Objective To establish appropriate correction models of serum marker α -fetoprotein (AFP) multiple of the median (MOM) for prenatal screening on patients with neural tube defect (NTD) at the second trimester to replace the foreign data currendy used in Beijing with a higher sensitivity.Methods A sample of 5815 mid-gestation pregnant women with normal pregnancy outcome were selected including 5557 cases of age ＜ 35 years and 258 cases of age ≥35 years.The regression relationship between AFP median and gestational age was builded by exponential model and the regression relationship between MOM and weight was builded by power model in age ＜ 35 years.The regression relationship between AFP median and gestational age was builded by S model and the regression relation ship between MOM and weight was builded by quadratic model in age ≥35 years.The normal reference values in two age sections were estimated approximately by percentiles method.Results Corrected AFP MOM values with mean value (age ＜ 35 years:1.001; age ≥35 years:1.113) and median value (age ＜ 35 years:0.934;age ≥35 years:0.990) obtained by regression analysis were more close to 1.00 than the data from the software[mean value(age ＜ 35 years:1.164; age ≥35 years:1.254) and median value (age ＜35 years:1.093; age ≥35 years:1.149)].There were significant differences (age ＜35 years:t =65.120,P =0.000;age ≥35 years:t =9.812,P =0.000).Conclusion Correction model for maternal serum marker is more applicable for Beijing population at the second-trimester prenatal screening.

目的以生物学变异为质量目标评价甲状腺功能五项的检测过程能力。方法根据室内、室间质控和生物学变异数据,计算各项目实际变异系数(CV)、实际偏倚(Bias)、实际总误差(TE),比较实际TE与不同水平允许总误差(TEa),计算σ值、质量目标指数(QGI),评价各项目检测性能。结果游离三碘甲状腺原氨酸(FT3)和促甲状腺素(TSH)的实际CV分别为3.79%和4.22%,其他项目实际CV均大于要求CV;5个项目实际Bias均小于要求Bias;除甲状腺素(TT4)的实际TE未达到最低TEa外,其他项目实际TE均小于合适TEa;以最低TEa、合适TEa作为质量目标时,TSH的σ值分别为6.61、5.26,提示该项目具有良好的检测性能,其他项目σ值均小于3.0,需重视其分析性能要求;全部项目QGI均小于0.8,提示改善项目精密度是提高分析性能的关键。结论以生物学变异确定的TEa作为质量目标,能较好了解各项目检测满足质量规范的程度。

目的对医院放射线职业暴露人员肝肾功能、血脂、血常规中8项血液检查指标进行检测,评估放射接触人员的健康状况。方法将放射线职业暴露人员分为<2年、2～5年和>5年3个观察组,对照组为同院不接触放射线的职工。检测对照组和观察组的谷丙转氨酶(ALT)、谷草转氨酶(AST)、尿素氮(BUN)、肌酐(Cr)、胆固醇(CHOL)、三酰甘油(TG)、白细胞(WBC)、血小板(PLT)8项血液检查指标,对检测结果分别分析比较,采用软件GraphPad Prism 5进行统计分析。结果 8项检测指标各观察组大多数结果与对照组相比均没有较大差异。8项检测指标对照组、接触放射线<2年、2～5年及>5年组的异常结果发生率,大多数没有随着接触放射线时间的增加而增加。结论职业暴露人员的这8项健康监控指标状况较好,本次检验结果更加肯定了医院现有的对于放射线职业暴露人员的保护政策。