Objective To evaluate early bone loss by radionuclide 99mTc-MDP bone imaging and to intervene in early stage.Methods Early bone loss and osteoporosis models were produce in rabbits by intramuscular injection of dexamethasone sodium phosphate (DX) and then a treatment was used on the model rabbits.The treatment drug 99Tc-MDP was injected once a week,up to 14 weeks.The ratio between region of interest (ROI) site of radionuclide bone imaging and the fixed radioactive standard source (RSF),bone histopathology,bone histomorphometry,bone mineral density,bone biomechanics,serum bone alkaline phosphatase (BALP),osteocalcin (BGP),and X ray and CT radiography of the lumbar vertebrae were determined,and the differences between the groups of were compared.Results After injection of different doses of DX on experimental rabbits,bone tissue pathological section,indexes of Bone morphological metrology,bone density,bone biomechanics,and BALP and BGP were used to confirm that the animal model was established successfully.After treatment for 14 weeks,early bone loss group showed that trabecular bone of the femoral head was arranged regularly and the trabecular bone was thickening comparing with those in the model group.However,the osteoporosis treatment group showed that trabecular bone was slightly sparse,and trabecular thickness was not uniform,but no fracture was found.The uptake of 99m Tc MDP bone scintigraphy agent in early bone loss model and osteoporosis bone tissue was significantly higher than that in control group (P ＜ 0.05),but the uptake of imaging agent in the treatment group was significantly decreased than the corresponding model group (P ＜ 0.05).Bone mineral density and bone histomorphometry were not significantly different between early bone loss treatment group and the control group (P ＞ 0.05).But the uptake of imaging agent in the early bone loss treatment group was significantly higher than that in the normal control group (P ＜ 0.05).Bone mineral density,bone biomechanics,and BALP and BGP were significantly different between bone osteoporosis therapy group and normal control group,and the greatest improvement was found in osteoporosis treatment group (P ＜ 0.05).Conclusion Radionuclide " 99m Tc-MDP" bone imaging can detect early bone loss in different individuals,and the effect of intervention on early bone loss stage is significantly better than that of severe osteoporosis.

目的:观察骨康灵联合锝-99亚甲基二磷酸钠(99Tc-MDP)干预兔股骨头无菌性坏死(ANFH)的疗效,探讨其作用机制及指导临床实践.方法:将兔子随机分成两组:正常组、ANFH组;采用肌肉注射地塞米松磷酸钠方法制作ANFH模型,8周后进行ANFH模型鉴定,将造模成功的兔子随机分成ANFH组、99Tc-MDP组、骨康灵组和99Tc-MDP联合骨康灵组,16周治疗后评价各效应指标.结果:HE染色提示,ANFH组兔骨小梁排列稀缺和断裂现象,呈骨组织明显破坏形态;99Tc-MDP组骨小梁形态较ANFH组明显的致密、增粗;骨康灵组骨小梁密度较ANFH组有所增加,骨小梁断裂现象消失;99Tc-MDP联合骨康灵组股骨头的骨组织形态排列较规则、均匀,无明显组织破坏.与ANFH组比较,99Tc-MDP组和99Tc-MDP联合骨康灵组骨密度、骨生物力学、骨形态计量、99mTc-MDP骨骼显像ROI比值、血清碱性磷酸酶(ALP)、血清骨钙素(BGP)等检测结果有差异(P＜0.05).结论:骨康灵对ANFH模型有一定的抑制骨吸收作用,与99Tc-MDP联合治疗后效应更明显,可能存在增效协同作用.

