Following the publication of this paper, it was drawn to the Editors' attention by a concerned reader that the HLA western blotting data shown for the HeLa cell line in Fig. 3D on p. 948 were strikingly similar to data appearing in different form in Fig. 3 in the following article written by different authors at different research institutes that was submitted for publication at around the same time, and for which an Expression of Concern has subsequently been published: Sun L, Xue H, Jiang C, Zhou H, Gu L, Liu Y, Xu C and Xu Q: LncRNA DQ786243 contributes to proliferation and metastasis of colorectal cancer both in vitro and in vivo. Biosci Rep 36: e00328, 2016. In addition, it was also noted that certain of the control western blotting data featured in Figs. 3D and 5B were strikingly similar, even though different experiments were being reported on in these figures.  In view of the fact that the contentious data were submitted for publication at around the same time, the Editor of International Journal of Oncology has decided that this paper should be retracted from the Journal. The authors were asked for an explanation to account for these concerns, but the Editorial Office did not receive a reply. The Editor apologizes to the readership for any inconvenience caused. [International Journal of Oncology 49: 943‑952, 2016; DOI: 10.3892/ijo.2016.3589].

目的:分析剖宫产同时剔除子宫肌瘤的临床效果.方法:将本院接收的80例剖宫产患者作为研究对象,研究时间段为2018年9月至2019年9月,按照患者入院顺序将其分为研究组与对照组,研究组患者剖宫产的同时剔除子宫肌瘤,对照组患者进行单纯的剖宫产术,随后对比两组临床指标及术后不良反应发生率.结果:临床指标:对照组手术时间短于研究组,差异显著,有统计学意义(P<0.05);对照组住院时间 、术中出血量及缩宫素用量相较研究组不存在明显差异(P>0.05).术后不良反应发生率:研究组患者术后不良反应发生率相较对照组不存在明显差异(P>0.05).结论:行剖宫产术的同时剔除子宫肌瘤具有可行性,该手术临床效果明显,手术过程中对患者损伤较小,且安全可靠.

目的 探究对于患有多囊卵巢综合征的患者,在治疗的过程中,采用吡格列酮联合他莫昔芬治疗的具体疗效.方法 选择医院在2017年10月～2018年10月在医院治疗的50例多囊卵巢综合征患者进行研究,将全部患者采用随机的方法平均分别为观察组25例和对照组25例,对照组服用他莫昔芬,观察组在对照组的基础上服用吡格列酮来治疗.结果 服用他莫昔芬护理的对照组不良反应情况发生率为20％,服用吡格列酮+他莫昔芬的观察组不良反应情况发生率为4％.观察组不良反应情况发生率远远低于对照组,差异具有统计学意义(P<0.05).结论 在治疗多囊卵巢综合征患者中采用吡格列酮+他莫昔芬的方式,疗效非常的好,能够改善患者的身体情况,可以使减轻患者的病痛,提升患者的生活质量,非常值得推广.

目的 探讨妊娠期糖尿病的饮食指导及运动干预减少胰岛素的应用.方法 选取2018年2月～2019年2月在医院就诊的妊娠期糖尿病孕妇100例作为研究对象,将其随机分为对照组和实验组,各50例.实验组实施饮食指导及运动干预,对照组实施常规护理.比较对照组和实验组的血糖水平和护理满意度.结果 实施饮食指导及运动干预实验组,血糖下降水平远远高于常规护理组,差异有统计学意义(P<0.05).实验组护理满意度为96％(48/50),均明显高于对照组,对照组护理满意度的70.00％(35/50),差异均有统计学意义(P<0.05).结论 饮食指导及运动干预可以一定程度上减少妊娠期糖尿病孕妇的的血糖水平,降低对于胰岛素的使用,有利于改善医患关系,值得推广.

目的:观察保留灌肠联合微波理疗治疗妇科慢性盆腔炎的临床效果.方法:针对本院妇科收治的慢性盆腔炎患者87例进行观察(2016年2月至2017年9月),随机分成两组,A组43例慢性盆腔炎患者单纯实施保留灌肠治疗,B组44例慢性盆腔炎患者在A组治疗基础上给予微波理疗,对比两组治疗效果.结果:两组慢性盆腔炎患者治疗后的治疗优良率、症状缓解时间及中医症状评分存在显著差异(P<0.05),统计学有意义.结论:针对妇科慢性盆腔炎患者实施保留灌肠联合微波理疗的疗效显著.

