We report the case of a 56-year-old male patient who underwent panretinal laser photocoagulation for left central retinal vein occlusion. One month after surgery, he developed blurred and distorted vision. Optical coherence tomography revealed macular edema in the left eye. The patient received three intravitreal anti-vascular endothelial growth factor (anti-VEGF) injections and oral Chinese herbal medicine for 4 months; however, no significant improvements in symptoms or imaging findings were observed. The patient subsequently presented with a sudden decrease in visual acuity in the left eye, distorted vision, dry eye, a sensation of swelling and friction, a narrowed visual field, and a cotton-like visual obstruction. He then visited a traditional Chinese medicine acupuncture clinic and received Bo’s abdominal acupuncture. The selected abdominal acupoints included Zhongwan (CV 12), Xiawan (CV 10), left Shangqu (KI 17), right KI 17, Qihai (CV 6), left Qipang (AB 7), Guanyuan (CV 4), left Qixue (KI 13), left Huaroumen (ST 24), left Shangfengshidian (AB 1), right ST 24, and right AB 1. After 3 months of treatment, ocular discomfort largely resolved, and the best-corrected visual acuity of the left eye improved from 0.08 (logarithm of the minimum angle of resolution [LogMAR] 1.10) to 0.25 (LogMAR 0.60). The maximum recognition distance for the same target character increased from 30 cm at the initial visit to 82 cm after treatment, representing an improvement of 52 cm. Fundus imaging showed that central subfield thickness decreased from 596 μm to 216 μm, cube volume from 16.5 mm3 to 11.4 mm3, and average cube thickness from 459 μm to 316 μm, with no significant differences observed between the left and right eyes. Bo’s abdominal acupuncture may serve as a complementary therapy for macular edema secondary to central retinal vein occlusion.

Rheumatoid arthritis (RA) is a common chronic systemic autoimmune disease that causes cartilage and bone damage in multiple joints, ultimately leading to disability. There is an urgent need to develop multidimensional strategies to treat RA. Sinomenine (SIN) has the distinctive pharmacological activity in treating RA, but its broader clinical application is limited by its exceedingly short half-life and adverse digestive tract effects. To overcome this obstacle, a self-assembled nanohydrogel (S-G hydrogel) was designed and produced with sinomenine (SIN) and glycyrrhizic acid (GA) without carriers or catalysts through noncovalent bonding. The S-G hydrogel could promote the absorption of SIN probably by protecting SIN from releasing and degrading in the acid circumstances. Oral intake of the S-G hydrogel significantly suppressed the overactivation of neutrophil via the Nf-κb and Mapk pathways in mice with RA. Furthermore, the S-G hydrogel regulated neutrophil activity by reversing apoptosis delay and decreasing autophagy-dependent NET formation. In summary, this study presents a self-assembled hydrogel with promising potential for clinical application, and offers a novel strategy to develop new drugs from the existing patent medicine composed of compounds from traditional Chinese medicine, as well as a special insight to elucidate the herb-matching mechanism in decoction prescriptions.

Bioactive compounds derived from medicinal plants have become a significant source of drugs for inflammatory diseases treatment, particularly those caused by immune system abnormalities. Quercetin, a flavonol found in a wide variety of herbs, fruits, and vegetables, has garnered attention for its diverse biological properties, including anti-inflammatory, anticancer, and antiviral activities. Numerous in vivo and ex vivo studies have validated quercetin's role in treating inflammatory diseases through multiple pathways, mainly involving anti-oxidative stress, modulation of metabolism, intestinal flora, apoptosis, endoplasmic reticulum stress, and macrophage polarization, indicating it a promising pharmaceutical candidate for managing inflammatory and autoimmune conditions. We aimed to systematically review quercetin's anti-inflammatory activity and the mechanisms of action across various inflammatory diseases in the digestive, respiratory, endocrine, neurological, and osteoarticular systems. By summarizing the therapeutic potential of quercetin in these multifaceted conditions, this review seeks to provide a solid foundation for future clinical research and application strategies involving quercetin.

