Objective:To explore the relationship between psychological capital, career decision-making difficulties, and employment anxiety among undergraduate nursing students, in order to help them improve their employability and mental health.Methods:From December 2022 to January 2023, a cross-sectional survey was conducted on 543 undergraduate nursing students from five medical colleges in Shanxi Province interning at the First Hospital of Shanxi Medical University, selected through convenience sampling method, using a General Information Questionnaire, Psychological Capital Scale, College Student Career Decision-making Difficulties Scale, and College Student Employment Anxiety Scale. Spearman correlation analysis was used to explore the relationship among them, and hierarchical model was used to explore the predictive ability of undergraduate nursing students ′ psychological capital and career decision-making difficulties on their employment anxiety by stratified regression analysis. Results:The score of College Student Employment Anxiety Scale of 543 undergraduate nursing students was 36(30, 44). The results of correlation analysis showed that employment anxiety was negatively correlated with psychological capital and its four dimensions (self-efficacy, hope, resilience and optimism), while employment anxiety was moderately correlated with career decision-making difficulties and its three dimensions (lack of preparation, difficulty in information exploration and conflict)( r values were -0.291 to 0.564, all P<0.05). The hierarchical model showed that psychological capital and career decision-making difficulties independently explained the 46.1% variation of employment anxiety after controlling the influence of general data. Conclusions:The score of employment anxiety of undergraduate nursing students is in the middle level, and the difficulty of career decision-making has a positive impact, while the psychological capital has a negative impact. College educators can continuously monitor the psychological capital and provide career development counseling for undergraduate nursing students through positive psychological intervention and effective management measures, so as to reduce the degree of employment anxiety of undergraduate nursing students.

Objective:To investigate the status quo and influencing factors of health self-management ability of scientific and technological workers in Shanxi Province.Methods:This study was a cross-sectional study. Using the general situation questionnaire and the adult health self-management ability evaluation scale, 467 scientific and technological workers who received physical examination in the First Hospital of Shanxi Medical University from January 2022 to September 2022 were investigated by questionnaire, and their height, weight, body mass index, fasting blood glucose, blood lipids and blood uric acid were collected on the day of physical examination. Multiple linear regression analysis was used to explore the influencing factors of health self-management ability, and Pearson and Spearman correlation analysis was used to analyze the correlation between health self-management ability and examination items.Results:The total score of health self-management ability of 467 scientific and technological workers was (153.7±16.5). The results of multiple linear regression showed that the type of medical insurance, self-assessment of health status, staying up late, and sleep quality were independent influencing factors of health self-management ability ( R2=0.141, adjusted R2=0.120, F=6.771; P<0.001). Health self-management ability was positively correlated with high-density lipoprotein ( r=0.114), behavioral subscale was positively correlated with high-density lipoprotein ( r=0.107), environmental subscale was negatively correlated with uric acid ( r=-0.103), triglyceride ( r=-0.118), and positively correlated with high-density lipoprotein ( r=0.129), and cognitive subscale was negatively correlated with triglyceride ( r=-0.125), all of which were statistically significant ( P<0.05). Conclusions:The ability of health self-management of scientific and technological workers in Shanxi Province belongs to the upper middle level, which is affected by the type of medical insurance, the self-assessment of health status, staying up late, and the quality of sleep. It is suggested that the ability of health self-management of scientific and technological workers can be improved by strengthening their health beliefs, providing a more convenient working environment, reducing the frequency of staying up late, and improving their sleep quality.

