Uncontrollable bleeding from non-compressible bone defects remains a significant clinical challenge. While silk fibroin-based hemostatic sponges hold promise, their development is plagued by the inherent conflict between rapid water absorption and poor dimensional stability. Herein, a combination of radially aligned microchannel architecture and a stable crosslinked network is designed to overcome this limitation. The sponge is fabricated via directional freezing and stabilized using a crosslinker, ethylene glycol diglycidyl ether. The formed elastic network reconciles mechanical robustness (2.4-fold increase in Young's modulus). The radial architecture creates a Laplace pressure gradient, enabling ultra-fast fluid absorption (16-fold) and blood cell sieving. Furthermore, surface modification with chitosan confers a positive charge, facilitating strong electrostatic adhesion to blood cells via a mechanism unraveled by molecular dynamics simulations, which reveal a binding free energy of -107.93 kcal/mol. By synergistically integrating thrombin protein corona particles, the final construct orchestrates a dual hemostatic mechanism: rapid physical blood cell sieving/enrichment, and activated biological coagulation. This synergy delivers exceptional hemostatic performance in rat calvarial defect models, achieving hemostasis in 64 s, faster than the 185 s required by the random sponge. This study provides a novel paradigm for developing high-performance hemostatic materials through rational structural and multi-mechanistic integration.

Achieving superior energy storage in antiferroelectric ceramics is limited by a fundamental compromise: realxor behavior comes at the cost of sacrificing polarization strength. This directly leads to a mutually restrictive balance between recoverable energy density (Wrec) and energy storage efficiency (η). To overcome this, we develop a Bi-induced local bonding modulation strategy in Pb0.92-1.5 xSr0.08BixZr0.49Sn0.5Ti0.01O3 ceramics that simultaneously strengthens the AFE framework and refines polarization response. This approach elevates both the breakdown strength and the AFE-FE transition field, allowing the material to withstand higher electric fields and release greater stored energy. The optimized composition achieves a record-high Wrec of 15.6 J cm-3 with ∼90% efficiency under 600 kV cm-1, alongside ultrafast discharge (t0.9 ∼64.5 ns) and excellent thermal/frequency stability. Atomic-scale characterization reveals a coexistence of robust long-range AFE order and local polar heterogeneity, which collectively smooths the field-induced transition path and suppresses early breakdown. This work provides a generalizable design principle for dielectric capacitors by strategically decoupling polarization enhancement from relaxor behavior, paving the way for high-energy, high-efficiency pulsed-power systems.

Efficient dielectric energy storage is critical for power electronics and electrical systems, driving the demand for polymer-based film capacitors capable of delivering high energy density, efficiency and stability at high temperatures. However, energy density and efficiency typically deteriorate under harsh thermal and electrical stress due to increased charge transport and conduction losses. Here, we introduce a multiscale interfacial design strategy that synergistically regulates charge injection and migration. This is accomplished by incorporating wide-bandgap, high-electron-affinity molecular fillers that create localized charge traps to inhibit bulk conduction, and by applying atomic layer deposition-enabled surface coatings to suppress charge injection from electrodes. These complementary interfaces across length scales effectively confine charge transport and enhance dielectric stability. The resulting polymer composites exhibit a remarkable discharged energy density at 200 degrees C and outstanding cycling endurance over 105 cycles, surpassing most reported dielectric systems. Finite element simulations and statistical modeling further reveal how interfacial synergies across scales modulates electrical conduction, field distribution, and electrical tree evolution. This work clarifies structure-property relationships and offers a promising approach for high-performance polymer dielectrics in demanding energy storage applications.

The effects of Erbium doping on the phase structure and electrical properties of 0.71Bi1-xErxFeO3-0.29BaTiO3 ceramics were investigated. All samples showed rhombohedral-tetragonal phase coexistence at morphotropic phase boundary. Erbium doping induces the dominant phase change from rhombohedral (R) to tetragonal (T) within the two phases coexistence. At x = 0.002, the phase proportion of R and T reaches a balance state, contributing to the optimal piezoelectric property. The air quenching was applied on all compositions to improve their piezoelectric performance. The highest value and largest increment of piezoelectric constant was achieved at x = 0.004, due to a new balance phase ratio and reduced defect concentration after quenching treatment. Upon quenching, in situ measurements of the electromechanical coupling factor (kp) and thermal depolarization studies further revealed an enhancement in the stability of the high-temperature piezoelectric properties.

