目的 挖掘大肠癌手术治疗患者高额住院费用出现的预警信息,为减轻大肠癌手术治疗患者经济负担提供依据和对策.方法 收集2018-2020年某医院大肠癌患者的住院信息,利用Apriori算法挖掘各因素与高额住院费用之间潜在的强关联规则.结果 共纳入305例患者,患者手术治疗次住院费用的中位数为83591元(IQR=22877元),P75为97776元.多元线性回归分析结果显示大肠癌患者住院费用的相关因素包括:住院天数、其他伴随手术数量、疾病发现途径、病理分期、分化程度、延迟就诊时间6项因素(P<0.05).Apriori算法挖掘出的14条与高额住院费用相关的强规则中,9条与住院天数相关,7条与病理分期、疾病发现途径相关.满足强关联规则的患者出现高额费用的概率均是全部患者的3倍以上.结论 大肠癌手术治疗患者高额住院费用的主要预警信息包括:住院天数≥30天、病理分期为D期、因症就诊.通过规范临床路径、建立住院天数监控反馈机制、优化住院患者诊疗流程、开展大肠癌健康教育和人群筛查或有利于控制高额住院费用的产生.

In this work, immune modified graphene quantum dot (GQD) and semiconductor quantum dot (SQD) with blue and red emission respectively were synthesized to assemble a dual-QDs ratios fluorescent probe, which could be efficient used for insulin determination. There may be the dynamic equilibrium of forster resonance energy transfer (FRET) and aggregation-induced emission (AIE) in the internal of the probe, thus emitted special dual fluorescent lights. However, this sate of probe was cleaved upon exposure to target insulin, resulting in changing of the dual fluorescent lights. The resulting ratios response can be correlated quantitatively to the concentration of insulin, and was found to have a detection limit (as low as 0.045 ng mL(-1)) and rapid response time (as short as 5 min). It has been preliminarily used for ratiometric sensing of insulin in biological samples and exhibited consistency of the insulin detected results and higher stability compared with conventional ELISA. Therefore, this sensitive, rapid and stable detection system has great potential for next generation of the bioassay platform for clinical diagnosis and other applications. (C) 2021 Elsevier B.V. All rights reserved.

We reported a platform for the reatiometric fluorescent sensing of C-peptide based on quantum dot-dylight (QD-DL) probe. Owing to the pre-built state of QD aggregation, there has been aggregation-enhanced fluorescence resonant energy transfer (AE-FRET) from a blue emissive QD aggregate donor to a red emissive DL acceptor in the internal of the QD-DL probe. The immune bridge between QD and DL was cleaved upon exposure to C-peptide through competition, resulting in termination of AE-FRET as the DL diffused away from QD. This results in QD emission enhancing and DL emission quenching. The resulting ratiometric response can be correlated quantitatively to the concentration of C-peptide, and was found to have a detection limit as low as 4.4 pM and rapid response time as short as 5 min. The potential for use in biological applications was demonstrated by measuring the response of the immunoassay into real serum samples. The methodology used here is built upon a highly multifunctional platform that offers numerous advantages such as low detection limit, enhanced photochemical stability, rapid sensing ability within a biological milieu.

目的 了解天津市社区医院慢性病患者使用新媒体获取健康知识的现状及影响因素,为健康传播策略的制定提供数据参考.方法 于2019年9月采取便利抽样的方法,选取天津市10家社区卫生服务中心(站)的520例慢性病患者进行问卷调查,获得其人口学特征、慢性病情况和使用新媒体获取健康知识的情况.采用SPSS 24.0软件进行r检验.应用多因素logistic回归模型分析慢性病患者在获取健康知识过程中新媒体使用情况的影响因素.结果 天津市社区医院慢性病患者中50.2％的人使用新媒体获取健康知识.其中,微信公众号的使用人次数占比最高(50.9％)而信任度最低(30.8％),医院和疾病预防控制中心官网的使用人次数占比最低(2.9％)而信任度最高(76.9％).66.7％的慢病患者愿意为获取健康信息学习新技能,78.5％的人会将学到的健康相关知识信息运用于自己的日常生活,并分享给亲友.多因素logistic回归分析结果显示,男性较女性不愿使用新媒体(OR=0.646,95％CI: 0.433～0.963),75岁及以上人群较30～59岁人群不愿使用新媒体(OR=O.132,95％CI: 0.064～0.274),初中及以下文化水平者较本科及以上者不愿使用新媒体(OR=0.250,95％CI: 0.145～0.432),有慢性病并发症者较没有并发症者不愿使用新媒体(OR=0.592,95％CI:0.354～0.989).结论 天津市社区医院慢性病患者在获取健康知识时对新媒体的使用率较低.面向慢性病人群的健康传播应该以可及性高的媒体为主,并制定有效的措施,加强重点人群的新媒体普及,提高慢性病人群对新媒体的使用率.

