目的 使用经典测量理论与项目反应理论(IRT)结合的方法对抑郁症生命质量测定量表(QLICD-DE V2.0)进行综合条目评价.方法 使用QLICD-DE V2.0测定210例抑郁症患者的生命质量,通过变异度法、相关系数法、因子分析法、克朗巴赫(Cronbach)系数法及IRT法对量表条目进行综合评价.结果 QLICD-DE V2.0条目的标准差在0.78～1.46,条目与量表总标准化得分之间的相关系数在0.161～0.695,两个条目的因子载荷小于0.5,总量表的Cronbach'α系数为0.914;单维性IRT分析显示各条目区分度为0～5.46,8个条目的难度偏大,各条目的平均信息量为0～4.20.经过综合评价,QLICD-DE V2.0中有27个条目的综合评价为良好,13个条目评价为待改进.结论 量表的大部分条目测量学特性良好,部分条目需要后续进行修订验证,该量表能较好地对抑郁症患者的生命质量进行评价.

目的:探究功能近红外光谱术为指导的经颅磁刺激治疗在抑郁障碍的脑网络机制研究患者中的应用效果.方法:选取2018年10月～2020年3月的80例抑郁障碍患者为研究对象,将其随机分为对照组(常规治疗组)和观察组(功能近红外光谱术为指导的经颅磁刺激治疗组),每组各40例.比较两组的临床总有效率、治疗前后的HAMD-17评分及静息态默认状态网络内功能连接z分.结果:观察组的临床总有效率显著高于对照组,差异有统计学意义(P<0.05),治疗前两组的HAMD-17评分及静息态默认状态网络内功能连接z分比较,差异无统计学意义(P>0.05),治疗后观察组的HAMD-17评分显著低于对照组,静息态默认状态网络内功能连接z分显著高于对照组,差异有统计学意义(P<0.05).结论:功能近红外光谱术为指导的经颅磁刺激治疗在抑郁障碍的脑网络机制研究患者中的应用效果较好,在本类患者中的应用价值较高.

目的 探讨颞叶癫痫发作间歇期脑电生理信号变化与抑郁症状的关系.方法 回顾性分析2016～2018年于广东三九脑科医院手术治疗的26例颞叶癫痫患者,采用立体定向脑电图(SEEG)采集癫痫发作间歇期的脑电生理信号,采用HAMD-24评价抑郁症状,分析两者之间的相关性.结果 1.HAMD-24量表总分与颞中回前部SEEG波幅绝对平均值、波幅标准方差、全频段总功率、delta功率及theta 功率相关系数显著(r=0.479,P=0.018;r=0.486,P=0.016;r=0.414,P=0.044;r=0.439,P=0.032;r=0.410,P=0.046).2.HAMD-24量表睡眠因子与颞中回前部SEEG波幅绝对平均值、波幅标准方差、全频段总功率、alpha 功率及 delta 功率相关系数显著(r=0.463,P=0.023;r=0.469,P=0.021;r=0.441,P=0.031;r=0.453,P=0.026;r=0.453,P=0.026).3.不伴抑郁组与伴抑郁组在颞中回前部SEEG波幅绝对平均值与波幅标准方差两个特征值中存在显著差异(t=2.182,P=0.041;t=2.214,P=0.042).结论 颞叶癫痫发作间歇期颞叶外侧脑电功率值的变异性可能与抑郁及睡眠症状相关.