BACKGROUND Adult-onset Still's disease (AOSD) is a rare autoinflammatory disease characterized by nonspecific symptoms such as fever, rash, sore throat and arthralgia. This paper reports a clinical case of AOSD successfully treated with Bo’s abdominal acupuncture (BAA). CASE SUMMARY We report a 20-year-old man who suffered from cold exposure, presenting with high fever, rash, sore throat, arthralgia, and elevated erythrocyte sedimentation rate, leukocytosis with neutrophilic predominance, elevated ferritin, elevated C-reactive protein, and negative rheumatoid factors. He was diagnosed with AOSD based on the Yamaguchi criteria. After treatment with traditional Chinese medicine (TCM) decoction and prednisone acetate tablets, there was some alleviation of sore throat, joint and muscle pain, and fever, but he still had persistent low-grade fever, rash, sore throat and arthralgia. He went to the TCM acupuncture outpatient department to receive BAA. Abdominal acupoints Zhongwan (CV12), Xiawan (CV10), 0.5 cm below Xiawan (CV10), Qihai (CV6), Guanyuan (CV4), bilateral Qixue (KI13), bilateral Huaroumen (ST24), bilateral Shangfengshidian (AB1) and bilateral Daheng (SP15) were selected. After 3 months treatment, all symptoms disappeared, and the laboratory examination returned to normal levels. He did not take glucocorticoids or nonsteroidal anti-inflammatory drugs afterwards, and no relapse was observed during the 3-year follow-up period. CONCLUSION BAA can be used as a complementary medical approach for treatment of AOSD.

Objective:Si Miao San is effective in ameliorating rheumatoid arthritis (RA) both clinically and experimentally. NETs play a fundamental role in the onset and progression of RA. The goal of this study was to explore the therapeutic effects of Si Miao San (SMS) on adjuvant-induced arthritis in mice and the regulatory mechanisms of NETs both in vivo and in vitro. Methods:SMS decoctions were identified using LC-MS/MS analysis and TCMSP. In the adjuvant induced RA murine model, SMS decoction and methotrexate were administered orally. Disease progression was analysed by assessing arthritic scores and joint diameter, H&E staining, safranin O-fast green staining, toluidine blue staining and micro-CT analysis. The expression of NE, MPO, PAD4, LC3B, CitH3, p-AKT and p-PI3K and the production of ROS were detected using IHC, WB and IF analyses. Cytokines in the sera of the mice were detected using cytometric bead arrays. After the in vitro culture of neutrophils, NE, MPO, PAD4, LC3B, CitH3, ROS, p-PI3K and p-AKT were measured using IF and WB analyses. Autophagy was further observed with TEM. Results:SMS decoction compounds were first identified. Compared with the model group, SMS significantly inhibited joint swelling, inflammation progression and bone destruction. The levels of NE, MPO, PAD4, CitH3, LC3B, ROS production and relative expression of p-AKT and p-PI3K in joint tissues were significantly reduced in the SMS group compared to the model group (P < 0.05). In vitro culture, SMS-containing serum significantly reduced the LC3B-II/LC3B-I ratio and the relative expression levels of p-AKT and p-PI3K, as well as the levels of ROS, NE, MPO, PAD4, and CitH3 compared with those in the PMA-treated group (P < 0.05), which was abolished by the treatment with the AKT activator SC79. Conclusion:The SMS-induced suppression of inflammation in experimental RA occurred through the modulation of the AKT/ROS/autophagy axis.

