In a clinical study we have compared rates of detection of clinico-functional parameters in 24 patients with vasospastic angina (VA) with intact coronary arteries and 40 patients with ischemic heart disease (IHD) with anatomical stenoses of coronary arteries with the aim of formation of a complex of most informative signs allowing to diagnose VA on the clinical stage. In all patients diagnosis was verified at coronary angiography. It has been established that for detection of VA in patients with IHD most informative are parameters of age with a shift to younger age, lack of relation of angina to physical effort, signs of neurotization and vegetative dysfunction, female sex, rhythm disturbances, lesser frequency of development of heart failure. Absence of occlusive atherosclerotic lesions in coronary arteries does not exclude manifestation of multifocal atherosclerosis however its clinical and biochemical signs are less pronounced than analogous derangements in patients with occlusive damage of coronary vascular bed.

Considering the important role of neurohumoral mechanisms in the development of adaptation processes in chronic hypoxia, we decided to investigate the activity of true cholinesterase in acquired and congenital heart diseases, the leading symptom in the clinical picture of which is chronic oxygen starvation.