Objective: To investigate the effect of platelet-rich plasma on the prognosis of elderly degenerative lumbar spinal stenosis by interfering with the catabolism of lumbar interbody fusion bone graft. Methods: A total of 100 elderly patients with degenerative lumbar spinal stenosis admitted to our hospital were recruited as the study objects. According to the treatment plan, the patients were divided into control group (n = 50) and experimental group (n = 50). The control group received conventional drug treatment during lateral lumbar interbody fusion surgery, and the experimental group received platelet-rich plasma therapy during interbody fusion surgery. Results: The rate of interbody fusion in the experimental group was higher than that in the control group (P < 0.05). At 1 month, 3 months and 6 months after surgery, the spinal ROM of the experimental group was higher than that of the control group (P < 0.05). At 1 month, 3 months and 6 months after surgery, the ODI score of the experimental group was lower than that of the control group (P < 0.05). The VAS score of the experimental group was lower than that of the control group at 1 month, 3 months and 6 months after surgery (P < 0.05). The complication rate of the experimental group was lower than that of the control group (P < 0.05). Conclusions: Platelet-rich plasma significantly improves interbody fusion rates, improves spinal range of motion and functional recovery, and effectively reduces postoperative pain while reducing the risk of surgical complications during lumbar fusion surgery for the treatment of degenerative lumbar spinal stenosis in the elderly. (c) 2025 Asian Surgical Association and Taiwan Society of Coloproctology. Publishing services by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

The focus of this study was to comprehensively assess the clinical outcomes of lumbar fusion utilizing autogenous bone grafting and platelet-rich plasma (PRP) for the management of degenerative lumbar spinal stenosis (DLSS) in elderly individuals. A cohort of 40 senior individuals diagnosed with DLSS, who underwent treatment at our hospital between January 2020 and March 2022. The control group consisted of 20 participants who underwent local bone grafting for intervertebral fusion, while the observation group comprised 20 individuals who received a combination of local bone grafting and PRP for lumbar fusion. MRI imaging was employed for a comprehensive assessment of spinal structure. The efficacy of spinal fusion was evaluated through MRI imaging. Clinical treatment outcomes were assessed using the Japanese Orthopaedic Association (JOA) and Oswestry Disability Index (ODI) scoring systems. Postoperative low back pain was quantified using a Visual Analog Scale (VAS). During the final follow-up, the observation group demonstrated a significant increase in the inner diameter of the spinal canal and the height of the disc space compared to the control group (P < 0.05).Moreover, the observation group displayed a larger spinal canal than the control group (P < 0.05).A reduced lesion score in the bone grafting region was observed in the observation group compared to the control group during the final follow-up (P < 0.05). Furthermore, the observation group displayed a higher intervertebral fusion continuity score than the control group (P < 0.05).The JOA score in the observation group was significantly higher than in the control group (P < 0.05), while the ODI score was significantly lower (P < 0.05). Of note, the back pain VAS score in the observation group was lower than in the control group at both the three months post-surgery mark and the final follow-up (P < 0.05).The satisfaction rate and overall satisfaction rate in the observation group were significantly higher than those in the control group (P < 0.05), while the dissatisfaction rate in the observation group was evidently lower than in the control group (P < 0.05). In the management of DLSS in elderly individuals, the utilization of local bone grafting and PRP in lumbar spinal fusion yields notable outcomes.