将"亲水-疏水"结构引入胶体晶体中,探讨新型光学检测材料——富集胶体晶体测定水质中阿特拉津残留的可行性.以阿特拉津为模板分子,由疏水胶体颗粒与亲水凝胶制备富集胶体晶体.富集胶体晶体对阿特拉津残留最低检测浓度为2 ng/mL,并展现出较高的检测特异性,在实际饮用水样品中阿特拉津加标回收率在89.0％～105.5％之间,具有良好的应用价值.

A cross-sectional study was conducted to explore the association between soft drink consumption and handgrip strength (HGS) in subjects aged 40 years and older (n = 14,925). After multivariable-adjustment (including demographics, lifestyles, family history of diseases, dietary intake, and other beverages consumption), the least square means (95% confidence interval) of HGS across soft drink consumption categories were 43.1(42.7, 43.5) kg for almost never drink, 42.9(42.4, 43.4) kg for <1 cup/week, 42.8(42.1, 43.5) kg for 1-6 cups/week and 41.2(40.1, 42.6) kg for >= 1 cup/day (p for trend < 0.001) in men, and 26.6(25.9, 27.8) kg for almost never drink, 26.5(25.8, 27.1) kg for <1 cup/week, 26.3(25.7, 27.2) kg for 1-6 cups/week and 25.2(24.9, 27.0) kg for >= 1 cup/day (p for trend < 0.001) in women, respectively. Our findings suggest that higher consumption of soft drinks was significantly associated with lower HGS in middle-aged and older adults. Additional prospective or interventional studies are needed to confirm this issue.

BACKGROUND:Previous studies suggest that muscle-derived cytokines (myokines) are linked with brain function. Although muscle strength measured by handgrip strength is a prognostic indicator of functional decline, epidemiological studies directly examining the association between grip strength and mental health remain scarce. The aim of this study is to clarify the association between grip strength and depressive symptoms in the general adult population. METHODS:This is a cross-sectional study of 24,109 Chinese adults (41. 5  ± 11.9 years; 46.0% females). Grip strength was measured by dynamometer and the greatest force was normalized to body weight (NGS, kg/kg). Depressive symptoms were assessed using the Self-Rating Depression Scale (SDS). Models of logistic regression were conducted to assess the association between NGS and depressive symptoms, with adjustment for established confounding factors. RESULTS:Of the 24,109 participants, the prevalence of depressive symptoms (SDS ≥45) was 16.8% (males 15.7%, females 18.0%). After adjusting for multiple confounding factors, the odds ratios and 95% confidence interval for depressive symptoms in the quartiles of NGS were 1.00, 0.96 (0.84-1.10), 0.91 (0.79-1.05), and 0.91 (0.78-1.07) (P = 0.03) in males; 1.00, 0.92 (0.80-1.06), 0.90 (0.77-1.04), and 0.80 (0.69-0.94) (P = 0.0002) in females, respectively. LIMITATIONS:This cross-sectional study cannot determine causality. CONCLUSIONS:Grip strength was inversely associated with depressive symptoms, with stronger association observed among females than males.  Further prospective studies or randomized trials are required to clarify these findings.

Abstract Evidence has suggested that honey intake has a beneficial impact on glycaemic control in patients with type 2 diabetes. Whether these findings apply to adults with prediabetes is yet unclear. The aim of the present study was to examine whether honey intake is associated with a lower prevalence of prediabetes. A cross-sectional study was performed in 18 281 participants (mean age 39·6 (sd 11·1) years; men, 51·5 %). Dietary intake was assessed through a validated 100-item FFQ. Prediabetes was defined according to the American Diabetes Association criteria: impaired fasting glucose, impaired glucose tolerance or raised glycosylated Hb. Multivariable logistic regression models were used to estimate the association between honey consumption and prediabetes. As compared with those who almost never consumed honey, the multivariable OR of prediabetes were 0·94 (95 % CI 0·86, 1·02) for ≤3 times/week, 0·77 (95 % CI 0·63, 0·94) for 4–6 times/week and 0·85 (95 % CI 0·73, 0·99) for ≥1 time/d (Pfor trend < 0·01). These associations did not differ substantially in sensitivity analysis. Higher honey consumption was associated with a decreased prevalence of prediabetes. More large prospective cohort studies are needed to investigate this association.

