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L. A. Litvinova | AMiner学者主页 | AMiner

L. A. Litvinova

ODESSA

41Papers / 论文

364Citations / 引用

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论文（41）

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1Synthesis, DNA-binding, and Interferon-Inducing Properties of Isatin and Benzoisatin Hydrazones

A. S. Karpenko,M. O. Shibinskaya,N. M. Zholobak,Z. M. Olevinskaya,S. A. Lyakhov,L. A. Litvinova,M. Ya. Spivak,S. A. Andronati

The ability of isatin derivatives (in particular, aminoacetylhydrazones) to intercalate into DNA and to induce interferon secretion is demonstrated for the first time. The toxicity of isatin derivatives is much lower and its interferon inducing activity is somewhat lower as compared to the analogous benzoisatin derivatives. The DNA affinity of benzoisatin derivatives is two orders of magnitude greater than that of isatin derivatives.

2006Pharmaceutical Chemistry Journal（2006）引用：23

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2Синтез, ДНК-связывающие И Интерферониндуцирующие Свойства Гидразонов Изатина И Бензоизатина

А. С. Карпенко,М. О. Шибинская,Zholobak Nm,З. М. Олевинская,С. А. Ляхов,Л. А. Литвинова, Spivak NIa,С. А. Андронати

В работе впервые установлена способность производных изатина, в частности их аминоацетилгидразонов, к интеркаляции в ДНК и индукции интерферона. Производные изатина оказались значительно менее токсичными и несколько менее активными интерфероногенами, чем аналогичные им производные бензоизатина. Последние обладают на два порядка большим аффинитетом к ДНК, чем производные изатина.

2006Химико-фармацевтический журнал引用：23

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3Synthesis and DNA-Binding Properties of 9-Formylacridine and 9-Formylanthracene Aminoacetylhydrazones

E. A. Lyakhova,S. A. Lyakhov,L. A. Litvinova,S. A. Andronati,M. N. Lebedyuk,V. P. Fedchuk,G. A. Khorokhorina

The dependence of the affinity of compounds to DNA on the structure of their fragments intercalating into the double helix was studied in a series of aminoacetylhydrazones of 9-formylacridine and 9-formylanthracene. The synthesized compounds were characterized by the intercalating properties and the ability to inhibit the polymerase chain reaction (PCR). The affinity to DNA was found to be higher for acridine derivatives (log Ka = 7.37 – 8.04) than for anthracene derivatives (log Ka = 5.37 – 6.12). At the same time, both acridines and anthracenes showed insignificant ability to inhibit PCR. Thus, no correlation between the affinity to DNA and the ability to inhibit DNA replication was observed for the compounds studied.

2005Pharmaceutical Chemistry Journal（2005）引用：5

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4Синтез И ДНК-связывающие Свойства Аминоацетилгидразонов 9-Формилакридина И 9-Формилантрацена

Е. А. Ляхова,С. А. Ляхов,Л. А. Литвинова,С. А. Андронати,М. Н. Лебедюк,В. П. Федчук,Г. А. Хорохорина

To reveal the influence of intercalating fragment on the affinity to DNA aminoacetylhydrazones of 9-formylacridine and 9-formylanthracene are synthesized and their properties as intercalators and ability to inhibit the polymerase chain reaction are studied. It is shown, that the acridine derivatives (lg K а = 7.37 - 8.04) are more affine to DNA than the anthracene derivatives (lg K а = 5.37 - 6.12). Both acridines and anthracenes are characterized by insignificant ability to inhibit PCR. Correlation between affinity to DNA and ability to inhibit replication is absent.

2005Химико-фармацевтический журнал

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5Синтез и ДНК-связывающие свойства аминоацетилгидразонов 9-формилакридина и 9-формилантрацена

е а ляхова,с а ляхов,л а литвинова,с а андронати,м н лебедюк,в п федчук,г а хорохорина

2005引用：23

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6ДНК-связывающие свойства несимметричных производных флуоренона

С. А. Ляхов,Е. А. Ляхова,А. С. Карпенко, Г. В. Мальцев,И. В. Вельчева,Л. А. Литвинова,М. Н. Лебедюк,Г. А. Хорохорина,В. П. Федчук

2004Химико-фармацевтический журнал引用：23

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7DNA-Binding Properties of Nonsymmetric Fluorenone Derivatives

S. A. Lyakhov,E. A. Lyakhova,A. S. Karpenko,G. V. Mal'tsev,I. V. Vel'cheva,L. A. Litvinova,M. N. Lebedyuk,G. A. Khorokhorina,V. P. Fedchuk

AbstractFor Abstract see ChemInform Abstract in Full Text.

