Objectives:We aimed to investigate how 24-h movement behaviors mediated the association between cardiovascular disease (CVD) and mortality, and to determine 24-h time-use patterns across different mortality risk strata for CVD patients. Methods:The study incorporated 90,858 UK Biobank adults (with a median age of 57 years, 56.2% female and 30.7% CVD patients) who undertook an accelerometer assessment. Cox compositional mediation models were used to determine the mediating effects of 24-h movement behaviors. The 24-h time-use patterns at varying risks were determined using risk stratification based on predicted mortality through isotemporal substitution models. Results:During a median follow-up of 13.4 years, 3047 deaths were recorded. The total indirect effect of CVD on mortality through 24-h movement behaviors was statistically significant with the mediation proportion being 16.9% for moderate-to-vigorous physical activity (MVPA) and 1.1% for sedentary behavior (SB). The 24-h time-use pattern of CVD patients with the low mortality risk was predicted to comprise 433, 606, 310, 91 min/day on sleep, SB, light-intensity physical activity and MVPA, respectively. Physical activity levels progressively decreased with rising mortality risk. CVD patients at high mortality risk were expected to gain 1.8 years of life by reallocating daily time to match the 24-h time-use pattern of those at low risk. Conclusion:The association between CVD and mortality is mediated by 24-h movement behaviors, particularly by MVPA and SB. For CVD patients, tailoring individual physical activity programs to 24-h time-use patterns at lower risk levels could serve as an effective behavioral intervention strategy for extending lifespan.

The European Association for the Study of Obesity (EASO) recently proposed a new obesity definition, yet the extent to which 24-hour movement behaviors mediate the obesity - mortality association under this framework remains unclear, and sex-specific time-use recommendations for individuals with obesity are lacking. This study aimed to quantify the mediating role of 24-hour movement behaviors, estimate mortality risk associated with time reallocation these behaviors, and identify the optimal daily composition for lowing mortality risk. Using UK Biobank data (N = 90,289), obesity was defined via BMI, waist-to-height ratio, and the EASO framework. Behaviors were measured by 7-day wrist accelerometry. Compositional mediation Cox models and isotemporal substitution analyses were applied. Results showed 24-hour movement behaviors mediated 37.7%-49.0% of the obesity - mortality association, with MVPA contributing most. Sex-stratified analyses revealed heterogeneous mediation effects (total indirect effect: 59.2% in males [43.0% via MVPA] vs. 38.6% in females [20.9% via MVPA]). Optimal compositions associated with lowest mortality risk were: females: 1 h MVPA, 7 h LPA, 7 h SB, 9 h sleep; males: 1.5 h MVPA, 7 h LPA, 7 h SB, 8.5 h sleep. These findings quantify the mediating role of daily movement and provide sex-specific time-use targets for obesity management.

Purpose:To investigate the level of medication literacy and explore the conditional associations among medication literacy, beliefs about medicines, self-efficacy for appropriate medication use, and illness perceptions in patients with coronary heart disease and comorbid diabetes mellitus using network analysis. Methods:A convenience sample of 417 patients with coronary heart disease and diabetes mellitus was recruited from two Grade A tertiary hospitals and a community health center in Guangdong, China between January and August 2025. Measures included a general information questionnaire, the Self-Assessment Scale for Medication Literacy in Patients with Coronary Heart Disease Comorbidity Diabetes, the Chinese version of the Beliefs about Medicines Questionnaire-Specific, the Chinese version of the Self-Efficacy for Appropriate Medication Use Scale, and the Chinese version of the Brief Illness Perception Questionnaire. Statistical analyses were conducted using SPSS 27.0 and R Studio. The network structure was estimated with the EBICglasso algorithm. Expected influence was used to identify central nodes, and bridge expected influence was used to identify bridge nodes. The stability and accuracy of the network were examined using case-dropping and bootstrap procedures. Results:The average score of medication literacy was 77.09±10.29. The network showed that the edge weight between node S1 (medication use under difficult circumstances) and node M5 (calculation) was 0.24, which was the largest among cross-network edges. The average node predictability was 48.6%. M2 (comprehension) had the largest expected influence index (0.89), and MB1 (necessity of medication) had the largest bridge expected influence index (0.35). The 95% confidence intervals for the edge weights were narrow. The correlation stability coefficients for both expected influence and bridge expected influence were 0.751. Conclusion:Patients with coronary heart disease and diabetes mellitus exhibited a moderate level of medication literacy. Network analysis identified M2 (comprehension) as a core node and MB1 (necessity of medication) as a key bridge node, suggesting that they may be considered potential priorities for assessment and intervention development.