Objective To study the therapeutic value of99 Tc-MDP for bone repairing in aseptic necrosis of the femoral head ( ANFH) .Methods The animal experiment included 2 stages:the establishment of animal model and the treatment observation. ANFH animal model was made by dexamethasone intramuscular injection.Intramuscular injection of dexamethasone was used to establish the ANFH model.In the first stage of 8 weeks, normal group ( Group A) and ANFH model group ( Group B) were set up.The successful animal model was proved by cell pathology, bone morphology, BMD, tetracycline double labeling, bone scintigraphy ROI value, X-ray, and CT.In the second stage of 16 weeks, normal control group ( Group C) , ANFH model control Group ( Group D) ,99 Tc-MDP therapy Group ( Group E) , and alendronate sodium therapy group ( Group F) were set up.The same tests were applied like in stage 1 and the efficacy in Group E and Group F was valued.SPSS13 was used for statistical analysis. Results At the end of stage 1, the pathology showed that no bone tissue was destroyed in Group A, but in Group B the surface soft tissue of the femoral head was destroyed, and bone trabecular breaking and bone lacuna increased. BMD, bone histomorphology, tetracycline double labeling decreased and bone scintigraphy ROI, serum BALP and BGP increased in Group B. ANFH could be seen by X ray and CT in Group B.After 16-week therapy in Group E and Group F, all the test results showed a nearly same results between Group A, C and Group B, D.Improved result showed in Group E and Group F, especially in Group E for bone repairing, bone trabecular increasing, and bone lacuna disappearing.All the results were comparable between Group E and Group C.Conclusion Animal study shows an apparent result of99 Tc-MDP treatment for ANFH.99 Tc-MDP not only has the same function like alendronate sodium showing increased bone trabeculae in tetracycline double labeling test, but also reveals the potential function in promoting osteoblast function and bone tissue repairing indicated by bone lacuna disappearing.

目的探讨不同双磷酸盐药物联合"骨康灵"治疗兔股骨头无菌性坏死（ANFH）模型的疗效分析。方法采用肌肉注射地塞米松磷酸钠方法制作ANFH动物模型;制作动物模型成功后,将实验兔设为A组（正常对照组）、B组（ANFH对照组）、C组（"99Tc-MDP"治疗组）、D组（"阿仑膦酸钠"治疗组）、E组（"骨康灵"治疗组）、F组（"99Tc-MDP"联合"骨康灵"治疗组）和G组（"阿仑膦酸钠"联合"骨康灵"治疗组）,疗程为16周,后比较各组之间骨密度、影像学及生化指标变化并评价疗效。采用SPSS17.0软件进行统计学处理。结果 ANFH模型组与正常组比较显示:骨组织病理学、99mTc-MDP骨显像,骨密度、骨生物力学、骨形态计量、ALP、BGP均有明显差异（P＜0.01）。经过不同药物联合治疗后,C、D、E、F、G组经治疗后与B组相比,骨组织病理学、99mTc-MDP骨显像,骨密度、骨生物力学、骨形态计量、ALP、BGP均比B组有有明显统计学意义;疗效评判结果显示:F组为显效基本接近A组,C组、G组和D组均为有效,但E组疗效相对不明显。结论药物"99Tc-MDP"联合联合"骨康灵"治疗骨质疏松效果优于其他药物治疗;因此,中草药联合"99Tc-MDP"可能成为治疗骨质疏松的有效治疗方法。

Objective To investigate the value of 99 Tc-MDP therapy in aseptic necrosis femur head ( ANFH) .Methods The animal experiment was divided into 2 stages: animal model establishment and clinical observation.In the first stage, Group A ( normal group) and Group B ( ANFH group) were set up.The animal ANFH model was established by intravenous injection of dexamethasone sodium phosphate for 8 weeks.Bone pathology, histomorphology, bone mineral density, tetracycline double labeling experiment, radionuclide bone scintigraphy ROI ratio value, X-ray, and CT were examined.The second stage of the experiment started until the ANFH model had been proved.During the second stage, these groups were set up for the further 16 week-therapy based on the ANFH animal model: Group C (normal control), Group D (ANFH control), Group E (99Tc-MDP therapy) , and Group F ( alendronate therapy) .After the treatment, the efficacy in Group E and Group F was valued.A SPPSS 13.0 software was used for statistical analysis.Results After 2 stages of ANFH model establishment and clinical observation, the results, including bone pathology, histomorphology, bone mineral density, tetracycline double labeling experiment, and ROI ratio of radionuclide bone scintigraphy, showed apparent difference between Group A and B (p<0.01), indicating the success of animal modeling.After the treatment, the bone pathology in Group E showed that trabecular bone in the femoral head lined regularly with a little scatter.But the repair was apparent comparing with that in Group D.In Group F trabecular bone in the femoral head showed scattered and irregular lining and little broken.Comparing with that in Group D, the situation improved in Group F.The results of bone mineral density, tetracycline double labeling experiment, and ROI ratio of radionuclide bone scintigraphy also supported the&nbsp;improvement ( p<0.05 ) .Conclusion On the bases of ANFH animal model,99 Tc-MDP and Alendronate have got different therapy value and 99 Tc-MDP showed an apparent remoulding result.99 Tc-MDP can reach the ANFH target tissue.Besides controlling bone absorption, it also can maintain the activity of superoxide dismutase( SOD) , protect the bone tissue absorption from free radius and prevent from its further damaging.From the tetracycline double labeling experiment we can conclude that the increased deposition rate maybe relate to the bone cell proliferation.

