目的:探讨消风润节汤对风湿性关节炎患者关节疼痛及免疫功能的影响.方法:将青海红十字医院2018年1月至7月半年期间收治的风湿性关节炎患者共80例,按随机双盲1:1平均分为对照组和观察组.对照组采用常规西药治疗,观察组口服消风润节汤治疗.12周后比较两组患者关节症状、炎性因子、免疫功能的变化,评价临床疗效,并观察治疗的不良反应.结果:治疗后,观察组关节压痛和四肢麻木评分显著低于对照组(P<0.05).观察组治疗后IgG、IgA、IgM、Th1、Treg、RF、ESR、CRP、IL-6改善显著优于对照组(P<0.05).观察组的总有效率显著高于对照组,不良反应发生率显著低于对照组(P<0.05).结论:消风润节汤能显著缓解风湿性关节炎患者的疼痛,控制炎症,提高免疫功能,且不良反应少.

目的 分析血清铁蛋白(serum ferritin,SF),载脂蛋白B(apolipoprotein B,ApoB),血清C肽(C-peptide,CP)在2型糖尿病(type 2 diatetes mellitus,T2DM)病人血清中的表达及其与胰岛素抵抗(insulin resistance,IR)的关系.方法 选取2015年3月—2018年9月青海红十字医院收治的51例T2DM合并IR患者作为观察组,51例单纯T2DM患者作为对照组,并同期选取50例健康体检者作为本组研究健康对照组;检测患者血中三酰甘油(triglyceride,TG)、总胆固醇(total cholesterol,TC)、高密度脂蛋白胆固醇(high density lipoprotein cholesterol,HDL-C)及低密度脂蛋白胆固醇(low density lipoprotein cholesterol,LDL-C)、ApoB、SF及CP水平,采用二项Logistic回归分析T2DM患者血清SF、ApoB、CP水平与IR的关系.结果 观察组血中TG、TC及LDL-C水平均显著高于对照组及健康对照组(P<0.05),且HDL-C水平显著低于对照组及健康对照组(P<0.05);观察组血中SF、ApoB及CP水平均明显高于对照组及健康对照组,且差异有统计学意义(P<0.05);SF、ApoB及CP异常高表达均是导致IR发生的独立危险性因素(P<0.05).结论 T2DM患者血清中SF、ApoB、CP水平常处于异常高表达状态,且与IR的发生密切相关.

OBJECTIVE To investigate the efficacy of teicoplanin on empirical therapy of patients with neutropenia and bacterial infection ,so as to provide references for clinical treatment .METHODS A total of 40 cases of hospital neutropenic patients administered teicoplanin from Jun .2013 to Jun .2015 were selected ,and the clinical efficacy were evaluated .The data were analyzed by SPSS 17 .0 .RESULTS The sustained accompanied neutrophil counts of the neutropenia patients treated by teicoplanin were < 1000 /μl ,and the effective treatment rate was 77 .5% . Drug‐related adverse reactions rate was 7 .5% ,which were mild adverse reactions and well tolerated .Daily dose or duration of teicoplanin would have slight adverse reactions .CONCLUSION Teicoplanin has sufficient clinical effica‐cy ,and is a kind of safe drug for treatment of bacterial infection of patients with hematologic diseases and neutro‐penia .

目的:探讨重组人促血小板生成素(rhT-PO)治疗西宁地区急性白血病化疗后血小板减少患者中的临床治疗效果.方法:选取2009年2月-2016年2月我院收治的急性白血病化疗后血小板减少患者资料进行分析,根据不同治疗方案将患者分为对照组和观察组,对照组采用重组人白介素-'11(rhIL-11)治疗,观察组采用重组人促血小板生成素治疗,观察两组血小板变化情况及不良反应发生率.结果:观察组患者血小板计数＜50×109/L的持续时间,恢复至70×109/L和恢复至100×109/L时间显著短于对照组(P＜0.05);观察组不良反应发生率为10.0％,显著低于对照组(不良反应发生率为16.7％)(P＜0.05).结论:西宁地区急性白血病化疗后血小板减少患者采用重组人促血小板生成素(rhT-PO)治疗效果理想,值得推广使用.

To determine the risk factors leading to acute high altitude disease(AHAD).Methods:A total of 1 200 volunteers,who worked in Yushu area for relief and reconstruction after earthquake,were collected from April 2010 to October 2012,and were divided into the AHAD(n=276) group and non-AHAD group(n=924),aged 20 through 50 years.The symptoms score of AHAD,ordinary circumstances,family genetic history,family situation and Eysenck questionnaire were studied in the both groups.And SaO2 level,lung function,ECG,heart rate,blood pressure were measured after 12,24 hours and 3,7 days exposed Yushu area.In the evening on the 6th and 7th day,the respiratory sleep testing was conducted consecutively for 12 hours when objects were complete rest only.Results:The results found that the occurrence of AHAD relates to the patient's BMI,smoking,family history of AHAD,bad mood,lung function,SaO2 level,ST segment,heart rate,blood pressure,breathing sleep testing so on.Conclusions:The occurrence of AHAD is a result of many factors.

本文对1998年3月至2003年3月我院入住的(西宁地区:海拔2 260m)慢性肺心病急性加重期患者536例进行分析,结果有198例为合并高血糖,比较高血糖组与非高血糖组对肺心病预后的影响及干预治疗后对肺心病预后的改进,现报告如下.