全尾砂絮凝沉降过程是膏体充填工艺的重要环节.为考察多因素耦合条件下尾砂絮凝沉降规律,开展全尾砂静态絮凝沉降实验,应用Design-Expert软件分析并筛选影响全尾砂絮凝沉降的重要因素,探究单位面积处理量最大时各重要影响因素的最优值.结果表明:不同影响因素耦合条件下,各絮凝沉降曲线形态基本一致,呈现先迅速下降后趋于水平的趋势.影响絮凝沉降的重要因素为尾砂入料浓度、絮凝剂用量、絮凝剂溶液浓度,其最优值分别为16.02％、28.35 g/t、0.1541％,此时单位面积固体处理量最大,为3.04 t/(m2·h).

In order to obtain the best flocculation settlement of unclassified tailings,the mathematical model was built by Box-Behnken method.For the response surface analysis,the flocculant consumption,flocculant solution concentration and tailings mass concentration were selected as the influencing factors and the solid processing volume per unit area was selected as the response value.The best parameters of flocculation settlement were obtained.Under 36.04 g/t of flocculant consumption,0.30％ of flocculant solution concentration and 21.02％ of tailings mass concentration,the solid processing volume per unit area was calculated as 3.14t· h-1 · m-2and was measured as 3.16 t · h 1 · m 2 in mine field,which only had difference of 0.63％.The results showed that the response surface methodology was reliable for analyzing the influencing factors of flocculation settlement.

将2种聚酯酸酐(P(SA∶RA 20∶80),P(SA∶RA 30∶70))分别与伊维菌素溶于三氯甲烷中作为有机相,以聚乙烯醇水溶液为水相,用乳化溶剂挥发法制备出2种伊维菌素聚酯酸酐微球.采用光学显微镜考察所制备微球的形态及粒径,紫外分光光度法测定载药量和包封率.结果显示,制备出的P(SA∶RA 30∶70)/IVM微球的平均粒径为(72.240±24.747) μm,载药量为19.67％,包封率为87.70％.P(SA∶RA 20∶80)/IVM微球的平均粒径为(64.18±26.14) μm,载药量为17.72％,包封率为87.27％.这表明采用乳化溶剂挥发法成功制备出2种伊维菌素聚酯酸酐微球.