<span id="ChDivSummary" name="ChDivSummary" class="abstract-text">目的:探讨谷氨酸（Glu）能神经递质及传递功能异常在双相障碍病理机制中的作用。方法:选取符合ICD-10诊断标准的双相障碍抑郁发作期患者35例,躁狂发作期患者33例,缓解期患者28例及40例正常对照,用汉密顿抑郁量表（HAMD-17）、汉密顿焦虑量表（HAMA）、贝克-拉范森躁狂量表（BRMS）评估被试临床症状,以酶联免疫吸附法测定血清Glu水平,以RT-PCR技术检测NR1亚基mRNA表达水平。结果:抑郁发作期组、躁狂发作期组血清Glu水平[（35.3±6.1） mg/L,（35.8±6.3） mg/L vs.（27.8±5.4） mg/L,（28.6±5.7） mg/L,P&lt;0.01]及NR1亚基mRNA水平[（1.6±0.4）,（1.4±0.3） vs.（0.7±0.4）,（0.6±0.5）,P&lt;0.01]高于缓解期组及对照组;抑郁发作期组血清Glu水平与HAMD总分呈正相关（r=0.58,P&lt;0.05）,躁狂发作期组NR1亚基mRNA水平与BRMS总分呈正相关（r=0.42,P&lt;0.05）。结论:双相障碍疾病发作期可能存在Glu能神经递质水平紊乱及NR1亚基表达异常,在疾病缓解期基本恢复正常。</span>

Objective:To understand the current status of nursing staff's mental health, job burnout, and self-efficacy, and to explore the effects of experiential group sandbox psychological technology on nursing staff's mental health, job burnout, and self-efficacy.Methods:The SCL-90, MBI, and CSES scales were used to evaluate 266 nursing staff in our hospital, and a three-stage experiential group sandbox psychological intervention was performed to compare the changes of SCL-90, MBI, and CSES before and after the intervention.Results:1. The factors of somatization, compulsiveness, anxiety, depression, hostility, terror, paranoia, and psychosis of SCL-90 self-rating scale in nursing staff before the intervention were higher than the national norm (all P<0.05), anxiety, hostility, terror, and psychotic factors decreased significantly after the intervention ( t=4.532, P=0.011; t=3.183, P=0.033; t=5.021, P=0.007; t=5.981, P=0.004). 2. Experiential group sand table technology significantly reduced the depersonalization, low achievement, and total burnout scores of burnout scale in the nursing staff ( t=8.255, P=0.001; t=15.799, P<0.001; t=25.022, P<0.001), but there was no significant change in emotional exhaustion before and after intervention ( P>0.05). 3. Experiential group sand table technology had a significant effect on the total score of self-efficacy of nursing staff ( t=6.777, P<0.001). Conclusion:The experiential group sand table technology can improve the mental health of nursing staff, improve the status of job burnout, and improve the sense of self-efficacy, which is worth promoting.

<span id="ChDivSummary" name="ChDivSummary" class="abstract-text">目的:测量抑郁症发作期与缓解期血清谷氨酸（Glu）、γ-氨基丁酸（GABA）系统水平,探讨这些递质在抑郁症病理机制中的作用。方法:选取符合DSM-5诊断标准的抑郁症发作期患者47例,缓解期患者34例及31例正常对照,以汉密顿抑郁量表（HAMD）、汉密顿焦虑量表（HAMA）评估患者抑郁、焦虑症状,酶联免疫吸附法测定被试血清Glu、 GABA、谷胺酰胺（Gln）及谷氨酸脱羧酶（GAD）水平。结果:与缓解期组及对照组相比,抑郁症发作期组血清Glu水平[（35.3±6.1）mg/L、（28.0±5.4）mg/L vs.（28.7±5.7）mg/L,P&lt;0.001]及Glu/GABA[（6.3±1.3）、（5.2±1.8）vs.（5.1±1.3）,P&lt;0.05]较高,而血清GABA[（5.1±0.7）μmol/L,（5.9±0.9）μmol/L, vs.（5.8±1.2）μmol/L,P&lt;0.01]、GAD[（29.7±6.0）U/L,（36.4±5.3）U/L vs.（35.8±7.2）U/L,P&lt;0.001]降低,但缓解期组与对照组间各物质水平差异无统计学意义（P&gt;0.05）;发作期组血清GABA水平与HAMA总分（r=-0.34,P&lt;0.05）、HAMD总分（r=-0.46,P&lt;0.01）及抑郁核心症状分（r=-0.32,P&lt;0.05）呈负相关。结论:本研究提示Glu能和GABA能神经元功能异常可能是抑郁症病理机制之一。</span>

