目的:探索和实践口腔修复印模技能诊断性考评联合角色互演的教学模式.方法:选择口腔修复科轮训的24名学员,随机分为实验组(n=12)与对照组(n=12),采用技能评分表考评结合考评角色互演,并调查学员满意度来评估教学质量.结果:实验组出科成绩比对照组高2.25分,学员满意度100％.结论:诊断性考评联合角色互演的教学模式有助于提升学员临床技能.

成釉细胞瘤是较为常见的牙源性肿瘤.它易复发、易恶变,属于临界瘤.成釉细胞瘤具有许多特殊的标志物,虽然目前其组织来源及发病机制尚未明确,但其发生与多种信号转导途径密切相关,包括有丝分裂原活化蛋白激酶(MAPK)信号通路、Sonic Hedgehog(SHH)信号通路和经典WNT/β-catenin信号通路.鼠类肉瘤滤过性毒菌致癌同源体B1(BRAF)突变、大鼠肉瘤病毒致癌基因同源物(RAS)突变和Smoothened(SMO)突变等多种突变基因型已在成釉细胞瘤中被发现,不同突变型的成釉细胞瘤有不同的临床特点和生物学行为,结合组织学特点可用于指导分型,对治疗及预后具有重要意义.为了进一步探讨这种与临床相关的基因型-表型相关性,本文就成釉细胞瘤的分类、分子水平标志物、发病机制、靶向治疗及预后进行综述,以期对今后的诊断和治疗有所帮助.

舵机装置是用来改变船舶航行方向的执行机构,为了测试其操作性能和可靠性,缩短研制周期,节约研制成本,需要对舵机装置的工作载荷进行模拟,从而满足舵机装置的性能测试需求.舵机负载模拟系统是一种半实物仿真系统,主要用来对舵机装置进行负载模拟加载,模拟船舶在实际航行过程中舵机装置所受到的水动力载荷.建立舵机负载模拟系统的数学模型与AMESim仿真模型,重点研究加载系统的力跟踪闭环控制特性.

To reduce the interpolation error of dual-NURBS tool paths by using the same node vector and to improve real time performance in the process of sculptured surfaces machining,a double-NURBS interpolation algorithm based on improved Cooperative Co-evolutionary Genetic Algorithms (CCGA) and Newton-like parameter calculating was proposed.Based on the error control,some of the cutter tip points and cutter points were selected to construct dual-NURBS curves with same node vector.To reduce the fitting error and improve the interpolation precision,weights of cutter points NURBS curve were adjusted with improved CCGA algorithms.Newton-like algorithm was utilized to calculate parameter in the process of NURBS interpolation so that interpolation error and calculation time were further reduced.The experimental result showed that the proposed algorithm could effectively improve the interpolation accuracy and real time performance by comparing to other methods.

An interpolation algorithm based on improved S-type velocity planning and Steffensen-like parameter calculating was proposed in order to improve accuracy of non-uniform rational b-spline(NURBS)interpolation and reduce feedrate fluctuation.The adaptive interpolation method was used to obtain information of each curve segment.S-type velocity planning method was improved by adaptively adjusting jerk and accurately controlling feedrate based on the information of curvature of these segments.Then the optimal interpolation that satisfied all the error constraints everywhere was realized.The proposed algorithm determined the starting point of deceleration area precisely by the way of positive and reverse interpolation.Steffensen-like method with parameters was used to calculate the interpolation parameters without derivative calculation in order to improve real time performance and to control feedrate fluctuation availably, The experimental results show that ,the proposed method can effectively improve the interpolation accuracy and reduce feedrate fluctuation compared to other methods.

为压缩逆向工程中重构物体轮廓的B样条曲线的控制顶点,提出一种基于特征点提取及改进粒子群算法的B样条曲线逼近技术。利用等弦长法计算离散点的曲率,基于曲率分析提取出离散点列的特征点并构造初始逼近曲线。在误差最大处插入新的插值点,构造新的逼近曲线。重复该过程,当增加插值点不能较大幅度地降低逼近误差时,利用改进的粒子群算法优化曲线控制顶点的位置,由此得到最终的B样条逼近曲线。实例验证表明,相比于其他方法,该方法能更有效地降低控制顶点个数,迭代效率高,逼近效果好。

目前,重建钛板越来越多的作为快速而安全的下颌骨缺损修复方法之一.我院2003年对63例肿瘤、囊肿及炎症术后的下颌骨缺损患者采用单张钛板重建或联合自体游离骨即刻修复,获得了满意的效果,现报告如下.

Objective To investigate the practical value of dynamic bone imaging with ~ 99m Tc -MDP in quantitatively evaluating the vascularization and ossification effects during the repairing of bone defect with the tissue-engineered bone graft. Methods 15 model rabbits of skull defect were built which were symmetrically implanted nano-hydroxyapatite/collagen-1-type (nHAC) and particle-hydroxyapatite/collagen-1-type (pHAC) respectively into the defect sites. They were randomly and averagely divided into 5 time-point groups, namely 2, 4, 8, 10 and 12 week groups. After intravenous injection of ~ 99m Tc -MDP via the auricle vein,the routinely dynamic bone imaging was performed. Using the ROI technique, the radioactivity peak and uptake ratio were calculated. The parameters mentioned obove were compared between the nHAC and pHAC. The X-ray of skull was done and the images were observed. Results (1) Dynamic bone imaging: at every time-point, the radioactivity peak of perfusion phase and uptake ratio of static phase in nHAC implanted area both were significantly higher than those in pHAC implanted area (P0.01). With the implantation time extending, the radioactivity peak of perfusion phase and uptake ratio of static phase in nHAC and pHAC implanted areas both increased; and these parameters after 8 week were significantly higher than those at 2 week in nHAC implanted area (P0.05), while after 10 weeks in pHAC implanted area (P0.01). (2) X-ray imaging: The bone repairing of nHAC was earlier than pHAC, and the density of neo-bone in nHAC was also greater than that in pHAC. Both edge and center of implanted area presented neo-born in nHAC, but only edge in pHAC. Conclusions In promoting early vascularization and accelerating ossification, the nHAC has obvious superiority to the pHAC. The dynamic bone imaging with ~ 99m Tc -MDP may evaluate the vascularization and ossification effects accurately, dynamically and quantitatively during the repairing of bone defect with the tissue-engineered bone graft.;

目的探讨Sturge-Weber综合征的临床特点、诊断方法及治疗手段.方法对1例不典型Sturge-Weber综合征的临床资料进行总结,复习文献以比较各种治疗方法的临床疗效.结果对症治疗效果良好.促脑代谢药物可减轻神经症状,激光治疗皮肤血管痣疗效确切,动脉栓塞治疗颊部血管瘤体积缩小60%以上,随访半年未见增大.结论该病综合治疗的效果明显好于单一疗法.

Sturge-Weber综合征是一种罕见的先天性神经皮肤综合征,以面部三叉神经分布区红葡萄酒色血管瘤为最典型表现.因发病率低,目前对其诊断和治疗有不同的意见.本文就该综合征的病因起源、临床特征、诊断及治疗作一综述.