目的 探讨胸腺五肽辅助抗菌药物治疗老年2型糖尿病合并肺部感染的效果.方法 选取2019年1月至2020年1月于该院内分泌科明确诊断为2型糖尿病合并肺部感染的90例符合标准的老年患者作为研究对象,采用随机数字表法分为观察组和对照组,每组各45例.观察组患者采用胸腺五肽(1次/天)联合敏感抗菌药物治疗,对照组患者采用胸腺五肽(1次/周)联合敏感抗菌药物治疗,比较并分析两组患者治疗前后感染指标、临床症状及体征好转时间和临床指标及总体临床治愈情况.结果 观察组和对照组患者治疗后白细胞计数(WBC)、C反应蛋白(CRP)、降钙素原(PCT)水平均较治疗前明显降低,差异均有统计学意义(P<0.05),且观察组患者治疗后WBC、CRP、PCT水平下降程度更明显,差异均有统计学意义(P<0.05);观察组患者咳嗽咳痰好转时间、肺部啰音消失时间、肺部影像学病灶吸收时间、体温恢复正常时间、住院时间、住院总费用均少于对照组,差异均有统计学意义(P<0.05);观察组患者临床总有效率明显高于对照组,差异有统计学意义(P<0.05).结论 胸腺五肽可提高2型糖尿病合并肺部感染老年患者的治愈率,值得临床推广应用.

目的 分析2型糖尿病(T2DM)患者发生幽门螺杆菌(Hp)再感染的相关危险因素,并提出相应的预防策略.方法 选取2018年1月至2019年1月在上海市杨浦区市东医院接受治疗的经13C尿素呼气试验Hp阳性的110例T2DM患者为研究对象.所有患者均给予标准四联疗法抗Hp治疗2周,停药4周后复查检测阴性者98例;至1年后再次行Hp检测,根据检测结果 将患者分为Hp再感染组23例和Hp阴性组75例.比较两组患者的性别、年龄、体质量指数等一般资料和空腹血糖(FBG)、空腹胰岛素(INS)、C肽、糖化血红蛋白(HbAlc)、甘油三酯(TG)、总胆固醇(TC)、低密度脂蛋白(LDL-C)、高密度脂蛋白(HDL-C)、血尿酸(UA)、胰岛素抵抗指数(HOMA-IR)、糖尿病病程等疾病相关资料及吸烟史、饮酒史等生活习惯,应用二分类Logistic回归分析探讨各因素对HP再感染的影响.结果 两组患者的年龄、男性比例、BMI、收缩压、舒张压、吸烟比例、饮酒比例比较差异均无统计学意义(P>0.05);再感染组和阴性组患者的病程[15(11,19)年vs 10(6,10)年]、INS[(12.26±2.34)mIU/L vs(9.78±1.32)mIU/L]、C肽[(1.97±0.22)ng/mL vs(1.73±0.29)ng/mL]、HbAlc[(8.42±0.96)％vs(7.12±0.56)％]、HOMA-IR(4.49±1.02 vs 3.09±0.65)比较,再感染组明显长于或高于阴性组,差异均具有统计学意义(P>0.05);两组患者FBG、TG、TC、LDL-C、HDL-C、UA比较差异均无统计学意义(P>0.05);二分类Logistic回归分析表明,糖尿病病程、HOMA-IR、HbAlc为Hp再感染的危险因素.结论 糖尿病病程、HOMA-IR、HbAlc是T2DM患者发生Hp再感染的危险因素,在治疗中,应强化对血糖的控制,并维持适当运动量以降低胰岛素抵抗,进而减少HP再感染的发生.