目的:观察经颅直流电刺激(tDCS)结合言语训练在卒中伴Broca失语患者抑郁障碍治疗中的疗效.方法:将60例卒中伴Broca失语后抑郁障碍患者按照随机数字表法分为2组,脱落1例后观察组30例、对照组29例.两组均采用基础治疗和护理,观察组在对照组言语治疗基础上加用tDCS治疗,共4周.治疗前后采用WAB、HAMD、HAMA量表评估2组疗效.结果:治疗后WAB评分显示2组较治疗前组内比较均有效(P＜0.05),且观察组自发言语、复述、命名,优于对照组自发言语、复述、命名,差异有统计学意义(P＜0.05);治疗第2周末、治疗第4周末组内比较对比于治疗前均有效(P＜0.05),治疗第4周末观察组HAMD、HAMA优于对照组组HAMD、HAMA,差异有统计学意义(P＜0.05).结论:tDCS结合言语训练治疗卒中伴Broca失语患者抑郁障碍有效.

Objective To translate English version of sensory-motor profile awake ( SMP-a) into Chinese version (the Chinese Version of SMP-a),and analyze the reliability and validity of the scale before and after craniotomy under awakening anesthesia. Methods Eighty-one patients whose tumors were located near or already in sensory-motor functional area were included in this study. Before and after awake cranioto-my,the Chinese version of SMP-a was used to accurately assess the sensory-motor function of each patient. Finally, the reliability and validity of the scale were analyzed by SPSS statistical software. Results Cronbach's α coefficient in the Chinese version of SMP-a was 0. 971,and Cronbach's α coefficient in the four subscales of face,hand,leg and sensation was 0. 965,0. 989,0. 981 and 0. 970,respectively. The test-retest reliability of the Chinese version of sensorimotor assessment scale was 0. 910,0. 904,0. 884,0. 898 and 0. 695 (total,face,hands,legs and sensory score respectively). The raters' consistency reliability was above 0. 949,0. 960,0. 934,0. 887 and 0. 660,respectively. The Pearson correlation coefficients of sensorimotor function score with SF-36 physiological function factors and KPS score were 0. 868 and 0. 790,respectively. Conclusion Before or after operation,the Chinese version of SMP-a has preferable reliability,internal con-sistency reliability and structural validity. It is feasible in awakening anesthesia craniotomy,and the degree of damage can be determined by repeated measurement of the sensorimotor sites that may be impaired by the patient.

Objective To compare the damage degrees between time-and event-based prospective memory (PM) tasks in schizophrenic patients,and to explore the relationship between prospective memory and mental symptoms,between individual and social function,and between quality of life and medical history.Methods On the basis of Einstein's and McDaniel's dual task paradigm,56 schizophrenic patients and 56 normal subjects were tested using graphical material prospective memory tasks,including time-based prospective memory task (TBPM) and event-based prospective memory task (EBPM).Results The patients were worse than the normal in the TBPM task for the correct number of prospective tasks,the correct number of ongoing tasks,and the response time of ongoing tasks [6.50(4.00) vs.8.00(l.50),61.00(19.75) vs.70.50(10.00),1 603.50(975.00)ms vs.1 196.00(429.50)ms,all P ＜ 0.01].In the EBPM task,the correct number of prospective tasks,the response time of prospective tasks,the correct number of ongoing tasks,and the response time of ongoing tasks were worse in the patients than in the normal [4.00(5.75)vs.6.00(4.00),2 903.00(3 168.50)ms vs.1 206.00(1 396.00) ms,73.00(14.25) vs.77.00(4.00),1 852.00(732.75)ms vs.1 354.00(398.75)ms,all P＜0.01].Spearman correlation analysis showed a significant negative correlation between the total score of the PANSS scale (47.75±8.24) and the ongoing task in EBPM (r=-0.35,P ＜ 0.01).The correct numbers of TBPM and EBPM prospective tasks in the patients were significantly positively correlated with the PSP scale score (71.70±22.79)(r=54,P ＜ 0.01;r=36,P ＜ 0.01).The correct number and the response time of TBPM prospective tasks,the correct number and the response time of TBPM ongoing tasks,and the correct number and the response time of EBPM ongoing tasks in the patients were significantly correlated with the SQLS scale score (23.07±12.89)(r=-0.35,P ＜ 0.01;r=0.48,P ＜ 0.01;r=-0.78,P ＜ 0.05;r=0.69,P ＜ 0.05;r=-0.35,P ＜ 0.01;r=0.58,P ＜ 0.01).Conclusion Prospective memory impairment exists in patients with schizophrenia;prospective memory ability in patients with schizophrenia is closely related to individual social function and quality of life.

