目的 检测转化生长因子-β1 (TGF-β1)、水通道蛋白3(AQP3)在妊娠早期胚胎停育患者蜕膜组织中的表达,探讨它们与胚胎停育的关系.方法 选择2017年10月-2018年5月就诊于华北理工大学附属医院妇科门诊经B超确诊为胚胎停育的患者为病例组,在妊娠同一时期正常妊娠要求行人工流产术的孕妇作为对照组.Western blot、免疫组化法检测TGF-β1、AQP3的蛋白在两组患者蜕膜组织中的表达;采用RT-PCR法检测两组蜕膜组织中TGF-β1、AQP3的mRNA的表达.结果 病例组中TGF-β1、AQP3的蛋白表达水平高于对照组,差异有统计学意义(P＜0.05);病例组中TGF-β1、AQP3的mRNA表达量高于对照组,差异有统计学意义(P＜0.05).结论 TGF-β1和AQP3两者可能与胚胎停育关系密切,可能共同参与了早孕期胚胎停育的发生.

目的 比较替格瑞洛与氯吡格雷治疗急性心肌梗死(AMI)患者的临床疗效及安全性.方法 收集2013年1月-2015年7月唐山市工人医院收治的行PCI术后双联抗血小板治疗的AMI患者512例,其中采用替格瑞洛治疗262例为研究组,采用氯吡格雷治疗250例为对照组,2组均服阿司匹林.比较2组治疗12个月后主要心脑血管不良事件(MACE)、出血事件及不良反应发生情况.结果 研究组MACE事件累积发生率为27.9%低于对照组45.6%,差异有统计学意义(P<0.01),其中支架内血栓形成发生率为1.1%低于对照组的4.0%、再发心绞痛发生率为14.5%低于对照组的21.2%,差异均有统计学意义(P<0.05).2组心血管病死率、AMI、卒中、靶血管血运重建发生率差异无统计学意义(P>0.05).研究组心动过缓发生率、轻微出血发生率高于对照组,差异均有统计学意义(P<0.05).2组次要出血发生率比较差异无统计学意义(P>0.05),均无主要出血发生.结论 AMI患者在随访1年的抗栓治疗期间,降低主要心脑血管事件方面替格瑞洛比氯吡格雷更优,尤其是降低支架内血栓、再发心绞痛发生率,但替格瑞洛相对增加轻微出血及心动过缓发生率.

Objective To investigate the characteristics of intravascular ultrasound in patients of coronary heart disease complicated with.Methods After coronary angiography,141 patients with coronary heart disease were enrolled in this study,and divided into two groups,according to with or without diabetes mellitus,observation group(diabetes mellitus) 51 cases,control group(without diabetes mellitus) 90 cases,IVUS were applied in all patients.Results The three lesions of observation group were significantly more than control group,a single lesion was less than control group,the difference was statistically significant(P<0.05).The incidence of double-vessel disease was similar(P>0.05).There was no significant difference in plaque type between two groups(P>0.05).The ratio of calcification in observation group was higher than that of control group,the MLA of lesion was significantly smaller than that of control group,the plaque load(PB) was higher than that of control group,the difference was statistically significant(P<0.05).Conclusion Patients with coronary heart disease and diabetes mellitus has more severe coronary lesions,bigger PB and smaller MLA compared to patients without diabetes.

①目的 探讨精神分裂症患者社会功能的相关影响因素.②方法 采用自编一般情况调查表、阴性与阳性症状量表(PANSS)、个人和社会功能量表(PSP)、社会支持评定量表,对60例精神分裂症患者分别从性别、文化程度、婚姻状况、吸烟和饮酒等方面来比较对社会功能的影响.③结果 性别不同的精神分裂症患者在个体和社会功能总分上不存在显著差异;文化程度不同的精神分裂症患者在个体和社会功能两个因素的评价总分上没有显著差异;婚姻情况不同的精神分裂症患者在个体和社会功能总分上不存在显著差异.是否吸烟与是否饮酒的精神分裂症患者在个体和社会功能总分上不存在显著差异.精神分裂症患者社会功能与社会支持的关系无显著差异.④结论 精神分裂症患者中存在不同程度残疾的最多;性别,文化程度,婚姻及吸烟、饮酒均不能成为精神分裂症患者社会功能的影响因素;精神分裂症患者在社会支持和社会功能的相互关系上无显著差异.

Objective:To evaluate the benefit of Bivalirudin on acute myocardial infarction for percutaneous coronary intervention.Method:A total of 122 AMI patients receiving PCI were divided into two groups,Heparin group(n=55) and Bivalirudin group(n=67).We compared the procedural success rate,creatinine,ST segment percentage fall back,platelet and NT-porBNP.The safety evaluation were the incidence of bleeding and major adverse cardiac events(MACE) within 30 days of PCI.Result:ST segment percentage fall back was similar at 1-hour after the PCI procedure between two groups(P>0.05).Bivalirudin group had higher NT-porBNP levels than Heparin group before the procedure(P=0.097>0.05),however,those in two groups were similar,Bivalirudin group had lower NT-porBNP levels than Heparin group at 24-hour after the procedure(P>0.05).The mild bleeding rate during two groups were meaningful(P=0.002<0.05).The levels of platelet and creatinine at 24-hour after the PCI,the procedural success rate and the survival rate within 30 days were similar(P>0.05).Conclusion:Bivalirudin is safe and effective during emergent PCI,bleeding rate is less than Heparin.

目的：观察主动脉内球囊反搏（ IABP）联合经皮冠状动脉介入（ PCI）治疗急性心肌梗死合并心源性休克的临床疗效。方法选择2013年5月-2014年6月在医院急诊救治的急性心肌梗死伴心源性休克患者160例，随机分为观察组和对照组各80例，2组患者均进行急诊PCI，观察组在PCI前接受IABP联合药物治疗，对照组在PCI前仅接受药物治疗。比较2组患者的血清N末端B型利钠肽原（ NT-proBNP）、心肌酶含量以及心脏彩色多普勒超声指标。结果观察组患者的NT-proBNP、肌酸激酶同工酶（ CK-MB）、心肌肌钙蛋白（ cTnI）含量以及病死率低于对照组（P<0.05），左室射血分数（LVEF）和左室舒张末径（LVEDD）高于对照组（P<0.05）。结论 IABP联合PCI治疗急性心肌梗死有助于改善神经体液指标、减少心肌细胞损伤、增强心功能，是理想的治疗方法。

清代著名医家黄元御以"中气升降"为中心,阐释脏腑气机的圆运动,在临床治疗中重视人体中气,调畅脏腑气机,复其升降枢转之常。黄氏第五代弟子麻瑞亭将"中气升降"理论进一步完善,认为脏腑气机升降紊乱所致之病,均当复其升降之常,而复其升降之常的关键,重在调理脾胃中气升降,并将黄氏气滞之主方下气汤加减完善为治疗脏腑功能失调、气机升降紊乱之内伤杂病方,可用以指导临床脏腑气机失调类疾病的治疗。