Wound dressings play a vital role in the management and healing of all types of wounds, ranging from minor cuts and chronic ulcers to severe burns. However, conventional dressings are often marred by issues such as a propensity for adhesion and inadequate barrier functions. These limitations underscore the urgency of research into innovative wound dressings. In this study, polycaprolactone and polyvinylpyrrolidone were composited into a bilayer film using electrostatic spinning technology. Different functional components linalool, black phosphorus, and triclosan were added to each layer to produce effects of bacterial inhibition and photothermal conversion, thereby fulfilling the criteria for use as a wound dressing. Due to differences in the hydrophilicity of the materials, the bilayer film exhibits a certain interfacial energy difference between its two sides, which allows liquid to be discharged from one side to the other. The results showed that the prepared bilayers possess excellent antimicrobial effects and good biocompatibility, as well as outstanding photothermal effects and unidirectional hydrophobicity. Present obtained multifunctional composite film was successfully fabricated by integrating a combination of properties, including antibacterial, photothermal, and asymmetric wettability, offering a novel approach for the development of wound dressings.

Cholesterol derivatives play a vital role in various fields, including medicine, biology, and smart materials. The Langmuir-Blodgett (LB) technology uses molecular self-assembly to create interfacially organized thin film materials with unique characteristics. This work primarily used two cholesterol derivatives (CCA and CCH) coupled with various dyes to create multilayer composite LB films. The SERS test determined the enhancement factor EF= 1.07 x 105 for the CCA/ST composite film and EF= 1.12 x 105 for the CCH/ST multilayer composite films, with relative standard deviation RSD= 12.58 % and 3.86 %, respectively. The result demonstrates the superior signal responsiveness and uniformity of the resultant LB films, offering a novel option for active substrate materials in SERS detection of trace compounds. The photoelectric response signal of the CCA/dye and CCH/dye composite LB films was demonstrated to be sensitive by the photoelectric conversion test, and the films' superior reusability was demonstrated by the persistence of the same pattern over several recurring cycles. It offers a novel idea for investigating the use of cholesterol derivatives in optoelectronic devices in more detail.

With the aging global population and a progressive annual rise in chronic diseases, the incidence of chronic skin trauma has increased significantly. Chronic skin wounds, which often remain unhealed for extended periods, are highly susceptible to bacterial infections. Consequently, the use of antibacterial dressings has become a crucial strategy for preventing and managing such infections. These dressings not only serve as a physical barrier protecting wounds from external contaminants, but also regulate the healing microenvironment, promote tissue regeneration, and accelerate the healing process. In this study, we designed a wound dressing with Janus structure by electrospinning technology. The inner layer consists of hydrophilic cellulose acetate (CA) incorporated with polylysine (epsilon-PL) to maintain a moist, bacteriostatic environment, while the outer layer is composed of hydrophobic polycaprolactone (PCL) integrated with tannic acid (TA)-modified black phosphorus (BP) to prevent microbial adhesion. The combination of the antibacterial activity of epsilon-PL and the photothermal effect of TA-modified BP (TABP) endows the Janus nanofiber membrane with a potent synergistic antibacterial capability. In vitro experiments demonstrate that the dressing exhibits excellent surface wettability and permeability, enhanced mechanical strength, potent antibacterial activity, and mild photothermal effects that help alleviate inflammatory responses. This Janus nanofiber membrane represents a promising strategy for enhancing and accelerating wound healing.

Amino acids, as the basic components of proteins, can cross the barrier of the digestive tract through oral administration and directly participate in human physiological activities. In this study, the amino acid derivative N-(benzyloxycarbonyl)-L-proline (Z-Pro) was selected to form aggregates as a carrier for the delivery of antioxidant drugs. And the composite system was developed by mixing Z-Pro, hydrophobic antioxidant drug and water, followed by heating. This process takes advantage of the hydrogen bonding between the amino acid derivative molecules and water molecules, as well as the hydrophobic interaction between the side chains of the amino acid derivatives and the drug, and converts the amino acid aggregates into oral liquid formulations based on a liquid-liquid phase separation mechanism. These oral liquid formulations significantly enhance the solubility of hydrophobic antioxidant drugs, exhibit suitable viscosity and fluidity, and demonstrate good stability in a simulated gastrointestinal biological environment. The stability of this formulation was further confirmed by exploring the retention of antioxidant properties of the drug. This drug delivery system improves the efficacy of hydrophobic antioxidant drugs and offers great potential for anti-aging therapeutic strategies.

