目的 了解山东省精神专科医疗机构药学人员的基本情况,为推动山东省精神专科药师制度改革和服务水平提高提供决策建议.方法 选取2021年1月山东省16家三甲医院精神专科的265名药学及相关人员作为调查对象,分别对其发放电子问卷调查,观察其专业的社会需求及发展、院校教育现状评估及专业知识培训需求.结果 精神专科药师中大学本科比例为72.41％,大学专科与硕士以上学历比例相同,为13.79％;希望定期培训的药学人员比例为60.71％,希望根据需求不定期培训的药学人员比例为39.29％;十分满意院校课程设计和教师职业能力教学安排的人员比例为34.48％,基本适应所从事药学业务的人员比例为72.41％.结论 精神类药学人员的学历层次在逐渐升高,且学历与专业度、晋升情况息息相关;院校对药学人员的培养制度在逐渐完善,药学人员对其满意度日趋高涨;精神类药学人员工作压力较大,较为强烈的专业知识需求与培训内容不匹配,药学行业培训制度亟待改革.

目的 探讨度洛西汀联合丙戊酸镁缓释片治疗伴有疼痛的抑郁症疗效及安全性.方法 将104例伴有疼痛的抑郁症患者随机分成两组,合用组52例,应用度洛西汀联合丙戊酸镁缓释片;单用组52例,单用度洛西汀,疗程为8周.采用McGILL疼痛评分表(McGILL),汉密尔顿抑郁量表(H AMD),汉密尔顿焦虑量表(HAMA),临床总体疗效量表(CGI),不良反应量表(TESS),评定疗效及用药不良反应.结果 两组患者的McGILL总分、HAMD总分、HAMA总分、CGI-SI、CGI-GI较治疗前显著下降,差异有统计学意义(P＜0.05),合用组疗效明显优于单用组,差异有统计学意义(P＜0.05),两组不良反应差异无统计学意义(P＞0.05).结论 度洛西汀联合丙戊酸镁缓释片治疗伴有疼痛的抑郁症疗效好,疼痛缓解明显,安全性高.

Objective To evaluate the personal and social functions and its influencing factors of female schizophrenic patients at acute phase.Methods 52 female schizophrenic patients at acute phase were assessed with the Personal and Social Performance scale(PSP) and Positive and Negative Syndrome Scale(PANSS).Analysis was performed to detect the influencing factors of personal and social functions.Results The maximum score of PSP was 51 and the minimum score of PSP was 15,the average score of PSP was 31.21±7.89.The personal and social functions showed significant negative correlation with score of SPSS,but no significant correlation with age,disease course,onset age.Regression analysis showed that the greatest influencing factor of PSP was the score of negative symptoms(absolute value of the standard coefficient was 0.454).Conclusion The personal and social functions of female schizophrenic patients at acute phase is impaired at different degree,which is mainly associated with psychiatric symptoms,especially the negative symptoms.

Objective:To study the cognitive effects of ziprasidone with female schizophrenia.Methods:A total of 60 female patients with schizophrenia,who were up to standard of CCMD-3,were randomly assigned to ziprasidone group(n=60) for 8 weeks.The dosage of ziprasidone was 40mg/day to 160mg/day.To make positive and negative syndrome scale(PANSS),as well as exploratory eye movement(EEM),cancellation test(CT),wisconsin card sorting test(WCST),before and after the cure of 8 weeks.All the datum was put into spss17.0 to dispose.Results: After treatment eye fixations(NEF)increased but had no statistic meaning,RSS increased(P=0.01),D decreased(p=0.008);the total score of CT was increased(P=0.0001);in WCST,CC,RC,RCP increased(P0.05),RE decreased(P0.05),RFP increased(P0.01),RP,RPE,RPEP decreased(P0.01).After 8 weeks,PSP and PANSS score increased(P=0.000).Conclusions: ziprasidone is effective in the treatment of schizophrenia,and more effective with the cognitive of schizophrenia also.

目的:探讨应用心理干预后脑卒中患者总体幸福感评分的变化情况及其影响因素。方法:本调查于1997-09/2000-12完成。选择在聊城市第四人民医院神经科、菏泽市第三人民医院神经科、济南市第一人民医院神经科及齐鲁医院神经科就诊的脑卒中患者206例,均自愿参加调查。根据随机原则 1:1配对分为2组,干预组和对照组各103例。①干预组在病后1个月末开始干预,干预措施采用以心理干预为主,必要时辅以药物干预的原则。20-30min/次,1次／周,连续五六周即结束干预。②对照组不进行干预。采用总体幸福感量表（共有33项,得分越高,幸福度越高。国内测试样本采用本量表前18项平均得分,男性为75分,在女性为71分。本调查仅使用前18项）对两组患者进行总体幸福感评定,评定时间分别在发病后1个月内、第3个月末、第6个月末、1年末,共进行4次,并进行两组患者总体幸福感评分的比较分析。结果:干预组和对照组各103例脑卒中患者,全部进入结果分析,无脱落。①两组患者总体幸福感量表评分比较:干预组患者干预后3次评定总体幸福感量表评分均明显高于对照组[77.7±12．8,80．0±13.2,82．7±14．0; 72.3±14．2,71．9±13．3,71.4±16．1（t=2．86-5.37,P＜0．01）],且干预组心理干预后3次评定量表得分均明显高于干预前（68．7±14．5）（t=-7．01-4．71, P＜0．01）。②影响脑卒中后患者总体幸福感量表评分的多因素分析:脑卒中后患者的总体幸福感受病情、多种社会心理因素及人口学资料因素的影响。结论:脑卒中后患者的总体幸福感与病情、多种社会心理因素及人口学资料因素有关。积极开展心理干预能有效提高脑卒中后患者的总体幸福感,改善其生活质量。

奥氮平是新型抗精神病药,为了解其对难治性精神分裂症的疗效,1998～2000年,我们对48例难治性精神分裂症患者进行临床观察.现将结果报告如下.

<span id="ChDivSummary" name="ChDivSummary" class="abstract-text">本文对１９９７年１月—１９９７年６月住院精神分裂症患者的家庭成员１８０名进行了情绪调研。其中：男性９６名，女性８４名。患者配偶６１名，患者父母５９名，患者子女６０名。平均年龄４１±１３岁。在对患者家庭成员使用Ｚｕｎｇ抑郁自评量表（ＳＤＳ）［１］、焦虑...</span>