T cell inhibitory receptors play important role in maintaining T cell homeostasis. The feature of such negative costimulator signal transduction pathway in cord blood (CB) T cells remains unclear. In this study, the expression levels of T cell inhibitory receptors including programmed death-1 (PD-1), cytotoxic T lymphocyte antigen-4 (CTLA-4), T cell immunoglobulin mucin-3 (Tim-3), lymphocyte activation gene-3 (LAG-3) and B and T lymphocyte attenuator (BTLA) were characterized in CB and compared with peripheral blood (PB). Significant lower expression of PD-1, CTLA-4, LAG-3 and BTLA was found in CB, while similar expression level of Tim-3 was showed between CB and PB. Together, different expression pattern of such T cell inhibitory receptor in CB is worthy to further discuss their role on immune response when CB is used in cord blood stem cell transplantation as well as allogeneic chimeric antigen receptor T-cell producing.

目的探讨乙肝表面抗原(HBsAg)阳性和e抗原(HBeAg)阳性(简称"双阳性")携带孕妇孕晚期应用乙肝免疫球蛋白(HBIG)对产后初乳的影响,及产妇初乳HBsAg阳性时的母乳喂养问题.方法将双阳性携带孕妇分为HBIG组和非HBIG组,并将初乳双阳性产妇所生新生儿分为母乳喂养组和人工喂养组;HBIG组孕妇从28周起肌肉注射HBIG 200IU/4周,共3次(部分仅注射1～2次),非HBIG组仅常规产检及监护;对两组产妇下乳24h～7 d内的初乳和新生儿0,6个月的静脉血作乙肝两对半和HBV-DNA检测.结果HBIG组与非HBIG组比较,产妇初乳的HBsAg阳性率差异无显著性;不同喂养方式0,6个月龄新生儿静脉血的HBsAg、抗-HBs阳性率差异无显著性.结论双阳性孕妇孕晚期应用HBIG对产妇初乳的HBsAg阳性率并无影响;产妇初乳HBsAg阳性时行母乳喂养不影响乙肝病毒(HBV)母儿传播率.

目的探讨陪伴分娩对产后抑郁症的影响.方法将220例产妇分成观察组和对照组,比较两组产妇产后的抑郁水平和抑郁症发生率.结果对照组的产后抑郁水平和抑郁症发生率均显著高于观察组(P＜0.01).结论陪伴分娩有助于降低产后抑郁症发生率和抑郁水平.