背景 目前我国基本公共卫生服务项目总体实施效果较好,但实施效果仍然是政府和社会关注的焦点,合理评价实施效果及找出影响实施效果的因素,是完善基本公共卫生服务的前提和基础.目的 评价基本公共卫生服务的实施效果及影响因素,分析其存在的问题并探讨项目规划的合理性,为促进基本公共卫生服务项目的 进一步完善提供支持.方法 采用目的 抽样法,在天津市和平区抽取居民代表及从事基本公共卫生服务的相关工作人员共26人.针对基本公共卫生服务项目实施效果、评价及影响因素,于2017年4月采取焦点访谈法收集资料,并运用扎根理论编码分析.结果 本次研究访谈形成53个综合开放式编码并汇聚为16个主轴编码和4个核心编码,即项目先导、项目牵引、实施保障和项目结果,前三者相互联系、相互影响并共同作用于项目结果.项目结果包括受认可项目、存在问题项目、医务人员满意度、居民满意度4个主轴编码."需求导向性-供需一致"(21次)、"服务运行模式-团队模式"(3次)、"管理经验-妇儿时间久根基深"(5次)及"经费管理-计件拨付经费较充足"(5次)为老年人管理及妇儿管理效果良好的主要原因;"需求导向性-供需一致"和"项目考核机制"则是健康档案、健康教育、重性精神疾病患者管理及肺结核患者管理项目的 实施障碍因素;"项目考核机制-指标量化要求高"(26次)、"经费管理-经费相对足实际不足"(22次)、"服务运行模式-医疗公共卫生两张皮"(10次)及"项目规划"(9次)是影响医务人员满意度的主要因素;"政策解读"(7次)、"医疗满意度"(7次)、"设备准确性"(5次)及"医务人员技术水平"(4次)是影响居民满意度的主要因素.结论 项目先导、项目牵引、实施保障3个环节是基本公共卫生服务项目有效落实的前提和保障.有关部门应以需求为导向优化项目设置,以效果指标为牵引优化项目考核,以政策落实为支撑确保项目实施,克服现有社区卫生服务中心资源条件在保障目标服务的数量和质量方面存在的困难,推进和完善基本公共卫生服务项目.

BACKGROUND:Animal studies have shown that soy protein and isoflavones can increase antioxidant capacity and improve insulin resistance, and thus ameliorate nonalcoholic fatty liver disease (NAFLD). However, only limited epidemiological studies have examined the association of soy food intake with NAFLD. OBJECTIVES:We investigated the association between soy food intake and NAFLD in a Chinese cohort. METHODS:A total of 24,622 participants aged 20-90 y were included in the study. Diet information was collected using a validated 100-item FFQ. NAFLD was defined as having fatty liver diagnosed by ultrasonography and excluding men and women who consumed >210 g alcohol/wk and >140 g/wk, respectively. Logistic regression analysis was used to assess the association of soy food intake with NAFLD. RESULTS:After adjustment for potential confounders, and taking those with <1 time/wk soy food intake as the reference group, the ORs for NAFLD across soy food intake frequency were 0.94 (95% CI: 0.83, 1.07) for 1 time/wk, 0.88 (95% CI: 0.78, 0.99) for 2-3 times/wk, and 0.75 (95% CI: 0.65, 0.87) for ≥4 times/wk (P-trend <0.0001). The results were similar when participants were categorized by the energy-adjusted soy food intake (grams per 1000 kilocalories) quartiles (OR = 0.80; 95% CI: 0.71, 0.91; comparing extreme quartiles). CONCLUSIONS:Higher soy food intake was associated with a lower prevalence of NAFLD in Chinese adults. Further prospective studies and randomized clinical trials are necessary to confirm if soy food intake is inversely related to the risk of NAFLD.