Objective To investigate the correlation among early changes in bone metabolism and99Tcm-MDP bone nuclear image,serum BGP,and BALP,and to focus on the importance of the value.Methods Rabbit osteoporosis model was established using intramuscular injection of dexamethasone sodium phosphate( DX).Three groups were set up including Group A( normal control group),Group B( osteoporosis group induced with DX injection,2 mg/kg,b.i.w),and Group C( bone mass loss group induced with DX injection,1 mg/kg,q.w).The time for the model establishment lasted for 8 weeks.99Tcm-MDP bone nuclear image was taken,and histopathological examination was performed.Bone mineral density,serum BALP and BGP were detected.Semi-quantitative detection of ROI in nuclear image was calculated by the ratio of L3/S4,the femur head/S4,the knee/S4,and the femoral diaphysis/S4.T test and variance analysis were conducted among the groups using a SPSS 13.0 software.Results At the 7th week,obvious wear and tear on the surface cartilage of the femoral head and bone destruction such as trabecular sparse and broken were observed in Group B.Bone mineral density decreased significantly,while serum BALP and BGP increased,and the ROI ratio of99Tcm-MDP nuclear image also elevated( P < 0.05).In Group C,the histopathological sections demonstrated slightly sparse trabecular only without signs of bone destruction.The serum BGP and the ROI ratio of99Tcm-MDP nuclear image increased( P < 0.05),but no significant changes of bone mineral density and serum BALP were observed( P > 0.05),which proved the establishment of animal model was successful.When comparing the results of Group B and Group C,all ROI ratios and BGP remained in same range except the ratio of the femoral diaphysis/S 4 increased in Group B,and significant difference of bone mineral density and serum BALP level was observed( P <0.05).Conclusion According to the results of the animal experiment,when the ratios of L 3/S 4,the femur head/S 4,the knee/S 4 in 99Tcm-MDP nuclear image increase while the ratio of the femoral diaphysis/S 4 remains unchanged,it may indicate the stage of bone mass loss,which is more valuable than serum BGP.This may provide reference for clinical prevention and intervention of the early stage of osteoporosis.

Objective To study the value of99mTc methylene diphosphonate(99mTc-MDP) bone scintigraphy in diagnosis of early bone mass loss. Methods Intramuscular dexamethasone(DX) injection for 6 weeks was used to build a rabbit model of osteoporosis. The rabbits were divided into group A(control group), group B(osteoporosis group, injection of 2 mg/kg DX twice a week), and group C(bone mass loss group, injection of 2 mg/kg DX once a week). The semi-quantative analysis of99mTc-MDP bone scintigraphy, bone tissue pathology, bone mass density(BMD), bone morphology, and serum bone alkaline phosphatase(BALP) and bone gamma-carboxyglutamic acid-containing protein(BGP) levels were investigated. Results At the 7th week, there were significant differences in semi-quantitative analysis of99mTc-MDP bone scintigraphy between groups A and B(P<0.05), suggesting the successful establishment of osteoporosis model. Compared with group A, although the bone scintigraphy showed significant changes in vertebra, femur head and knees(P<0.05) as well as significant increase in serum BALP and BGP(P<0.05) in group C, there were no significant changes in the middle of femur, femur head BMD,lumbar spine BMD and bone morphology(P>0.05). Conclusion The radionuclide bone scintigraphy shows a decreased uptake of tracer99mTc-MDP in the middle of femur, but there are no significant changes in region of interest(ROI) ratio and BMD value. It may reveal early bone mass loss and give some advices on preventive therapy.

