Objective To determine the pharmacodynamic parameters of vecuronium in tuberculosis patients with different genders.Methods Eighty patients ( ASA gradeⅠorⅡ) received selective general anesthesia were enrolled in this study, and divided into tuberculosis group ( Group T) and non-tuberculosis group ( Group N) .They were further di-vided into male groups ( Group TM and NM) and female groups ( Group TF and NF) .Each patient received intravenous injection of midazolam by 0.1 mg/kg, fentanyl by 4 μg/kg, and propofol with target plasma concentration of 1~3 μg/mL.The neuromuscular block efficacy was measured by neuromuscular transmission monitor after patients'consciousness disappeared.With an intravenous vecuronium by 0.1 mg/kg, the responses were defined in terms of the percentages of maximum suppression at the first ( T1 ) of the train-of-four ( TOF) of the adductor pollicis muscle.Endotracheal intu-bation was conducted when T1 fell to its lowest and repeated no less than 3 times.The onset time, the maximum inhibition of T1 , the clinical effect time, the recovery index, the pharmacological effect time and the endotracheal intubation condi-tions were recorded.MAP and HR were measured before anesthesia induction ( t0 ) , and 5 min ( t1 ) , 15 min ( t2 ) , 30 min ( t3 ) , 45 min ( t4 ) , and 1 h ( t5 ) after general anesthesia.Results Compared with Group N, the clinical effect time of vecuronium in Group T was significantly shorter ( P<0.05 ) , but there was no significant difference between genders (P>0.05).However, the clinical effect time of vecuronium in Group NF was longer than Group NM (P<0.05).No statistical difference was found in the maximum inhibition of T1 , the onset time, the recovery index, the pharmacological effect time, the endotracheal intubation conditions or, hemodynamics before or after anesthesia induction among the four groups.Conclusion Anesthesiologists could neglect the consequence of blocking aging of vecuronium in tuberculosis pa-tients with different gender.

Objective:To investigate the radiographic and computed tomographic(CT) findings of patients with pulmonary mycobacterium abscessus infection.Methods:Between January 2009 and December 2010,the radiographic and thin section chest CT images and histopathologic lung tissue specimens from 18 patients with pulmonary infection caused by mycobacterium abscessus were restrospectively reviewed.Results:The radiographic findings were reticulonodular opacities(89%,16/18),cavity(44%,8/18),lobar volume loss(44%,8/18),consolidation(22%,4/18) and bronchiectasis(44%,8/18).Thin section CT findings were bronchiectasis(12/18,66.7%),nodules less than 10mm(17/18,94.4%),tree in bud sign(15/18,83.3%),nodules larger than 10mm(13/18,72.2%),lobular consolidation(6/18,33.3%),segmental and subsegmental consolidation(9/18,50%),cavity(9/18,50%),cylindric bronchiectasis(9/18,50%),cystic bronchiectasis(5/18,27.8%),varicose bronchiectasis(3/18,16.7%) and volume loss(7/18,38.9%).Conclusion:The main radiologic and CT manifestations of mycobacterium abscessus lung infection are bilateral small nodular opacities,bronchiectasis,and cavity formation.

Objective:To investigate the ultrasonic diagnosis of abdominal ultra sonogram in patients with hepatic veno-occlusive disease (HVOD) who received he mopoietic stem cell transplantation (HSCT).Methods: We regularly practiced abdomi nal ultrasound examination weekly in 45 HSCT patients, and compared the ultrason ographic characte ristics in 9 HVOD patients with the other patients who did no t present HVOD. Results:The abdominal ul trasonic images of patients with HVOD were obviously characterized by hepatomegaly, hepatic vein tenuous, gallbladder wall thickening, increased spleen volume, and abdominal dropsy (P0.05).Conclusion:The conventional abdom inal ultrasound examination in HSCT patients could provide reliable diagnosis evidence of HVOD.

Objective To investigate the ultrasonic diagnosis of abdominal ultrasonography in patients with acute graft anti-host disease(AGAHD) who received allogenic hemopoietic stem cell transplantation(Allo-HSCT).Methods We regularly practiced abdominal ultrasound examination weekly in 43 Allo-HSCT patients,and contrasted ultrasonographic characteristics in 33 AGAHD patients with those in 10 patients who did not present AGAHD.Results As compared with those of the control group,the abdominal ultrasonic images of the AGAHD patients were obviously changed (P<0.05),including liver diffuse parenchyma lesions,gallbladder wall thickening,cholestasis,increased spleen volume,and abnormal enterokinesia.Conclusions The conventional abdominal ultrasound examination in Allo-HSCT patients provides reliable diagnosis evidence of AGAHD.

目的 探讨血液病患者造血干细胞移植治疗后腹部超声特点及相关临床意义.方法对51例接受造血干细胞移植患者进行常规腹部超声检查,观察腹腔脏器声像图变化.结果同移植前比较,患者在移植后发生弥漫性肝实质损害、肝静脉纤细、胆囊壁增厚、胆汁淤积、脾体积缩小、肠蠕动异常及腹水等一系列变化,差异有显著性意义(P 0.05).结论造血干细胞移植后患者常发生一系列腹腔脏器超声特征性变化,常规腹部超声检查能为移植相关并发症早期诊断提供及时、可靠的诊断依据。