To reveal the influence of intercalating fragment on the affinity to DNA aminoacetylhydrazones of 9-formylacridine and 9-formylanthracene are synthesized and their properties as intercalators and ability to inhibit the polymerase chain reaction are studied. It is shown, that the acridine derivatives (lg K а = 7.37 - 8.04) are more affine to DNA than the anthracene derivatives (lg K а = 5.37 - 6.12). Both acridines and anthracenes are characterized by insignificant ability to inhibit PCR. Correlation between affinity to DNA and ability to inhibit replication is absent.
V. P. Fedchuk合作论文数6M. N. Lebedyuk合作论文数6е а ляхова合作论文数5G. A. Khorokhorina合作论文数5Liakhov S A合作论文数5L. A. Litvinova合作论文数5I. V. Vel'cheva合作论文数3S. A. Andronati合作论文数3V. V. Bocharova合作论文数2L. V. Kuts合作论文数2M. M. Lebediuk合作论文数1владимир иванович бойко合作论文数1volodymyr ivanovych boiko合作论文数1Yu. I. Bazhora合作论文数1N. B. Prokofyeva合作论文数1M. E. Zapolskiy合作论文数1Vasily Bocharov合作论文数1Bazhora Iu I合作论文数1A. V. Egorova合作论文数1Alexander S Karpenko合作论文数1Zoya M. Topilova合作论文数1
