing can release •OH specifically in the bacterial-infected skin wound, rather than in normal tissues, and in vivo skin wound-healing experiments proved that the synthesized copper peroxide-loaded gelatin sponge could combat E. coli effectively; in addition, Cu2+ released from the gelatin sponge could stimulate angiogenesis and collagen deposition simultaneously. The study provides a strategy to improve antibacterial efficacy and reduce the toxic side effects through the release of •OH by bacterial self-activation.

Traditional organic and inorganic sunscreens suffer from the disadvantages of low stability and poor biocompatibility. In the study, we developed a novel hydrogel sunscreen based on the yeast and gelatin, which demonstrated excellent UV protection property and broad absorption of UV across UVA and UVB region. Yeast was used as effective component and gelatin as matrix to fabricate the hydrogel, which is high hydrated and reasonable to simulate natural living tissue. As a common probiotic, yeast shows safety and satisfactory UV protection capability. Furthermore, the hydrogel sunscreen shows excellent biocompatibility and UV protection performance both in vitro and in vivo. Moreover, they can be prepared conveniently and provide an eco-friendly strategy, which provides experience and inspiration of probiotics in the cosmetics application.

Nitric oxide (NO) gas therapy has aroused intense interest in recent years. L-Arginine (L-Arg) reacts with reactive oxygen species (ROS) in tumor cells to generate NO. This phenomenon represents an effective method for tumor therapy. However, endogenous ROS levels in most types of tumor cells cannot enable an effective reaction. beta-Lapachone is generally used to increase H2O2, which can oxidize guanidine derivatives to form nitric oxide in tumor cells. In addition, based on the ferrocene (Fc)-catalyzed Fenton reaction, center dot OH is generated from H2O2, and the ONOO- could be generated from an interaction between center dot O-2(-) (generated through the Haber-Weiss reaction) and NO. Arg-rich poly(e-caprolactone) (PCL)-b-PArg, a macromolecular NO donor, was accurately synthesized to avoid premature L-Arg leakage during in vivo transport. In this design, the self-assembled PCL-b-PArg nanoparticles were dressed with the tumor-shreddable masking (PEG-b-PDMA, a negatively charged pH-sensitive hydrophilic diblock polymer), to prepare P-lapa-Fc nanoparticles and hide penetrative capability in the circulation. The experimental results confirmed that this synergistic therapy based on ROS and NO had a significant inhibitory effect on cancer cells, thereby providing new inspiration for NO gas treatment.

A novel fiber optic sensor based on optical composite oxygen-sensitive film was developed for determination of 2,4-dichlorophenol (DCP). The optical composite oxygen-sensitive film consists of tris(2,2′-bipyridyl) dichloro ruthenium(II) hexahydrate (Ru(bpy)3Cl2) as the fluorescence indicator and iron(III) tetrasulfophthalocyanine (Fe(III)PcTs) as bionic enzyme. A lock-in amplifier was used for detecting the lifetime of the composite oxygen-sensitive film by measuring the phase delay of the sensor head. The different variables affecting the sensor performance were evaluated and optimized. Under the optimal conditions (i e, pH 6.0, 25 °C, Fe(III)PcTs concentration of 5.0·10−5 mol/L), the linear detection range, detection limit and response time of the fiber optic sensor are 3.0×10−7–9.0×10−5 mol/L, 4.8×10−8 mol/L(S/N=3), and 220 s, respectively. The sensor displays high selectivity, good repeatability and stability, which have good potentials in analyzing DCP concentration in practical water samples.

With the development of the optics communication system and optical signal modulation technology, the amplitude-shift keying (ASK) and phase-shift keying (PSK) are both used in different optical communication sub-networks. In this paper, a novel all-optical modulation format from PSK to ASK based on phase-sensitive amplification is proposed and demonstrated. Using the nonlinear interference of the single-pump phase-sensitive amplification, the signal wavelength can be preserved while the modulation format is conversed. The proposed scheme provides the flexible intermediate node interface transformation in future optical networks.