目的 探讨α-硫辛酸注射液对糖尿病肾病患者氧化应激和代谢指标的影响.方法 回顾性选取2017年6月至2019年6月上海市东医院收治的糖尿病肾病患者200例,依据治疗方法分为两组:常规对症治疗组和 α-硫辛酸注射液组,每组各100例.常规对症治疗组患者采用常规对症方法治疗,α-硫辛酸注射液组患者在常规对症治疗的基础上联合 α-硫辛酸注射液治疗.统计分析两组患者的谷胱甘肽(GSH)、超氧化物歧化酶(SOD)、丙二醛(MDA)、8-羟基脱氧鸟苷(8-OHdG)、糖化血红蛋白(HbA1c)、空腹血糖(FPG)、三酰甘油(TG)、总胆固醇(TC)、视黄醇结合蛋白(RBP)、胱抑素C(CysC)、24 h尿微量白蛋白(24 h mAlb)水平和临床疗效.结果 α-硫辛酸注射液组患者治疗前的GSH、SOD、MDA、8-OHdG水平分别为(18.0±1.9)U/L、(114.6±12.5)U/L、(45.8±5.6)U/L、(62.2±7.6)U/L,治疗后分别为(23.4±3.4)U/L、(188.5±21.6)U/L、(27.2±4.0)U/L、(33.4±5.5)U/L;常规对症治疗组患者治疗前的GSH、SOD、MDA、8-OHdG水平分别为(18.4±2.2)U/L、(116.1±13.2)U/L、(46.1±5.3)U/L、(63.1±7.0)U/L,治疗后分别为(56.7±6.6)U/L、(312.5±36.3)U/L、(14.6±2.3)U/L、(19.6±2.4)U/L.α-硫辛酸注射液组患者治疗后较治疗前的GSH、SOD升高幅度、MDA、8-OHdG降低幅度均显著高于常规对症治疗组,差异具有统计学意义(P<0.05).两组患者治疗前后的FPG、HbA1c、TG、TC水平比较,差异均无统计学意义(P>0.05).α-硫辛酸注射液组患者治疗后较治疗前的RBP、CysC、24 h mAlb水平降低幅度均显著高于常规对症治疗组,差异具有统计学意义(P<0.05).在治疗的总有效率方面,α-硫辛酸注射液组患者为91.0％(91/100),常规对症治疗组为64.0％(64/100),前者显著高于后者,差异具有统计学意义(P<0.05).结论 α-硫辛酸注射液能够有效降低糖尿病肾病患者的氧化应激水平和血糖、血脂水平,改善患者的肾功能,提升治疗的总有效率,值得推广应用.

[目的]探讨糖尿病发展过程中外周血白细胞端粒长度的变化及其影响因素.[方法] 以2012-2014年上海市杨浦区市东医院招募的387例志愿者为研究对象,其中2型糖尿病(T2DM)患者65例、糖耐量减低(IGT)者112例、正常对照210例,进行问卷调查、体格检查和血液生化指标检测,提取外周血白细胞基因组DNA,采用实时荧光定量PCR法检测端粒长度.采用多元线性回归分析影响端粒长度变化的因素.[结果] T2DM组和IGT组的体质量指数、空腹血糖、餐后2h血糖、糖化血红蛋白均高于对照组,但其端粒相对长度分别为0.70±0.09和0.88±0.10,均低于对照组(1.06±0.22)(均P＜0.05).多元线性回归分析显示:T2DM组的年龄、体质量指数、空腹血耱和餐后2h血糖与端粒相对长度呈负相关(b=-0.042、-0.006、-0.037、-0.034,均P＜0.05);IGT组的年龄和餐后2h血糖与端粒相对长度呈负相关(b=-0.041、-0.042,均P＜0.05).[结论]端粒长度缩短可能是T2DM发生的一个危险因素.端粒长度缩短不仅受到年龄和体质量指数的影响,而且受到血糖水平的影响.

Objective To explore the correlations between bone mineral density (BMD) and C peptide level in male type 2 diabetes patients.Methods BMDs of lumbar spine 1-4 (L1-4) were measured using dual energy X-ray absorptiometry (DXA) in 143 patients with T2DM and 63 normal controls.The data collected in all cases include age, body mass index (BMI) and DM duration.The level of serum glycosylated hemoglobin (HbAlc), bone metabolic markers, fasting and postprandial glucose and C peptide were measured.C peptide was used in modified homeostasis model to evaluate islet β cell function (HOMA-β) and insulin resistance (HOMA-CR).According to the level of BMD, patients were divided into two groups:normal BMD group (DM-A) and osteopenia/osteoporosis group (DM-B).Results BMD, FCP and 2 h CP were significantly reduced in T2DM patients compared with the control group (P ＜ 0.05).Compared with the DM-A group, the levels of HOMA-CR and βCTX were higher, and of PICP were lower in the DM-B group (P ＜ 0.05).Multiple stepwise regression analysis revealed that BMI and FCP were the main factors that influenced BMD of lumbar spine.Conclusion BMD was closely related to the level of FCP in male type 2 diabetes patients,and subjects with lower FCP were more likely to have low BMD.