BACKGROUND:Ulcerative colitis (UC) is characterized by abdominal pain and bloody diarrhoea and restoring the gut barrier is the core goal of UC treatment. Activation of aryl hydrocarbon receptor (Ahr) was reported to effectively alleviate symptoms and repair the gut barrier damage. Neutrophil extracellular traps (NETs) have been recognized as potential targets in the treatment of UC. Ahr activation has been found to be capable of upregulating Nqo1, thereby reducing the production of reactive oxygen species (ROS), which is important in the formation of NETs. Quercetin (QUE), which is derived from natural plants and herbs used in traditional Chinese medicine (TCM), is able to strengthen gut barrier function by activating Ahr. PURPOSE:The aim of this study is to investigate how QUE suppresses NETs in UC and activates Ahr in neutrophils. METHODS:In this study, the dextran sulfate sodium (DSS)-induced UC model was used. Histopathological assessments were performed in the paraffin slides of tissues after H&E, PAS, Masson and alcian blue staining. The concentration of cytokines was also detected using cytometric beads array kits. Based on the transcriptomic analysis of colon tissues, western blot (WB) analysis, immunohistochemistry (IHC) assays and immunofluorescence (IF) assays were conducted to validate the significantly regulated genes and pathways. In vitro, the binding of quercetin to Ahr was calculated by molecular dynamic simulations (MDS) and biolayer interferometry (BLI) analysis. Primary neutrophils isolated from mice were cocultured with LPS or PMA with or without quercetin. The regulated genes were detected using WB, real-time quantitative PCR, enzyme-linked immunosorbent assay (ELISA) and IF analysis. The agonists and antagonist of Ahr were used as the control. RESULTS:After the administration of quercetin, colon inflammation and gut barrier disruption was significantly prevented through inhibiting the NF-κB pathway and upregulating the expression of Ahr/Arnt and Nqo1. The transcriptomic analysis and IHC assays showed that inflammation and NETs were greatly decreased by QUE treatment. In vitro, quercetin inhibited LPS-induced inflammatory responses through NF-κB pathway. Furthermore, MDS and BLI analysis revealed that QUE is an agonist of AHR. QUE activated Ahr translocation and reduced ROS production via regulation of Arnt and Nqo1. CONCLUSION:This study proved that quercetin greatly improved gut barrier function in the DSS-induced colitis model by regulating NET formation and that quercetin was able to activate Ahr and upregulate Arnt in neutrophils to regulate NET formation.

Aristolochia pulvinata Yi-Fan Wang & Zhi-Jian Yin, a new species of Aristolochia subgenus Siphisia (Aristolochiaceae) from Yunnan Province, southwest China, is described and illustrated. Aristolochia pulvinata is distinguished by its unique characters: an elevated and thickened pulvinate structure in the inferior calyx limbs of its perianth. Morphologically, it resembles A. ovatifolia, A. melanocephala, A. utriformis, and A. luudamcui due to the similar thickening on the calyx limb region, but it differs in terms of degree, surface texture, color, and angle, as well as leaf morphology. This species, discovered and known only from one region, is assessed as Critically Endangered (CR) according to IUCN categories and criteria. This publication includes detailed morphological illustrations of A. pulvinata, with comparative photo plates and a table that highlights distinguishing features relative to similar species.

Abstract Background: The aim of this study was to compare the clinical effectiveness of acupuncture and related therapies in adults with constipation-predominant irritable bowel syndrome (IBS-C) and to provide guidance for clinical management. Methods: PubMed, The Cochrane Library, Embase, Web of Science, CNKI, Wanfang and VIP databases were searched for clinical randomised controlled trials (RCTs) of acupuncture and related therapies for IBS-C published from the inception of the database to January 2023. The literature was assessed for quality using the Cochrane 5.3 risk of bias assessment tool, and StataSE 15.0 and GeMTC 0.14.3 software were used for network meta-analysis (NMA).. Results: Twenty-seven trials were finally included in the NMA, including 7 acupuncture-related therapies. The results of the NMA showed that 7 acupuncture-related therapies were more effective than conventional medicine. The overall efficacy rate showed that acupuncture combined with medication was the most effective therapy (OR=6.33, 95% CI: 2.01, 41.74, P<0.05). The recovery rate showed that acupoint catgut embedding was the best treatment for IBS-C (OR=8.38, 95% CI: 2.65, 38.00, P<0.05). The overall efficacy rate at follow-up showed that acupuncture combined with medication had the best sustained effect. Conclusion: Acupuncture-related therapies are more clinically effective than conventional medicine in the treatment of IBS-C. Acupoint injection combined with medication has the best effect in both the short and long term, and combination therapy may be more beneficial. However, the existing trials have limitations and more high-quality randomised controlled trials are needed to confirm our findings.