This study aims to ascertain the mediating role of 24-h movement behaviors, including moderate-to-vigorous intensity physical activity (MVPA), light-intensity physical activity, sedentary behavior (SB), and sleep, in the relationship between obesity, obesity-related comorbidities and depression. In a large-scale cohort study, 32,861 UK biobank participants aged 40–69 years with wrist-worn accelerometer data were included. The exposure were obesity and obesity-related comorbidities (obesity only, or with 1, 2, or ≥ 3 chronic conditions), with a non-obesity group as reference. Accelerometer-derived 24-h movement behaviors were served as mediators. The main outcome was depression at follow-up that was assessed by Patient Health Questionnaire-9. Compositional mediation model was applied to explore the mediating effect of 24-h movement behaviors. Subsequently, compositional logistic isotemporal substitution model was employed to quantify the changes in depression risk associated with reallocation among different physical activities in individuals with obesity. Compared to the non-obesity group, individuals with obesity exhibited an elevated risk of depression that increased with the number of chronic conditions. 24-h movement behaviors mediated approximately 20

INTRODUCTION:The aim of this study was to identify the heterogeneous classes of CD4/CD8 ratio trajectory and their impacts on prognosis in people living with HIV (PLHIV) during long-term antiretroviral therapy. METHODS:A retrospective cohort study of PLHIV receiving ART treatment was conducted in the Eighth Affiliated Hospital of Guangzhou Medical University, and the latent growth mixture model (LGMM) was used to identify the trajectories of longitudinal changes in the CD4/CD8 ratio between February 10, 2004, and January 31, 2019. Cox proportional hazard model and proportional subdistribution hazard model were conducted to explore the impact of CD4/CD8 ratio trajectory on prognosis. RESULTS:Three heterogeneous trajectories were identified: the baseline-low-level slow increase class (Class 1: 57.45%), the baseline-moderate-level rapid increase class (Class 2: 34.29%), and the baseline-high-level sharp increase class (Class 3: 8.26%). Cox proportional hazard model showed that CD4/CD8 ratio trajectory was associated with all-cause mortality among PLHIV, with adjusted hazard ratios (aHR) (95% confidence interval [CI]) for Class 2, and Class 3 being 0.53 (0.38-0.75), and 0.35 (0.14-0.86) respectively, compared with Class 1. The result of the proportional subdistribution hazard model showed that the CD4/CD8 ratio trajectory was associated with the risk of AIDS-related and non-AIDS-related mortality. CONCLUSIONS:Our study demonstrated that there were three different trajectories of CD4/CD8 ratio during long-term ART. Personalized interventions and treatment plans can be developed based on individual changes in CD4/CD8 ratio, which is important for improving the survival of the PLHIV and reducing disease burden.

The mediation effect of 24-hour physical activities on the association between type 2 diabetes and mortality is unclear. Additionally, Little evidence was found on the isotemporal substitution effect of 24-hour physical activities components on changing Life expectancy among patients with type 2 diabetes diagnosed. To address the abovementioned research gap, the study has a two-fold aims: first, to examine the mediation effect of 24-hour physical activities in type 2 diabetes and mortality; and second, to address how reallocating time on different daily activities would affect life expectancy. Analysis was conducted on the accelerometer data of 103,359 participants in the UK Biobank, with a median age of 57 years (range 39 to 70). Compositional mediation cox model was conducted to analyze the mediating effects of 24-hour physical activities. Additionally, the cohort Life table method was utilized to estimate the changes of Life-years over the next 10 years resulting from the substitution effect of different physical activities. During a mean follow-up of 13.95 (range 2.95–16.28) years, 2,649 deaths were recorded. Diabetes was significantly associated with increased time spent engaging in sedentary behavior (SB), and reduced time spent on moderate-to-vigorous physical activity (MVPA) and light-intensive physical activity (LPA), thereby demonstrating an association with higher mortality risk. The indirect effect of physical activity (HR = 1.27, 95