Objective To explore the correlation between bone mineral density (BMD) and thyrotropin (TSH) level in elderly patients with type 2 diabetes.Methods One hundred and seventy-two elderly patients with type 2 diabetes whose thyroid stimulating hormone(TSH) level in normal range were chosen from hospitalized patients in our endocrinology department.BMDs of lumbar spine 1-4 (L~) were measured by dual energy X-ray absorptiometry (DXA).According to the levels of T score,the patients were divided into two groups:normal BMD group (NC) and osteopenia/osteoporosis group (OP).The data of all cases were collected,including age and gender,height,weight and body mass index (BMI).The levels of serum fasting glucose,glycosylated hemoglobin (HbA1c),bone metabolic markers and TSH were measured.Results Compared with the NC group,TSH and BMI were lower in the OP group(P ＜ 0.05).The level of β-C-terminal telopeptides of type Ⅰ collagen (βCTX) in the OP group was higher than that of the NC group (P ＜ 0.01).The level of type Ⅰ procollagen carboxyl-terminal peptide (PICP) was lower than that of the NC group (P ＜ 0.01).BMD was positively associated with TSH and BMI.Multiple stepwise regression analysis revealed that TSH and BMI were the main factors that influenced BMDs of lumbar spine.Conclusion BMD is closely related to the level of TSH in elderly type 2 diabetic patients,and patients with lower TSH levels are more likely to have low BMD.

目的 观察增龄及不同类型高脂肪酸饮食对大鼠骨骼肌葡萄糖转运蛋白4 (GLUT4) mR-NA表达的影响,探讨老年大鼠IR的机制. 方法 高饱和脂肪酸(HSF)、高不饱和脂肪酸(HUFA)饲养成年大鼠24周,观察FPG、FIns、FFA的变化;采用钳夹技术葡萄糖输注率(GIR)评价IR;RT-PCR测定骨骼肌GLUT4 mRNA水平. 结果 (1)12周和24周GIR比较,高饱和脂肪酸(HSF)组最低;24周时HSF、高不饱和脂肪酸(HUF)及正常对照(NC)组与0周相比较,分别下降了52.1％、51.6％和26.4％.(2)12周和24周HSF、HUF组与NC组比较,骨骼肌GLUT4 mRNA表达差异有统计学意义,其表达与FFA呈负相关,与GIR呈正相关.(3)HSF、HUF组GIR与体重(BW)、TG、FFA、FPG、FIns呈负相关(r=-0.6076、-0.3562、-0.4228、-0.5419、-0.6441,P＜0.01);多元回归分析显示,FFA、TG是GIR的影响因素.(4)随着周龄的增加,HSF、HUF组GLUT4 mRNA表达比较,差异有统计学意义,其表达与周龄呈负相关. 结论 HSF、HUFA饮食长期摄入可诱导大鼠IR,并造成其骨骼肌GLUT4mRNA的表达降低,IR可能与高脂肪酸饮食、增龄有关,但饮食结构的影响更重要.

Objective To explore the impact of metabolic syndrome (MS)in bone mineral density (BMD) in elderly male type 2 diabetics (T2DM). Methods One hundred and fourty cases were divided into MS group and non-MS(NMS)group according to with or without MS. Height,weight were measured, body mass index(BMI) were calculated and the total cholesterol (TC), triglyceride (TG), high-density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C), glycated hemoglobin (HbA1c)were tested. The bone mineral density (BMD) was measured by dual-energy X-ray absorptiometry (DEXA). The differences among these groups were compared and the risk factors for MS were analyzed. Results The MD, BMI, TC,TG in MS group was higher than that in NMS group (P < 0.05 vs. P < 0.01),and HDL-C was lower than NMS group (P < 0.05). Correlation analysis showed that BMD was negatively correlated with age , TG , HDL-C , and was positively correlated with BMI.The results of multiple stepwise regression analysis showed that age ,HDL-C,BMI were independent risk factors for BMD. Conclusion The BMD significantly increases in T2DM with MS.Obesity and low HDL-C have positive effects in bone mass.