2004Pharmaceutical Chemistry Journal（2004）引用：6

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8Synthesis and DNA-Binding Properties of N,N-Dialkylglycine Acridinylhydrazides

E. A. Lyakhova,S. A. Lyakhov,L. A. Litvinova,Z. M. Topilova,I. V. Vel'cheva,A. I. Gren',M. N. Lebedyuk,V. P. Fedchuk,G. A. Khorokhorina

ChemInformVolume 34, Issue 35 Natural Products Synthesis and DNA-Binding Properties of Acridinylhydrazides (VI) of N,N-Dialkylglycines. E. A. Lyakhova, E. A. Lyakhova Fiz.-khim. inst. im. Bogatskogo Nats. Akad. nauk Ukr., Odessa 270080, UkraineSearch for more papers by this authorS. A. Lyakhov, S. A. Lyakhov Fiz.-khim. inst. im. Bogatskogo Nats. Akad. nauk Ukr., Odessa 270080, UkraineSearch for more papers by this authorL. A. Litvinova, L. A. Litvinova Fiz.-khim. inst. im. Bogatskogo Nats. Akad. nauk Ukr., Odessa 270080, UkraineSearch for more papers by this authorZ. M. Topilova, Z. M. Topilova Fiz.-khim. inst. im. Bogatskogo Nats. Akad. nauk Ukr., Odessa 270080, UkraineSearch for more papers by this authorI. V. Vel'cheva, I. V. Vel'cheva Fiz.-khim. inst. im. Bogatskogo Nats. Akad. nauk Ukr., Odessa 270080, UkraineSearch for more papers by this authorA. I. Gren', A. I. Gren' Fiz.-khim. inst. im. Bogatskogo Nats. Akad. nauk Ukr., Odessa 270080, UkraineSearch for more papers by this authorM. N. Lebedyuk, M. N. Lebedyuk Fiz.-khim. inst. im. Bogatskogo Nats. Akad. nauk Ukr., Odessa 270080, UkraineSearch for more papers by this authorV. P. Fedchuk, V. P. Fedchuk Fiz.-khim. inst. im. Bogatskogo Nats. Akad. nauk Ukr., Odessa 270080, UkraineSearch for more papers by this authorG. A. Khorokhorina, G. A. Khorokhorina Fiz.-khim. inst. im. Bogatskogo Nats. Akad. nauk Ukr., Odessa 270080, UkraineSearch for more papers by this author E. A. Lyakhova, E. A. Lyakhova Fiz.-khim. inst. im. Bogatskogo Nats. Akad. nauk Ukr., Odessa 270080, UkraineSearch for more papers by this authorS. A. Lyakhov, S. A. Lyakhov Fiz.-khim. inst. im. Bogatskogo Nats. Akad. nauk Ukr., Odessa 270080, UkraineSearch for more papers by this authorL. A. Litvinova, L. A. Litvinova Fiz.-khim. inst. im. Bogatskogo Nats. Akad. nauk Ukr., Odessa 270080, UkraineSearch for more papers by this authorZ. M. Topilova, Z. M. Topilova Fiz.-khim. inst. im. Bogatskogo Nats. Akad. nauk Ukr., Odessa 270080, UkraineSearch for more papers by this authorI. V. Vel'cheva, I. V. Vel'cheva Fiz.-khim. inst. im. Bogatskogo Nats. Akad. nauk Ukr., Odessa 270080, UkraineSearch for more papers by this authorA. I. Gren', A. I. Gren' Fiz.-khim. inst. im. Bogatskogo Nats. Akad. nauk Ukr., Odessa 270080, UkraineSearch for more papers by this authorM. N. Lebedyuk, M. N. Lebedyuk Fiz.-khim. inst. im. Bogatskogo Nats. Akad. nauk Ukr., Odessa 270080, UkraineSearch for more papers by this authorV. P. Fedchuk, V. P. Fedchuk Fiz.-khim. inst. im. Bogatskogo Nats. Akad. nauk Ukr., Odessa 270080, UkraineSearch for more papers by this authorG. A. Khorokhorina, G. A. Khorokhorina Fiz.-khim. inst. im. Bogatskogo Nats. Akad. nauk Ukr., Odessa 270080, UkraineSearch for more papers by this author First published: 04 August 2003 https://doi.org/10.1002/chin.200335157Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat No abstract is available for this article. Volume34, Issue35September 2, 2003 RelatedInformation