Background: While the association between socioeconomic status (SES) and depression is well-documented, the relative contributions of physical activity (PA) and sedentary behavior (SB) to this association remain unclear. This study was to explore the effects of PA, SB in the associations between SES and depressive symptoms, respectively. Methods: Our study included 15,906 adults (age >= 20 years) from the National Health and Nutrition Examination Survey (NHANES), 2011-2020. A four-way decomposition was applied with PA and SB as mediators to explore the mediation and interaction effects between SES and depressive symptoms. Results: It was found that low SES was associated with greater risk of depressive symptoms (odds ratios 3.18, 95 % confidence interval 2.56 to 3.94), as well as insufficient moderate-to-vigorous recreational activities (MVRA) (1.45, 1.24 to 1.70) and prolonged SB (0.77, 0.67 to 0.90). MVRA also showed a significant mediation effect that accounted for 5.48 % of the total effect of SES on depressive symptoms. Meanwhile, the interaction between MVRA and SES was also significant, accounting for 28.25 % of the total effect. In the single measure of SES, only the interaction between employment status and MVRA was statistically significant and accounted for 39.41 % of the total effect. Limitation: This study had a cross-sectional design, thus limiting our capacity to draw conclusive causal relationships. Conclusion: People with low SES may be suffered from higher risk of depressive symptoms. However, our findings showed that sufficient MVRA (at least 150 min per week) could buffer against the risk of depressive symptoms, particularly for those who are unemployed.

Chronic pain was associated with a higher risk of mental disorders (e.g., depression and anxiety). However, the role of 24-h movement behaviors in the association remains unclear. A total of 72,800 participants with accelerometer data and free of mental disorders from the UK Biobank were analyzed. The compositional mediation model and isotemporal substitution model were used to explore the associations between chronic pain, 24-h movement behaviors, and the incidence of overall mental disorders, depression, and anxiety. With a median follow-up of 13.36 years, participants with chronic pain had a higher rate of incident overall mental disorders (hazard ratio (HR): 1.281, 95

Background Given the increased risk of chronic diseases and comorbidity among middle-aged and older adults in China, it is pivotal to identify the disease trajectory of developing chronic multimorbidity and address the temporal correlation among chronic diseases. Method The data of 15895 participants from the China Health and Retirement Longitudinal Study (CHARLS 2011 – 2018) were analyzed in the current study. Binomial tests and the conditional logistic regression model were conducted to estimate the associations among 14 chronic diseases, and the disease trajectory network analysis was adopted to visualize the relationships. Results The analysis showed that hypertension is the most prevalent disease among the 14 chronic conditions, with the highest cumulative incidence among all chronic diseases. In the disease trajectory network, arthritis was found to be the starting point, and digestive diseases, hypertension, heart diseases, and dyslipidemia were at the center, while memory-related disease (MRD), stroke, and diabetes were at the periphery of the network. Conclusions With the chronic disease trajectory network analysis, we found that arthritis was prone to the occurrence and development of various other diseases. In addition, patients of heart diseases/hypertension/digestive disease/dyslipidemia were under higher risk of developing other chronic conditions. For patients with multimorbidity, early prevention can preclude them from developing into poorer conditions, such as stroke, MRD, and diabetes. By identifying the trajectory network of chronic disease, the results provided critical insights for developing early prevention and individualized support services to reduce disease burden and improve patients’ quality of life.

Background: Studies have shown that subjective cognitive decline (SCD) is a major risk factor for mild cognitive impairment or even dementia, but the relationship between physical activity (PA) and SCD is still unclear. The goal of current study is to address how various physical activities relate to SCD.Methods: 216,593 adults from the Behavioral Risk Factor Surveillance System (BRFSS) were included in this study. We measured SCD and PA with participants' self-report. With the unconditional logistic regression model, the association between PA and SCD was investigated. We used a four-way decomposition method to explore the mediation roles of depression between PA and SCD. The nearest matching method of propensity score and multinomial propensity score were used to reduce the effects of confounding factors.Results: Compared with those inactive, the weighted adjusted odds ratios (AORs) of SCD among those who were physically active were <1 (p < 0.005), regardless of the type of PA. The top three PA in weighted AORs were: running (AOR: 0.51, 95 % CI: 0.50-0.52), aerobics exercise (AOR: 0.55, 95 % CI: 0.53-0.56), and weightlifting (AOR: 0.60, 95 % CI: 0.59-0.62). The dose-response relationship between PA and SCD was found. Participants who engaged in PA for 241-300 min per week (AOR: 0.61, 95 % CI: 0.59-0.62) or exercised metabolic equivalent of 801-1000 per week (AOR: 0.62, 95 % CI: 0.62-0.65) had the lowest risk of SCD.Conclusions: Regardless of the specific PA types, engaging in PA is associated with a reduced risk of having SCD, and people who engage in running had the lowest risk of SCD. There was a dose-response relationship between PA and SCD, and PA-based interventions should be developed accordingly to prevent cognitive deterioration in older age.

