Objective To explore the antitumor action of Tagalsin(extracted from Ceriops tagal) and its effect on the expression of bcl-2/bax. Methods Models of Ehrlich ascites tumor were created in rats,which were randomly divided into five groups as follows: high-dose Tagalsin(Tagalsin 16.50 mg·kg-1·d-1),moderate-dose Tagalsin(3.30 mg·kg-1·d-1),low-dose(Tagalsin 0.66 mg·kg-1·d-1),blank-control and positive control.In Tagalsin groups,a corresponding dose of Talgasin was offered;in the blank group,a same volume of edible oil was given;in positive control group,carmofur tablets 100 mg/(kg·d),which were all administrated intragastrically for 10 days.The oncostatic rate,the spleen and thymus indexes were calculated,and the expressions of bcl-2/bax detected by immunohistochemistry. Results Compared with the blank control group,the tumor grew more slowly in the positive control and different-dose Tagalsin groups(F=1 588.82,t=36.38-75.19,P0.05),and the oncostatic rate of the high-,middle-,low-dose and positive control group was 37.25%,34.10%,29.51%,and 61.03%,respectively.Compared with the blank control group,the indexes of spleen and thymus in the positive control and Tagalsin groups were significantly lower;compared with the positive control,the index of thymus in Tagalsin groups was lower(F=95 874.12,t=2.54-474.59,P0.05).The differences of the ratio of bcl-2/bax among the blank control,the positive control and Tagalsin groups were statistically significant(F=342.89,t=23.30-47.19,P0.05). Conclusion Tagalsin inhibits the growth of tumor by decreasing bcl-2 and increasing bax expression,which has a certain regulation action on humoral immunity in mice.

Objective: To investigate the epidemiological features,diagnosis and treatment of splenic inflammatory myofibroblastic tumor in China during the past 25 years.Methods: The clinical data of 64 patients diagnosed splenic inflammatory myofibroblastic tumor(Splenic inflammatory pseudotumor) published from 1985 to 2010 from various databases,including China National Knowledge Infrastructure(CNKI),VIP,and the epidemiological features,diagnosis and treatment of SIMT patients were retrospectively analyzed.Results: There were 64 patients,including 39 males and 25 females(1.56:1).And their age spread from 24 to 74 with an average of 49.2.Most of patients had not special symptoms,and were diagnosed through routine examinations such as type-B ultrasonic or CT scan.Epigastric pain,debilitation,low-grade fever and some other untypical symptoms might appear in some patients.A solitary splenic lesion might be seen during medical imageologcal examination.Histological types: hypocellular fibrous pattern(n=26),myxoid/vascular pattern(n=12),compact spindle cell pattern(n=5).Immunophenotypic findings show that the spindle cells were positive for Vimentin,SMA in most cases.For most patients,splenectomy were the mainly treatment,and there were no signs of relapse and metastasis after the operation.Conclusion: Splenic inflammatory myofibroblastic tumor is extremely rare in china,and there are not special clinical symptoms or signs.It can be identified by characteristics of medical imaging,histologic and immunophenotypic findings with other splenic lesions.But it is difficult to define its nature preoperatively.Splenectomy is the mainly treatment with a satisfactory prognosis.