将2种聚酯酸酐(P(SA∶RA 20∶80),P(SA∶RA 30∶70))分别与伊维菌素溶于三氯甲烷中作为有机相,以聚乙烯醇水溶液为水相,用乳化溶剂挥发法制备出2种伊维菌素聚酯酸酐微球.采用光学显微镜考察所制备微球的形态及粒径,紫外分光光度法测定载药量和包封率.结果显示,制备出的P(SA∶RA 30∶70)/IVM微球的平均粒径为(72.240±24.747) μm,载药量为19.67％,包封率为87.70％.P(SA∶RA 20∶80)/IVM微球的平均粒径为(64.18±26.14) μm,载药量为17.72％,包封率为87.27％.这表明采用乳化溶剂挥发法成功制备出2种伊维菌素聚酯酸酐微球.

Capsaicin/OMMT composites with different drug-loaded amounts were successfully prepared by solution intercalation method.The composite products were characterized by X-ray diffraction(XRD),Fourier transform infrared spectroscopy(FTIR)and thermal gravimetric analysis(TGA).The results show that the layer space of OMMT increased from 1.9nm to 3.7nm and capsaicin insert into the OMMT interlayers.The thermal stability of capsaicin was obviously improved by the intercalation and the decomposition temperature of the composite was improved to 240℃.The time of the drug sustained release was 48hby in vitro release test,such composite shows sustained release of capsaicin.These composite could be an antibacterial plastic additives.

SiO2载药微球由于具有良好的热稳定性、生物相容性和无毒无刺激等优点,近年来在医药、化妆品及化工分析等领域受到了普遍关注。对于一定化学组成的载药微球,其微结构对载药稳定性、药物释放行为等都有重要影响,不同微结构的载药微球制备方法也有所不同,根据微球结构和药物在微球中分布的不同,SiO2载药微球可分为基质型、核壳型、多核型和复合型。主要按照载药微球结构的不同,综述了各类微球的制备、药物释放特点及其在生物医学领域的应用。目前,通过调控SiO2载药微球的结构和组成以实现功能的多样性以及药物释放的精确调控是其发展的一个重要方向。