膝关节韧带损伤的病因病机为外伤、劳损或风寒湿外邪入侵致膝关节局部气血瘀滞,不通则痛,或肝肾亏虚,脾不运化,气血生化不足,筋脉不荣则痛,屈伸不利.岭南火针长于温通开郁、温养筋脉,与本病病因病机十分契合.李丽霞治以活血化瘀、温通筋脉为法,取患侧内膝眼、外膝眼、曲泉、鹤顶、血海、阿是穴,采用岭南火针深刺法,速进疾退不留针,进针深度约25 mm,配合普通针刺,每周1次,4周为1个疗程,疗效尚可.

目的:探讨岭南地区中风病的中医证候分布特点和"醒脑调枢启阖"法对中风病的中医证候疗效.方法:将324例缺血性中风患者随机分为"醒脑调枢启阖"穴位组(159例)和康复组(165例).康复组接受基础治疗和康复训练;穴位组在康复组治疗的基础上分别选取经数据挖掘技术整理后的古籍穴位方案,在合适体位下行常规针刺,每日1次,1周5次,连续治疗2周.观察治疗前中风证候要素评价表,分析岭南地区中风病证候特征;观察治疗前后中风病临床证候评价量表,比较证候群改善情况.结果:组内治疗前后比较,治疗2周后,上下肢体功能不遂、口角歪斜、言语不利、肢体感觉异常主证均较前改善(P＜0.05);组间比较,"醒脑启阖调枢"法治疗后改善效果比康复疗法显著.结论:在缺血性中风病内风、风火、痰湿、血瘀、气虚、阴虚几个证候要素中,以痰湿证、气虚证、血瘀证为主,痰湿证在岭南地区中风病发病中,起重要作用."醒脑调枢启阖"穴位组和康复组均能改善中风病中医证候,"醒脑调枢启阖"穴位组比康复组在改善中医证候上疗效更显著.

Background:Acupuncture is a well-known treatment option for ischemic stroke recovery, but evidence of its effectiveness remains limited. This is a randomized controlled trial to evaluate the effectiveness of acupuncture treatment for ischemic stroke rehabilitation. Methods:Rehabilitation training was provided to the control group. In acupuncture arm 1, these acupoints were derived from the ancient books, including GV20 (baihui), GV26 (shuigou), PC9 (zhongchong), ST6 (jiache), ST4 (dicang), LI15 (jianyu), LI11 (quchi), LI4 (hegu), GB30 (huantiao), GB31 (fengshi), GB34 (yanglingquan), and GB39 (xuanzhong). In acupuncture arm 2, the acupoints used were GV20 (baihui), PC6 (neiguan), LI11 (quchi), LI10 (shousanli), SJ5 (waiguan), LI4 (hegu), GB30 (huantiao), ST36 (zusanli), GB34 (yanglingquan), SP6 (sanyinjiao), ST41 (jiexi), and LR3 (taichong), which were extracted from Acupuncture and Moxibustion Science. After acupuncture, the needles were left in for 30 min and manually manipulated every 10 min. The three groups received treatment once a day, 5 times a week for 2 weeks. The primary outcome was the National Institutes of Health Stroke Scale (NIHSS), and the secondary outcomes were the Barthel Index (BI) and the Modified Ashworth Scale (MAS). Outcomes were measured in patients both before and after treatment. Results:A total of 497 patients with ischemic stroke were randomized into either arm 1 (159 cases), arm 2 (173 cases), or the control group (165 cases). After 2 weeks of treatment, the NIHSS scores for arm 1 were lower than those of the control group (P = 0.017); the BI scores were higher in arm two than that in the control group at T2 (P = 0.016) and follow-up (P = 0.020). Additionally, there was no significant difference between arm one and the control group for either the BI scores or the MAS scores (P > 0.05) and no significant difference between arm two and the control group for the MAS scores or the NIHSS scores (P > 0.05). Conclusion:The clinical efficacy of arm 1 and arm 2 (acupuncture groups) was superior to that of the control group, but there was no difference between the effects of the two acupuncture groups. Clinical Trial Registration:http://www.chictr.org.cn/index.aspx, identifier: ChiCTR-IOR-16008627.