目的 调查老年女性骨质疏松性椎体压缩骨折(OVCF)病人行椎体强化术(PVA)后再发椎体骨折的情况及影响因素.方法 回顾性调查205例接受PVA术的老年女性OVCF病人,收集其年龄、BMI、入院血常规、血生化指标及骨密度(BMD)等基本情况,调查时间为PVA术后2～40个月,根据是否出现椎体再骨折分为再骨折组及对照组.采用单因素及多因素Cox回归分析老年女性OVCF病人PVA术后再发椎体骨折的影响因素,采用Logistic回归计算独立影响因素的概率,绘制ROC曲线.结果 老年女性OVCF病人PVA术后再发椎体骨折发生率为20.5％.Cox回归分析显示,预后营养指数(PNI)、BMD、年龄、是否服用抗骨质疏松(OP)药物是PVA术后再发椎体骨折的独立影响因素;与低PNI病人相比,高PNI病人PVA术后再发骨折风险更低;PNI与是否服用抗OP药物存在交互作用,在高PNI组抗OP药物疗效更好,Pinteraction<0.05.ROC曲线结果显示,相较于无PNI因素模型,含有PNI因素的模型ROC曲线面积增加了0.066(0.003～0.127).结论 高PNI是老年女性OVCF病人PVA术后再发椎体骨折的保护因素,对PVA术后椎体再骨折有预测价值,可以通过提高抗OP药物的疗效进一步降低再发骨折发生率.

目的 对比电针及核心稳定性训练(core stability exercises,CSE)不同疗程组合治疗慢性非特异性腰痛(chronic non-specific low back pain,CNLBP)的疼痛及功能改善情况,并探讨治疗方案的优化.方法 选择2019 年1 月～2020 年5 月本院诊断为CNLBP的221 例患者为研究对象,随机分为四组,共脱落21 例,最终每组各50 例入组.常规组:腰部理疗;电针组:理疗+电针刺激肾俞、委中、阿是穴;CSE组:理疗+CSE;组合组:理疗+电针+CSE.分别记录患者治疗前、治疗2 周和4 周后的疗效指标,并进行比较.结果 与治疗前相比,四组患者治疗2 周后的VAS评分显著降低、JOA评分显著升高(P<0.05);与治疗 2 周后相比,上述指标在4 周后得到进一步改善(P<0.05).上述指标治疗2 周后的疗效:组合组>电针组>CSE组>常规组,差异有统计学意义(P<0.05);治疗 4 周后的疗效:组合组≥CSE组>电针组>常规组,差异有统计学意义(P<0.05).结论 电针及CSE对CNLBP均有疗效,电针治疗在2 周内的疗效更显著,且在2 周内与CSE可产生叠加效果;而CSE对腰痛的改善效果在4周内均持续起到主要作用.CSE及电针在同组间不同性别的治疗效果相同;年龄越大,治疗效果越差.CNLBP 的治疗优化方案,推荐在2 周内电针联合CSE,2 周后持续CSE.

目的 调查影响单髁置换术(unicompartmental knee arthroplasty,UKA)治疗膝前内侧骨关节炎术后临床疗效的影响因素.方法 回顾性分析2019年1月至2020年12月期间在石家庄市人民医院骨科采用UKA治疗的90例(136膝)膝前内侧骨关节炎患者资料,其中男21例(32膝),女69例(104膝);年龄52～75岁,平均(63.8±6.0)岁.分析患者年龄、性别、侧别、合并内科疾病、合并髌骨关节炎、骨密度(bone mineral density,BMD)、身体质量指数(body mass index,BMI)、预后营养指数(prognostic nutritional index,PNI)、软骨磨损程度、前交叉韧带(anterior cruciate ligament,ACL)功能、术前美国特种外科医院(hospital for special surgery,HSS)膝关节评分、疼痛视觉模拟评分(visual analogue scale,VAS)、膝关节活动度(range of motion,ROM)等资料.根据术后HSS评分分为优良组及非优良组,通过Logistic回归分析筛选影响术后膝关节功能的主要因素.结果 全部患者均获随访,随访时间15～21个月,平均(17.4±2.0)个月.UKA优良率为83.8％.单因素分析结果显示:术前软骨磨损程度、BMD、BMI、术前VAS与术后膝关节功能恢复有关,差异有统计学意义(P＜0.05);多因素Logistic回归分析结果表明:术前软骨磨损程度、BMI、术前VAS评分是影响术后膝关节功能的独立危险因素(P＜0.05).PNI同部分软骨磨损存在交互作用(P＜0.05).结论(1)UKA治疗膝前内侧骨关节炎优良率较高;(2)BMI＜30 kg/m2、术前VAS＜5分、全层软骨磨损是UKA术后疗效的保护因素;(3)营养因素不可忽视,关注术前营养因素可提高UKA术后疗效的优良率.

