该文在"益火之源,以消阴翳"的理论基础上提出"益阳消阴"理论,即温补心阳、脾阳、肾阳,消除瘀血、痰浊、水饮的方法,以期为临床治疗慢性心力衰竭提供参考.

目的 基于网络药理学探讨防己黄芪汤治疗慢性心力衰竭的作用机制.方法 通过中药系统药理学分析平台(TCMSP)检索防己黄芪汤中的有效成分和作用靶点,通过GeneCards和OMIM检索慢性心力衰竭的相关靶标基因,获取防己黄芪汤治疗慢性心力衰竭交集靶标基因,采用Cytoscape构建"药物-成分-疾病-靶点"网络,以Network analyzer插件进行网络分析,获取重要化合物和关键靶点;通过STRING构建蛋白质相互作用(PPI)网络;利用R语言clusterProfiler包进行基因本体(GO)功能富集分析和基于京都基因与基因组百科全书(KEGG)通路富集分析,注释识别基因功能和信号通路.结果 防己黄芪汤中有156个有效成分,1174个作用靶点,与治疗慢性心力衰竭相关的靶标基因共113个,137个GO条目,35条信号通路,主要有磷脂酰肌醇-3-激酶/丝苏氨酸蛋白激酶(PI3K-Akt)信号通路、丝裂原活化蛋白激酶(MAPK)信号通路、细胞凋亡、肿瘤坏死因子(TNF)信号通路等.结论 防己黄芪汤中的槲皮素、山柰酚等成分与毒蕈碱乙酰胆碱受体M(CHRM)、半胱氨酸蛋白酶(CASP)等靶蛋白结合,通过DNA结合转录、神经递质结合等过程以及PI3K-Akt、MAPK等信号通路,达到治疗慢性心力衰竭的作用.

目的:基于心肺同治理论观察益气化痰活血方治疗慢性肺源性心脏病(CPHD)合并冠心病(CHD)气虚痰瘀互结证的临床疗效.方法:将符合纳入标准的CPHD合并CHD患者60例随机分为治疗组30例和对照组30例,治疗组在西医综合治疗基础上给予益气化痰活血方,对照组30例给予单纯西医综合治疗,7d为1个疗程,2个疗程后比较两组综合临床疗效、中医证候积分及实验室检查相关指标.结果:治疗组中医综合临床疗效、中医证候积分、血气分析、血流变、肺功能及心功能相关指标改善均优于对照组(P＜0.05).结论:益气化痰活血方治疗CPHD合并CHD气虚痰瘀互结证疗效较好,作用肯定,值得临床推广.

香苏散出自《太平惠民和剂局方》，由香附、紫苏叶、陈皮、炙甘草4味药组成，功能是散寒解表、理气消滞，主治外感风寒、内伤气滞，症见恶寒发热、头身疼痛、胃脘胀满、纳呆呕恶、苔白腻、脉浮紧。当代人嗜食肥甘厚味及烟酒摄入增多必然引起湿热内蕴，又加之工作生活压力大导致情志郁结化热，且二者常结合致病，因此致使当今胃病以实证、热证为多见，虚寒之证少见。针对此病因病机变化，北京中医药大学东直门医院田德禄教授以香苏散为基础，将方中苏叶换为苏梗，变解表为理气消胀，去方中炙甘草防其甘温壅滞胃气，加炒枳实、生薏苡仁、清半夏、茯苓、焦三仙、连翘等组成理气消胀合剂，将本方变为理气消胀、化痰和胃的方子，作为胃病治疗的基础方，治疗胃气壅滞引起的胃脘痞满胀闷、纳呆食少、嗳气吞酸、大便不畅等。临床用于多种内科病症的治疗，拓宽了本方临床使用范围，取得了较好的疗效。

Objective To observe the therapeutic effects of yiqi huatan tongluo formula on chronic obstructive pulmonary disease(COPD). Methods The patients diagnosed by the inclusive criteria were ran-domized into two groups according to random number table. In the treatment group,yiqi huatan tongluo formu-la was used on the base of the western medicine treatment for relieving cough and reducing sputum. In the control group,the routine western medicine treatment was adopted for relieving cough and reducing sputum. After 1-month specific treatment,TCM comprehensive effects,TCM syndrome scores,FEV 1 ,FEV 1 / FVC and 6MWT were compared before and after treatment in the two groups. Results Regarding TCM comprehensive effects,the differences were not remarkably between the treatment group and the control group(P > 0. 05). Regarding TCM syndrome scores,the scores after treatment were lower than the results before treatment in the two groups,indicating the significant differences(P < 0. 01). Compared with the control group,the scores were reduced remarkably in the treatment group,indicating the significant differences(P < 0. 01). Regarding the lung function,FVC and FEV 1 / FVC after treatment were higher than the results before treatment in the two groups,indicating the significant difference(P < 0. 01). Compared with the control group,the values were increased remarkably in the treatment group,indicating the significant differences(P < 0. 01). Regarding 6min walking test(6MWT),the values after treatment were increased as compared with the results before treatment in the two groups,indicating the significant difference (P < 0. 01). Compared with the control group,the values were increased remarkably in the treatment group,indicating the significant differences(P <0. 01). Conclusion Compared with the western medicine for resolving phlegm and relieving asthma,yiqi huatan tongluo formula remarkably relieves the symptoms of COPD of the middle and severe stages in the eld-erly patients and improves the relevant indicators of lung functions as well as the living quality of the pa-tients.