目的 观察针刺结合岭南火针点刺百会穴治疗慢性主观性头晕的临床疗效.方法 选取2019年1月—2019年10月广州市中医医院针灸科、脑病科门诊及耳鼻喉科门诊就诊的60例慢性主观性头晕病人,随机分为观察组和对照组,各30例.对照组采用盐酸舍曲林片治疗,观察组在对照组基础上采用传统辨证选穴结合岭南火针点刺百会穴治疗.比较两组眩晕残障程度评定量表(DHI)评分及总有效率变化.结果 治疗后,观察组总有效率高于对照组,差异有统计学意义(93.33％和73.33％,P<0.05).治疗后,两组DHI总分及功能、情感和躯体评分均较治疗前降低(P<0.05),且观察组DHI总分及功能、情感和躯体评分均低于对照组,差异有统计学意义(P<0.05).结论 在西药治疗基础上联合针刺结合岭南火针点刺百会穴治疗慢性主观性头晕的临床疗效较好,可缓解病人头晕症状.

目的 选择急性痛风性关节炎患者为研究对象,基于子午流注理论采用火针治疗方式,观察临床疗效及对血清尿酸水平的影响.方法 将符合急性痛风纳入标准的60例随机分组,治疗组采用基于子午流注火针疗法,对照组采用口服依托考昔及少量秋水仙碱.疗程1周,观察对比患者治疗前后临床证候(关节疼痛、压痛、红肿及活动度)积分、疗效指数及血清尿酸水平.结果 治疗组总有效率达100.00％,明显优于对照组总有效率83.33％(P＜0.01);治疗组血清尿酸降低水平优于对照组.结论 子午流注火针疗法可明显改善急性痛风患者的临床症状,降低血清尿酸水平.

Background: Direct oral anticoagulants (DOACs) have been widely used in patients with atrial fibrillation (AF) for antithrombotic prophylaxis, which were shown to have a favorable risk–benefit profile. However, there are no guidelines for the use of DOACs in elderly patients (aged ≥75 years) with AF, which creates uncertainty about the optimal antithrombotic treatment in these patients. Methods: After comprehensively searching Embase, PubMed, and Cochrane databases, five phase III randomized controlled trials involving 28,137 elderly participants were included in this study. The efficacy outcome was stroke or systemic embolism, and the safety outcome was major bleeding. We conducted a network meta-analysis by using a Bayesian random-effect model for the first time to evaluate the efficacy and safety of main DOACs (apixaban, edoxaban, rivaroxaban, and dabigatran) and warfarin in elderly patients with AF. Hazard ratios (HRs) and their corresponding 95% confidence intervals (CIs) were used to assess the effect of drugs on efficacy and safety. The rank probabilities were used to reflect the hierarchy of drugs, and a larger rank probability value symbolized a better rank of drugs. Results: In the prophylaxis of stroke or systemic embolism, apixaban was found to be the best among DOACs compared to warfarin (HR, 0.71; 95% CI: 0.33–1.50), though this finding was not statistically significant. Apixaban ranked the best (rank probabilities, 41.2%) in efficacy of drugs, followed by rivaroxaban, edoxaban, dabigatran, and warfarin (rank probabilities, 31.8, 15.9, 10.9, and 0.2%, respectively). In reducing the risk of major bleeding, apixaban was found to be the best among DOACs too, compared to warfarin (HR, 0.64; 95% CI: 0.33–1.30), though this finding was not statistically significant. In safety, apixaban ranked the best (rank probabilities, 71.4%), followed by edoxaban, dabigatran, warfarin, and rivaroxaban (rank probabilities, 21.0, 5.8, 0.9, and 0.8%, respectively). Conclusions: DOACs showed a lower incidence of stroke/systemic embolism and major bleeding compared with warfarin in antithrombotic therapy in elderly patients (aged ≥75 years), with apixaban being the best of those interventions. Therefore, apixaban should be given priority as an anticoagulant in stroke prevention for elderly patients with AF.