高功率平顶光束在激光加工领域具有广泛的应用.针对光束平顶化的问题,提出利用大芯径多模光纤对高斯光束整形的方法.采用RP Fiber Power建立高斯光束传输模型,仿真分析光纤内光束的传输及强度分布特性.研究结果表明,多模光纤对高斯光束具有整形作用.高斯光束经多模光纤传输后,传导模数量增加,能量由中心向径向移动,光束质量下降,能量分布趋于均匀化.光纤的芯径越大,传输长度越长,匀化效果越明显.采用D型纤芯结构,或凹面折射率分布光纤,均可快速匀化光束.

The box-like optical filter is one of the most important key optical switching components in the dense-wavelengthdivision-multiplexing (DWDM) fiber-optic communication system and the intelligent optical network. The integrated high-order silicon microring resonators (MRRs) are one of the best candidates to achieve the box-like filtering spectrum response. In general, the spectrum response rectangular degree of the single MRR is very low, so that it can not be used in the DWDM system. Using the race-track high order MRRs, the bandwidth of flat-top pass band, the out-of-band rejection degree and the roll-off coefficient of the edge will be improved obviously. In this paper, a box-like optical filter based on the race-track high order MRRs with uniform couplers is presented and demonstrated. Using 15 coupled racetrack MRRs with 10 pm radius, the 3 dB flat-top pass band of 2 nm, the out-of-band rejection ratio of 30 dB and the rising and falling edges of 48 dB/nm are realized successfully.

本文针对我校光电信息科学与工程专业应用型人才培养目标,对目前的专业核心课程进行了深入研究.针对本专业课程理论性、应用性较强等特点,重点研究仿真软件在各门课程教学中的具体应用.提出理论知识与软件教学有机衔接的课程设置,强化软件实践操作,采取多样灵活有效的方式辅助教学.该教学模式能够激发学生学习兴趣,加深学生知识的深入了解,提高学生系统设计及项目开发技能.

The rectangular optical filter is one of the most important optical switching components in the dense wavelength division multiplexing (DWDM) fiber-optic communication system and the intelligent optical network. The integrated highorder silicon microring resonator (MRR) is one of the best candidates to achieve rectangular filtering spectrum response. In general, the spectrum response rectangular degree of the single MRR is very low, so it cannot be used in the DWDM system. Using the high-order MRRs, the bandwidth of flat-top pass band, the out-of-band rejection degree and the roll-off coefficient of the edge will be improved obviously. In this paper, a rectangular optical filter based on highorder MRRs with uniform couplers is presented and demonstrated. Using 15 coupled race-track MRRs with 10 μm in radius, the 3 dB flat-top pass band of 2 nm, the out-of-band rejection ratio of 30 dB and the rising and falling edges of 48 dB/nm can be realized successfully.

Three-port tunable optical filter is a key device in the all-optic intelligent switching network and dense wavelength division multiplexing system. The characteristics of the reflecting spectrum, especially the reflectivity and the isolation degree are very important to the three-port filter. Angle-tuned thin film filter is widely used as a three-port tunable filter for its high rectangular degree and good temperature stability. The characteristics of the reflecting spectrum are greatly influenced not only by the incident angle, but also by the wedge angle parameter of the non-paralleled wedge thin film filter. In the present paper, the influences of the wedge angle parameter to the reflectivity and the half bandwidth are analyzed, and the reflecting spectrum characterstics are simulationed in different wedge angle parameter and polarity. The wedge angle-tuned thin film filter with 0.8° wedge angle parameter is fabricated. The experimental results show that keeping the wedge angle the same orientation to the incident angle will worsen the reflectivity and the rectangular degree of the reflecting spectrum. However, keeping the wedge angle orientation reverse to the incident angle will enhance the reflectivity and decrease the bandwidth, which will give higher reflectivity and isolation degree to the three-port filter than that of high parallel degree angle-tuned thin film filter.