Valvuloplasty for rheumatic aortic valve disease remains controversial. We conducted this study to explore whether aortic valvuloplasty is appropriate for the rheumatic population. A comprehensive search was conducted, and 7 eligible retrospective studies were identified from PubMed, Embase, Medline and Cochrane (up to April 7, 2020) according to the inclusion and exclusion criteria. The data for hospital mortality, 5-year survival, 5-year reoperation, aortic insufficiency grade (AIG) and aortic valve gradient (AVG) were extracted by 2 independent reviewers and were analysed to evaluate the safety and availability of aortic valvuloplasty for rheumatic patients. The heterogeneity of the results was estimated using the Q test and I 2 statistics. The fixed pooling model was used when I 2 ≤ 50%; otherwise, the random pooling model was selected. 7 articles with 418 patients were included. The pooled hospital mortality, 5-year survival and 5-year reoperation rates were 3.2%, 94.5% and 9.9%, respectively. The heterogeneities of the weighted mean differences (WMD) values of the AIG and AVG between preoperation and postoperation were extremely high (I 2 = 81.5%, p < 0.001 in AIG, I 2 = 97.6%, p = 0.003 in AVG). Subgroup analysis suggested that the AIG and AVG were improved by 3.03 grades (I 2 = 0%, p < 0.001) and 3.16 mmHg (I 2 = 0%, p < 0.001) in the European group, respectively. In the Asian group, the AIG and AVG were improved by 2.57 grades (I 2 = 0%, p < 0.001) and 34.39 mmHg (I 2 = 0%, p < 0.001), respectively. Compared with the values at discharge, the AIG was increased by 0.15 grades (I 2 = 0%, p = 0.031) and the AVG was still decreased by 2.07 mmHg (I 2 = 0%, p = 0.031) at the time of follow up. Valvuloplasty is safe and effective to treat rheumatic aortic insufficiency and stenosis, and the duration of maintenance required to improve stenosis was longer than that of insufficiency.

糖尿病周围神经病理性疼痛(diabetic peripheral neuropathic pain,DPNP)是糖尿病常见的并发症之一,目前针对DPNP的传统治疗仍以对症止痛、抗抑郁为主,而中医药治疗该病有优势.本文结合DPNP的临床特点,应用六经辨证理论探讨其病情演变及病证特点,并分为邪入太阴、阳经余邪,太阴厥阴合病,太阴少阴合病和少阴厥阴合病四型论治,同时提出对应的治法及未病先防理念,为DPNP提供了一种新的治疗思路.

In recent years, quercetin plays an increasingly important role in the medical field. However, the absorption and effect of quercetin as a drug in vivo are limited due to its extremely poor solubility in water. In addition, chitosan nanoparticles can deliver poorly soluble drugs as drug delivery carriers. Herein, chitosan nanoparticles were prepared by oxidative degradation and ionic cross-linking technology to study the drug loading properties of quercetin. On the other hand, the application of chitosan for fluorescent materials can improve the biocompatibility of fluorescent materials and increase the adsorption of fluorescent materials. Fluorescently labeled chitosan nanoparticles, especially chitosan microsphere fluorescent probes prepared using the abundant amino groups on chitosan chains to react with fluorescein isothiocyanate (FTIC), have been widely used as fluorescent probes in biomarkers and medical diagnostics. Therefore, chitosan–quercetin (CS–QT) drug-loaded nanoparticles are labeled with FITC, and the drug-loaded rate, encapsulation efficiency, and antioxidant properties were investigated. The drug-loaded rate of the sample reaches 8.39%, the encapsulation rate reaches 83.65%, and exhibits good antioxidant capacity. The fluorescence aperture of the obtained sample was consistent with the inhibition zone, which could realize the visualization of the antibacterial performance of the sample. The fluorescent-labeled nano-system exhibit superior antibacterial properties, which provide a strategy for observing the release and function of drugs.

In this chapter, a comprehensive review of graphene-based composite films is provided, including the preparation and performance of graphene-based composite Langmuir-Blodgett (LB) films, graphene-based composite electrospinning films, and other graphene-based composite films. At the same time, this chapter describes the latest developments in the preparation strategies and application fields for graphene-based composite films. In addition, the application prospects and challenges of graphene-based composite films are described.

