介绍了MINItrace医用回旋加速器的原理及构成,详细分析了该设备水冷系统CP泵(冷却泵)出现的CCAB CB(控制柜断路器)故障和绕组电阻不平衡故障,提出了具体的排除方法,确保了机器的正常运行,为其他维修人员维修类似故障提供了参考.最后指出了回旋加速器结构复杂,维修人员只有熟悉其基本原理及电路图才能快速排除故障,提高工作效率,更好地为临床服务.

OBJECTIVE:To compare the performance of the GE cyclotron MINItrace system before and after the upgrade.METHODS:The upgrade of the MINItrace system included replacing the silver target with the Nb syetem and adopting the latest RF control and management system and lastest ion source system.The failrue rate and production efficiency were retrospectively analyzed before and after the upgrade.RESULTS:After the upgrade, the cyclotron failure rate decreased by 86.2%, the average capacity increased by 45%.CONCLUSIONS:After the upgrade of MINItrace cyclotron, the failure rate is sharply reduced, and the production efficiency is grately improved.

目的 检测及分析PET/CT检查受检者周围剂量水平.方法 选取2019年3月-2019年5月期间于郑州大学附属肿瘤医院接受PET/CT检查的10例受检者作为研究对象,测定受检者注射18F-FDG(氟代脱氧葡萄糖)后不同时间、不同体表方向(正面、背面、左侧、右侧),与受检者相距0.5 m、1 m处周围剂量当量率.结果 受检者注射18F-FDG后,体表周围剂量当量率为(423.41±29.65)μSv/h,18F-FDG注射后与检查后时间间隔为(84.36±5.64)min,检查结束后体表周围剂量当量率为(196.58±14.13)μSv/h.10例受检者注射18F-FDG后,不同体表方向周围剂量当量率0.5 m处为(68.19±4.38)μSv/h,1 m处为(24.25±3.01)μSv/h10例受检者PET/CT检查后,不同体表方向周围剂量当量率0.5 m处为(43.28±3.94)μSv/h,1 m处为(13.75±1.64)μSv/h.结论 受检者行PET/CT检查时,注射18F-FDG放射性药物后,其周围辐射水平处于较高水平,应加强对家属的防护及受检者管理.

目的 研究靶向磷酸二酯酶5(PDE5)正电子核素探针制备的新方法.方法 以去甲基西地那非为原料,通过亲核反应引入侧链制备18F正电子核素标记的前体与标准品,并采用经典18F亲核取代反应一步法制备靶向PDE5的核素标记探针.结果 成功制备了靶向PDE5的正电子核素探针,并通过在线制备HPLC系统纯化了该探针,收率达到了35％.结论 采用一步法标记该靶向PDE5的核素探针,避免了传统两步法制备探针容易出现的收率低、副反应多、时间长等缺点,简化了操作步骤,提高了收率,有助于该探针的临床应用.

Aim:To evaluate the radiation dose(RD) of the related personnel during PET-CT scanning of patients with esophageal cancer.Methods: A total of 100 esophageal cancer patients underwent whole-body 18F-FDG PET-CT scanning were selected.Each patient was accompanied by one family member.The effective doses from CT scan(EDCT) were calculated based on dose-length product,and EDPET was calculated based on International Commission on Radiological Protection recommendations.The RD of the family members and wardpatients were calculated based on the initial dose-equivalent rate(IDR).Results: EDCT of the patients was (15.50±1.24) mSv,EDPET was (5.37±1.03) mSv,EDtotal was (20.87±2.06) mSv,EDCT/EDtotal was (0.74±0.03).BMI of the patients was (23.64±3.89) kg/m2,which was positively related to EDCT(r=0.780,P<0.05).The 8 mm Pb lead screen could reduce the RD of the accompanied family members by about 50%,and the 1 mm Pb lead screen could reduce it by about 10%,and the lead screen could reduce the RD of the wardmates by about 40%(P<0.05).Conclusion: The enhanced protection methods would play an important role in the PET-CT examination.

目的 为了观察盐酸美金刚对治疗血管性痴呆(VaD)的疗效及其安全性.方法 选取来自干部病房或门诊的轻中度VaD患者共62例,随机分成治疗组和对照组,治疗组32例,对照组30例,两组患者在年龄、性别、文化程度、病程、痴呆程度等方面比较差异无统计学意义(P＞0.05),具有可比性.治疗组给予盐酸美金刚,起始剂量是5 mg/d,前3周以每周5 mg递增,从第4周起,使用剂量维持在20 mg/d,口服,共24周;对照组给予吡拉西坦0.8g,3次/d口服,共24周.治疗前和治疗24后周均给予简易智能痴呆量MMSE、ADL行为量表进行评分,比较得分的情况.结果 两组治疗前后MMSE、ADL评分分别进行比较,均有明显的改善;两组治疗24周后MMSE、ADL评分比较差异有统计学意义.治疗组有2例(占6.25％)、对照组有2例(占6.67％)出现轻度的不良反应,均为一过性反应.结论 盐酸美金刚对老年轻中度VaD患者的认知功能、日常行为能力有明显改善作用,安全性好且其疗效优于吡拉西坦.