Background The purpose of our study was to explore the relationship between body weight and short- and long-term clinical outcomes in patients with sepsis. Methods We retrospectively analyzed 11,499 patients with sepsis at the Beth Israel Deaconess Medical Center (Boston, MA, USA) registered in the Medical Information Market Intensive Care (MIMIC-III) database from 2001 to 2012. Cox proportional hazards regression assessed the relationships between body mass index and 30-day and 1-year mortality. Results Patients were divided into four groups according to body mass index (underweight: 336 [6.0%]; normal weight: 1,752 [31.4%]; overweight: 1,563 [28.1%]; and obese: 1,920 [34.5%]), 30-day mortality (42.3%, 36.6%, 32.2%, and 29.6%; p<0.001), 1-year mortality, (64.6%, 56.8%, 52.5%, and 46.7%; p<0.001), and in-hospital mortality (35.4%, 34.3%, 31.6%, and 29.9%; p=0.018). In addition, obese patients had notably longer mechanical ventilation periods and intensive care unit and hospital lengths of stay. The Cox proportional hazards regression analysis confirmed that underweight patients had a 13% and 24% increased risk of death within 30 days and 1 year, respectively, compared with normal-weight patients. For overweight patients, these risks were 17% and 14% lower, respectively, than those reported for normal-weight patients. For obese patients, these risks were 22% and 21% lower than those observed in normal-weight patients. Conclusion This retrospective analysis showed that overweight or obese patients showed improved survival within 30 days and 1 year after admission to the intensive care unit.

[目的]观察关节错缝术配合针刺疗法治疗老年腰椎间盘突出症的临床疗效.[方法]将120例老年腰椎间盘突出症患者随机分为关节错缝术组、针刺组和关节错缝术配合针刺组,每组各40例,关节错缝术组给予腰椎斜扳法与整盆法治疗,针刺组给予针刺治疗,关节错缝术配合针刺组给予关节错缝术配合针刺治疗.3组患者均每2d治疗1次,治疗7次为1个疗程,共治疗4个疗程.治疗8周后,观察3组患者治疗前后日本骨科协会评估治疗分数(JOA)评分的变化情况,并评价3组患者的临床疗效.[结果](1)治疗后,3组患者的JOA评分均明显改善(P<0.01),且关节错缝术配合针刺组改善最明显,关节错缝术配合针刺组JOA评分明显优于关节错缝术组和针刺组,差异均有统计学意义(P<0.01).(2)关节错缝术组总有效率为80.0％(32/40),针刺组为77.5％(31/40),关节错缝术配合针刺组为95.0％(37/40).关节错缝术配合针刺组疗效明显优于关节错缝术组和针刺组,差异有统计学意义(P<0.05).[结论]关节错缝术配合针刺治疗老年腰椎间盘突出症,能明显改善患者的腰椎功能,临床疗效显著.

目的:观察八卦头针对缺血性脑卒中后轻度认知障碍患者血浆同型半胱氨酸(Hcy)的影响.方法:将80例缺血性脑卒中后轻度认知障碍患者随机分为治疗组和对照组各40例,治疗组采用八卦头针治疗,对照组采用口服尼莫地平片治疗,比较两组患者治疗前后血浆同型半胱氨酸水平及简易精神状态检查表MMSE评分的变化.结果:治疗后治疗组MMSE评分高于对照组,差异有统计学意义(P＜0.01);治疗后治疗组血浆Hcy水平低于对照组,差异有统计学意义(P＜0.05).结论:采用八卦头针治疗缺血性脑卒中后轻度认知障碍,能降低患者血浆Hcy水平,改善患者的认知功能.

目的 观察毫火针点刺根结穴结合针刺治疗眼肌麻痹的临床疗效.方法 将60例受试者采取随机数字表法分为两组.观察组根结穴予毫火针点刺,其余穴位采用针刺治疗.对照组所有穴位均采用针刺.隔日治疗1次,7次为1个疗程,两组均治疗3个疗程,治疗3个疗程后比较两组患者的复视像距离、症状积分及疗效.结果 观察组治疗后复视像距离及症状积分分别为(3.17±0.56) cm、(4.98±4.03)分,对照组治疗后复视像距离及症状积分分别为(9.10±0.85) cm、(6.98±5.60)分,观察组结果明显优于对照组,差异具有统计学意义(P＜0.05).观察组显示总有效率为93.33％,而对照组显示总有效率为80.00％,两组相比,差异具有统计学意义(P＜0.05).结论 毫火针点刺根结穴结合针刺治疗眼肌麻痹疗效优于单纯针刺治疗.