目的 了解甘肃省2010-2016年围生儿出生缺陷的现况,为甘肃省制定围生儿出生缺陷防控工作提供参考依据和理论指导.方法 收集甘肃省2010年10月1日-2016年9月30日出生的围生儿数据资料,采用EpiData 3.0进行数据的录入,运用Excel 2010、SPSS 19.0对数据进行整理和统计学分析.采用年估计变化百分比法(EAPC)来评价发生率的变化趋势.结果 甘肃省2010-2016年围生儿出生缺陷发生16 336例,平均发生率为74.16/万,经EAPC检验,7年内围生儿出生缺陷发生率逐年升高;围生儿出生缺陷发生顺位中,先天性心脏病发生率逐年升高,顺位连续3年排第1位,神经管畸形发生率逐年下降,其他畸形变化趋势不明显;甘肃省2016年围生儿出生缺陷发生3 153例,大多数的围生儿出生缺陷是通过超声和临床诊断的.在围生儿出生缺陷患儿中,男女比例相当,少数发生性别畸形,患儿体重＜4 000 9居多,大多数胎龄42周以下,患儿中单胎居多数,有一半患儿在出生前或者出生后死亡.2016年甘肃省围生儿出生缺陷患儿母亲年龄20 ～35岁居多,35岁以上占8.66％,超过一半孕妇怀孕2次以上,初中文化程度居多,农村户口妇女占67.94％,家庭人均收入2000～8000元占多数.围生儿出生缺陷母亲孕期有发热史占0.67％,有糖尿病史者占0.22％,围生儿出生缺陷母亲均无病毒感染史、无磺胺类药物服用史、无抗生素药物服用史、无避孕药物服用史、无镇静药物服用史、无饮酒史、无农药接触史、无射线接触史、无化学制剂接触史.结论 甘肃省围生儿出生缺陷发生率逐年升高,尤其是先天性心脏病在出生缺陷顺位中排第1位,应加强甘肃省围生儿出生缺陷防控工作,加大先天性心脏病的预防,进一步开展围生儿出生缺陷的影响因素研究,为完善围生儿出生缺陷三级预防提供可靠理论.

The cultivated land changes of Gansu in 1997-2006 were researched. By using statistical analysis methods,we analyzed the dynamic changing relation between the cultivated lands and the growth of population and economic development in Gansu Province. The results showed that cultivated land change trend was opposited to the population change trend. However,the correlation between the cultivated land area and the fixed asset investment,GDP per capita and urbanization showed cubic curve. That is with the increasing of population and economy growth,the tendency of the cultivated land decreasing presented a change of firstly decreasing,then in-creasing,and decreasing again.

Land consolidation is improving farmers' living conditions and intensive land utilization and conservation of the important measures. Based on the synthesis of Gansu economy,land and environmental factors of Gansu province, 14 municipal is divided into six regions, and combining the actual situation, put forward consolidation patterns, and analyse the operation model, organization leadership pattern, financing mode.Providing the strategy to solve problems in process of land consolidation.