目的 比较慢性硬膜下血肿的钻孔和小骨窗开颅治疗的临床疗效.方法 选取我院自2018年6月至2019年1月收治的40例慢性硬膜下血肿患者,按照治疗方式分为观察组(20例)与对照组(20例),给予对照组患者采用钻孔引流术对患者进行治疗,给予观察组患者采用小骨窗开颅清除术对患者进行治疗,对比两组患者经过治疗后的疗效、术后复发情况以及两组患者术后的并发症发生率.结果 观察组患者经过治疗后的效果显著高于对照组患者(P<0.05);观察组患者复发率显著低于对照组患者(P<0.05);观察组患者经过治疗后的并发症发生率显著低于对照组患者(P<0.05).结论 对于慢性硬膜下血肿患者采用小骨窗开颅清除术对患者进行治疗能够更为彻底的为患者颅内血肿进行清除,有效减少了患者的复发率,极大地降低了患者经过治疗后的并发症发生率,有效提高了慢性硬膜下血肿患者的临床疗效以及患者治疗的安全性,值得广泛推广使用.
<正>恶性肿瘤的无限制侵袭性生长及其转移依赖于血管生成。肿瘤血管生成(angiogenesis)是指在血管生成因子的刺激下,肿瘤中业已存在的微血管内皮细胞重新进入细胞增殖周期,通过芽生方式形成新生毛细血管的过程。1971年Folkman[1]提出肿瘤生长依赖血管生成假说。从血管生成的角度,将恶性肿瘤的发展分为血管生长前期和血管生长期2
Objectives To investigate the effect of Ligustrazine(LZ) on the apoptosis of neurons, the expression of Bcl-2 and Bax genes and cerebral neuroprotection after the severe brain injury(SBI) in rats.Methods SBI model was established according to Feeney's method.One hundred-twenty rats were divided into 3 groups, i.e.treatment group, control group and sham injury group.The rats were treatment by imtraperitoneal injection of LZ in the treatment group.The neuronal apoptosis and expressions of Bcl-2 and Bax in the brain tissue were determined respectively by TUNEL and immunohistochemical technique in all the rats.Results The rates of TUNEL positive cells and the positive expression of Bcl-2 and Bax were significantly higher in both the treatment and control groups than those in the sham injury group(P0.05).The rates of TUNEL positive cells and the positive expressions of Bax were significantly lower and the rates of the positive expression of Bcl-2 was significantly higher in the treatment group than that in the control group 72 and 68 hours after SBI(P0.05).The neurological deficit score was significantly lower in the treatment group than that in the control group(P0.05).Conclusions The neuronal apoptosis can be inhibited by LZ which can cause down-regulation of Bax expression and up-regulation of Bcl-2 in the rats with SBI.
我院自2003年2月至2004年6月,选择性的对48例高血压脑出血病人进行了床边锥颅微创手术吸除血肿,手术效果比较满意,对此种治疗方法在高原地区的应用取得了一定的经验,现总结报告如下.
一、临床资料 1.一般资料:本组男10例,女1例,年龄最小1个月,最大45岁,平均16.8岁.儿童7例,成人5例.病程最短3天,最长3年,平均6个月.
临床资料 男性,3岁。以腰骶部一囊性肿物,头大,言语及行走不能3年之主诉收入院。患儿出生时腰骶部正中有一核桃大小囊性肿物,头颅明显大于正常儿,并随年龄逐渐增大,尤于哭闹时明显,且伴大小便失禁、双下肢无力及双足内翻畸形,曾在……