Objective:To investigate the correlations between serum E selectin, intercellular adhesion molecule 1 (ICAM-1), vascular cell adhesion molecule 1 (VCAM-1) and left ventricular geometry and function in patients with obstructive sleep apnea syndrome (OSAS) combined with prehypertension (pre-HT).Methods:A total of 462 patients with pre-HT and OSAS diagnosed by polysomnography (PSG) in the sleep monitoring unit of the Department of Respiratory and Critical Care Medicine at the First Hospital of Shanxi Medical University from July 2019 to July 2022 were restrospectively analysed, and 52 patients with pure pre-HT (pre-HT group) and 73 patients with pure OSAS (OSAS group) in the same period were selected as the control group. OSAS and pre-HT patients were divided into four groups according to left ventricular geometry: normal geometry (NG) group, concentric remodeling (CR) group, eccentric hypertrophy (EH) group and concentric hypertrophy (CH) group. The general clinical data, PSG parameters, blood biochemical parameters and left ventricular structure and function parameters were compared among the six groups. Pearson correlation and multivariate Logistic regression were used to analyze the correlation between E-selection, ICAM-1, VCAM-1, general clinical data, PSG parameters, blood biochemical parameters with left ventricular geometry and function.Results:①Serum E selectin, ICAM-1, and VCAM-1 concentrations increased sequentially from the NG, CR, and EH to CH groups, with the most significant increase in CH group (all P<0.05). In addition, there were statistically significant differences in age, body mass index (BMI), OSAS severity, neck circumference, waist circumference, systolic blood pressure (SBP), diastolic blood pressure (DBP), Glu, lowest oxygen saturation (Lowest-SaO 2), mean oxygen saturation (Mean-SaO 2), percentage of time with oxygen saturation below 90% of total sleep time (T90), left ventricular end-diastolic diameter (LVEDd), interventricular septal thickness (IVST), left ventricular posterior wall thickness (LVPWT), left ventricular mass index (LVMI), relative ventricular wall thickness (RWT), left ventricular ejection fraction (LVEF), peak mitral early diastolic flow velocity/peak mitral late diastolic flow velocity (E/A), E wave deceleration time (DT), A wave duration (AD), and isovolumic relaxation time (IVRT), and overall long-axis longitudinal strain (GLS) and so on(all P<0.05). ②Pearson correlation analysis showed that E selectin was negatively correlated with LVEF, E/A, e′, E/e′, IVRT, and GLS ( r=-0.236, -0.131, -0.224, -0.215, -0.285, -0.336; all P<0.05). ICAM-1 was negatively correlated with LVEF, E, E/A, e′, IVRT, and GLS( r=-0.130, -0.129, -0.104, -0.351, -0.252, -0.259; all P<0.05). VCAM-1 was negatively correlated with E, e′, and IVRT ( r=-0.132, -0.312, -0.387; all P<0.001). ③Multifactorial logistic regression analysis showed that E selectin and VCAM-1 were independently correlated with EH (β=1.139, OR=3.124, P=0.030; β=1.288, OR=3.626, P<0.001) and with CH (β=1.178, OR=3.248, P=0.013; β=1.108, OR=3.028, P<0.001). Conclusions:E selection and VCAM-1 were independently correlated with hypertrophic left ventricular geometry, suggesting that E selectin and VCAM-1 may be involved in the process of abnormal left ventricular structure and function in patients with OSAS combined with pre-HT.

目的 血清25羟维生素D[25(OH)D]水平与抑郁症状以及前期糖尿病有关.但关于患有前期糖尿病和血清25(OH)D浓度较低的个体,其出现抑郁症状风险增加的相关证据有限.此外,尚未证实这种可能的关联是否发生在中国人群中.本研究旨在确定中国前期糖尿病患者的血清25(OH)D水平与抑郁症状的关联.方法 本次研究为横断面研究,以天津人群慢性低度系统性炎症与健康队列的成年人群为研究对象(n=4051).使用抑郁自评量表(SDS)(截断值SDS≥45)评估抑郁症状.血清25(OH)D浓度通过IDS 25(OH)D EIA试剂盒测量.血清25(OH)D浓度分为三个等级:等级1:<50nmol/L,等级2:50-75nmol/L,等级3:>75nmol/L.依据美国糖尿病协会的标准将前期糖尿病定义为空腹血糖(IFG)受损、糖耐量(IGT)受损、糖化血红蛋白(IA1c)受损.在调整混杂因素后,采用多元Logistic回归评估血清25(OH)D浓度水平与前期糖尿病患者抑郁症状之间的关联.结果 本研究总人群中,有14.2％的人群有抑郁症状(SDS≥45).在对潜在混杂因素进行调整后,男性血清25(OH)D各水平的抑郁症状比值比(95％置信区间)分别为1.00、1.03(0.77,1.36)和0.92(0.59,1.40).女性的比值比(95％置信区间)分别为1.00、1.03(0.57,1.39)和0.28(0.12,0.57).结论 我们观察到中国女性前期糖尿病患者的血清25(OH)D水平与抑郁症状之间存在显着的负相关.这种低25(OH)D浓度与加重的抑郁症状间的关联表明维生素D缺乏可能是晚年患抑郁症的危险因素.

对国内外特定职业群体自我报告测量工具的开发和应用进行综述,评价特定环境背景下测量工具的信效度以及优缺点,旨在借鉴国外经验的基础上研制开发适合我国人群的久坐行为测量工具,为我国久坐职业群体疾病风险预防和临床干预提供参考.