High-pressure arterial bleeding is a life-threatening condition that can rapidly lead to hemorrhagic shock or death. However, effective noncompressive hemostatic strategies for managing such bleeding remain a significant clinical challenge. To address this, we developed a Janus-structured silk fibroin-based sealant (designated SFM@STF) for rapid hemostasis. The SFM@STF sealant features a bilayer structure: an adhesive silk fibroin/tannic acid/fibrin (STF) layer and a supportive silk fibroin membrane (SFM) layer. The STF layer, designed to mimic the underwater adhesion of mussel proteins via a double-network hydrogel incorporating hydrophobic and catechol groups, ensures robust bonding to wet tissues. In contrast, the SM layer, comprising densely packed crystalline β-sheet structures, offers mechanical robustness. The resulting SFM@STF sealant demonstrated remarkable wet tissue adhesion strength (43.43 ± 8.42 kPa), coupled with superior structural stability, high burst pressure resistance, and a low swelling ratio. Excellent cytocompatibility and a low hemolysis rate were also confirmed. In arterial injury models, SFM@STF rapidly achieved hemostasis in high-pressure wounds. Furthermore, it continuously promoted endothelial regeneration without inducing thrombosis. This Janus-structured SFM@STF sealant, with its robust wet adhesion and rapid hemostatic performance, presents a promising strategy for managing high-pressure arterial bleeding in clinical settings.

The effective repair of female reproductive tract (FRT) mucosal injuries is a significant clinical challenge, often hindered by the poor mechanical integrity and uncontrolled drug release profiles of conventional biomaterials. To address these limitations, a hierarchical "system-in-a-system" dressing, [CC@La]-$-[CP@F], was engineered entirely from natural polysaccharides. This integrated platform combines a mechanically robust primary scaffold with a secondary therapeutic delivery system. The primary scaffold, a fiber-reinforced sponge (CP@F), was fabricated via a pH-responsive Schiff base reaction between carboxymethyl chitosan and oxidized pullulan, followed by lyophilization. The incorporation of chitosan fibers resulted in a nearly three-fold increase in compressive strength to 348.97 kPa, transforming the fragile matrix into a resilient, load-bearing structure with excellent shape-memory and injectability. Embedded within this sponge are antioxidant (α-lipoic acid)-loaded microspheres (CC@La), engineered using Layer-by-Layer assembly. This dual-barrier architecture effectively suppresses burst release, enabling a sustained, multi-day therapeutic delivery specifically triggered by the acidic wound microenvironment (pH 5.5). The engineered composite demonstrated superior hemostatic efficacy in challenging in vivo models, including non-compressible liver hemorrhage, reducing bleeding time by over 55% compared to commercial gelatin sponges. Furthermore, the dressing exhibited potent, broad-spectrum antimicrobial activity (>99% efficacy) and antioxidant capacity. In a rat model of FRT mucosal injury, the multifunctional dressing significantly accelerated wound closure and promoted high-quality, regenerative healing, characterized by complete re-epithelialization and organized collagen deposition. This work presents a comprehensive engineering strategy, demonstrating how integrating mechanical reinforcement with programmed, multi-stage therapeutic action can orchestrate the entire wound healing cascade.

The management of Mayer-Rokitansky-K & uuml;ster-Hauser (MRKH) syndrome is severely hampered by the inability of existing therapies to achieve conformal fitting and sustained drug release within the dynamic, moist vaginal environment. Herein, we report a novel Janus-structured microneedle (MN) system engineered from a poly(vinyl alcohol)/silk fibroin (PVA/SF) hybrid that overcomes these critical limitations through intelligent, hydration-triggered shape adaptation. A facile one-pot process induces spontaneous spatial segregation, forming an asymmetric bilayer architecture with a PVA-rich upper layer and an SF-enriched lower layer. This unique structure enables the device to be pre-programmed into a compact coil for minimally invasive insertion, which subsequently unfurls upon vaginal moisture exposure to achieve conformal contact with irregular wound surfaces. Crucially, we decipher the shape memory mechanism through 2D correlation spectroscopy and molecular dynamics simulations. These analyses reveal a sequential disruption of hydrogen bonds, while hydrophobic interactions from SF beta-sheets provide exceptional mechanical stability in the hydrated state. In a rat model of severe vaginal injury, the arbutin-loaded MN (ARMN) scaffold orchestrates a holistic healing process-effectively scavenging ROS, suppressing IL-6-mediated inflammation, promoting VEGF-driven angiogenesis and PCNA-enhanced proliferation, and mitigating surgery-induced dysbiosis. This work establishes a pioneering paradigm of stimuli-responsive, self-adapting medical devices for transformative therapy in complex mucosal tissue regeneration.