Introduction: Prediabetes has been a growing health problem in China, and it is a high-risk state for developing diabetes and cardiovascular disease. In previous studies, low grip strength has been associated with diabetes. However, few population-based studies have examined the relationship between grip strength and prediabetes. Thus, the purpose of this study was to investigate whether grip strength is related to prediabetes in a large-scale adult population. Methods: A total of 27,295 participants aged 20 to 90 years were included from the 2013-2016 Tianjin Chronic Low-grade Systemic Inflammation and Health Cohort Study. Grip strength was assessed using an electronic hand-grip dynamometer and the greatest force was normalized to body weight. Prediabetes was diagnosed based on the American Diabetes Association criteria. Multiple logistic regression analysis was conducted in 2018 to assess the relationship of grip strength to the prevalence of prediabetes, while controlling for age, BMI, smoking, drinking, physical activities, dietary patterns, and other confounders. Results: Of the 27,295 participants, 28.5% (7,783) had prediabetes. After adjusting for potential confounders, a one unit increase in grip strength per body weight was associated with 52% lower odds of having prediabetes for men (OR=0.48, 95% CI=0.30, 0.74, p<0.01) and 62% lower odds of having prediabetes for women (OR=0.38, 95% CI=0.20, 0.70, p<0.01). Conclusions: Increased grip strength is independently associated with lower prevalence of prediabetes in Chinese adults, suggesting that grip strength may be a useful marker for screening individuals at risk of prediabetes. (C) 2019 American Journal of Preventive Medicine. Published by Elsevier Inc. All rights reserved.

Background: Honey has been shown to have multiple positive effects on human health. However, data on the associations of honey consumption with prehypertension are scarce. The aim of this study was to investigate whether honey consumption is associated with prehypertension in a Chinese population. Method: A cross-sectional study was conducted in 4,561 individuals aged ≥40 years. A validated 100-item semi-quantitative food frequency questionnaire was used to assess honey consumption. Blood pressure was measured at least twice by trained nurses. Multiple logistic regression models were used to explore the associations between honey consumption and prehypertension. Results: After adjustment for potential confounders, the odds ratios and 95% confidence intervals of prehypertension across increasing frequency of honey consumption were 1.00 (reference) for almost never, 1.17 (0.96, 1.41) for ≤6 times/week, and 1.25 (0.86, 1.84) for ≥7 times/week in men (P for trend = 0.09); 1.00 (reference) for almost never, 0.76 (0.62, 0.92) for ≤6 times/week, and 0.84 (0.63, 1.12) for ≥7 times/week in women (P for trend = 0.055), respectively. Conclusion: Our results showed that light-to-moderate intake of honey was associated with lower prevalence of prehypertension in women, but not men. Future studies are required to confirm these associations.

In this study, a easy-to-prepare biosensor for the sensitive detection of the antibody (Ab) protein was developed using a novel microgel photonic crystal (MPC). The MPC was fabricated by the spin-coated self-assembly method with the monodisperse Ab-sensitive poly (methyl methacrylate-acrylamide-glutaraldehyde-hapten) (P(MMA-AM-GA-HP)) microgels. Morphology characterization showed that the P(MMA-AM-GA-HP) microgels possessed round shapes and the large specific surface area, and the formed MPC had a highly ordered three dimensional (3D) periodically-ordered structure with the desired structural color. The Ab-response event of the P(MMA-AM-GA-HP) microgels can be directly transferred into a readable optical signal through a change in Bragg reflection of the periodic structure of the MPC. With the sensory system, the sensitive and selective detection of Ab was achieved without labeling techniques and expensive instruments. Therefore, this easy and sensitive detection system has great potential for next generation of the bioassay platform for clinical diagnosis and other applications.

收集整理2016-2018年天津市50家放射诊疗机构的放射工作人员职业性外照射个人剂量监测数据,对放射作业区域防护效果进行评估,从而为放射性疾病的预防、诊断和治疗提供有效的数据支持.通过热释光个人剂量测量(TLD)系统对进行职业性外照射个人剂量监测,并对监测结果进行统计分析.结果 显示,2016-2018年3年间共监测3 525人次,人均年有效剂量达0.22mSv.从工种分析,介入放射学作业人员的人均年有效剂量值最高,达0.47 mSv.从医院级别分析,三级医院人均年有效剂量值要高于一级和二级医院.提示,天津市放射工作人员在的年均有效剂量没有超过职业照射个人剂量限值;在医院、工种之间照射剂量的明显差别仍值得注意.