目的:研究胃癌高发区山西省幽门螺旋杆菌(Hp)感染与血清胃蛋白酶原Ⅰ(PGⅠ)、胃蛋白酶原Ⅱ(PGⅡ)、PGⅠ/PGⅡ(PGR)以及胃泌素-17(G-17)浓度的相关性.方法:选取2019年7月1日至12月31日山西医科大学第一医院健康管理中心参与胃癌筛查项目的体检人群为研究对象,剔除无14C呼气试验493例,血清胃功能检测不全1例,最终纳入2547例,检测G-17、PGⅠ、PGⅡ、PGR,并行14C呼气试验检测,比较分析G-17、PGⅠ、PGⅡ、PGR及Hp在不同性别及年龄段的差异及变化.结果:Hp感染率是34.93％,其中男性感染率是63.92％,女性感染率是33.06％;Hp感染率是34.93％,其中男性感染率是63.92％,女性感染率是33.06％,不同性别Hp感染率比较,差异无统计学意义(χ2=2.581,P>0.05);男性PGⅠ、PGⅡ、PGR浓度水平较女性均高,男性G-17浓度水平较女性低,不同性别G-17、PGⅠ、PGⅡ及PGR比较,差异有统计学意义(P<0.05);HP阳性组的血清PGⅠ、PGⅡ及G17浓度水平均高于阴性组,PGR低于阴性组,差异有统计学意义(P<0.05);PGⅠ、PGⅡ及G17浓度水平随着年龄段的增长而升高,5组间差异有统计学意义(P<0.05),PGR浓度水平40～49岁组较小于40岁组有微小的升高,但总体水平呈随年龄段的增长而降低的趋势,5组间差异有统计学意义(P<0.05).结论:Hp阳性者中血清G-17、PGⅠ及PGⅡ浓度较阴性者高,血清G-17、PGⅠ及PGⅡ浓度随着年龄的增长而增高,应密切关注Hp阳性的中老年者血清G-17、PGⅠ、PGⅡ浓度及PGR的变化.

Objective:To explore the influence of group combined Internet+personalized health management mode on physiological indexes and self-management ability of physical examination population with chronic disease.Methods:A total of 88 people with abnormal chronic disease associated indicators who underwent physical examination in the Health Management Department of the First Hospital of Shanxi Medical University from May 2019 to December 2019 were recruited as the research subjects by purposive sampling. They were randomly divided into the control group and experimental group according to the random envelope method, with 44 patients in each group. The control group was treated with routine health return visit management, while the experimental group was treated with group combined Internet+personalized health management for 6 months, once a month. The differences of physiological indexes and self-management ability scores before and after the intervention were analyzed and compared between the two groups.Results:Comparison of physiological indicators: after intervention, systolic blood pressure, diastolic blood pressure, triglyceride, total cholesterol, low density lipoprotein and fasting blood glucose in experimental group were significantly lower than those in control group[(138.5±16.7) vs (147.2±16.1) mmHg (1 mmHg=0.133 kPa), (82.3±9.4) vs (86.4±9.4) mmHg, (2.14±0.99) vs (2.96±2.43) mmol/L, (5.27±0.83) vs (6.09±1.02) mmol/L, (3.40±0.66) vs (3.96±0.72) mmol/L, (7.37±2.03) vs (8.67±2.90) mmol/L]( t=2.476, 2.046, 2.072, 4.132, 3.814, 2.437, all P<0.05). Comparison of self-management ability score: all scores and total scores of self-management ability in two groups after intervention were higher than those before intervention (all P<0.05 in experimental group, but all P>0.05 in control group), and all scores and total scores of self-management ability in experimental group were significantly higher than those in control group after intervention (all P<0.05). Conclusion:The application of group combined Internet+personalized health management mode in physical examination population with chronic disease is conducive to improving their physiological indicators of chronic diseases and enhancing their ability of self-management.