目的 探究经前期紧张综合征的认知神经机制及综合干预研究.方法 本次研究对象选取88例,选取时间为2013年6月～2018年6月,患者均在本院确诊为经期前紧张综合征,根据随机数字表法将患者分为对照组和观察组,每组44例患者,对照组患者行常规的用药治疗,观察组患者在常规治疗的基础上行心理干预,比较两组治疗效果.结果 观察组生存质量各维度得分、睡眠质量、居住环境、社会支持、人际关系得分明显高于对照组,异比较有统计学意义(P＜0.05).结论 通过对经前期紧张综合征患者行药物治疗和心理干预综合干预可有效改善患者的症状,提高患者的生活质量,利于家庭的和谐,对女性朋友的健康和家庭的安定有重要的意义.

目的 探讨不同剂量米非司酮治疗子宫肌瘤效果比较.方法 根据随机数字表法进行2016年3月～2017年2月90例子宫肌瘤患者分成不同组.对照组给予高剂量25mg/d米非司酮治疗,观察组则给予低剂量12.5mg/d米非司酮治疗.比较两组子宫肌瘤病灶缩小效果;病灶消失时间;治疗前后患者瘤体体积;药物不良反应率.结果 观察组子宫肌瘤病灶缩小效果和对照组无明显差异,P>0.05;观察组病灶消失时间和对照组无明显差异,P>0.05;治疗前两组瘤体体积相近,P>0.05;治疗后观察组瘤体体积和对照组无明显差异,P>0.05.观察组药物不良反应率和对照组无明显差异,P>0.05.结论 低剂量12.5mg/d米非司酮治疗子宫肌瘤的应用效果确切,在低用量情况下同样可保持良好疗效且安全可靠,经济性高.

目的:探究分析紫杉醇治疗妇科恶性肿瘤的效果.方法:选取2014年3月至2017年6月我院收治的妇科恶性肿瘤患者87例,随机分为两组,实验组45例,采用紫杉醇治疗,对照组42例,采用异环磷酰胺治疗.结果:实验组总有效率为66.67％,对照组总有效率为30.95％,实验组总有效率明显高于对照组,P<0.05,差异具有统计学意义.结论:对妇科恶性肿瘤患者使用紫杉醇治疗效果显著,能够改善患者的临床症状,值得推广使用.

The long non-coding RNA HOX transcript antisense RNA (HOTAIR) has been found overexpressed in many human malignancies and involved in tumor progression and metastasis. However, little is known about the potential biological roles of HOTAIR in tumor escape. In the present study, the expression of HOTAIR was detected in 59 paired cervical cancer tissue samples by real-time PCR and then subjected to correlation analysis with clinical features. The effects of HOTAIR on cervical cancer cells as well as the expression of human leukocyte antigen (HLA)-G were studied by overexpression and RNA interference approaches. Insight into the mechanism of HOTAIR acting as competitive endogenous RNAs (ceRNAs) was gained from bioinformatic analysis and luciferase assays. HOTAIR expression was obviously increased in cervical cancer tissue. HOTAIR upregulation was associated with advanced pathological stage, histology, lymph node invasion and lymphatic metastasis, and also correlated with shorter overall survival of cervical cancer patients. Furthermore, HOTAIR overexpression promoted the proliferation, migration and invasion of cervical cancer cells, while HOTAIR knockdown inhibited cell invasion and cell viability, induced apoptosis and inhibited growth in vitro and in vivo. Moreover, HOTAIR modulated human leucocyte antigen-G (HLA-G) expression by competitively binding miR-148a. Our data suggest that HOTAIR plays an important oncogenic role in cervical cancer and might serve as a marker for cervical cancer prognosis and a potential target for therapeutic intervention.

女性绝经体内氧化应激反应致使心血管循环系统紊乱风险增加〔1〕。目前普遍应用雌孕激素治疗来减轻或消除更年期前后临床症状〔2〕。雌孕激素治疗能否影响蛋白质氧化、减缓细胞老化目前没有确切的结论，本研究评估绝经期女性，雌孕激素治疗后体内羰基化水平，为临床治疗提供依据。

目的 探讨血绒毛膜促性腺激素(HCG)与阴道超声联合检测在异位妊娠诊断中的价值.方法 138例异位妊娠者行阴道超声与血β-HCG检测,手术完成后第4天与第7天再次检测血β-HCG,第10天再次B超检测.结果 手术治疗103例,其中100例检测报告显示:3例有蜕膜组织,其余均有绒毛组织;患者手术后第8天的β-HCG恢复正常水平.结论 阴道超声及HCG动态监测对提高异位妊娠早期诊断具有积极意义.

