Many people engagingin medical scienceasked me,"You’ve beenworking on the exploration of Holistic Integrated Medicine（HIM）for quite awhile.What is the progressyou have made in your research?Have you got your article published?May I beyour first reader?"
Objective To study the effect of tofacitinib on tendon sheath thickness and synovial thickness in patients with rheumatoid arthritis.Methods A total of 74 patients with rheumatoid arthritis diagnosed and treated in our hospital from July 2021 to July 2022 were selected as the research objects.They were divided into control group and observation group by random number table method,with 37 patients in each group.The control group was treated with methotrexate+leflunomide,and the observation group was treated with methotrexate+tofacitinib.The clinical efficacy,clinical symptom improvement indicators(joint swelling number,joint tenderness number,morning stiffness time),pain(VAS)score,DAS28 score,tendon sheath and synovial thickness,and incidence of adverse reactions were compared between the two groups.Results The total effective rate of treatment in the observation group(94.59％)was higher than that in the control group(81.08％)(P＜0.05).The number of joint swelling,the number of joint tenderness relief and the proportion of morning stiffness relief in the observation group were higher than those in the control group(P＜0.05).After treatment,the VAS score and DAS28 score of the two groups were lower than those before treatment,and the scores of the observation group were lower than those of the control group(P＜0.05).After treatment,the thickness of tendon sheath and synovial membrane in the two groups were smaller than those before treatment,and those in the observation group were smaller than those in the control group(P＜0.05).The incidence of adverse reactions in the observation group was 5.41％,which was lower than 13.51％in the control group(P＜0.05).Conclusion Tofacitinib has a good clinical effect in the treatment of patients with rheumatoid arthritis,which can reduce the clinical symptoms and pain scores of patients,and plays an important role in improving the thickness of tendon sheath and synovium.High-frequency color Doppler ultrasound can be used to evaluate the clinical efficacy and safety of tofacitinib in the treatment of rheumatoid arthritis.
Objective To observe the effect of oxytocin combined with motherwort injection on postpartum hemorrhage and coagulation function in elderly parturient women.Methods Sixty elderly parturient women who gave birth in our hospital from January 2020 to June 2022 were selected as the research objects.They were divided into control group(n=30)and observation group(n=30)by random number table method.The control group was treated with oxytocin,and the observation group was treated with motherwort injection on the basis of the control group.The incidence of postpartum hemorrhage,bleeding volume at different time periods,coagulation function indexes[activated partial thromboplastin time(APTT),prothrombin time(PT),fibrinogen(FBG)],duration of uterine contraction and lochia,uterine involution and incidence of adverse reactions were compared between the two groups.Results The incidence of bleeding in the observation group was 6.67％,which was lower than 16.67％in the control group(P＜0.05).The amount of bleeding at 2 and 24 hours after delivery in the observation group was less than that in the control group(P＜0.05).APTT and PT in the observation group were lower than those in the control group,and FBG was higher than that in the control group(P＜0.05).The duration of uterine contraction in the observation group was longer than that in the control group,and the duration of lochia was shorter than that in the control group(P＜0.05).The vertical height of the uterine fundus and the midpoint of the upper edge of the pubic symphysis in the observation group was lower than that in the control group at 2 and 6 days after delivery(P＜0.05).The incidence of adverse reactions in the observation group was lower than that in the control group(P＜0.05).Conclusion Oxytocin combined with motherwort injection can effectively prevent postpartum hemorrhage in elderly parturient women,reduce the amount of bleeding within 24 hours after delivery,improve coagulation function to a certain extent,promote uterine contraction,shorten the duration of lochia,and reduce the incidence of adverse reactions.It has good application effectiveness and safety.
Objective To study the effect of rabeprazole combined with Lanqin oral solution in the treatment of chronic pharyngitis and its effect on clinical symptoms,inflammatory factors and immune function.Methods A total of 74 patients with chronic pharyngitis who were admitted to the Department of Otorhinolaryngology,Branch of Tianjin Third Central Hospital from June 2021 to June 2022 were selected and divided into control group(37 patients)and observation group(37 patients)by random number table method.Both groups were treated with budesonide atomization inhalation.On this basis,the control group was treated with Lanqin oral solution,while the observation group was treated with rabeprazole combined with Lanqin oral solution.The therapeutic effect,clinical symptoms,symptom relief time,inflammatory factors[tumor necrosis factor-α(TNF-α),interleukin-6(IL-6)],immune function[peripheral blood T lymphocyte subsets(CD4+,CD8+,CD4+/CD8+)]were compared between the two groups.Results The total effective rate of treatment in the observation group was 94.59％,which was higher than 78.38％in the control group(P＜0.05).The symptom scores(throat itching,hoarseness,foreign body sensation,pharyngeal obstruction)in the observation group were lower than those in the control group(P＜0.05).The symptom relief time(throat itching,hoarseness,foreign body sensation,pharyngeal obstruction)in the observation group was shorter than that in the control group(P＜0.05).The levels of TNF-α and IL-6 in the observation group were lower than those in the control group(P＜0.05).CD4+and CD4+/CD8+in the observation group were higher than those in the control group(P＜0.05).Conclusion Rabeprazole combined with Lanqin oral solution is effective in the treatment of chronic pharyngitis,which can improve the clinical symptoms of patients,accelerate the relief of symptoms,down-regulate inflammatory factors in the body,and promote the improvement of immune function.
Objective To explore the related risk factors of rupture of very small intracranial aneurysms(VSIA),and to provide guidance for the clinical management of unruptured intracranial microaneurysms.Methods A total of 99 patients of single very small intracranial aneurysms at Calmette Hospital Affiliated to Kunming Medical University from January 2016 to November 2021 were continuously included in the study.They were divided into ruptured group(n=48)and non-ruptured group(n=51)according to whether or not they ruptured.The clinical features,tumor location,shape and morphological parameters of the patients were retrospectively analyzed.Independent sample t test orx2test was used to analyze the significance of these factors.Multivariate logistic regression analysis was further performed on the statistically significant factors in the univariate analysis.The receiver operating characteristic curve was used to analyze the optimal threshold of each parameter to predict the rupture of microaneurysms.Results There were significant differences in aneurysm location,morphology,inflow angle,aneurysm angle,aspect ratio,volume to neck ratio,diameter-width ratio,size ratio,hypertension history and smoking history between the ruptured group and the non-ruptured group(P＜0.05).Multivariate Logistic regression analysis showed that smoking history,inflow angle,diameter-width ratio,volume to neck ratio and shape were independent risk factors for rupture of microaneurysms(P＜0.05).The ROC curve showed that the maximum area under the curve of the inflow angle was 0.864,which was the most accurate to evaluate whether the VSIA was ruptured.Conclusion Very small intracranial aneurysm with large inflow angles,diameter-width ratio,volume to neck ratio,irregularities in the aneurysm,and location in the anterior communicating artery are considered to be at high risk of rupture,and aggressive surgical intervention is recommended if conditions warrant.For patients with a history of hypertension and smoking,it is recommended to control blood pressure well,quit smoking,undergo regular digital subtraction angiography review,and timely surgical intervention if aneurysm morphology changes.