2003ChemInform（2003）引用：12

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9Синтез И ДНК-связывающие Свойства Акридинилгидразидов N,N-диалкил Глицинов

Е. А. Ляхова,С. А. Ляхов,Л. А. Литвинова,З. М. Топилова,И. В. Вельчева,Agnieszka Greń,М. Н. Лебедюк,В. П. Федчук,Г. А. Хорохорина

2003Химико-фармацевтический журнал引用：23

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10Синтез И Свойства Нового Типа Лигандов ДНК — Комбилексина И Бисинтерлексинов На Основе Амиксина

С. А. Ляхов,Е. А. Ляхова,Л. А. Литвинова,С. А. Андронати,ANASTASIYA V. EGOROVA,И. В. Вельчева,Agnieszka Greń,М. Н. Лебедюк,В. П. Федчук,Г. А. Хорохорина

2003Химико-фармацевтический журнал引用：23

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11Synthesis and Properties of DNA Ligands of a New Type: Combilexein and Amyxin-Based Bisinterlexeins

S. A. Lyakhov,E. A. Lyakhova,L. A. Litvinova,S. A. Andronati,A. V. Egorova,I. V. Vel'cheva,A. I. Gren',M. N. Lebedyuk,V. P. Fedchuk,G. A. Khorokhorina

2003Pharmaceutical Chemistry Journal（2003）

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12ChemInform Abstract: Synthesis and Antiviral Activity of Novel Bis‐Acridinylhydrazides of Aryloxyacetic Acids.

S. A. Lyakhov,E. A. Lyakhova,N. N. Panchenko,L. A. Litvinova,S. A. Andronati

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.

2002ChemInform（2002）

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13Synthesis and Antiviral Activity of New Bisacridinylhydrazides of Aryloxyacetic Acids

S. A. Lyakhov,E. A. Lyakhova,N. N. Panchenko,L. A. Litvinova,S. A. Andronati

2001Pharmaceutical Chemistry Journal（2001）引用：1

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14[Biochemical Mechanisms of Realization of Antiviral and Interferon-Inducing Activity of Amixine and Its Analogs].

S A Liakhov,L A Litvinova,S A Andronati,L K Berezina,B N Galkin,V E Osetrov,T O Filippova,N Ia Golovenko

Antiviral and interferon inducing activity of the amixine and its some derivatives, as well as their influence on the proteolytic enzymes activity, monooxygenase activity of the microsomal fraction, level of the lipids peroxidation were studied. Lack of correlation between antiviral and interferon inducing activity in the investigated series of compounds was found. Vice versa, the good correlation between interferon inducing activity and the elastase-like activities inhibition ability of the compounds was observed. It allows to state the assumption, that only one ability of compounds to induce of an interferon doesn't suffice for obtaining of high titres of interferon, and while their rather high antiproteolitic activity is necessary. It's shown, that except for one compound the influence of amixine and its derivatives on the red-ox enzymes activity well correlates with their ability to the interferon-inducing. All presented above allows to attribute amixine and its derivatives to polymodal antiviral agents.

2001Ukrains'kyi biokhimichnyi zhurnal (1999 )（2001）引用：23

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15Antiviral Activity of Acridinylaminoalcohols and Acridinylaminoacid Esters

Ya. I. Suveyzdis,S. A. Lyakhov,L. A. Litvinova,S. L. Rybalko,S. T. Dyadyun

2000Pharmaceutical Chemistry Journal（2000）引用：5

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16Biological Activity of the Liposomal Form of Amixin

L. A. Litvinova,S. A. Lyakhov,S. A. Andronati,L. K. Berezina, N. N. Nosik

2000Pharmaceutical Chemistry Journal（2000）引用：2

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17Interferon Induction Properties of Mono- and Bisacridines

S. A. Lyakhov,L. A. Litvinova, Ya. I. Suveyzdis,S. A. Andronati,S. L. Rybalko,S. T. Dyadyun

2000Pharmaceutical Chemistry Journal（2000）引用：3

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18ChemInform Abstract: Synthesis and Pharmacological Properties of Novel Aminoacylaminoanthraquinones.