目的 分析预后营养指数(prognostic nutritional index,PNI)与老年女性冠心病人群发生骨质疏松症(osteoporosis,OP)的关联性及其预测价值.方法 收集2019年6月至2022年2月就诊于石家庄市人民医院和石家庄市第五医院的181例老年女性冠心病病人的临床资料,根据是否合并OP分为OP组和对照组.先后通过单因素分析和多因素Logistic回归分析PNI对老年女性冠心病人群患OP的影响,分析PNI与骨密度的相关性,采用ROC曲线分析PNI对OP的预测价值.结果 在老年女性冠心病人群中,PNI≥45是发生OP的保护因素(P<0.05);PNI与骨密度值呈线性相关(r=0.538,P<0.001).根据ROC曲线:相对无PNI模型,含PNI模型的曲线下面积(AUC)增加了0.0453(P<0.05).结论 PNI是老年女性冠心病人群中发生OP的独立影响因素,且与骨密度相关,对OP的发生有预测价值;PNI可能对于OP和冠心病的协同防治有临床意义.

目的 研究合并高血压病的老年女性骨质疏松患者口服维生素K2联合咪达普利对骨密度(bone mineral density,BMD)、骨代谢、新发骨折率及不良反应的影响.方法 选择2018年7月至2019年8月石家庄市第一医院收治的合并高血压的老年女性骨质疏松患者40例为研究对象,随机分为观察组、对照组,各20例,对照组服用咪达普利,观察组在此基础上加服四烯甲萘醌软胶囊.6个月后,观察两组患者新发骨折率、不良反应率,测定血清骨代谢指标和腰及髋部BMD的水平.结果 治疗6个月后,与治疗前相比两组25(OH)D3增加、PTH下降(P<0.05),两组OC、BAP及各处BMD升高,TRACP-5b、s-CTX降低(P<0.001);与对照组相比,观察组BAP、OC更高,TRACP-5b、s-CTX更低,经校正P<0.001;与对照组相比,观察组腰椎、股骨颈BMD较高(P<0.05),△BMD差异有统计学意义(P<0.001);协方差校正股骨粗隆BMD及△BMD两组间比较差异有统计学意义(P<0.05);观察组治疗前BMD同治疗后BMD水平呈线性相关(P<0.001),BMD水平治疗前、后回归线斜率(b)不同.新发骨折率及不良反应率组间对比差异无统计学意义(P>0.05).结论 ①维生素K2及咪达普利对合并高血压的老年女性骨质疏松患者联合用药效果有叠加作用,对骨代谢及骨密度有更好的改善作用;②联合用药对身体各处骨密度改善水平并不一致,骨密度基线水平可能对骨密度改善的曲线存在影响.