目的 本研究旨在进行阴道骶棘韧带固定术治疗阴道穹窿脱垂(VVP)时应用使用简化程序CapioTM缝合生产设备与传统的技术相比其可行性和结果如何.材料与方法 VVP患者86例被纳入该研究.传统阴道骶棘韧带固定术组(TSC)44例;使用Capio设备组(CSC组),患者42例.另外有盆底缺陷的进行修补手术.结果 平均总手术时间:CSC组(71.7±24.5分钟),在TSC组(105.5±31.5分钟,P＼0.001),前者手术时间显著降低.术中失血量相比:TSC组明显高于CSC组.在CSC组需要进行阴道骶棘韧带固定术,平均手术时间为21.4±3.2分钟.接受阴道骶棘韧带固定术的患者,CSC组(20.9±3.3分),TSC组(39.1±5.2分钟,P＼0.001)前者较后者进行的手术的时间显著降低.两个研究组之间的手术并发症的发生率无显著差异.在3年随访的客观和主观的成功率TSC组分别为88.1和92.9%的,而在CSC组分别为86.4和92.9%.结论 传统的骶棘韧带固定术与修改后的使用Capio设备的技术相比,后者有效地减少了手术时间,失血量.

桡骨小头骨折是肘部外伤中较常见的关节内骨折.现在对桡骨小头骨折采取手术或保守治疗仍存在不同意见,各有良好疗效的报道[1].笔者现将成人桡骨小头骨折疾病情况及治疗状况报道如下.

目的 观察Sanders IV 型跟骨骨折经外侧切开复位与闭合复位斯氏针石膏固定两种治疗方法的临床疗效.方法 选择2009 年9月-2010 年9 月70 例(81 足) 关节面移位的Sanders IV 型跟骨骨折患者,随机分成两组,分别采用传统外侧"L"切口复位钢板内固定及闭合复位斯氏针石膏外固定两种方法治疗.比较两组术后并发症,AOFAS 踝后足评分、改良Zwipp 影像摄片评分.结果 70 例81 足全部获得随访,时间14~25 个月,平均20.4 个月.斯氏针组36 足术后无切口感染、皮肤坏死或切口愈合不良、腓肠神经损伤等软组织并发症,切开钢板组术后切口感染6 足,3 足皮瓣坏死,2 足腓肠神经损伤,1 足内固定移位,两组并发症比较差异有统计学意义(P=0.037).两组AOFAS 踝后足评分、改良Zwipp 影像摄片评分比较差异均无统计学意义(P 值分别为0.064、0.057).结论 闭合复位斯氏针固定在Sanders IV 型跟骨骨折治疗中综合疗效评价优于切开复位钢板内固定.

OBJECTIVE:To investigate the effectiveness of modified percutaneous suture in repairing acute closed Achilles tendon rupture by comparing with conventional open suture.METHODS:Between January 2006 and October 2009, 50 patients with acute closed Achilles tendon rupture were treated with modified percutaneous suture by making 5 small incisions at both sides of Achilles tendon and zigzag suture (improved group, n=22) and with Kessler suture (conventional group, n=28), respectively. No significant difference was found in gender, age, time from injury to operation between 2 groups (P > 0.05).RESULTS:In improved group, the patients achieved healing of incisions by first intention after operation and no complication occurred; however, incision infection occurred in 1 case, Achilles tendon re-rupture in 1 case, and incision scar contracture in 2 cases in conventional group. The operation time of improved group [(38.7 +/- 6.6) minutes] was significantly shorter (t=-12.29, P=0.00) than that of conventional group [(52.3 +/- 6.9) minutes]; the blood loss of improved group [(4.9 +/- 2.0) mL] was significantly less (t=-25.20, P=0.00) than that of conventional group [(40.7 +/- 7.1) mL]. The patients were followed up 2-3 years (mean, 29.9 months). The American Orthopaedic Foot and Ankle Society (AOFAS) score was 99.6 +/- 1.0 in improved group and was 98.4 +/- 3.0 in conventional group, showing no significant difference between 2 groups (t=1.66, P=0.10).CONCLUSION:Comparison with conventional open suture, modified percutaneous suture has some advantages, such as easy operation, less complications, rapid recovery of limb function, and so on. Modified percutaneous suture is one of the best choices for the treatment of acute closed Achilles tendon rupture.