Objective To evaluate the correlation between osteoporosis and bone biomechanics using a semi-quantitative method of 99mTc-MDP bone scintigraphy. Methods In order to establish rabbit osteoporosis model,female New Zealand rabbits were selected and given intramuscular injection of dexamethasone( DX). Rabbits were divided into 3 groups: normal control model( Group A),osteoporosis model( Group B,with intramuscular injection of 2 mg / kg DX twice a week),and bone mass loss model( Group C,with intramuscular injection of 1mg / kg DX once a week). The whole modeling process lasted for 6 weeks. At the 7thweek,99mTc-MDP bone scintigraphy was performed to evaluate the ROI ratio of the spongy bone( the lumbar spine,the femoral head,and the knee),the compact bone( the middle femur),and the 4thcoccygeal vertebra. Meanwhile,lumbar spine X-ray imaging,CT,bone pathology,BMD,bone biomechanics,bone morphology,and serum BALP and BGP test were performed. A SPSS 13. 0 software was used for statistical variance analysis and t-test. Results The bone tissue pathology test at the 7thweek showed that trabecular of the femur in Group A lined regularly and no bone mass destruction was observed. Compared with that in Group A,the results in Group B showed bone mass destruction on the surface of the femoral head and the appearance of thin or broken trabecular bone. The functional markers including ROI ratio of 99mTc-MDP bone scintigraphy,serum BALP,and BGP increased( P < 0. 05),while the morphologic indexes such as bone mechanics and bone mineral density decreased( P < 0. 05). Only a little thin trabecular was found in Group C. In the 99mTc-MDP bone scintigraphy,except for no increase in the ROI of the middle femur,the radioactivity of the spongy bone,serum BALP,and BGP increased,and the bone biomechanics decreased( P < 0. 05). However,BMD and morphologic markers only showed a little change( P > 0. 05). Conclusion 99mTc-MDP bone scintigraphy can demonstrate the abnormity of bone metabolism at early stage. During the early stage of bone mass loss( Group C),the increased radiotracer uptake ratio was only found in the spongy bone but not in the compact bone. Serum BALP and BGP increased at the same time. In fact,when BMD does not decrease apparently,bone biomechanics has already decreased. So,interventional therapy at this stage is the best choice for the prevention of osteoporotic fractures.

目的 应用锝99-m-亚甲基二磷酸钠(99mTc-MDP)骨骼显像对早期骨量减少和骨质疏松期的特点进行研究,为早期诊断骨质疏松提供依据.方法 采用肌肉注射地塞米松磷酸钠针剂(“DX”)制作兔骨质疏松动物模型.设正常对照组(A组)和肌肉注射不同剂量的“DX”制作骨质疏松模型组(B组)以及骨量减少模型组(C组),造模时间为8周.核素骨骼显像(在骨代谢变化时,取骨显像反差较大的、具有代表性的骨组织区域)的感兴趣区(ROI)部位(第3腰椎、股骨头、膝关节、股骨中段、肱骨中段)与第4尾椎进行比较,进行腰椎X线、CT摄片、骨病理组织学、骨密度、骨生物力学、骨形态计量、血清骨碱性磷酸酶(BALP)、骨钙素(BGP)等实验检测,比较三组间的差异.采用SPSS13.0统计软件分析数据,P＜0.05为有统计学意义.结果 制作模型8周后骨组织病理切片显示:A组股骨头骨小梁排列规则、均匀,无骨质破坏.B组表现为股骨头骨小梁排列不规则、稀疏伴断裂,存在骨破坏现象.C组则显示骨小梁排列轻度稀疏.核素99mTc-MDP骨骼显像在A、B、C组的腰椎、股骨头、股骨中段等处摄取“99mTc-MDP”各有特点.A组与B组的核素99mTc-MDP骨骼显像ROI比值及骨密度、骨生物力学、骨形态计量、ALP、BGP实验结果比较差异明显(P＜0.01),但在X线、CT摄片见骨小梁略呈稀疏改变,但变化不明显.C组与A组比较,C组核素骨骼显像ROI比值及椎体生物力学、ALP、BGP实验结果差异明显(P＜0.05).B组与C组比较,骨组织病理切片、骨密度、骨生物力学、骨形态计量、BALP等结果比值差异明显(P＜0.05),但核素骨骼显像ROI比值差异小(P＞0.05).结论 核素99mTc-MDP骨骼显像对不同程度的骨量减少具有显像特点,松质骨部位在核素骨骼显像ROI比值升高伴血清ALP、BGP增高时,提示骨代谢已经开始异常,可能进入骨量减少期；当99mTc-MDP骨骼显像显示在密质骨(股骨中段、肱骨中段)的ROI比值升高,并伴有骨量减少时,已属于较严重的骨质疏松,需要及时治疗,同时存在骨折的风险.