目的 探讨沉默信息调节因子2相关酶1(SIRT1)在肢体脂肪肉瘤组织中的表达及其与预后的关系.方法 采取回顾性病例对照研究方法.使用免疫组织化学SP法检测67例肢体脂肪肉瘤患者脂肪肉瘤组织中SIRT1蛋白的表达,并与其中11例肢体脂肪肉瘤肺转移组织和30例正常肢体脂肪瘤组织比较.比较不同临床病理特征肢体脂肪肉瘤患者SIRT1蛋白的阳性表达率.多因素Cox逐步回归模型分析影响肢体脂肪肉瘤患者生存预后的危险因素.结果 正常肢体脂肪瘤组织、肢体脂肪肉瘤组织及肢体脂肪肉瘤肺转移组织中SIRT1蛋白阳性表达率分别为10.00％、59.70％及90.91％,3组比较,差异有统计学意义(P<0.05);肢体脂肪肉瘤组织及肢体脂肪肉瘤肺转移组织中SIRT1蛋白阳性表达率均高于正常肢体脂肪瘤组织(P<0.014),肢体脂肪肉瘤肺转移组织中SIRT1蛋白阳性表达率高于肢体脂肪肉瘤组织(P<0.014).肢体脂肪肉瘤患者不同性别、年龄、肿瘤大小及发病部位的SIRT1蛋白阳性表达率比较,差异无统计学意义(P>0.05);不同肿瘤深度、Enneking外科分期、病理学类型及有无肺转移患者的SIRT1蛋白阳性表达率比较,差异有统计学意义(P<0.05).40例SIRT1蛋白阳性表达者中存活13例,死亡27例,最短总生存期为2个月,最长总生存期为74个月.27例SIRT1蛋白阴性表达者中存活20例,死亡7例,最短总生存期为5个月,最长总生存期为81个月.SIRT1蛋白阳性表达者的总生存期短于SIRT1蛋白阴性表达者(P<0.05).不同年龄、Enneking外科分期、SIRT1蛋白表达、病理学类型及有无肺转移患者的生存预后比较,差异有统计学意义(P<0.05).不同性别、肿瘤大小、发病部位及肿瘤深度患者的生存预后比较差异均无统计学意义(P>0.05).Cox逐步回归模型结果显示,SIRT1蛋白阳性表达者的死亡风险是SIRT1蛋白阴性表达者的1.403倍(P<0.05).结论 SIRT1蛋白的异常表达可能与肢体脂肪肉瘤的发生发展和侵袭转移有关,SIRT1蛋白不仅在肢体脂肪肉瘤组织和肢体脂肪肉瘤肺转移组织中高度表达,且与患者预后显著相关,可作为临床判断肢体脂肪肉瘤预后的一个潜在标志物.

目的 探讨快速康复外科(enhanced recovery after surgery,ERAS)在椎旁肌间隙(Wiltse)入路行胸腰椎骨折内固定取出中的应用效果.方法 选取2017年2月～2020年1月本科针对胸腰椎骨折术后行内固定取出的患者100例,按照随机数字表法分为研究组和对照组各50例.两组均采用Wiltse入路将内固定取出.对照组采用骨科常规干预模式,研究组应用快速康复外科理论指导,通过多学科协助,制订围手术期快速康复干预方案,在患者术前、术中、术后全程实施快速康复,比较两组治疗效果.结果 两组均未出现断钉、断棒现象.与对照组相比,研究组患者术中出血量、术后引流量显著减少,术后首次下床活动时间、住院时间均显著缩短,术后6 h～7d的VAS评分显著降低、术后并发症显著减少,康复生活质量评分、患者满意度显著升高,差异均有统计学意义(P<0.05).结论 在Wiltse入路行胸腰椎骨折术后内固定取出中应用快速康复外科干预,可减轻手术痛苦,提高围手术期的体验,提高临床效果及日常生活质量.

目的 研究快速康复外科理论(ERAS)对老年股骨粗隆间骨折患者围手术期指标及髋关节功能、生活质量以及术后认知功能的影响.方法 老年股骨粗隆间骨折患者100例,按照随机数字表法分为研究组和对照组,每组50例.2组均采用PFNA内固定术式治疗.对照组行常规围手术期干预,研究组行ERAS措施干预.比较2组患者围术期指标、髋关节功能(Harris评分)、生活质量[简明健康调查量表(SF-36)]、术后认知功能[简易智力状态量表(MMSE)]及并发症发生情况.结果 研究组术后各时间段疼痛评分、住院时间、住院费用及术后引流量、血红蛋白下降值、术后并发症均低于对照组,差异有统计学意义(P<0.05);研究组髋关节功能(Harris)评分、治疗满意度(Likert)评分高于对照组,差异有统计学意义(P<0.05);2组术后6个月SF-36各维度评分均升高,且研究组高于对照组(P<0.05).2组术后简易智力状态量表(MMSE)评分均较术前降低,但研究组高于对照组(P<0.05),研究组的认知功能障碍(POCD)发生率低于对照组(P<0.05).结论 老年股骨粗隆间患者围术期间联合ERAS,可促进患者术后早期康复,减轻认知功能损害及并发症发生率,同时还可有效改善髋关节功能及生活质量.