Background: The prevalence of depression in the general population has risen sharply over the past few decades and has become a major health problem throughout the world. Increasing evidence suggests that inflammation plays an important role in the pathogenesis of depression. To better understand the role of inflammation in the pathogenesis of depression we can use the neutrophil-to-lymphocyte ratio (NLR) because it is a simple and effective marker of inflammation and immunity. Methods: This cross-sectional study was conducted among adults from the healthy general population in Tianjin, China. NLR was measured according to the complete blood count. Depressive symptoms were assessed using the Zung Self-Rating Depression Scale (SDS), and a cutoff score of 45 was used to indicate the presence of depressive symptoms in the study participants. The relationship between NLR and the prevalence of depressive symptoms was evaluated separately for men and women using the multiple logistic regression analysis. Results: In the present study, the overall prevalence of depressive symptoms was 17.0% among all participants. In women, the multivariable-adjusted OR of having depressive symptoms was 1.28 (95% CI 1.10, 1.49; p for trend < 0.01) for the fifth compared with the first quintile of NLR, and was 1.22 (95% CI 1.07, 1.39; p < 0.01) per unit increase of NLR. However, no significant association was found between NLR and depressive symptoms in men. Conclusion: This study suggests that increased NLR levels are independently related to depressive symptoms in women, but not in men. Further research is required to investigate this relationship with longitudinal data to establish the temporal ordering between these variables.

Background: Banana contains many kinds of substances that are beneficial to depressive symptoms. However, there are no epidemiological researches directly to explore the association between banana consumption and depressive symptoms. This study aimed to investigate whether the banana consumption is related to depressive symptoms in a general adult population. Methods: A cross-sectional study was performed in 24,673 adults in Tianjin. Banana consumption was evaluated via a validated food frequency questionnaire. Depressive symptoms were assessed by using Self-Rating Depression Scale (SDS). The association between banana consumption and depressive symptoms was analyzed by multiple logistic regression analysis. Results: The prevalence of depressive symptoms was 16.1% in males and 18.4% in females (SDS >= 45), respectively. In males, comparing to the reference group (almost never), the multivariable adjusted odds ratios (ORs) (95% confidence intervals) of depressive symptoms across banana consumption were 0.86 (0.74, 0.99) for <1 time/week, 0.76 (0.66, 0.88) for 1-3 times/week and 0.97 (0.82, 1.16) for >= 4 times/week. By contrast, the multivariable adjusted ORs (95% confidence intervals) were 1.11 (0.94, 1.32) for <1 time/week, 0.99 (0.85, 1.16) for 1-3 times/week and 1.22 (1.02, 1.46) for >= 4 times/week in females. Similar association was observed when other cut-offs (SDS >= 48 and 50) were used to define depressive symptoms. Limitation: This is a cross-sectional study, causality remains unknown. Conclusion: Findings from this study suggested a negative association between moderate banana consumption and depressive symptoms in males. In females, high banana consumption is positively related to depressive symptoms.

Objectives: Non-alcoholic fatty liver disease (NAFLD) is one of the most common public health issues worldwide. Oranges are the most popular fruit consumed in the world. Admittedly, flavonoids in oranges act as antioxidants and improve liver steatosis. However, oranges also are rich in fructose, which is a risk factor in the progress of NAFLD. Therefore, we hypothesize that orange intake may be a double-edged sword in the development of NAFLD. To our knowledge, there currently is little evidence of the effect of dietary orange intake on NAFLD. The aim of this study was to investigate how orange intake is related to NAFLD in a general adult population. Methods: We randomly recruited 27,214 adults into the Tianjin Chronic Low-Grade Systemic Inflammation and Health Cohort Study. NAFLD was diagnosed by liver ultrasonography. Raw orange intake was assessed by a validated self-administered food frequency questionnaire. Multiple logistic regression analysis was used to evaluate the association between orange intake and the prevalence of NAFLD. Results: There was a 27.18% prevalence of NAFLD among the participants. Consumption of orange was positively associated with the prevalence of NAFLD after adjustment for all potential confounding factors (P-trend = 0.04). The odds ratios (95% confidence interval) of the categories of orange intake in the NAFLD were 1.00 (reference) for less than once per week, 1.02 (0.95-1.11) for 1 to 6 times per week, and 1.17 (1.03-1.33) for >= 7 times per week, respectively. Conclusions: The present study demonstrated that orange intake is positively associated with the prevalence of NAFLD. (C) 2018 Elsevier Inc. All rights reserved.