以太原地区健康成年人为研究对象,根据BMI指数将其分为3组,采集粪便样本提取DNA,进行肠道菌群16S rDNA高通量测序、OUT聚类、物种注释以及生物信息分析,探讨健康成年人肠道菌群分布特点及其与BMI的关系.结果 表明:太原地区健康成年人肠道菌群分12个菌门、139个菌属,在门水平上以厚壁菌门(Firmicutes)(占51.16％)、拟杆菌门(Bacteroidetes)(占33.29％)、变形菌门(Proteobacteria)(占10.95％)、放线菌门(Actinobacteria)(占2.49％)为主,占到微生物总量的98％;在属水平上以拟杆菌属(Bacteroides)(占20.65％)、栖粪杆菌属(Faecalibacterium)(占7.10％)、毛螺菌属(Lachnospira)(占5.52％)、普氏菌属(Prevotella)(占4.8 1％)、Lachnoclostridium(占3.93％)、Parasutterella(占3.86％)、[Eubacterium] rectale group(占2.95％)、杆菌属(Dialister)(占2.84％)、Subdoligranulum(占2.82％)、Phascolarctobacterium(占2.79％)为主,占微生物总量的57％;健康成人肠道菌群复杂多样,但主要菌群相对稳定,BMI与肠道菌群具有一定的相关性.

目的 研究C57BU/6J小鼠耳蜗内神经生长因子(NGF)随年龄改变的分布特点及鼠神经生长因子干预小鼠耳蜗毛细胞的凋亡机制.方法 对不同月龄C57BU/6J小鼠注射NGF后,通过Western blot方法检测各组耳蜗基膜中NGF蛋白的表达,同时检测caspase-3的表达变化情况.结果 与对照组相比,注射NGF处理组小鼠耳蜗基膜NGF蛋白表达明显高于对照组(P<0.001),而caspase-3在对照组中的表达显著低于NGF处理组小鼠(P<0.001).结论 NGF注射后可提升小鼠耳蜗基底膜中该蛋白的表达,通过降低耳蜗组织中caspase-3的表达,抑制老龄大鼠内耳毛细胞凋亡而发挥相应保护作用.

Objective:To establish self management guidelines and specification of home nursing therapy for patients in COPD when using the noninvasive ventilator ,to improve ability patients’ self management and life quality. Method:Sixty cases of standard patients for study were collected, and then they were divided into two groups. The control group was given routine health education mode while the testing group was given related knowledge and operation skill training before hospital discharge.After discharge of hospital,the standardization of self management guidelines was applied as a manual mission.The patients of two groups were tested by questionnaire of breathing self management ability and questionnaire of SGRQ life quality to test the self management and life quality after using noninvasive ventilator.Result:The difference of self management of control group and test group before intervention had no statistical significance (P>0.05).While after six mouths’ intervention,the different self management questionnaire scores were statistically significant(P<0.05).Conclusion:The self management guidelines of noninvasive ventilator and specification of home nursing therapy strengths patients’ ability of self management and improve the quality life of patients.

护理人员在多年临床工作后发现,大多数老年突发性耳聋病人会出现急性应激反应,而这种应激反应常常在临床上被忽视.目前,对老年突发性耳聋病人急性应激反应的评价缺少深入研究,而对早期护理干预也缺乏足够重视.针对急性应激反应需要尽早进行护理干预,如果干预不及时,病情加重,则会伴发急性应激障碍,导致下一步的治疗更加困难.而老年突发性耳聋病人由于各种原因更易导致发生急性应激反应,所以要求临床护理工作者,针对老年性突发性耳聋病人发病后急性应激反应进行系统评估,并对相应护理工作进行更细致全面的研究.

<正>护理人员在多年临床工作后发现,大多数老年突发性耳聋病人会出现急性应激反应,而这种应激反应常常在临床上被忽视。目前,对老年突发性耳聋病人急性应激反应的评价缺少深入研究,而对早期护理干预也缺乏足够重视。针对急性应激反

Objective:Through the early comprehensive nursing of patients with senile sudden deafness to release the acute stress reaction degree of patients and summarize the main points of early nursing intervention.Methods:A total of 60 cases of patients who met the inclusion criteria were collected and were divided into observation group and control group based on random principle,30 cases in each.Observation group patients and control group patients used the same treatment,besides that,early comprehensive nursing intervention was given to observation group,and general routine care measures for control group patients.Stanford Acute Stress Reaction Questionnaire was used for scored before the nursing intervention and after 7 d of intervention.Results:There was no statistically significant difference in Stanford Acute Stress Reaction Questionnaire score before nursing intervention between observation group and control group(P>0.05);there was statistically significant difference in Stanford Acute Stress Reaction Questionnaire score after 7 d of nursing intervention between observation group and control group(P<0.01).Conclusion:Early comprehensive nursing intervention has significant effect for reducing acute stress reaction.