Oral ulcers pose significant clinical challenges due to the moist, dynamic environment of the oral cavity, which leads to poor adhesion and rapid washout of conventional dressings. This study developed a multifunctional mucoadhesive patch, (CMC/CS@Lid)@PLAca-SF, integrated with lidocaine-loaded microspheres to provide synergistic therapeutic effects. The adhesive patch matrix, synthesized via green chemistry from alpha-lipoic acid, caffeic acid, and silk fibroin, utilizes dynamic covalent crosslinking to achieve superior mechanical properties, including high tensile strength (564 kPa), excellent extensibility (>1200%), and rapid self-healing. Characterization confirmed stable covalent integration and robust wet adhesion (36.4 kPa) through multiple interactions. To address pain, pH-responsive CMC/CS microspheres were embedded to ensure sustained, localized lidocaine release specifically within the acidic ulcerative microenvironment. Experimental evaluations demonstrated broad-spectrum antibacterial activity, efficient ROS scavenging (>90%), and high biocompatibility. In a rat oral ulcer model, the patch significantly accelerated re-epithelialization (99.7% healing by day 8) and modulated the immune microenvironment by promoting M2 macrophage polarization. This innovative strategy offers a comprehensive approach to oral mucosal repair, combining protection, analgesia, and regenerative bioactivity.

Driven by the growing environmental concerns and the demand for stable and high-performance electronic components, lead-free piezoelectric ceramics with substantial electrostrain have attracted considerable research interest. Bi0.5Na0.5TiO3-based ceramics are regarded as promising candidate materials to replace the lead-based counterparts in actuator applications. In this work, a series of (1-x%)(0.94Bi(0.5)Na(0.5)TiO(3)-0.06BaTiO(3))-x%SrSnO3 (BNBT-xSS) ceramic samples were prepared via two-step traditional solid-state process. The incorporation of Sr2+ and Sn4+ was designed to regulate the microstructure and the temperature-dependent phase boundaries of BNT-based ceramics. A set of systematic studies were conducted to investigate the phase composition, crystal structure, electrical properties, ferroelectric properties and electrostrain performance. The perovskite crystal structure confirmed by X-ray diffraction indicates that the Sr2+ and Sn4+ have successfully dissolved into the lattice. Notably, for BNBT-2SS composition, the depolarization temperature (T-d) is reduced to near room temperature, enabling a large electrostrain of similar to 0.48% under 80 kV/cm (d(33)* = 599 p.m./V) at room temperature. In addition, it retains a stable electrostrain of similar to 0.31% at 120 degrees C (d(33)* = 385 p.m./V), reflecting its excellent temperature stability. These results highlight the BNBT-2SS ceramics as a strong candidate for actuators. This study provides a further understanding and a strategy for designing a high performance BNBT-based ceramics for piezoelectric actuators.

Acute myocardial infarction (AMI) requires rapid diagnosis beyond conventional methods, which suffer from biological interference and complexity, limiting point-of-care (POC) application. To tackle these issues, we have devised an anthraquinone (AQ)-calibrated sensor unit coupled with smartphone-based analysis for universal detection of AMI biomarkers in untreated whole blood. Our novel dual-channel biosensing platform integrates AQ as an intrinsic reference standard, establishing a self-correction mechanism to effectively counteract hematological matrix influences. The platform enables swift quantification at pg/mL levels within 5 min without sample preprocessing, achieving detection limits of 0.3, 19.7, and 0.7 pg/mL for cTnI, Mb, and CK‑MB, respectively. The smartphone‑based intelligent analyzer automates real-time signal processing, creating a closed-loop POC diagnostic setup that shows promise for future at‑home AMI risk monitoring. This technological breakthrough showcases notable resilience to biological matrix interference while upholding analytical sensitivity comparable to clinical standards, representing a significant step toward decentralized cardiovascular emergency management.

Antiferroelectric (AFE) ceramics have emerged as promising materials for high-power energy-storage applications, yet their practical performance is fundamentally constrained by the intrinsic trade-off among phase-transition stability, polarization response, and hysteresis loss. Here, we report a local disorder engineering strategy in lead zirconate titanate-based ceramics, in which Sn4+ incorporation induces a spatially heterogeneous AFE modulation that enables the simultaneous optimization of energy density and efficiency. Atomic- resolution high-angle annular dark-field scanning transmission electron microscopy (HAADF-STEM) reveals that Sn4+ partially disrupts the pristine long-range fourfold antiparallel AFE order, giving rise to the coexistence of conventional AFE domains and nanoscale microdomains with reduced displacement amplitudes and disordered polarization orientations. Phase-field simulations further demonstrate that this locally disordered AFE configuration lowers the AFE-FE phase-transition barrier and suppresses hysteresis loss, resulting in pronounced relaxor-like behavior under electric fields. As a result, the optimized (Pb0.92Sr0.08)(Zr0.54Sn0.45Ti0.01)O-3 ceramic delivers a recoverable energy density of similar to 10.49 J cm(-3) with an efficiency of similar to 87.14% at 445 kV cm(-1), together with a high power density of 275.9 MW cm(-3) and an ultrafast discharge time (t(0.9)) of 58.8 ns. In addition, robust thermal and frequency stability is maintained. These results demonstrate that engineering locally disordered AFE modulation provides an effective pathway for developing high-efficiency and robust energy-storage ceramics.