目的：探讨中心性肥胖对不同糖代谢人群胰岛β细胞功能的影响。方法：146例中心性肥胖者根据血糖水平分为正常糖耐量（NGT组）50例、糖调节受损（IGR组）50例和T2DM组46例。并选取50例无中心性肥胖且正常糖耐量者为对照组（NC组）。所有受试者均检测空腹血游离脂肪酸（FFA）水平，并行口服葡萄糖耐量试验（OGTT），计算胰岛素抵抗指数（HOMA-IR）、胰岛素分泌指数（HOMA-β）和早期胰岛素分泌指数（△I30／△G30）。分析中心性肥胖对不同糖耐量人群胰岛β细胞功能的影响。结果：NGT、IGR和DM 3组间△I30／△G30呈逐渐下降趋势（P ＜0．05），且NGT组△I30／△G30高于NC组（P ＜0．05）。4组间HOMA-IR呈逐渐上升趋势（P ＜0．05）。4组间FFA呈升高趋势，其中DM组明显高于NC组（P ＜0．05）。相关分析表明，腰围与HOMA-IR呈正相关（r ＝0．536， P ＜0．01）。结论：中心性肥胖对不同糖耐量人群胰岛β细胞功能影响各不相同。在正常糖耐量阶段，中心性肥胖者早期胰岛素分泌功能代偿性增加，随着血糖水平升高，这种代偿功能逐渐降低。

目的 调查上海市杨浦区某社区55岁以上常住居民代谢综合征(metabolic syndrome,MS)患病状况,并分析吸烟、户外运动等日常行为习惯与MS的关系.方法 采用随机整群抽样方法,选择上海市杨浦区某社区中老年常住居民进行问卷调查及体格检查、相关实验室检查,并分析与MS患病相关的影响因素.结果 问卷填写完整并完成相关检查的共1 002人.根据2010年版中国2型糖尿病防治指南中MS的诊断标准,该社区55岁以上常住居民MS的患病率为18.66％(187/1 002),其中女性患病率为17.70％(120/678),男性患病率为20.68 ％(67/324).经单因素和多因素分析显示,超重或肥胖、高血压、糖尿病史、高LDL-C及吸烟是患MS的主要因素(P＜0.05).结论 杨浦社区中老年居民MS患病率高,超重或肥胖、高血压、糖尿病史、高LDL-C及吸烟是该地区中老年居民MS的患病因素,提示积极控制体质量和戒烟可作为预防该地区MS发生的社区早期干预性策略.

[目的]分析TRB3基因＋251A/G多态性分布,并探讨该多态性与糖耐量减低（IGT）及胰岛素抵抗的相关性。[方法]在112例IGT者和209例对照者中,采用Taqman探针方法对TRB3基因＋251A/G位点进行基因分型;同时进行问卷调查、体格检查及血糖、血脂、胰岛素等生化指标的检测,并计算稳态模型法β细胞功能指数（HOMA-B）、早期相胰岛素分泌指数（ΔI30/ΔG30）、稳态模型法胰岛素抵抗指数（HOMA-IR）、Cederholm胰岛素敏感指数（ISIc）等评价胰岛素分泌及胰岛素敏感性。[结果]在IGT组与对照组中,性别、年龄差异无统计学意义;两组临床指标比较：BMI、血糖（空腹及糖后2 h）、糖化血红蛋白、游离脂肪酸、胰岛素（空腹及糖后2 h）、ΔI30/ΔG30、HOMA-IR、ISIc等10项差异有统计学意义。TRB3基因＋251A/G位点存在多态性。AA、AG、GG 3种基因型的频率分布在IGT组、对照组分别为64.29%、64.11%,28.57%、32.54%,7.14%、3.35%,其分布差异无统计学意义（χ-2=0.006,P=0.938）。两组不同基因型的临床指标比较：在IGT组中,AG/GG基因型者空腹胰岛素、HOMA-IR高于AA基因型者（P〈0.05）;对照组＋251A/G不同基因型者血糖、血脂、胰岛素、HOMA-B、HOMA-IR等各指标差异均无统计学意义。[结论]TRB3基因＋251A/G多态性与研究人群IGT的发生无关,但可能与IGT者肝脏胰岛素抵抗存在相关性。

目的 了解上海市杨浦社区老年代谢综合征(MS)及其组分的患病情况及其影响因素.方法 用分层整群抽样的方法,入选上海市杨浦区2个社区常住老年人2004例,男性705例,女性1 299例,60～69岁931例,70～79岁618例,80～89岁408例,≥90岁47例.对入选者进行MS流行病学调查,包括问卷调查、体格检查及实验室检查,MS诊断根据2013年中华医学会糖尿病学会建议的诊断标准.结果 MS的总体患病率为25.2％,60～69岁MS患病率为24.0％,70～79岁MS患病率为25.9％,80～89岁MS患病率为27.9％,≥90岁MS患病率为17.0％,＜90岁MS患病率有随年龄递增趋势.高血压、TG、腹型肥胖、高血糖、低HDL-C血症的患病率依次为68.4％、37.0％、36.3％、26.9％、6.8％,其中男性高血压和低HDL-C血症患病率高于女性(73.2％ vs 65.7％,10.8％ vs 4.6％,P＜0.05),缺乏运动及吸烟为患MS的危险因素(P＜0.05).结论 上海市杨浦社区老年人MS患病率高,男女总MS患病率无差异,强化运动和戒烟可作为预防MS发生的早期干预性策略.