目的 探讨不同手术方式治疗早期股骨头缺血性坏死的临床疗效.方法 回顾性分析2015年12月至2018年12月早期股骨头缺血性坏死患者,并选取获得完整随访的112例患者,其中56例实施髓心减压+自体髂骨移植术(A组)治疗,56例实施经皮扩张式铰刀髓心减压+注射型可再生人工骨植骨(B组)治疗,于治疗前后行功能评定(VAS评分、Harris评分、JOA评分),比较2组患者手术指征、临床疗效、并发症.结果 2组患者治疗后VAS评分较治疗前显著降低(P<0.05).2组患者治疗后Harris评分、JOA评分较治疗前显著增加(P<0.05).B组患者治疗后VAS评分低于A组(P<0.05).B组患者治疗后Harris评分、JOA评分高于A组(P<0.05).B组患者充分刮出死骨者所占比例、充分减压者所占比例、优良率高于A组(P<0.05).B组患者术后软骨表面的应力值、破坏极限点载荷低于A组(P<0.05).2组患者并发症(迟发性感染、下肢深静脉血栓、股骨头塌陷)比较,差异无统计学意义(P>0.05).结论 经皮扩张式铰刀髓心减压+注射型可再生人工骨植骨治疗早期股骨头缺血性坏死的疗效显著,值得临床推广使用.

目的 探讨脂代谢异常与腰椎间盘退行性疾病的关系.方法 选取2015年02月-2017年02月在本院行手术治疗的腰椎间盘退行性疾病患者79例作为腰椎间盘组,选取同期年龄、性别相匹配的因其他骨折入院接受手术治疗的60例患者作为对照组,比较两组基本资料及血脂水平,对腰椎间盘退行性疾病的危险因素进行Logistic多因素回归分析,探讨脂代谢异常与腰椎间盘退行性疾病的相关性.结果 两组患者性别、年龄及吸烟、高血压、糖尿病发生率比较,差异无统计学意义(P＞0. 05);腰椎间盘组超重及肥胖率为39. 24% ,高于对照组的21. 67% ,腰椎L1-4 骨密度低于对照组,差异有统计学意义(P<0. 05);两组患者高密度脂蛋白胆固醇、低密度脂蛋白胆固醇比较,差异无统计学意义(P＞0. 05),腰椎间盘组总胆固醇、甘油三酯水平高于对照组,差异有统计学意义(P<0. 05);Logistic多因素回归分析显示,体质量指数、甘油三酯是影响腰椎间盘退行性疾病的重要危险因素.结论 甘油三酯可能增加腰椎间盘退行性疾病发生风险,但具体机制尚待深入研究.

Objectives A relationship exists between sirtuin-1 expression and growth and survival of malignant tumors. This study aimed to investigate the prognostic value of sirtuin-1 and vascular endothelial growth factor (VEGF) expression in patients with liposarcoma by examining associations between their expression levels and clinical outcomes. Methods Clinical and histopathological characteristics and follow-up and survival information were retrospectively reviewed for 42 liposarcoma cases. Sirtuin-1 and VEGF protein expression levels were evaluated by immunohistochemistry and their associations with clinical parameters were analyzed using the Spearman-rho test. Univariate and multivariate Cox regression analyses were performed to identify potential prognostic factors. Kaplan–Meier analysis was performed to analyze overall survival. Results Sirtuin-1 and VEGF protein expression levels were significantly associated with histological grade, metastasis, and American Joint Committee on Cancer stage. A significant positive correlation was observed between sirtuin-1 and VEGF expression levels (R = 0.677). In univariate analysis, sirtuin-1 and VEGF expression were correlated with shorter overall survival, but the association was significant only for sirtuin-1 (hazard ratio = 3.752, 95% confidence interval 1.553–9.062) in multivariate analysis. Conclusion Sirtuin-1 and VEGF expression levels are significantly correlated with progression of liposarcoma, and sirtuin-1 expression significantly predicts a poor prognosis in patients with liposarcoma.