目的 观察壮灸神阙穴治疗阳虚质抑郁症的疗效和安全性.方法 将符合纳入标准的72例阳虚质抑郁症受试者纳入课题研究中,随机分为对照组和治疗组,各36例,对照组采用口服左洛复,每日50mg,每日1次,共观察6周;治疗组在此基础上加用壮灸神阙穴疗法,每日1次,共观察6周.采集治疗前、治疗2周、4周和6周受试者汉密尔顿抑郁量表(HAMD-24)、抑郁自评量表(SDS)、副反应量表(TESS)和中医体质分类和判定量表测评评分,建立数据资料库,比较分析所收集的数据资料的前后变化情况.结果 从(HAMD-24)积分减分率评定总疗效来看,两组均有一定的疗效,治疗组疗效优于对照组,两组比较有统计学意义(P＜0.05);在(HAMD-24)积分变化方面,治疗组各观察时间点积分评分的下降情况,与对照组相比有统计学意义(P＜0.05);两组治疗后的各观察时间点体质积分均有所下降,且治疗组积分下降的更加显著,两组相比有统计学意义(P＜0.05);在SDS积分情况方面,治疗组各观察时间点积分的下降情况,与对照组相比有统计学意义(P＜0.05);在TESS积分改变方面,治疗组各观察时间点积分的下降情况,与对照组相比有统计学意义(P＜0.05).结论 壮灸神阙穴不仅对抑郁症的治疗有显著的疗效优势,同时对患者阳虚体质状态进行较好的调整和优化效应,且安全无毒副反应.

Objective To investigate the subjective sleep quality, mood and mental health level of obese patients with obstructive sleep apnea hypopnea syndrome (OSAHS). Methods According to the apnea hypopnea index (AHI) monitored by polysomnography, obese patients were divided into OSAHS group (103 patients) and control group (59 patients). OSAHS group was further divided into severe group (58 patients) and mild-moderate group (45 patients). The Pittsburgh Sleep Quality Index (PSQI), Epworth Sleepiness Scale (ESS), Self-rating Depression Scale (SDS), Self-rating Anxiety Scale (SAS) and Symptom Checklist 90 (SCL-90) were for comparison. Results The scores of PSQI, ESS, SAS and SDS in OSAHS group were significantly higher than those in control group, and the scores of ESS, SDS and SAS in severe group were significantly higher than those in mild-moderate group (P＜0.05). There were significant differences in total score of SCL-90 and its all factors except for obsessive state between OSAHS group and control group; and between severe group and mild-moderate group (P＜0.05).Conclusion The subjective sleep quality, daytime excessive sleepiness, depression, anxiety and mental health of obese patients with OSAHS are all severer than those without OSAHS, and the degree is increased with the severity of OSAHS.

目的:探讨首发青少年抑郁障碍(MDD)患者静息态脑磁图(rMEG)频谱特点. 方法:对15例首发青少年MDD患者(MDD组)及14名正常对照者(对照组)进行rMEG扫描,比较两组频谱分布特点,分析MDD组频谱分布与汉密尔顿抑郁量表(HAMD)评分的关系. 结果:①MDD组alpha频段能量左枕叶高于右侧,左颞叶低于右侧;theta频段能量左额、枕叶高于右侧;对照组alpha频段能量左枕叶高于右侧,beta频段能量左枕叶高于右侧,theta频段能量左额、颞及枕叶高于右侧,delta频段能量左颞叶高于右侧,左额叶低于右侧.②与对照组相比,MDD组alpha频段能量右中央区、颞及枕叶明显增高;beta频段能量双侧枕叶明显增高;theta频段能量右颞、枕叶明显增高;delta频段能量右颞、双顶叶明显增高;③MDD组HAMD总分与双侧颞、左顶及双侧枕叶delta频段能量呈正相关;HAMD焦虑因子与右枕叶theta频段能量及左顶、枕叶delta频段能量正相关,与左右顶叶alpha频段能量差呈正相关(P均＜0.05). 结论:首发青少年MDD患者rMEG的alpha频段能量右侧过度激活,枕叶beta频段能量左侧优势减弱,右枕叶delta频段能量增强且与抑郁程度及焦虑症状相关.

