[Objective] Observing the influence of electroacupuncture on Leptin of both sexes in the hypothalamic obesity rats through the animal experiment.[Methods] Duplicated rat hypothalamic obesity model by injecting L-MSG under the skin of neck.They were randomly divided into model male groups,model female group,EA male group,EA female group and setting normal control male and female group.Electroacupuncture male and female groups were fellowed by switching WQ2F-type electroacupuncture.Measuring 6 rats weight,Lees' index,serum leptin and hypothalamic leptin.[Results] EA male and female groups of Lees index and serum leptin levels,respectively,and model male and female between the two groups were significntly lower(P<0.01),while hypothalamic leptin levels were significantly higher(P<0.01).EA Lees index of male group were significantly lower than the female group(P<0.05);EA female group of serum leptin levels lower than the EA male group significantly(P<0.05);EA female hypothalamic leptin levels were highter than the EA male(P<0.05).[Conclusion] Electroacupuncture of the male and female obese rats with varying degrees of weight loss,but the lower Lees index regulates lipid metabolism,both the existence of certain differences between the EA can significantly reduce the Lees index of male rats and adjust the Leptin.