[目的]分析TRB3基因+251A/G多态性分布,并探讨该多态性与糖耐量减低(IGT)及胰岛素抵抗的相关性.[方法]在112例IGT者和209例对照者中,采用Taqman探针方法对TRB3基因+251A/G位点进行基因分型;同时进行问卷调查、体格检查及血糖、血脂、胰岛素等生化指标的检测,并计算稳态模型法β细胞功能指数(HOMA-B)、早期相胰岛素分泌指数(△I30/△G30)、稳态模型法胰岛素抵抗指数(HOMA-IR)、Cederholm胰岛素敏感指数(ISIc)等评价胰岛素分泌及胰岛素敏感性. [结果]在IGT组与对照组中,性别、年龄差异无统计学意义;两组临床指标比较:BMI、血糖(空腹及糖后2h)、糖化血红蛋白、游离脂肪酸、胰岛素(空腹及糖后2h)、△I30/△G30、HOMA-IR、ISIc等10项差异有统计学意义.TRB3基因+251A/G位点存在多态性.AA、AG、GG 3种基因型的频率分布在IGT组、对照组分别为64.29％、64.11％,28.57％、32.54％,7.14％、3.35％,其分布差异无统计学意义(x2=0.006,P=0.938).两组不同基因型的临床指标比较:在IGT组中,AG/GG基因型者空腹胰岛素、HOMA-IR高于AA基因型者(P＜0.05);对照组+251A/G不同基因型者血糖、血脂、胰岛素、HOMA-B、HOMA-IR等各指标差异均无统计学意义. [结论]TRB3基因+251A/G多态性与研究人群IGT的发生无关,但可能与IGT者肝脏胰岛素抵抗存在相关性.

目的 调查门诊2型糖尿病药物治疗费用,探讨其影响因素.方法 采集425例门诊2型糖尿病患者的基本信息,并详细记录降糖和代谢相关药物、糖尿病并发症的日均治疗费用.结果 ①按糖尿病病程分为≤5年组、＞5～10年组和＞10年组,≤5年组的降糖药物、总药物日均费用均显著低于＞5～10年组和＞10年组(P值均＜0.01),＞5～10年组又显著低于＞10年组(P值均＜0.01).②按有无并发症分为有并发症组和无并发症组.有并发症组的降糖药物、总药物日均费用均显著高于无并发症组(P值分别＜0.05、＜0.01).③按糖化血红蛋白(HbA1 c)水平分为HbA1 c＞7％组和HbA1 c≤7％组,HbA1 c＞7％组的降糖药物、总药物日均费用均显著高于HbA1c≤7％组(P值均＜0.05).④糖尿病教育组(33例)干预后的降糖药物、总药物日均费用较干预前有减少的趋势,但差异均无统计学意义(P值均＞0.05).结论 糖尿病的病程、HbA1c水平、并发症与药物治疗费用有关,早发现、早诊断、早治疗能有效降低糖尿病治疗费用.

Objective:To explore the therapeutic efficacy of alfacalcidol on senile osteoporosis and to discuss its preventive measures.Methods:Two hundred elderly patients with primary osteoporosis were divided into two groups (each n=100).Patients in the control group were treated with basic daily oral calcium while alfacalcidol therapy was additinally given in the treatment group besides the basic treatment.Results:Before the treatment, no statistically significant difference was found between the two groups (P>0.05).After the treatment, the indicators of patients in the two groups were significantly increased, however bone mineral density (BMD) at the femoral neck and L 2-4 were significantly higher in the treatment group than in the control group (P<0.05).The total response rate of pain improvement was 78.0%in the treatment group and 35.0%in the control group, and the treatment group was superior to the control group (P<0.05). Conclusion:Alfacalcidol for the treatment of senile osteoporosis can effectively improve bone mineral density and relieve the pain.