L. A. Litvinova,S. A. Lyakhov,S. A. Andronati,N. A. Zhukova,O. G. Yasinskaya,B. N. Galkin,T. O. Filippova,N. Ya. Golovenko

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.

1999

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19Synthesis and Pharmacological Properties of New Aminoacylaminoanthraquinones

L. A. Litvinova,S. A. Lyakhov,S. A. Andronati,N. A. Zhukova,O. G. Yasinskaya,B. N. Galkin,T. O. Filippova,N. Ya. Golovenko

1998Pharmaceutical Chemistry Journal（1998）引用：3

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20Nitro- and amino-tilorone derivatives

S. A. Lyakhov,L. A. Litvinova, A. N. Poplavsky, G. V. Maltzev,M. K. Semenovykh,L. K. Berezina,S. A. Andronati

1992Pharmazie（1992）引用：23

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作者统计

合作学者

合作机构

D-Core

合作者
学生
导师

S. A. Andronati

S. A. Andronati合作论文数32

Sergey A. Lyakhov合作论文数A. V. Bogatskii Physical Chemistry Institute, Academy of Sciences of the Ukrainian SSR Odessa18

T. O. Filippova

T. O. Filippova合作论文数12

G. A. Khorokhorina

G. A. Khorokhorina合作论文数9

V. P. Fedchuk

V. P. Fedchuk合作论文数9

G. V. Lempart

G. V. Lempart合作论文数9

O. G. Yasinskaya

O. G. Yasinskaya合作论文数9

Av Bogatskii

Av Bogatskii合作论文数7

Liakhov S A

Liakhov S A合作论文数7

I. V. Vel'cheva

I. V. Vel'cheva合作论文数6

E. A. Lyakhova

E. A. Lyakhova合作论文数6

е а ляхова

е а ляхова合作论文数5

A. I. Gren’

A. I. Gren’合作论文数5

м н лебедюк

м н лебедюк合作论文数5

Boris Galkin合作论文数5

V. V. Ivanova

V. V. Ivanova合作论文数4

M. N. Lebedyuk

M. N. Lebedyuk合作论文数4

Alexander S Karpenko

Alexander S Karpenko合作论文数4

Nataliya a Zhukova

Nataliya a Zhukova合作论文数4

G. V. Dimitrishchuk

G. V. Dimitrishchuk合作论文数3

Kavetskiĭ R E

Kavetskiĭ R E合作论文数3

Golovenko N Ia

Golovenko N Ia合作论文数3

Balitskiĭ K P

Balitskiĭ K P合作论文数3

Berezina L K

Berezina L K合作论文数3

I. G. Veksler

I. G. Veksler合作论文数3

N. Ya. Golovenko

N. Ya. Golovenko合作论文数3

S. T. Dyadyun

S. T. Dyadyun合作论文数2

L. V. Yakimenko

L. V. Yakimenko合作论文数2

R. V. Denisenko

R. V. Denisenko合作论文数2

IA VINOGRAD

IA VINOGRAD合作论文数2

V. I. Musienko

V. I. Musienko合作论文数2

O. Ya. Pentsarskii

O. Ya. Pentsarskii合作论文数2

N. N. Panchenko

N. N. Panchenko合作论文数2

A. V. Egorova

A. V. Egorova合作论文数2

Yu. A. Umanskii

Yu. A. Umanskii合作论文数2

Sergei Rybalko

Sergei Rybalko合作论文数Phys. Fac., Moscow State Univ.2

M. M. Kozlovskii

M. M. Kozlovskii合作论文数2

Nadezhda Zholobak合作论文数2

Zoya M. Topilova

Zoya M. Topilova合作论文数2

M. O. Shibinskaya

M. O. Shibinskaya合作论文数1

з м олевинская

з м олевинская合作论文数1

V E Osetrov

V E Osetrov合作论文数1

м о шибинская

м о шибинская合作论文数1

O V Khait

O V Khait合作论文数1

L. N. Yakubovskaya

L. N. Yakubovskaya合作论文数1

Ivanova Va

Ivanova Va合作论文数1

V A Barinov

V A Barinov合作论文数1

o v zhuk

o v zhuk合作论文数1

AN POPLAVSKII

AN POPLAVSKII合作论文数1

相似学者

S. A. Andronati

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Sergey A. Lyakhov

T. O. Filippova

T. O. Filippova

G. A. Khorokhorina

G. A. Khorokhorina

O. G. Yasinskaya

O. G. Yasinskaya

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