Objective. To investigate the correlation between thyroid nodules and microalbuminuria in type 2 diabetic mellitus. Methods. A total of 270 patients with type 2 diabetes at Tongzhou Branch of Dongzhimen Hospital were enrolled in this retrospective study. Data were collected from the inpatient electronic files between January 2018 and January 2020. The laboratory indexes of the two groups (thyroid nodule group with 172 cases and control group including 98 cases without thyroid nodules) were statistically analyzed by binomial logistic regression analysis and Spearman correlation analysis. Results. The proportion of microalbuminuria (MAU) in the thyroid nodule group was larger than that in the control group. Age, serum TT4, and FT4 in the thyroid nodule group were significantly higher compared with the control group. The binary logistic regression analysis indicated that age, sex, FT4, and MAU were the risk factors for thyroid nodule in T2DM patients. Spearman correlation analysis showed that the thyroid nodule was significantly positively correlated with MAU, age, FT4, and TT4. Conclusions. MAU might be an independent risk factor for thyroid nodule in type 2 diabetic mellitus.

Diabetes is one of the global chronic diseases, which is mainly caused by the abnormal increase of blood sugar level. Therefore, it is particularly important to monitor glucose in real time. In this work, based on the principle that phenylboronic acid can react with diol rapidly and reversibly in aqueous medium, phenylboronic acid functionalized reduced graphene oxide (rGO-PBA) and polyhydroxy modified carbon spot fluorescent probe (CD1) were designed for detecting important glucose molecules. Among them, reduced graphene oxide (rGO) has high specific surface area and strong fluorescence quenching performance. When CD1 is close to the surface of rGO-PBA, the fluorescence of carbon dots was quenched. With the addition of glucose, the fluorescence of carbon dots increased continuously. The detection of small molecule glucose can be realized quickly and sensitively by using the "on" and "off" strategies of fluorescence.

桥本甲状腺炎是以弥漫性甲状腺肿大及甲状腺自身抗体阳性为特征的一种自身免疫性甲状腺炎,西医尚无针对自身免疫病因的治疗方法.桥本甲状腺炎属于中医"瘿病"范畴,是因天霾土荒,水秽菜焦,膏腴毒积,加之素体本虚,脾胃受损,升降失常,气血失和,致郁、痰、瘀结于颈前喉结两侧而发,其发病均离不开脾胃升降失司.故治以辛开苦降法,取其辛散升发阳气、苦寒以降泄阴火,使脾胃得和,阳升阴降,清浊归位,气血冲和,以期改善自身免疫而病解.

With the development of various nanofiber materials in the world, polymer nanofiber materials have been widely used, and advanced polymer nanofiber materials obtained through electrospinning technology are of great significance. Electrospinning technology is a green and simple and effective method for directly and continuously preparing polymer nanofibers. In addition, the prepared electrospun fibers have unique characteristics such as specific surface area and high porosity. This chapter provides a comprehensive review of the preparation process of various electrospun fiber materials and applies these composite nanofiber materials to the fields of adsorption, catalysis, and air filtration. At the same time, the recent research progress in the preparation of composite nanofibers by electrospinning technology is reviewed. Finally, the application prospects and challenges of electrospinning technology in composite nanofibers are described.

A novel catalyst composed of Ag3PO4 bridged by Ni/Ti LDH-graphene heterojunction structure was successfully prepared by a simple in-situ deposition method, which has excellent catalytic performance for 4-NP and 2-NA. Various characterizations to the samples such as XRD, SEM, TEM, STEM-EDS, XPS, TG-DSC, and UV-vis DRS were adopted. Because the ternary structure is mixed with each other to form more heterojunctions and higher specific surface area, the ternary composite Ag3PO4/Ni-Ti LDH/GO has excellent catalytic and cycle performance. Compared to the precursors Ag3PO4/GO and Ni-Ti LDH/GO, the finally as-obtained nanocomposite Ag3PO4/Ni-Ti LDH/GO degraded 4-NP and 2-NA solutions represented more dominant degradation efficiency. In addition, the pseudo-first-order rate constants of the composite catalyst for 4-NP and 2-NA are 0.178 min(-1) and 0.089 min(-1), respectively. The complex and irregular surfaces of Ni-Ti LDH/GO provided an ideal carrier with abundant active sites for in-situ depositing and stabilizing of Ag3PO4 NPs, formed the Ag3PO4/Ni-Ti LDH/GO hybrid possessed an acceptable catalytic performance on the degradation of azo dyes, which could be applied in the efficient treatment of wastewater from industries.

