目的 探讨Fascin和Wnt5a在卵巢上皮性癌中的表达及临床意义,分析两者表达的相关性.方法 应用免疫组织化学法检测Fascin和Wnt5a在20例正常卵巢组织、16例卵巢良性肿瘤,18例卵巢交界性肿瘤和79例卵巢上皮性癌组织中的表达情况.结果 (1) Fascin在卵巢上皮性癌中的表达明显高于正常卵巢组织、卵巢良性肿瘤(P＜0.01);在卵巢交界性肿瘤中Fascin的表达高于其在正常卵巢组织的表达(P＜0.01);Fascin的表达与组织病理分级(P＜0.05)、临床分期(P＜0.05)以及淋巴转移(P＜0.01)密切相关.(2) Wnt5a在卵巢上皮性癌中的表达明显低于正常卵巢组织、卵巢良性肿瘤(P＜0.01);Wnt5a的表达与组织病理分级(P＜0.01)、临床分期(P＜0.01)以及淋巴转移(P＜0.05)密切相关.(3) Fascin与Wnt5a在卵巢上皮性癌中的表达呈负相关(P=0.0000,r=0.526).结论 Fascin和Wnt5a可能在卵巢上皮性癌的发生、发展、预后过程中起重要作用.

目的 探讨钙化上皮瘤的临床及组织病理学特点.方法 对30例钙化上皮瘤患者临床病理资料进行回顾性分析.结果 年龄小于25岁者占63.3％,男女比例为1:1.5;病变以头面部为主,其次是颈项部,肿瘤直径0.5～2.3cm,临床误诊率达93.3％;肿瘤大部分有包膜,由嗜碱性细胞和影子细胞组成,间质由纤维结缔组织构成,伴有不同程度的钙化、异物巨细胞形成和炎症细胞浸润等.结论 加强对钙化上皮瘤临床病理特征的认识,从而提高诊断的正确率.

Objective To explore the expression of fascin and galectin-3 in cervical carcinoma and to understand the role of them in lymph node metastasis and clinical prognosis in cervical carcinoma.Methods Immunohistochemical method was used to assess the expression of fascin and galectin-3 in 10 cases of normal cervical tissues,32 cases of cervical intraepithelial neoplasia and 108 cases of cervical carcinoma.The relationship between the expression of fascin and galectin-3 and pathologic parameters was analyzed.Results The expression of fascin protein in cervical carcinoma was significantly higher than that in cervical intraepithelial neoplasia and in normal cervix;that in cervical intraepithelial neoplasia was significantly higher than in normal cervix;that was closely related with tumor size and lymph node metastasis;and that in cervical adenosquamous carcinoma was higher than that in cervical adenocarcinoma(P 0.05).The expression of galectin-3 protein in cervical cancer,cervical intraepithelial neoplasia and normal cervical tissues had no significant differences(P 0.05);but the expression of galectin-3 protein in cervical non-squamous cell carcinoma was significantly higher than in normal cervix,cervical intraepithelial neoplasia and cervical squamous cell carcinoma;that was closely related with deep myometrial invasion and lymph node metastasis;that protein in cervical adenosquamous carcinoma was higher than that in cervical adenocarcinoma and cervical squamous cell carcinoma.The expression of fascin and galectin-3 in cervical carcinoma was positively correlated.Conclusions Fascin and galectin-3 may be involved in cervical carcinoma development,invasion and lymph node metastasis.Both of them may play a synergistic role in the process of cervical lymph node metastasis.Fascin may have some reference value in the clinical differential diagnosis of cervical adenosquamous carcinoma and adenocarcinoma.Galectin-3 could be used as one of the important indexes in the diagnosis of cervical adenosquamous carcinoma.

Fascin protein as a kind of actin-binding protein,by increasing the cell membrane bumps,participate in cell signaling pathways and changes in cell adhesion and extracellular matrix and other ways to promote tumor cell invasion and metastasis.It's related to tissue differentiation,tumor grade and lymph node metastasis and other factors of gynecological malignancies.Fascin protein is expected to be the effective judgment of prognosis of the patients of gynecological tumors.The fascin protein as a target for the treatment of gynecological cancer treatment may provide a new way of thinking.