目的 对初产妇产后腰痛(postpartum low back pain,PLBP)持续状态的影响因素进行分析,提供其预防的依据.方法 于本地医疗机构应用出院随访系统对初产妇产后1年仍存在的PLBP情况进行调查分析.将调查对象分为PLBP组与对照组(非PLBP组),分别调查两组人员年龄、职业、家庭、体质量等基本情况,通过单因素及多因素 Logistic 回归分析确定初产妇PLBP持续状态的影响因素.结果 共纳入211例患者,产后1年仍存在腰痛55例,患病率26. 07% .单因素分析显示:体质量指数(body mass index,BMI) 、职业满意度、家庭收入及腰痛病史影响产后腰痛的持续状态( P<0. 05) ; Logistic回归分析显示:BMI≥28 kg/m2 、有腰痛病史、家庭收入(月<5000元)、职业满意度(不满意),是初产妇PLBP 1年后仍持续的独立影响因素(P<0. 05) .结论 初产妇PLBP发病率高,持续时间长,影响因素多,BMI≥28 kg/m2、有腰痛病史、家庭收入(月<5000元)、职业满意度(不满意),会增加PLBP产后1年仍持续存在的风险.

目的 进行城市人群非特异性下腰痛(nonspecific low back pain,NLBP)的影响因素分析,为其防治提供理论依据.方法 于2016年1月～2017年1月对社区居民采用问卷调查NLBP的发生情况.将调查对象分为NLBP组与正常组,调查两组人员性别、年龄、职业、劳动强度等基本情况,通过单因素及多因素Logistic回归分析确定城市人群NLBP的独立影响因素.结果 355例中,NLBP者80例,发生率22.53％.单因素分析显示:NLBP组与正常组身体质量指数(Body Mass Index,BMI)、工作涉及全身振动、每周锻炼次数、年龄、工作状态、日均工作时间、劳动强度、饮酒史差异有统计学意义(P<0.05);Logistic回归分析显示:BMI≥28 kg/m2、每周锻炼<1次、工作涉及全身振动、工作固定姿势、年龄>60岁是城市人群发生NLBP的独立影响因素(P<0.05).结论 城市人群NLBP发病率较高,BMI≥28kg/m2、每周锻炼<1次、工作涉及全身振动、工作固定姿势、年龄>60岁均会增加NLBP发生风险.

目的 探讨不同后关节囊修复重建方法在髋关节置换术中的临床研究.方法 选取265例单侧股骨颈骨折患者作为研究对象,根据患者意愿将其分成三组.A组(n=110):仅缝合外旋肌群;B组(n=90):常规方法修复后关节囊和外旋肌群;C组(n=65):克氏针于股骨大粗隆钻两个骨性通道,将舌形外旋肌和关节囊联合瓣分别穿过骨性通道,并系紧缝合.对比三组手术情况、术后并发症及临床疗效等指标.结果 三组在手术时间、围术期出血量及住院天数等方面差异无统计学意义(P>0.05);三组术后感染、压力性溃疡及静脉血栓等并发症发生率方面比较差异无统计学意义(P>0.05),而B组和C组关节脱位或松动发生率明显低于A组,且B组和C组患者关节脱位或松动发生率差异无统计学意义(P>0.05);术前、术后6个月三组Harris评分差异无统计学意义(P>0.05).术后1个月时,C组和B组Harris评分明显高于A组,且C组患者Harris评分显著高于B组(均P<0.05).每组患者术后6个月和术后1个月Harris评分明显高于术前,且每组患者术后6个月Harris评分显著高于术后1个月(P<0.05).结论 髋关节置换术中重建后关节囊可在不增加手术时间、出血量及住院时间基础上降低假体脱位或松动的发生概率,确保临床疗效,安全性好.

