目的 基于文献研究,总结现代中医经验方治疗多发性抽动症(TS)的用药规律,阐明其药理作用机制.方法 检索由中国知网、万方、维普建库以来至2022年3月30日与中医治疗小儿多发性抽动症相关的文献资料.运用SPSS 25.0、SPSS Modeler 18.0软件分析中药复方用药规律;通过TCMSP、Uniprot、GeneCards、OMIM等数据库筛选高频药对核心药物活性成分、药物与疾病相互作用靶点,构建"药物-活性成分-靶点"网络,绘制PPI网络,利用R软件进行GO和KEGG分析.通过TCMSP、PDB数据库获取分子结构,运用Autodock Tools 1.5.6软件进行分子对接验证.结果 共纳入医案132篇,药物194味,频次排名前6药物为白芍、钩藤、甘草、石菖蒲、茯苓、天麻.分析得到15个核心药对,4个药物组方.茯苓-石菖蒲-白芍药组分析筛选得到17个有效成分,交集靶点30个.GO富集分析和KEGG通路分析显示交集靶点参与膜电位调控、神经递质受体活性等进程,AGE-RAGE信号通路、C型凝集素受体信号传导途径.分子对接表明山柰酚与AKT1、TNF结合活性较好.结论 温胆汤及龙骨牡蛎汤可能是治疗TS的主方.茯苓-石菖蒲-白芍可能是治疗TS的关键药组,推测茯苓-石菖蒲-白芍可能是通过山柰酚调节AKT1、TNF的表达起到抗抽动治疗.

目的:通过问卷调查分析固表解毒灵颗粒对儿童新型冠状病毒(SARS-CoV-2)感染相关症状的防治效果.方法:对武汉市中西医结合医院职工子女符合入组标准的儿童,给予固表解毒灵中药颗粒剂口服.分别于服药前后进行两次问卷调查,分析入组儿童的一般资料、规律口服固表解毒灵颗粒情况以及服药前后SARS-CoV-2感染相关症状发生的情况.结果:共188名儿童入组参与问卷调查,服用固表解毒灵颗粒后发热、咽痛、咳嗽咳痰等相关不适症状得到改善,并且未出现新的SARS-CoV-2感染相关症状,但差异无统计学意义(P＞0.05);≥7～18岁组累计口服固表解毒灵颗粒时间及规律口服中药情况优于1～＜7岁组.结论:≥7～18岁儿童口服固表解毒灵颗粒依从性好,固表解毒灵颗粒对SARS-CoV-2感染相关症状具有一定的防治作用,但仍需进一步大样本研究进行证实.

卒中后抑郁症是指卒中后出现以情绪低落、兴趣减退为主的一种常见并发症,中医学认为卒中后抑郁症与肝、脑密切相关,其强调肝为发病之源头,脑为病所之地,二者相互影响.肝经络脑是肝脑相关的结构基础,肝血、脑髓是肝脑相关的物质基础,并以此为理论依据,通过浅析肝脑相关性,确立疏肝解郁、养血益精、开窍醒神的治则,对指导临床从肝论治卒中后抑郁症具有重大意义.

随着儿童新型冠状病毒肺炎病例报道逐渐增多,无症状感染群体引起临床重视.该类患儿并无任何临床症状,但病原学核酸检测阳性,可能具有一定传染性,成为现阶段防疫工作的一大难题.无症状感染属于中医温病"伏邪"范畴,该文从伏邪角度探讨其病因病机及治疗方法,以期为临床实践提供帮助.

Abstracts:Objective To explore the pharmacological action of Angelica -Chuanxiong’s anti -inflammatory and analgesic effects along with those of the different proportions between Angelica and Chuanxiong.Methods To prepare decoction of Angelica and Chuanxiong in pro-potion of 1∶1,3∶2,2∶1,3∶1, use Xylene auricle swelling method and Egg white toes swelling method to detect anti -inflammatory effects on the different proportions.The analgesic effects of Angelica -Chuanxiong were observed by hot plate test, acetic acid and formaldehyde -in-duced pain respectively.Results Different proportions of Angelica and Chuanxiong can reduce the inflammation induced by Xylene auricle swelling method and Egg white toes swelling method, in which the effect of 3∶2 group is the best; can increase pain threshold induced by hot plate, and reduce the pain caused by formaldehyde and acetic acid, in which 1∶1 and 3∶2 group are the better.Conclusion Angelica -Chuanxiong has an anti -inflammatory and analgesic effect, there are apparent differences between groups of different proportions.

The patients with hepatic primary cancer often present symptoms which indicate the syndrome of intertwined blood stasis and heat.Guided under the theory of blood stasis and heat created by Professor ZHOU Zhongying,this article states the definition,pathogenesis,syndrome differention as well as common clinical manifestations of HPC of intertwined blood stasis and heat.This type of HPC is treated under the principle of cooling as well as activating blood,by using herbs and decoctions of that function.The role value and modern investigations of these herbs and decoctions will also be discussed in the article.

PURPOSE:This phase II study was undertaken to determine the efficacy and safety of Loubo® (Lobaplatin) in combination with pemetrexed in treating patients with metastatic breast cancer who failed to respond to anthracycline or taxanes.PATIENTS AND METHODS:Metastatic breast cancer cases who had previously received an anthracycline and a taxane in either adjuvant or metastatic settings, were enrolled. All patients were recruited from Jiangsu Cancer Hospital and Research Institute, and were treated with Loubo® (Lobaplatin) 35 mg/m2 (intravenous; on day 1) and pemetrexed 500 mg/m2 (intravenous; on day 1) every 21 days. Efficacy and side effects were evaluated after at least two cycles of chemotherapy.RESULTS:All eligible 19 patients completed at least 2 cycles of chemotherapy with pemetrexed and lobaplatin, and were evaluable. Overall, 3 (15.8%) patients achieved partial response, 11 (57.9%) stable disease, 5 (26.3%) progression of disease, with no complete remission. Response rate was 15.8%, disease control rate was 42.1%. The median survival time was 10.3 months. Neutrophil suppression occurred in 36.8% of patients who had grade 2 toxicity, and 26.3% had grade 3, 26.4% had grade 4. Thrombocytopenia was encountered as follows: 21.1% grade 2, 15.8% grade 3 and 5.5% grade 4. Incidences of anemia were 10.5% in grade 2, 5.3% grade 3 and 0% grade 4. Only 5.3% of patients required packed red blood cell transfusion. Grade 3 digestive tract toxicity occurred in 5.5% of patients. Other toxicities included elevated transaminase, oral mucositis and skin rashes.CONCLUSIONS:The regimen of lobaplatin and pemetrexed is modestly active in metastatic breast cancer patients who failed anthracycline or taxanes, and the toxicity profile suggesting that the doses of chemotherapy should be further modified.

Primary bronchogenic carcinoma of lung is a malignant tumor with melanoma in bronchial epithelium and alveolar wall.Modern medicine considers that lung cancer is a high degree of malignancy and difficult to be cured.Western medicine drug treatment,radiotherapy and chemotherapy often lead to serious side effects,and the effect is not satisfactory.Chinese medicine study the causes and pathogenesis of lung cancer,guiding by theories of syndrome differentiation and classification,therapeutic principles of lung cancer,and the whole of human.The symptoms of patients have been studied to make different treatment regimen.Chinese medicine plays an important role in the treatment of lung cancer.