Intestinal mucosal barrier dysfunction plays a crucial role in the pathogenesis of irritable bowel syndrome with diarrhea (IBS-D). In order to explore the mechanism of electroacupuncture (EA) treatment on intestinal mucosal barrier, this study observed the effect of EA on aquaporins (AQPs), tight junctions (TJs), NF-κB pathway and the gut microbiota in IBS-D rats. The IBS-D model was established by acetic acid enema combined with chronic restraint method. The effects of EA on the treatment of IBS-D were examined by the abdominal withdrawal reflex score, Bristol's fecal character score, fecal water content, small intestine propulsion rate and HE staining. AQPs, TJs and inflammation-related molecular mechanisms were explored. The fecal samples were applied for 16S rRNA sequencing to assess the effect of EA intervention to the intestinal bacterial abundance. EA reduced intestinal sensitization, restored intestinal motility and improved inflammatory cell infiltration. Furthermore, EA improved intestinal inflammation and flora environment significantly, inhibited NF-κB signaling and inflammatory factors (IL-1β and TNF-α). It can also increase the gene and protein expression of AQPs (AQP1, AQP3, and AQP8) and the gene levels of TJs (ZO-1 and Occludin). EA has an inhibitory effect on the NF-κB signaling pathway, and regulates the proteins of AQP1, AQP3, AQP8, and TJs to restore the balance of water metabolism and intestinal permeability in IBS-D, which also restored the function of the intestinal mucosa by regulating the intestinal flora. Irritable bowel syndrome with predominant diarrhea (IBS-D) is a common gastrointestinal disease in clinical practice, which was affected by intestinal mucosal barrier dysfunction, intestinal mucosal inflammation production and abnormal intestinal flora, then there is currently no specific drug for treating IBS-D. Electroacupuncture (EA), as a non-pharmacological therapy, has good therapeutic effects in treating IBS-D. Aquaporins (AQPs) are distributed in the intestinal mucosa of the intestine and are important factors in mediating water–liquid transmembrane transport. Changes in AQPs expression have been identified as a common factor in the etiology of certain gastrointestinal diseases. AQP1, AQP3, and AQP8 are distributed in the distal colon. EA can inhibit NF-κB signaling pathway, and regulate the proteins of AQP1, AQP3, AQP8, and TJs to restore the balance of water metabolism and intestinal permeability in IBS-D, which also can restore the function of the intestinal mucosa by regulating the intestinal flora.

目的 观察眼周穴位贴敷、揿针联合羧甲基纤维素钠滴眼液治疗近距离工作视疲劳患者的疗效.方法 将我院眼科近距离工作视疲劳患者120例(240只眼)随机分为治疗组与对照组各60例(120只眼).对照组采用羧甲基纤维素钠滴眼液治疗,治疗组在对照组治疗基础上采用眼周穴位贴敷+揿针治疗.观察两组泪液分泌试验(Sit)、泪膜破裂时间(BUT)、负相对调节(NRA)、正相对调节(PRA)、双眼调节功能变化.结果 治疗后,治疗组总有效率显著高于对照组(P＜0.05);两组Sit、BUT明显增加,且治疗组Sit、BUT明显多于对照组(P＜0.05);两组NRA、PRA明显增加,且治疗组NRA、PRA明显多于对照组(P＜0.05);两组双眼调节功能增加,治疗组双眼调节功能高于对照组(P＜0.05).结论 眼周穴位贴敷+揿针联合羧甲基纤维素钠滴眼液治疗近距离工作视疲劳患者疗效较好,能提高调节幅度和调节灵敏度,改善泪液分泌,缓解视疲劳症状.