Objective To induce the psychological stress-asthmatic rat model by ovalbumin (OVA)mix-ture sensitization with restraint,which simulated the pathogenic factors of bronchial asthma with liver -qi stagnation pattern,as well as to evaluate the model using indicators of the macro characterization,behav-iors,pulmonary function,peripheral blood inflammatory cells,bronchial tissue pathomorphology.Meth-ods A total 32 male rats were randomly divided into four groups—control group,stress group,asthmatic group,and stress-asthmatic group.Rats of stress group and stress-asthmatic group were immobilized in&nbsp;restrained box once daily at different time,ten minutes more than the day before with the first duration of 2 hours.Rats of stress-asthmatic group and asthmatic group were sensitized by intraperitoneal injection 1 mL mixture of OVA with aluminium hydroxide on the first day,and after 13 days,they were stimulated by inhalation of 1 % OVA for 20 min for consecutive 14 days.The rats of control group were sensitized and stimulated by saline,without immobilizing .28 days later,the macro characterization,behaviors, peripheral blood eosinophils,pulmonary function,bronchial tissue pathomorphology were observed.Re-sults Stress asthmatic rats showed low mood,loss of interest,dull hair,loose stools,reducing food in-take,slowly weight gain,and scratched noses and abdominal skin,coughed,sneezed and wheezed in the throat when stimulated.Compared with control group,the points of vertical movement decreased signifi-cantly(P <0.05 or P <0.01).Preference for sucrose,the times of active moves in tail suspension test (TST)of stress-asthmatic rats obviously decreased(P <0.01),and the duration of immobility increased significantly(P <0.01 ).Pulmonary function indicators,including peak expiratory flow(PEF),forced expiratory flow (FEF 25% -75% ),forced expiratory volume in 0.3 s [FEV(0.3]/forced expiration volume capacity (FVC)significantly declined(P <0.05,P <0.01,P <0.01 ),while mean inspiratory airway resistance (Ri)and mean expiratory airway resistance (Re)increased remarkably (P <0.05,P<0.01).Peripheral blood eosinophil cells increased(P <0.01),and infiltration of inflammatory cell in lung tissue was obvious.Compared with the stress group or asthmatic group,the signs and indicators of stress-asthmatic group were all much worse.Conlusion The psychological stress-asthmatic rat model, induced by VOA mixture with restraint,was proved to be successful.It is in accordance with clinical characteristics of bronchial asthma with liver-qi stagnation pattern,which can be used to study asthma caused by emotion .

中医药是由我国历代以来的医药学家在不断的实践后总结出来的精华，故而应用于诸多疾病的治疗中。下文将详细阐述在小儿咳嗽变异性哮喘中使用中医药治疗的研究进展。

The pathogens of chronic hepatitis B is affiliated to the latent pathogens of TCM. HOW to treat it, Wen Bing experts provide the method of Expelling the pathogens, this method is important to treat chronic hepatitis B .The author will explore where the latent pathogens is and what's its trait and how to treat it, In order to use an new theory to treat chronic hepatitis B.

目的对2005年10月～2006年6月解脲支原体药敏试验结果进行分析,为临床合理选用抗生素提供依据。方法对186份疑为非淋菌性尿道(宫颈)炎患者的泌尿生殖道标本进行支原体检测,并对其中104份支原体检测阳性标本进行抗生素敏感性检测。结果186份标本中支原体分离率为55.9%,男性和女性标本中支原体分离率分别为24.1%和68.9%。药敏结果显示,支原体主要对强力霉素、美满霉素、克拉霉素敏感,敏感性分别为91.3%、87.5%、74.0%;而对红霉素、帕珠沙星、阿齐霉素、壮观霉素的敏感性分别为:0、1.9%、2.9%、3.8%。结论非淋菌性尿道(宫颈)炎患者中支原体是主要的病原,美满霉素和强力霉素可作为治疗支原体感染非淋菌性尿道(宫颈)炎的首选药物,监测支原体耐药性对于指导临床治疗具有重要意义。

肝气虚一证,《内经》中即有论述,但后世医家多强调肝为刚脏,体阴而用阳,肝阴肝血常不足,肝气肝阳常有余,以致肝气虚较少被论及。当代医家对肝气虚证的论述不乏其人,如秦伯未在《谦斋医学讲稿》中指出肝的虚证“应该包括气、血、阴、阳在内,即肝血虚、肝气虚、肝阴虚、肝阳虚四种”。张伯臾老中医指出:“临床中肝气虚、肝阳虚并不少见,在肝炎、肝硬化病例中尤多。”表明肝气虚正在日益受到重视。因此,对肝气虚证的诊治进行探讨,有着现实意义。