目的:探究番石榴叶提取物调节脂肪细胞分化的作用机制.方法:6周龄雄性SPF级db/db小鼠24只、同龄C57BL/6J正常组小鼠6只,将符合纳入标准的db/db小鼠根据体重、血糖随机分为模型组和番石榴叶提取物高剂量组、番石榴叶提取物中剂量组、番石榴叶提取物低剂量组,并将番石榴叶提取物按高、中、低剂量进行灌胃,于4周后空腹脱臼处死所有小鼠,分别取后腿腓肠肌组织、皮下脂肪组织进行原代成肌细胞、原代脂肪组织SVF细胞的培养、接种和传代.培养48 h后收集细胞并提取蛋白,Western blot法检测各组成肌细胞PGC-1α、FNDC5蛋白和各组脂肪组织SVF细胞Prdm16蛋白的表达.结果:第4周时,与模型组小鼠相比,番石榴叶提取物高剂量组小鼠体重、血糖、低密度脂蛋白降低(均P<0.05).番石榴叶提取物高剂量组小鼠成肌细胞PGC-1α、FNDC5蛋白表达升高,脂肪组织SVF细胞Prdm16蛋白表达较模型组升高(均P<0.05).结论:番石榴叶提取物高剂量可通过促进白色脂肪细胞向棕色脂肪细胞分化,提高棕色脂肪水平,从而通过增加机体的能量代谢来调节脂质代谢.

In this work, Langmuir-Blodgett (LB) composite thin films were successfully prepared using black phosphorus nanosheets (BPNS) and dye molecules. Black phosphorus (BP) was first exfoliated in isopropanol solution to form BPNS, and then, BPNS were modified with 4-azidobenzoic acid (Az-BPNS) to improve their stability. The characterization results showed that the synthesized Az-BPNS-dye LB films have a uniform and ordered structure. In addition, the synthesized Az-BPNS-dye LB films exhibit excellent photo-electrochemical performance, and Az-BPNS-methylene blue (MB) produces higher photocurrent compared to Az-BPNS-Neutral red (NR) films. The current work shows an effective way to prepare functionalized BP-based materials and provide evidence for their application in optoelectronic devices.

The construction of low-cost, high-performance electrocatalysts instead of platinum catalysts is critical to solving the energy crisis. Here, using simple electrospinning and hydrothermal methods, new MoS2 nanosheets on SrTiO3 nanofibers (NFs) and 2D SrTiO3@MoS2 heterostructure NFs are synthesized. In addition, SrTiO3@MoS2 heterostructure NFs are compared with bare SrTiO3 NFs and MoS2 nanosheets. Importantly, the prepared SrTiO3@MoS2 heterostructure shows better hydrogen-evolution reaction performance than other MoS2-based electrocatalysts with an overpotential of 165 mV at 10 mA cm(-2), a Tafel slope of 81.41 mV dec(-1), and long-term electrochemical durability of 3000 cycles. Therefore, the present work strongly demonstrates the positive synergy between SrTiO3 NFs and layered MoS2, and also provides a strategy for preparing low-cost and high-activity water-decomposition electrocatalysts.

A seed-mediated co-reduction (SMCR) method that is simple to operate and produces heterogeneous components by the simultaneous co-reduction strategy to grow crystal was used to prepare a bimetallic nanomaterial, composed of two components of uniform metal elements. In this work, three different cationic surfactants were studied to control the morphology of bimetallic compound materials: cetyltrimethylammonium bromide (CTAB), cetyltrimethylammonium chloride (CTAC), and cetylpyridinium bromide (C16Py). Three mature and stable palladium crystal particles and the same number of Pd-Cu bimetallic nanomaterials (BNMs) products were obtained. The system of Pd and Cu bimetallic components, which has a large lattice mismatch, was grown uniformly by atomic layer-by-layer deposition under the SMCR method. The experimental results of BNMs for two nitro compounds (2-NA and 4-NP) were obtained by UV-vis spectral characterization. The prepared BNMs showed excellent catalytic ability in the reduction reaction and completed the catalytic reaction within 93 s. After eight consecutive catalytic cycles, the conversion of the catalytic reaction reached more than 90%. A set of surface-enhanced Raman scattering (SERS) experiments were also used to test the Raman enhancement properties of these BNMs, demonstrating a good SERS enhancement effect and good uniformity. These research results provide a new research topic for the exploration of morphology-controlled bimetal nanomaterials.