目的:探讨眼周中药膏摩配合羧甲基纤维素钠滴眼液治疗眼部视频终端综合征的效果与安全性.方法:选取 2019 年 2 月-2022 年 2 月北京市二龙路医院眼科接收的 80 例眼部视频终端综合征患者,按随机数字表法分为两组.对照组(n=40)予以羧甲基纤维素钠滴眼液治疗,研究组(n=40)予以眼周中药膏摩配合羧甲基纤维素钠滴眼液治疗.对比两组症状缓解情况、总有效率、结膜与角膜恢复情况、泪液分泌情况及不良事件发生情况.结果:研究组治疗后不耐久视、眼酸胀痛、干涩灼热、畏光评分均比对照组低,差异均有统计学意义(P<0.05);研究组总有效率为 95.00%,比对照组的 77.50%高,差异有统计学意义(P<0.05);研究组治疗后的结膜充血、角膜荧光素染色(corneal fluorescein staining,CFS)评分均比对照组低,差异均有统计学意义(P<0.05);研究组治疗后的泪膜破裂时间(breakup time of tear film,BUT)、基础泪液分泌试验(Schirmer Ⅰ test,SⅠT)均优于对照组,差异均有统计学意义(P<0.05);两组治疗期间均未出现不良事件.结论:眼周中药膏摩配合羧甲基纤维素钠滴眼液治疗眼部视频终端综合征可有效缓解患者症状,提高疗效,并进一步促进结膜与角膜恢复,改善泪液分泌功能,且安全性较高.

Objective To explore the acupoint selection rule in acupuncture and moxibustion treatment of external humeral epicondylitis using data mining technology. Methods The literature on the acupuncture and moxibustion treatment of external humeral epicondylitis collected from January 1, 2016 to December 31, 2021 were searched in CNKI database,VIP database, Wanfang database, China Biomedical Literature Database and PubMed database. The prescription database was established, the high-frequency acupoints, meridians and acupoint combinations were counted, and the association rules were analyzed by software to explore the selection rules of acupoints. Results A total of 91 articles were included after screening according to the criteria for admission and discharge, involving 119 acupuncture prescriptions and 43acupoints, and the total frequency of use of acupoints was 622 times. The acupoints with higher frequency of use were Ashi,Quchi and Shousanli respectively. The large intestine meridian of hand-Yangming, Sanjiao meridian of hand-Shaoyang and small intestine meridian of hand-Taiyang were often choosen; the Fiveshu was often used in specific point; the most commonly used combination of acupoints was Ashi-Quchi-Shousanli; most of them were local acupoints and the meridian acupoints. Through the analysis of association rules, 21 rules with high correlation were obtained, and the high-frequency acupoints could be systematically clustered into 4 categories. Conclusion According to data mining, the acupoints selection in the treatment of external humeral epicondylitis by acupuncture and moxibustion are mainly local acupoints selection and local meridian matching, and the points use of Ashi and the three Yang meridians of hand are emphasized.

甲状腺手术的患者术后会出现咽痛、头晕头痛、咳痰、恶心、声音嘶哑等不适症状.而声音嘶哑是甲状腺手术术后的严重并发症,多与术中喉返神经损伤或术后积液、血肿有关,对此西医尚无良好治疗方法.腹针是一种以神阙系统为核心,通过针刺腹部的特定穴位,治疗各种急、慢性疾病的针灸疗法.本文结合病例分析腹针治疗甲状腺癌术后声音嘶哑的选穴,为临床治疗提供一个思路.

目的:观察比较电针印堂与大肠俞穴对肠易激综合征(IBS)大鼠结肠动力的影响,探讨其相关机制.方法:40只Wistar新生大鼠随机分为空白组、模型组、印堂组和大肠俞组.应用母子分离、醋酸灌肠和结直肠扩张法联合制备IBS大鼠模型.印堂组和大肠俞组分别予电针相应穴位干预,20min/次,隔日1次,共5次.记录Bristol粪便评分,腹部回撤反射(AWR)的潜伏期、90s内收缩波个数、峰峰值,免疫组化法检测迷走神经背核(DMV)和结肠肌层多巴胺D2受体(D2R)的表达.结果:与空白组比较,模型组Bristol评分显著升高、AWR的潜伏期显著缩短、收缩波个数显著增多、峰峰值显著上升、DMV和结肠肌层D2R阳性表达显著降低(P＜0.01);与模型组比较,印堂组、大肠俞组的Bristol评分均显著下降(P＜0.05,P＜0.01),DMV及结肠肌层中D2R阳性表达显著升高(P＜0.01,P＜0.05);大肠俞组潜伏期显著上升,收缩波个数和峰峰值均显著降低(P＜0.01),且大肠俞组优于印堂穴组(P＜0.01,P＜0.05).结论:电针印堂与大肠俞穴均可缓解IBS模型大鼠腹泻症状,但电针大肠俞穴作用更强,证实了经穴效应特异性存在且具有相对性.

