AbstractThe reaction behavior of fluorinated azides (II) towards several strained and unstrained unsaturated systems is investigated.

Reactions of α-difluoro azides with olefins result in oxidative fluoroamination or amination of the C=C bond.

Nanocrystalline (NC) samples of ageing and nonageing Ti49.4Ni50.6 and Ti50.2Ni49.8 alloys have been produced using high pressure torsion (HPT) by the technique that allows obtaining disc-shaped samples of 20 mm in diameter and 0.7 mm thick. It was revealed that in these Ti-Ni alloys a structure of a mix of amorphous phase and nanocrystalline B2 phase forms after HPT. Microstructure and mechanical properties of the Ti-Ni alloy after HPT and annealing with different temperatures and time (from 5 minutes to 6 days) were investigated. It was revealed that in Ti49.4Ni50.6 alloy after HPT and annealing at 400-500 degrees C for 1 h a nanostructure forms with the grain size of 30 and 50 nm respectively. In Ti50.2Ni49.8 alloy after HPT and annealing at 400 degrees C for 1 h a structure with a considerably larger grain size of about 150 nm forms.

Three-component reactions of 6-aminouracils and 6-aminothiouracils with formaldehyde and primary amines gave 6-alkyl-5,6,7,8-tetrahydropyrimido[4,5-d]pyrimidine-2,4-diones and 6-alkyl-2-thioxo-5,6,7,8-tetrahydropyrimido[4,5-d]pyrimidin-4-ones.

The present work deals with the synthesis of sixteen compounds with putative inhibiting activity towards NO-synthase on the basis of 2-amino-2-thiazoline and 2-amino-5,6-dihydro-4H-1,3-thiazine.

Previously unknown amino-derivatives of the natural sesquiterpene lactone α -santonin were synthesized. The activity of the products against several human tumor-cell lines was studied.

A simple and convenient method is proposed for the synthesis of 2-amino-5-hydroxymethylthiazolines with various substituents in the amino group, which is based on hydrolysis of the corresponding 5-halomethyl derivatives of thiazoline in the presence of divalent lead oxide.

Two spiro analogues of 2-amino-5,6-dihydro-4H-1,3-thiazine, a known NO-synthase inhibitor, were synthesized by means of cyclization of N-2-(1-cyclohexenyl)ethylthioureas.

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A series of 2-amino-2-thiazoline derivatives have been synthesized and characterized with respect to NOS-inhibitor activity in vivo. It was established that the dimensions of the substituents in 2-N-mono-and 2-N,N-disubstituted 2-amino-2-thiazolines are not significant for the biological activity of the products.

Intramolecular cyclization of 1-allyl- and 1-methallyl-6-amino-2-thiouracils afforded 5-amino-2,3-dihydrothiazolo[3,2- a ]pyrimidin-4-ones, whose structures were proved by chemical transformations.

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.

Cyclocondensation of N-substituted imines of methyl trifluoropyruvate with monosubstituted ureas afforded novel 5-amino-5-trifluoromethylhydantoins.

A series of derivatives of the natural sesquiterpene lactones alantolactone ( 1 ) and isoalantolactone ( 2 ) was prepared. The α-methylene-γ-lactone moiety was retained in the structures of these for further modifications using reactions that affected exclusively the nonconjugated double bonds of the decalin ring.