Objective To find out if the adding of short-effect GnRH-a in ultra-long protocol of endometriosis will do some benefits.Methods We compared the Gn duration and ampoules,retrieved oocytes numbers,clinical pregnancy rate,and abortion rate between the control group without the adding of short-effecct GnRH-a and the subject group statistically. Results There were no significant differences in Gn amount and duration,retrieved oocytes number,fertility rate,and cleavage rate between the two groups. The pregnancy rate,implantation rate,abortion rate,and cryopreservation rate of the two groups were not different statistically. The ongoing pregnancy rate of the control group was higher than that of the subject group statistically. Conclusions The adding of short-effect GnRH-a in ultralong protocol of endometriosis can not reduce the Gn amount and the Gn days. The number of oocytes retrieved are not increased through the adding. The adding doesn't affect the clinical outcomes statistically as well.
The experiment was conducted to prepare Compound Chlorhexidine Acetate Gel,it was used to treat the endometritis in dam, and establish its quality control method. The Compound gelata was prepared with Chlorhexidine Acetate and Metronidazole as chief medicine using carbopol-940 as base. The content of Chlorhexidine Acetate and Metronidazole in the gel was determined by HLPC method. The results showed the preparation was white or light yellow semisolid gel, and had good precision and repetion rate about Chlorhexidine Acetate and Metronidazole.The mean recoveries were 99.23% and 99.37%. The preparation is simple in preparation process,and the determination is accurate and reproducible.
为了验证复方醋酸氯己定凝胶的安全性,观察其对动物毒性和阴道黏膜的刺激性作用,试验对健康家兔进行毒性试验和阴道黏膜刺激试验.结果表明:复方醋酸氯己定凝胶剂对家兔的最大给药量大于8g/kg,不会对机体产生毒性作用；低剂量组和高剂量组对家兔阴道黏膜的刺激指数分别为0.7,1.3.说明复方醋酸氯己定凝胶阴道用药无毒性,低剂量对阴道黏膜无刺激性,高剂量组有极轻度的刺激性,但在可接受范围内,临床可放心使用.
The experiment was conducted to prepare Compound Chlorhexidine Acetate Gel,it was used to treat the endometritis in dam, and establish its quality control method. The Compound gelata was prepared with Chlorhexidine Acetate and Metronidazole as chief medicine using carbopol-940 as base. The content of Chlorhexidine Acetate and Metronidazole in the gel was determined by HLPC method. The results showed the preparation was white or light yellow semisolid gel, and had good precision and repetion rate about Chlorhexidine Acetate and Metronidazole.The mean recoveries were 99.23% and 99.37%. The preparation is simple in preparation process,and the determination is accurate and reproducible.