"按之应手"初见于《灵枢·本输第二》,是指以手指按压穴位表面皮肤,医者感觉有动脉搏动的指下感觉.《黄帝内经》中详细记载了"按之应手"常见的生理、病理表现.生理状态下,人体的常动之脉可以体现经络的气血盛衰;病理状态下,本应平静的穴位因邪气的侵袭出现异常的搏动,指导临床确定有效穴位.因此"按之应手"在临床中是一个非常重要的概念和技术,医者通过体会手下动脉的感觉进行选穴,使穴位位置更加准确,从而实现气至病所,达到良好的治疗效果.

OBJECTIVETo observe and compare the effect of electroacupuncture (EA) of "Tianshu" (ST25) and "Dachangshu" (BL25) on intestinal sensitivity and the expression of M3 muscarinic acetylcholine receptor (M3R) and 5-hydroxytryptamine 3A receptor (5-HT3AR) in the colon tissue in irritable bowel syndrome (IBS) rats, so as to explore its mechanism underlying improvement of IBS.METHODSForty newborn Wistar rats were randomly divided into blank control, model, ST25 and BL25 groups (n＝10 rats per group). The IBS model was established by joint application of maternal separation, acetic acid enema plus colorectal distension from day 8 to 21 after birth. At the age of 9 weeks, EA (2 Hz/100 Hz, 0.1－0.3 mA) was applied to ST25 and BL25 for 20 min, once every other day for 5 times. The modified method was used to record the abdominal withdrawal reflex (AWR), so as to evaluate the visceral sensitivity by referring to the modified Al-Chaer's and colleagues' methods. The threshold (initial wave), the number and peak-peak value of contraction waves (AWR) within 90 s were recorded. The immunoactivity of M3R and 5-HT3AR in the colon tissue was detected by immunohistochemistry.RESULTSAfter modeling, the latency was obviously shortened, the number and peak-peak values of contraction waves of intestine were significantly increased, and the immunoactivity of M3R and 5-HT3AR was notably up-regulated in the model group compared with the blank control group (P<0.01). After the EA intervention, the latency was obviously prolonged, the peak-peak value in both ST25 and BL25 groups, and the number of contraction waves in the ST25 group were significantly decreased (P<0.01), and the expression levels of M3 and 5-HT3A R were considerably down-regulated in both ST25 and BL25 groups relevant to the model group (P<0.01). The therapeutic effects were significantly better in the ST25 group than in the BL25 group in prolonging the latency and reducing the contraction wave number, and in down-regulating the expression of colonic M3R and 5-HT3AR (P<0.05, P<0.01).CONCLUSIONEA at ST25 and BL25 can reduce the intestinal sensitivity in IBS rats, which is probably associated with its effects in down-regulating the expression of M3R and 5-HT3AR in the colon. The therapeutic effects of ST25 were obviously better than those of BL25 in suppressing intestinal sensitivity and expression of colonic M3R and 5-HT3AR.

