目的 观察不同剂量阿托伐他汀对脑梗死预后的影响及其血清CRP的变化.方法 将2010年10月~2011年10月收治的80例脑梗死患者随机分为两组,每组40例,观察组常规治疗加上阿托伐他汀40 mg/d,对照组常规治疗加上阿托伐他汀10 mg/d;两组均在治疗前及治疗后4周测定C-反应蛋白( CRP) 浓度,并且进行NIHSS及BI评分.结果 两组治疗后CRP降低,观察组较对照组效果更明显(P<0.05),两组治疗前后NIHSS评分和BI评分均有改善,观察组较对照组改善明显(P均<0.05).结论 阿托伐他汀强化治疗使CRP水平明显下降,并能改善脑梗死患者的预后.

目的 探讨局部亚低温对重症脑梗死患者血清神经元特异性烯醇化酶(NSE)水平的影响.方法 84例重症脑梗死患者分为治疗组和对照组各42 例,对照组采用常规治疗,亚低温组在此基础上进行局部亚低温治疗,两组患者均在治疗前和治疗后第3 、7、14 d测定血清NSE 水平,并在治疗后14 d进行临床疗效的判定.结果 亚低温组第7 d和第14 d的NSE明显低于对照组(P<0.05).亚低温组治疗14 d后临床疗效明显高于对照组(P<0.05) 结论亚低温治疗可降低重症脑梗死患者血清NSE 水平,改善重症脑梗死患者的预后.

Objective To discuss the influence of using local mild hypothermia to the NSE of the blood serum of those suffering from severe cerebral infarction.Methods 84 patients suffering from severe cerebral infarction were equally divided into two groups.The control group of 42 were adopted routine therapy,while the other group using local mild hypothermia as well.Both of the two groups had been tested the level of NSE of the blood serum before the treatment and on the 3rd,7th and 14th day respectively during the treatment.Results The judgement on the clinical effect was drawn on the 14th day.Accordingly,the NSE of the treatment group was apparently lower than the control group(P<0.05) on the 7th and the 14th day and the clinical effect better than the control group(P<0.05) on the 14th day.Conclusions Mild hypothermia can reduce the level of NSE of the blood serum of those suffering from severe cerebral infarction and improve their prognosis.