Objectives? To study the association between neurobiochemical markers and cognitive dysfunction in patients with depression. Methods? Patients with depression were divided into cognitive dysfunction group and normal cognitive function group according to the Chinese version of Montreal Cognitive Assessment (MoCA). Multivariate analysis was performed with binary logistic regression model to identify the association between serum homocysteine (Hcy), corticoid (COR), dehydroepiandrosterone (DHEA), interleukin-18 (IL-18), brain-derived neurotrophic factor (BDNF) and cognitive dysfunction in patients with depression. Results? After adjusting for gender, age, educational years and the 24-item Hamilton Depression Scale (HAMD-24) scores, serum Hcy, COR, DHEA and IL-18 were associated with cognitive dysfunction in patients with depression, and their odds ratio (OR) were 2.458 (95%CI: 1.343-4.918), 2.034 (95%CI: 1.217-4.837), 1.954 (95%CI: 1.122-4.129) and 2.173 (95%CI: 1.226-4.909), respectively. Conclusions? Serum Hcy, COR, DHEA, and IL-18 were associated with cognitive dysfunction in patients with depression, which might be used in the prediction of cognitive dysfunction in patients with depression.

目的:探讨抑郁症患者BDNF表达变化及对疾病严重程度的影响,为临床预防和治疗提供有效依据.方法:选取2014年4月至2016年7月在我院心理科确诊为抑郁症的患者60例作为研究组,选取同期到我院进行健康体检者40例作为对照组,使用汉密尔顿抑郁量表(Hamilton depression rating scale,HAMD)和贝克抑郁自评量表(Beck self-rating depression scale,BDI)对患者进行评定,采用酶联免疫吸附法(ELISA)测定抑郁症患者和健康体检者的血清BDNF水平,分析血清BDNF水平与抑郁症发病之间的相关性.结果:研究组患者HAMD评分、BDI评分显著高于对照组,两组比较具有显著统计学差异(P<0.05);研究组与对照组BDNF含量分别为(854.86±103.27)pg/mL与(1523.12±232.67)pg/mL,研究组显著低于对照组,两组比较具有显著统计学差异(P<0.05).重度抑郁症患者HAMD评分、BDI评分均高于中度、轻度抑郁症患者及对照组(P<0.05),重度抑郁症患者BDNF水平均显著低于中度、轻度抑郁症患者及对照组(P<0.05);中度抑郁症患者HAMD评分、BDI评分均高于轻度抑郁症患者及对照组(P<0.05),中度抑郁症患者BDNF水平均显著低于轻度抑郁症患者及对照组(P<0.05),轻度抑郁症患者HAMD评分、BDI评分均高于对照组(P<0.05),其BDNF水平均显著低于对照组(P<0.05).多元回归logistic分析显示,血浆BDNF水平降低是抑郁症发生的危险因素(P>0.05).结论:抑郁症患者BDNF表达显著降低,且抑郁症患病情况越严重BDNF表达越低,BDNF表达降低是抑郁症发病的危险因素.