Objective To observe and compare the effect of electroacupuncture(EA)of"Tianshu"(ST25)and"Dachangshu"(BL25)on intestinal sensitivity and the expression of M3 muscarinic acetylcholine receptor(M_(3R))and5-hydroxytryptamine 3 Areceptor(5-HT_(3A)R)in the colon tissue in irritable bowel syndrome(IBS)rats,so as to explore its mechanism underlying improvement of IBS.Methods Forty newborn Wistar rats were randomly divided into blank control,model,ST25 and BL25 groups(n=10 rats per group).The IBS model was established by joint application of maternal separation,acetic acid enema plus colorectal distension from day 8 to 21 after birth.At the age of 9 weeks,EA(2 Hz/100 Hz,0.1-0.3 mA)was applied to ST25 and BL25 for 20 min,once every other day for 5 times.The modified method was used to record the abdominal withdrawal reflex(AWR),so as to evaluate the visceral sensitivity by referring to the modified Al-Chaer's and colleagues' methods.The threshold(initial wave),the number and peak-peak value of contraction waves(AWR)within 90 swere recorded.The immunoactivity of M_(3R) and 5-HT_(3A)R in the colon tissue was detected by immunohistochemistry.Results After modeling,the latency was obviously shortened,the number and peak-peak values of contraction waves of intestine were significantly increased,and the immunoactivity of M_(3R) and 5-HT_(3A)R was notably up-regulated in the model group compared with the blank control group(P<0.01).After the EA intervention,the latency was obviously prolonged,the peak-peak value in both ST25 and BL25 groups,and the number of contraction waves in the ST25 group were significantly decreased(P<0.01),and the expression levels of M3 and 5-HT_(3A)R were considerably down-regulated in both ST25 and BL25 groups relevant to the model group(P<0.01).The therapeutic effects were significantly better in the ST25 group than in the BL25 group in prolonging the latency and reducing the contraction wave number,and in down-regulating the expression of colonic M_(3R) and 5-HT_(3A)R(P<0.05,P<0.01).Conclusion EA at ST25 and BL25 can reduce the intestinal sensitivity in IBS rats,which is probably associated with its effects in down-regulating the expression of M_(3R) and 5-HT_(3A)R in the colon.The therapeutic effects of ST25 were obviously better than those of BL25 in suppressing intestinal sensitivity and expression of colonic M_(3R) and 5-HT_(3A)R.

目的 比较电针和单纯针刺治疗首发轻中度抑郁症的临床疗效. 方法 将50例首发轻中度抑郁症患者随机分成电针组和针刺组各25例.两组针刺取穴相同,均为百会、四神聪、太阳(双侧)、印堂、合谷(双侧).电针组于百会、印堂、太阳(双侧)4穴接电针仪,频率为1 Hz,连续波.两组均每周治疗3次,持续6周,治疗后6个月进行随访.比较两组治疗前后汉密尔顿抑郁量表(HAMD)和抑郁自评量表(SDS)评分,随访时用HAMD进行评分.治疗后进行临床疗效评价.结果 电针组最终纳入统计23例,针刺组最终纳入统计22例.电针组临床疗效总有效率为91.3％,针刺组为68.1％,两组总有效率比较差异无统计学意义(P=0.16);两组治疗后HAMD总分及各因子评分均较本组治疗前降低(P＜0.05);两组睡眠障碍因子前后差值比较,差异有统计学意义(P=0.01).两组治疗后SDS评分均较本组治疗前降低(P＜0.05);两组SDS评分治疗前后差值比较,差异无统计学意义(P＞0.05).治疗后及随访时两组间HAMD评分比较,差异无统计学意义(P＞0.05). 结论 电针和单纯针刺治疗首发轻中度抑郁症疗效相当,且治疗后6个月疗效仍可以维持;在改善睡眠方面,电针更具有优势.

The researches on the acupoint effect specificity were summarized to explore whether the integrality of the acupoint effect specificity existed and analyze the connection between the relativity and integrality of the acupoint effect specificity. The literature on the clinical and experimental researches relevant with the acupoint effect specificity was retrieved through CNKI from January 2007 to October 2017. A total of 39 papers met the retrieving criteria. Separately, in terms of the holism of TCM theory, the holism of meridian theory and modern research, the integrality of acupoint effect specificity was analyzed. The relativity and the integrality are indicated in the acupoint effect specificity. The integrality of acupoint effect specificity is closely related to the holism of TCM theory as well as the meridians. Just because of its integrality, the acupoint effect specificity is relative, rather than absolute.