目的 了解东丽区金钟街户籍居民主要死因的分布及其死亡率变化趋势,掌握居民健康影响因素,为进一步完善重点疾病防制措施和健康促进策略,延长居民寿命提供科学依据.方法 利用2007-2016年金钟街户籍居民死因监测资料,分析死因构成比、死亡率等指标.死因分类按照国际疾病分类(ICD-10)对根本死因进行编码.人口资料来源于东丽区公安局户籍部门统计资料.采用Excel 2010、SPSS 17.0软件进行x2检验、u检验.死亡时间趋势用年度变化百分比(APC)检验.结果 2007-2016年户籍居民年均粗死亡率为566.59/10万,年均标化死亡率为516.12/10万,全人群、男性的标化死亡率呈下降趋势,有统计学意义(APC分别为-2.57％、-3.05％,P＜0.05).金钟街户籍居民前10位死因依次为心脏病、恶性肿瘤、脑血管病、呼吸系统疾病、伤害、内分泌营养和代谢疾病、消化系统疾病、泌尿生殖系统疾病、神经系统疾病、肌肉骨骼和结缔组织疾病,占全部死亡人数的96.54％.全人群恶性肿瘤分类中胰腺癌标化死亡率呈上升趋势,而脑血管病、消化系统疾病、泌尿生殖系统疾病呈下降趋势,有统计学意义(APC分别为16.07％、-7.41％、-13.93％和-16.97％,P＜0.05).男性肺癌标化死亡率呈上升趋势,脑血管病呈下降趋势,有统计学意义(APC分别为5.97％、-11.31％,P＜0.05).女性胰腺癌标化死亡率呈上升趋势,消化系统疾病及伤害则呈下降趋势,有统计学意义(APC分别为16.88％、-24.50％和-20.07％,P＜0.05).结论 以心脑血管疾病、肿瘤等疾病为代表的慢性非传染性疾病正在成为影响金钟街居民健康的公共卫生问题,重视老年人慢性病干预工作,应采取全人群和高风险人群策略相结合的综合防控措施降低慢性病死亡率.

BACKGROUND:Atherosclerosis is an inflammatory disease. Many studies demonstrated that hyperglycemia is not only increased inflammatory response, but also is a cause of atherosclerosis, implying that glucose metabolic status may be an important stratification factor when analyzing the relationship between inflammatory levels and subclinical carotid atherosclerosis. The aim of the present study is to assess the relationship between inflammatory levels and subclinical carotid atherosclerosis, stratified by different glucose metabolic status in a general population.METHODS:An assessment was performed in 7975 participants living in Tianjin, China. In the present study, we examined subclinical carotid atherosclerosis, as defined by increased carotid intima-media thickness [IMT] and plaques. Measurements were performed using a carotid artery B-mode ultrasound system. The glucose metabolic status was defined by the criteria of the American Diabetes Association, and high-sensitivity C-reactive protein (hs-CRP) as an inflammatory indicator, was measured by immunoturbidimetric assay. Multiple logistic models were used to assess a stratified relationship between hs-CRP levels and subclinical carotid atherosclerosis. Strata were defined according to glucose metabolic status.RESULTS:The prevalence of increased IMT and plaques were 27.3% and 21.3%, respectively. The adjusted odds ratios (95% confidence interval) for IMT across hs-CRP quartiles were as follows: 1.00 (reference), 1.10(0.88-1.38), 1.08(0.86-1.35) and 1.32(1.06-1.66) in blood glucose-normal subjects; 1.00 (reference), 1.33(0.92-1.91), 1.33(0.93-1.91), and 1.59(1.10-2.30) in prediabetic subjects; 1.00 (reference), 0.94(0.54-1.62), 1.17(0.65-2.12) and 0.98(0.55-1.76) in diabetic subjects, respectively. Similar results were observed for plaques.CONCLUSIONS:Our results suggest that inflammatory levels are differently related to subclinical carotid atherosclerosis by the different glucose metabolic status.

目的 了解癌症幸存者担忧复发(FCR)现状及影响因素.方法 采用便利抽样法,选取2017年6-9月在门诊复查的癌症幸存者166例,采用中文版癌症幸存者担忧复发量表(CARQ-4)、中文版Mishel患者疾病不确定感量表(MUIS-A)测量癌症幸存者的FCR和疾病不确定感水平,探讨影响癌症幸存者担忧复发的因素.结果 癌症幸存者FCR得分为(23.60±8.61)分,其中总得分≥12分为154例(90.1％),疾病不确定感总分为(74.88±13.16)分,为中等水平;FCR与疾病不确定感呈正相关(P＜0.05).治疗方式、医疗保险、工作状态及疾病不确定感是影响癌症幸存者FCR的重要因素(P＜0.05).结论 癌症幸存者普遍存在FCR,其中无医疗保险、待业者及疾病不确定感强烈的癌症幸存者更易出现FCR,建议临床和社区护理人员结合具体情况对此类人群予以关注,鼓励他们回归工作,降低疾病不确定感,减少对癌症复发的担忧,提高生活质量.