患者,女,16 岁,高二学生,因反复发作性晕倒1年余,于2017年8月30日就诊. 患者"无力晕倒"发作前自感恶心,想吐,全身无力,双眼视物模糊,持续 2 min 开始倒地,意识清醒,否认小便失禁,否认肢体抽搐,否认严重头部外伤史,否认头昏及头痛,否认经休息和睡眠充足情况下病情改善. 体格检查心肺无特殊. 专科情况,意识清,定向力完整,言语清晰切题,未获得幻觉、妄想,情绪稳定,对晕倒一次不关注,不担心,自知力存在. 既往史:2016年9月在校操场跑步时被男同学撞到后头部,"晕倒"在地时意识清醒,5 min缓解后无明显不适. 2017 年7 月14 日14:00时在当地车站"无力晕倒",被送到当地医院救治,于当天 19:00 时醒来,于次日上午11:00时"无力晕倒",被送到当地医院救治,静脉输液后于16:00时醒来,于20:00时左右"无力晕倒",醒来后不久再次"无力晕倒", 8月26日19:00时在家"无力晕倒",被送到当地医院就诊于22:00 时醒来,诊断为"癔症发作",具体治疗不详. 经仔细询问病史发现患者就诊时近1周睡眠时好时差,主要为夜眠中多梦,近1个月伴有稍明显的头胀痛及头晕,日间伴有心慌、心情易烦躁,于2个月前无明显诱因出现轻生念头.

目的 探讨青少年首发重性抑郁障碍患者的静息态脑磁频谱分布及与症状严重程度的相关性.方法 对16例首发的青少年重性抑郁障碍患者(研究组)和14例正常健康者(对照组)进行脑磁图静息态扫描,分析两组频谱分布特点,并对研究组的各频谱能量值与汉密尔顿抑郁量表(HAMD-24)总分进行相关分析.结果 与对照组相比,研究组患者右侧中央区、颞区、枕区alpha波(t=2.058,P=0.049;t=2.356,P=0.026;t=2.469,P=0.020),左、右两侧枕区beta波(t=2.583,P=0.015;t=2.513,P=0.018),右侧颞区、枕区theta波(t=3.005,P=0.006;t=4.506,P=0.000),左右双侧顶区、右侧颞区及右侧枕区delta波(t=2.519,P=0.018;t=2.841,P=0.008;t=2.434,P=0.022;t=2.241,P=0.033)差异均有统计学意义;研究组患者右侧顶区theta波及左右侧额、颞、顶、枕区delta波与HAMD-24总分均呈正相关(r=0.518,P=0.040;r=0.540,P=0.031;r=0.524,P=0.037;r=0.653,P=0.006;r=0.569,P=0.021;r=0.539,P=0.031;r=0.655,P=0.006;r=0.519,P=0.040;r=0.609,P=0.012).结论 青少年首发重性抑郁障碍患者静息态脑磁频谱分布异常,头后部delta波能量值与抑郁障碍的严重程度呈正比,为青少年重性抑郁障碍的发病机制提供一定的电生理学依据.

目的 探讨抑郁症患者中医体质类型与皮质醇水平的关系.方法 2017年1月-2018年1月期间诊治的抑郁症患者中选取29例作研究组,同期取29例健康体检者作为对照组,并测定其治疗后血清内皮质醇水平、促肾上腺皮质激素水平;参考《中医体质分类与判断》标准分为9大类中医体质,就抑郁症患者中医体质类型与皮质醇水平的关系作相关性分析.结果 ①抑郁症患者经中医九大类体质类型辨别显示:气郁体质、气虚体质、痰湿体质占比位居前三,分别是86.21％、62.07％、51.72％;②本组患者的血清皮质醇、促肾上腺皮质激素水平均远高于对照组(均P＜0.05);③本组患者的中医体质类型中痰湿体质、气虚体质、气郁体质同血清内皮质醇之间存在明显正相关关系(P＜0.05);气郁体质、阳虚体质与促肾上腺皮质激素之间存在正相关关系(P＜0.05),而阴虚体质与促肾上腺皮质激素之间存在明显负相关关系(P＜0.01);结论 肾上腺皮质功能亢进可能与抑郁症发作、进展有关,而中医体质类型的可在某种程度上反应病人抑郁状态.