The prompt and accurate early diagnosis of acute myocardial infarction (AMI) requires the development of rapid, sensitive, and precise diagnostic tools suitable for home use. However, conventional methods typically entail complex pretreatment steps and rely on bulky laboratory instrumentation, limiting their practicality for point‑of‑care applications. Here, we present an electrochemical sensing integrated chip (Sensing IC) incorporating a dual‑signal drift‑correction mechanism with dual‑reporter capability and broad applicability. The Sensing IC employs AuNPs/MXene‑based sensing electrodes, achieving exceptional sensitivity with a limit of detection in the picomolar range. When coupled with a smartphone‑based portable analyzer, the system enables real‑time, high‑sensitivity, multiplex detection of cardiac markers directly in whole blood. By utilizing dual redox reporters, this quantitative point‑of‑care testing (POCT) system effectively minimizes signal drift and supports in situ calibration of multiple cardiac markers. Compared with standard clinical assays, the system delivers comparable accuracy while reducing detection time by approximately 90% and substantially simplifying sample preprocessing procedures. Furthermore, it supports wireless communication with user‑friendly interfaces, such as smartphones, enabling real‑time data analysis and meeting the demands of rapid, decentralized diagnostics. Collectively, these findings demonstrate the potential of this platform to facilitate early AMI diagnosis and timely clinical warning, thereby paving the way for intelligent, home‑based cardiovascular monitoring.

The simultaneous improvement of recoverable density (Wrec) and efficiency (η) are currently major focuses and challenges in dielectric ceramic capacitor research. This study constructs 0–3 type composites using non-ferroelectric additive AlN doped 0.585Bi0.5Na0.5TiO3-0.35Sr0.7Bi0.2TiO3-0.065Sr (Ga0.5Nb0.5)O3 (BSS) ceramics, which enhances the breakdown strength (Eb) and refines the P-E loop. Ultimately, when the doping amount reaches 4

This study proposes a stepwise optimization strategy aimed at improving the overall performance of 0.91Na05BiozTiO3-0.09K07Lao.iNbO3 (NBT-KIN) based ceramics by doping with Bi(Mg2/3Nbi/3)O3 (BMN) and further refining its preparation process. The incorporation of BMN effectively increases structural disorder, thereby significantly improving the relaxor behavior of the material. To further improve the material's properties, the viscous polymer processing (VPP) technique was utilized to significantly enhance the structural density, thus markedly improving the polarization strength difference (AP) and breakdown strength (Eb). Especially, the 0.15BMN-vpp ceramics prepared by this strategy obtain an elevated energy storage density (W,,) of 7.58 J/cm3 under 470 kV/cm. Furthermore, the 0.15BMN-vpp ceramics demonstrate excellent stability and pulse discharge performance over a wide temperature range and frequency spectrum, which confirms the effectiveness of the adopted optimization strategy. In summary, this study provides a viable approach for developing high-performance dielectric ceramic materials, potentially advancing the development and application of related technologies.

Antiferroelectric (AFE) ceramic materials, especially those based on lead zirconate (PZ) materials, are renowned for their outstanding energy storage properties, which stem from their unique field-induced phase transitions. These features make them excellent candidates for high-power pulse capacitor applications. However, PZ-based antiferroelectric materials currently suffer significant challenges, including low energy storage density and the inability to simultaneously enhance energy storage efficiency, which greatly impedes their practical application. To address these challenges, this study optimizes both the phase transition and electric breakdown fields, ultimately developing a relaxation antiferroelectric system that facilitates the collaborative improvement of energy storage characteristics. Specifically, Sr2+ doped Pb0.98La0.02[(Zr0.5Sn0.5)0.88Ti0.12]0.995O3 ceramics were fabricated using the conventional solid-state reaction. The incorporation of Sr2+ effectively disrupts the antiparallel polar order of the antiferroelectric phase, thereby stabilizing it. It reduces the potential barrier for phase transition switching and improves the breakdown electric field, thus simultaneously enhancing recoverable energy density and efficiency. The efficiency peaked at 90 % when x = 0.06. Building on this, a viscous polymer processing was used to prepare the ceramic at x = 0.06, showing a recoverable energy density of 6.5 J/cm3 and an energy efficiency of 84 % at 450 kV/cm. Additionally, the ceramic shows remarkable stability within 30-150 degrees C range, with an efficiency variation of 5.9 %. Furthermore, it performs well in actual discharge energy density (3.22 J/cm3) and power density (131 MW/cm3) at 240 kV/cm.

