·AIM: To study the effect of synthetic borneol on transcorneal permeability of dexamethasone. The ocular irritation was also evaluated. ·METHODS:The freshly excised corneas,whole corneas or de-epithelialized corneas, were immediately mounted in perfusion cells. Dexamethasone containing free -borneol or borneol was added into the deliver chamber respectively in each group. At different time point after addition of solution, 50μL of the receptor solution was removed. The concentration of dexamethasone was determined and the apparent&nbsp;permeability coefficient ( Papp ) was calculated. Hydration level of cornea was measured and irritation test was observed. ·RESULTS: The Papp for dexamethasone in whole cornea increased by 2. 40 fold in borneol group ( P<0. 05). The Papp for dexamethasone in de-epithelialized cornea did not increased apparently (P>0. 05). Synthetic borneol did not increase hydration level and irritation of cornea(P>0. 05). ·CONCLUSION: Synthetic borneol can improve the corneal permeation of lipophilic drug dexamethasone and do not damage corneal tissue.

目的:探讨蛛网膜下腔出血(SAH)合并脑积水的治疗方法.方法:回顾性分析31例SAH合并脑积水患者的临床资料,除常规脱水、防治血管痉挛、营养神经等治疗方法外,其中10例给予行脑室-腹腔分流术,21例行侧脑室外引流术,对比分析两种治疗方案的利弊.结果:10例脑室-腹腔分流术患者9例手术效果良好,术后复查颅脑CT显示脑室明显减小,间质水肿消失,1例患者术后1月内再次出现脑积水,给予行同侧分流管探查再通、对侧脑室-腹腔分流术,术后效果良好,颅脑CT示脑室减小.21例行侧脑室外引流术患者,术后感染2例,全部患者均术后7天内拔除引流管,术后1月9例复发脑积水,给予再次行脑室-腹腔分流术,术后效果良好.结论:在手术指征明确的情况下,早期给予SAH合并脑积水患者行脑室腹腔分流术,分流管堵塞可能性小,术后感染发生率低,临床效果令人满意.

目的:识别并分析神经胶质瘤疾病进程中的动态模块,找出在胶质瘤病程中发生变化的功能机制.方法:整合基因表达谱数据(GEO数据库中的GDS1962)与蛋白质互作网络信息(I2D),得到各疾病分期中的共表达互作网络,并采用MCL算法进行模块挖掘,对模块进行融合,并对动态模块进行功能注释.结果:找出了两个在胶质瘤疾病进程中涉及到互作关系以及互作强度发生显著变化的功能模块.结论:对模块中的节点(蛋白质)进行功能注释发现在胶质瘤的疾病进程中涉及到了金属离子转运、信号传导和DNA、RNA复制、修复等功能的改变.

Objective To investigate the microscopic anatomic structures of posterior ciliary arteries.Methods Thirty cranium specimen(60 sides) were selected to take vascular perfusion of red emulsion,blue emulsion or silicone rubber.The origin,branches,courses and adjacent structures of the posterior ciliary artery were observed and measured.Results Posterior ciliary arteries derived from the 1st ophthalmic artery segment,the angle of the ophthalmic artery,the 2nd ophthalmic artery segment,the ophthalmic artery bend and the 3rd ophthalmic artery segment.The patterns of branching of the posterior ciliary arteries were medial-lateral and medial-lateral-superior.The most frequently observed posterior ciliary artery was medial-lateral pattern.Medial posterior ciliary artery derived from ophthalmic artery bend.Lateral and superior posterior ciliary arteries derived from ophthalmic arteries angle.The diameters of medial,lateral and superior posterior ciliaries artery were(0.71±0.24)mm,(0.69±0.22)mm and (0.63±0.19)mm,respectively.Conclusions The variations in origin and course of posterior ciliary arteries are much.The anatomical study of the posterior ciliary arteries can reduce bleeding and injury in operation and avoid the loss of vision caused by ischemia of optic nerve in rabbits.

目的:观察颅脑损伤患者眼内压与颅内压的关系。方法:压陷式眼压计测量眼内压,腰穿法测量颅内压,分析眼内压与颅内压的相关性。结果:眼内压与颅内压之间存在正相关关系,相关系数r=0.822。结论:颅脑损伤患者监测眼内压可以在一定程度上了解颅内压的变化,是一种无创性监测方法,具有临床应用价值。

目的 总结经单侧额下入路切除嗅沟大脑膜瘤的手术治疗经验.方法 回顾性分析11例经单侧额下入路手术治疗嗅沟大脑膜瘤.结果 Simpson Ⅰ级切除8例,Ⅱ级切除3例,术后2例出现脑脊液鼻漏,无手术死亡.结论 对于嗅沟大脑膜瘤,术前完善的检查,选择单侧额下入路,并结合显微神经外科技术,可取得的良好疗效.

AIM:To observe the irritation and chronic toxicity effect of natural borneol or synthetic borneol on rabbit eyes.·METHODS:Draize eye irritation test was carried out.Chronic toxicity experiment:32 rabbits were randomly divided into 8 experimental groups.Rabbits in 6 experimental groups received topical 50μL 1,0.5g/L,and 0.25g/L natural borneol or synthetic borneol eye drops,respectively,4 times daily for 4 weeks.Rabbits in control group 1 received nothing as normal control and rabbits in control group 2 received 50 uL of vehicle without borneol as negative control.Hematological parameters and organ coefficient were detected.Histopathological examination was made by light microscope and transmission electron microscopy.·RESULTS:Natural borneol and synthetic borneol could not lead to eye irritation.Compared with the control group,blood routine biochemical parameters and organ body coefficient of liver spleen and kidney of experimental group showed no significant differences.Histopathological examination indicated no change in experimental group.·CONCLUSION:There is a well tolerance on rabbit eye to natural borneol and synthetic borneol.Borneol has value for incorporation into ocular formulations.·