[目的]观察中西医集成方案治疗中、重度抑郁症的临床疗效.[方法]将160例原发性中、重度抑郁症患者随机分为试验组(中西医集成方案治疗组)和对照组(西药组),每组各80例.对照组给予艾司西酞普兰治疗12周,试验组在对照组的基础上,给予中药加味逍遥汤颗粒治疗12周,并于治疗开始后前4周进行针刺干预(以百会、印堂为主穴).在治疗前及治疗后第2、4、6和12周分别用汉密尔顿抑郁量表(HAMD)、抑郁自评量表(SDS)和抗抑郁药副反应量表(SERS)进行评分,并随访治疗结束后1年内的复发情况,比较试验组与对照组的临床疗效.[结果](1)试验组和对照组各脱落7例,最终146例患者纳入研究.(2)治疗12周后,试验组的总有效率为79.45％,对照组为63.01％,试验组的疗效明显优于对照组(P<0.05).(3)治疗开始后第2、4、6和12周,试验组和对照组的HAMD评分及其焦虑躯体化因子评分、睡眠因子评分、迟缓因子评分和SDS评分均较治疗前显著降低(P<0.001),且试验组均显著低于对照组(P<0.001).(4)试验组治疗开始后第2周、4周、6周和12周的SERS评分均显著低于对照组(P<0.001).(5)试验组和对照组1年内的复发率分别为24.14％和43.49％,试验组的复发率显著低于对照组(P<0.05).[结论]中西医集成方案对中、重度原发性抑郁症的总体疗效及对HAMD各因子的改善效果均显著优于单纯西药治疗,安全性也优于单纯西药治疗,且1年内的复发率低于单纯西药治疗.

Objective:To analyze the characteristics of the magnetoencephalography(MEG) and frontal asymme-try in alpha oscillations of teenagers with first-episode major depressive disorder,to explore the electrophysiological mechanism of the occurrence of depressive disorder, and to provide reference for the clinical application of MEG. Methods:Selected the adolescents(13-19 years old) patients with first-episode major depressive disorder from Oc-tober 2016 to June 2017 in Guangdong 999 brain hospital,and recruited 10 healthy volunteers as a control group.Scanned magnetic fields signals in the brain(Left and right sides of the central area, frontal lobe, temporal lobe, parietal lobe and occipital lobe) from the two groups using the 148-channel MEG system. Calculated and analyzed the spectral power. Results:Compared with the control group,the power of delta band in the left parietal lobe was increased(P<0.05) in the patient groups.The power of theta band in the right temporal lobe and parietal lobe are both increased(P<0.01)in the patient groups. For male patients,the power of delta band in the left parietal lobe was increased more than female patients(P<0.05). Frontal asymmetry in alpha oscillations was not to be proved on MEG(P >0.05). Conclusion: The present study suggests that teenagers with first-episode major depressive disorder have impaired neural activity at many bands, the changes of the power of delta and theta bands might be relevant to teenagers major depressive disorder.

目的 研究SLC25A12基因多态性与孤独症谱系障碍的关系.方法 随机选取2015年5月～2017年5月我院收治的孤独症谱系障碍患儿500例(1000例父母),运用常规酚/氯仿/乙醇法提取基因组DNA,将人群中多见的SNP位点从NCBI的dbSNP数据库中选取出来,同时将对SNP进行扩增的引物设计出来,进行PCR扩增及SSCP分析,然后对SLC25A12基因2个SNPs的基因型及等位基因频率、2个SNPSs等位基因进行统计分析.结果 SSCP分析结果表明,基因型不同,其显示出来的条带就不同,SLC25A12基因在4℃的温度下降其基因型所特有的条带显示出来.HardyWeinberg平衡检验50例孤独症家庭的2个SNP的基因型及等位基因分布情况,发现Rs3770448基因型及等位基因分布均和Hardy Weinberg平衡定律相互(P＞0.05);传递不平衡检验结果表明,50例孤独症家庭的SLC25A12基因的2个SNPs均有连锁不平衡存在,即Rs3770448和孤独症致病基因座不连锁,杂合子父母向患病子女传递的致病等位基因的频率没有偏离50％.结论 SLC25A 12基因多态性与孤独症谱系障碍无相关性,需要相关医学学者进一步研究孤独症的病因基因.