AIM To investigate effect of insulin detemir(Det) on coefficient of variation(CV) of fasting blood glucose(FBG) in patients with type 2 diabetes.METHODS A total of 60 ptients with type 2diabetes inadequately controlled were randomized into once-daily Det(n = 30) versus isophane protamine biosynthetic human insulin(NPH,n = 30) for 12 weeks.Outcome measures included FBG,glycosylated hemoglobin A_(1c)(HbA_(1c)),CV-FBG,body weight and events of the hypoglycemia.RESULTS After 12 weeks of the treatment,FBG and HbA_(1c) decreased significantly in both groups(P < 0.05).There was no statistical significance in FBG and HbA_(1c) between the two groups(P > 0.05).The CV-FBG was lower in the Det group than that in the NPH group(12.49±2.47 vs.14.95±3.31,P < 0.05).The mean weight gain and events of hypoglycemia were significantly lower in the Det group than those in the NPH group((1.25±0.75) kg vs.(1.98±0.84) kg,7%vs.17%,P<0.05).No severe adverse reaction occurred in the two groups.CONCLUSION Insulin detemir is as effective as NPH in glycemic control,and with reduction in CV-FBG,hypoglycaemia and weight gain.

Objective To analyze the changes in blood lipid profile in type 2 diabetes with retinopathy,and the relationship with diabetic retinopathy(DR).Methods 224 patients with type 2 diabetes were divided into a group without retinopathy(NDR)(110 patients)and a DR group(114 patients).To analyze the correlation between disease course,HbA1C,blood lipid indices and DR.Results The levels of ApoB and Lp(a)in the DR group were higher than those in the NDR group(P0.05),while the ratio of ApoA/ApoB was lower than that in the NDR group(P0.05).Logistic regression analysis showed that the incidence of retinopathy was correlated with Lp(a)(OR=1.30,95%CI:1.01～1.67),ApoA /ApoB(OR=0.54,95%CI:0.33～0.87)and disease course(OR=1.73,95%CI:1.30～2.30).Conclusion The Lp(a)and ApoA /ApoB might be the risk factors of DR.To monitor the lipid profile and actively correct the dyslipidemia might be benefit to the prevention and treatment of DR.

Objective To investigate the clinical characteristics and risk factors for carotid atherosclerosis in type 2 diabetes mellitus combined with nonalcoholic fatty liver disease.Methods A total of 350 patients with type 2 diabetes mellitus were divided into group A(n=164,not complicated with nonalcoholic fatty liver disease) and group B(n=186,complicated with nonalcoholic fatty liver disease).The degrees of lipid disorder and carotid atherosclerosis were compared between two groups.Results The levels of body mass index,waist circumference,triacylglycerol,cholesterol,alanine aminotransferase and aspartate aminotransferase were higher in group B than those in group A,which showed significant differences(P0.05).There were no significant differences in blood glucose,glycosylated hemoglobin,blood pressure and course of diabetes mellitus between two groups(P0.05).In 350 cases,188 cases(53.71%) were complicated with carotid atherosclerosis disease.The morbidity of carotid atherosclerosis was higher and intima-media thickness was obviously thicker in group B compared with group A(P0.05).Conclusion The morbidities of carotid atherosclerosis and nonalcoholic fatty liver disease are higher in patients with type 2 diabetes mellitus.Carotid atherosclerosis usually occurs in those with type 2 diabetes mellitus complicated with nonalcoholic fatty liver disease.

Objective To investigate the incidience of anxiety or depression in the families of chronic diseases and to discuss the relationship between anxiety or depression and coping style. Methods Using SAS, SDS,SCSQ as main tools,questionnaire investigation was made in 232 families of chronic diseases. Results The incidence of anxiety was 25.9%, and that of depression was 43.1%, and the incidence of concurrence was 25.9%. The mental health level was asscociated with the sex, active response of families, the age, disease course of the patients, hospitalization costs, economic conditions. Conclusions The families of chronic diseases patients have different degrees of negative mood, which affects the patients. Therefore, enchancing the mental intervation of families of chronic diseases will do good to the recovery of diseases and improvement of life quality.

[目的]观察烫疮油治疗卧床老年病人摩擦红斑的疗效。[方法]122例卧床老年摩擦红斑病人,采用随机分组,治疗组皮损处外涂烫疮油;对照组用3%硼酸溶液湿敷皮损处,观察两组疗效。[结果]两组红斑开始消退、渗出停止时间比较差异有统计学意义(P<0.05或P<0.01);两组疗效差异有统计学意义(P<0.05)。[结论]在加强护理的同时运用烫疮油,可促进卧床老年病人摩擦红斑的愈合。