BACKGROUND:Because of complicated biomechanics of lumbar vertebra, mast facet osteoarthritis, degenerative joint disease and vertebral subluxation usual y occur fol owing lumbar fusion. To avoid adjacent segment disease, researchers have transformed strong internal fixation into elastic fixation, but the treatment outcomes are barely satisfactory. Furthermore, factors involving adjacent segment disease remain unclear. OBJECTIVE:To explore the relationship between L3-4 segment disease fol owing lumbar fusion and gender. METHODS:200 patients undergoing lumbar fusion of L4-5 and L5-S1 in the First Hospital of Shijiazhuang ranging from 2007 to 2016 were enrol ed, and then al otted into male and female groups (n=100 per group) for retrospective analysis. The incidence of L3-4 segment disease was compared between two groups. RESULTS AND CONCLUSION:Compared with the male group, in the female group, the incidence of L3-4 segment diseases at different fusion locations and ranges, the Oswestry disability index and visual analogue scale and each migration range were significantly higher. Logistic regression analysis showed that gender was one of the independent factors of L3-4 segment disease following lumbar fusion of L3-4 and L5-S1. These findings suggest that gender is one of the influencing factors of L3-4 segment disease after instrumented lumbar;thereby, adjacent segment disease occurs frequently in female patients.

目的：探讨同年龄段男女性别差异对腰椎退行性滑脱发生情况的影响，以期对临床工作和康复指导提供理论依据。方法选取2012年1月至2014年6月于我院骨科接受手术且符合纳入和排除标准的150例腰椎滑脱患者，对患者的年龄、腰椎滑脱节段、滑脱分度和性别因素进行统计学分析，并探讨各因素间的相关性。结果 L4椎体滑脱发病方面，男性各年龄段腰椎滑脱数呈正态分布(Z=0.493，P=0.968>0.05)，女性各年龄段腰椎滑脱数也呈正态分布(Z=0.537，P=0.857>0.05)；L5椎体滑脱发病方面，男性各年龄段腰椎滑脱数呈正态分布(Z=0.623，P=0.932>0.05)，女性各年龄段腰椎滑脱数则呈非正态分布(Z=0.526，P=0.037<0.05)。结论腰椎滑脱中女性为主要发病人群，其中以40~60岁中年人为发病高峰人群，且以Ⅱ度和Ⅲ度滑脱为主。

OBJECTIVE To study the correlation between time of the use of antibiotics and infection after spine sur‐gery ,so as to provide evidences for clinic prevention of infection after spinal surgery .METHODS A total of 150 ca‐ses of patients underwent spinal surgery in the hospital from Jan .2013 to Dec .2015 were selected as the objects of study ,and were divided into two groups according to the different times of the use of antimicrobial agents in the surgery .Patients of group A (70 cases) ,were given antibiotics half an hour before surgery and did not take anti‐biotics after surgery ,and patients of group B (80 cases) were given 3 days of antibiotics after surgery and without preoperative use of antibiotics .RESULTS A postoperative infection rate of group A and B were 7 .1% and 16 .3% , with significant difference (P<0 .05) .The usage time of antibiotics ,postoperative fever clearance time ,hospital‐ized time and treatment costs of group A were (1 .1 ± 0 .3) d ,(1 .3 ± 0 .4) d ,(11 .7 ± 3 .2) d ,(2643 .8 ± 321 .8) yuan ,of group B were (3 .4 ± 0 .8) d ,(2 .7 ± 0 .6) d ,(18 .2 ± 4 .1) d ,(3174 .5 ± 355 .1) yuan ,and differences two sets of data were significant (P<0 .05) .CONCLUSION The perioperative use of antimicrobial drugs at differ‐ent times during clinical spine surgery has some influence on the infection after surgery .Taking antimicrobial drugs half an hour before surgery can better prevent postoperative infections and shorten the length of hospital stay of patients .