Oral ulcers (OU) represent a highly prevalent mucosal disease; however, treatment using existing dressings is often challenging due to insufficient wet adhesion and limited efficacy. In this study, a polyphenol-functionalized silk fibroin (SF) adhesive incorporating a drug delivery platform was developed for the treatment of OU. Silk fibroin (SF) was functionalized with epigallocatechin gallate (EGCG) to form dry granules (termed pwd#ES). Subsequently, drug delivery platforms loaded with dexamethasone (denoted CMC/CS@Ca@Dex) were doped into these granules, resulting in a composite dry granular SF dressing [pwd#ES-(CMC/CS@Ca@Dex)] designed for ulcerated mucosal tissue. The CMC/CS@Ca@Dex platform was prepared by self-assembling chitosan (CS) and carboxymethyl cellulose (CMC) layer-by-layer onto CaCO₃ cores, followed by dexamethasone loading. The resultant composite SF dressing exhibited strong wet tissue adhesion (32.8 kPa), mediated by synergistic interactions within the polyphenol-functionalized SF matrix, alongside excellent reactive oxygen species (ROS) scavenging and bactericidal activity attributed to EGCG. In a mouse model of OU, the pwd#ES-(CMC/CS@Ca@Dex) dressing significantly accelerated healing and promoted faster re-epithelialization. This pwd#ES-(CMC/CS@Ca@Dex) dressing is anticipated to improve the efficiency of OU treatment and inspire the rational design of wet tissue adhesives for the repair of moist tissue defects.

Dielectric ceramic capacitors are candidates for a new generation of pulsed power supplies, owing to their superior power density. Nevertheless, low energy storage density and poor working reliability (such as temperature stability and fatigue resistance) have hindered the wide application of dielectric ceramic capacitors. To this end, a new composition-based optimization and process improvement strategy is proposed to build relaxor ferroelectric ceramic systems with weak pinning effect domain structure, which not only ensure the performance of ceramic energy storage, but also take into account the reliability of actual work. In this study, lead-free ceramics with formula 0.75(0.94Na0.5Bi0.5TiO3-0.06BaTiO3)-0.25CaTiO3, prepared by viscous polymer processing, exhibit an extremely high energy storage density, reaching up to 6.62 J/cm3 under a field strength of 520 kV/cm. In addition, after 106 cycles at 200 kV/cm, the efficiency remains at 85.9 %, with the sample's energy storage density exhibits a change rate of only 4 %. Additionally, under 300 kV/cm and across a temperature range of 30-150 degrees C, the change rate is a mere 1.7 %, which indicates that it has exhibited great fatigue resistance and excellent temperature stability. Therefore, this developed ceramic possesses great potential for practical industrial application as dielectric capacitors.

High temperatures and high humidity pose significant challenges for thrombin-based hemostatic materials in hemorrhage control and cold chain storage. In this study, we developed a silk fibroin nanofiber-based protein corona (SFN-PC) enriched with coagulation factors, integrated with silk fibroin-polydopamine (SP). The resulting composite, SP@SFN-PC, demonstrates exceptional stability under elevated temperature and humidity, maintaining procoagulant activity and wet adhesion. The coagulation factors within SFN-PC rapidly initiate the coagulation cascade, promoting swift clot formation. Polydopamine (PDA) facilitates strong adhesion to wet tissue through both covalent and noncovalent interactions, ensuring the effectiveness of SP@SFN-PC in varying environmental conditions. The combined procoagulant and adhesive properties enable SP@SFN-PC to rapidly form a robust barrier, effectively sealing hemorrhagic wounds. Notably, SP@SFN-PC retains its coagulation efficacy even over one month of exposure to high-temperature conditions, as well as over 24 h of exposure to hightemperature and high-humidity conditions. In vivo tests demonstrate rapid hemostasis in a rat tail amputation model under harsh conditions, with successful cessation of severe femoral artery bleeding in rabbits within 120 +/- 30 s. It was further confirmed with good biocompatibility in hemolysis, cytotoxicity, and in vivo implantation assays. SP@SFN-PC holds significant promise for advancing hemostatic treatments, particularly in resourcelimited underdeveloped regions.