Objective To investigate the correlation among early changes in bone metabolism and 99 Tcm-MDP bone nuclear image , serum BGP, and BALP, and to focus on the importance of the value .Methods Rabbit osteoporosis model was established using intramuscular injection of dexamethasone sodium phosphate ( DX ) .Three groups were set up including Group A ( normal control group) , Group B ( osteoporosis group induced with DX injection , 2 mg/kg, b.i.w) , and Group C ( bone mass loss group induced with DX injection, 1 mg/kg, q.w).The time for the model establishment lasted for 8 weeks.99Tcm-MDP bone nuclear image was taken, and histopathological examination was performed .Bone mineral density , serum BALP and BGP were detected .Semi-quantitative detection of ROI in nuclear image was calculated by the ratio of L 3/S4 , the femur head/S4 , the knee/S4 , and the femoral diaphysis/S4 .T test and variance analysis were conducted among the groups using a SPSS 13.0 software.Results At the 7th week, obvious wear and tear on the surface cartilage of the femoral head and bone destruction such as trabecular sparse and broken were observed in Group B.Bone mineral density decreased significantly , while serum BALP and BGP increased , and the ROI ratio of 99 Tcm-MDP nuclear image also elevated ( P<0.05) .In Group C, the histopathological sections demonstrated slightly sparse trabecular only without signs of bone destruction .The serum BGP and the ROI ratio of 99 Tcm-MDP nuclear image increased ( P<0.05 ) , but no significant changes of bone mineral density and serum BALP were observed ( P>0.05 ) , which proved the establishment of animal model was successful .When comparing the results of Group B and Group C , all ROI ratios and BGP remained in same range except the ratio of the femoral diaphysis/S4 increased in Group B , and significant difference of bone mineral density and serum BALP level was observed (P<0.05).Conclusion According to the results of the animal experiment , when the ratios of L3/S4, the femur head/S4, the knee/S4 in 99Tcm-MDP nuclear image increase while the ratio of the femoral diaphysis /S4 remains unchanged , it may indicate the stage of bone mass loss , which is more valuable than serum BGP .This may provide reference for clinical prevention and intervention of the early stage of osteoporosis .

Objective To discuss the value of clinical application and choice with MRI/CT for diagnosing ovarian serous cystadenocarcinoma and ovarian mucinous cystadenocarcinoma. Methods To analyse 22 cases of ovarian through MRI confirmed by surgicopathology and compare with those of the relevant CT cystadenocarcinoma retrospectively. Results MRI revealed 14/22 cases of ovarian serous cystadenocarcinoma,8/22 cases of ovarian mucinous cystadenocarcinoma, and pathology confirmed 13/14 cases as the serous cystadenocarcinoma,1/14 case as the ovarian seromucinous cystadenoma,5/8 cases for mucinous cystadenocarcinoma. 3/8 cases for mucinous cystadenoma. CT showed 10/20 cases as the serous cystadenocarcinoma, 10/20 cases as the mucinous cystadenocarcinoma, and pathology proved 9/10 cases for serous cystadenocarcinoma, 1/10 case for ovarian clear cell carcinoma, 9/10 cases for mucinous cystadenocarcinoma, 1/10 case for serous cystadenocarcinoma complicated with bleeding. Furthermore, the characteristic or unique features contributed with MRI and CT were comprehended as follows. Both of MRI and CT can demonstrate ovarian cystadenocarcinoma as cystic and consistent mass that means no significant difference in sensitivities. As regards to specificities, plain MRI can unveil more clearly the mass ingredients than those through CT, outcoming with profitable benefit in specificity; but conversely enhanced CT can demonstrate the enhanced regional wall irregularities and nodules while MRI can't do so clearly and precisely due to the presence of higher signal intensities caused by mucin on enhanced MRI. T1WI with intermingling of the paramagnetic substance (GD. DTPA), leading to comparatively lower specificity. Conclusion MRI and CT are nearly equal in application of diagnosing ovarian serous cystadenocarcinoma. But CT is superior to MRI in diagnosing the qualification of ovarian mucinous cystadenocarcinoma.

目的探讨3D CE-MRA对下肢动脉硬化性闭塞症临床应用价值。方法检查40例疑有下肢动脉疾的患者行三维增强下肢磁共振血管成像（3D CE-MRA）检查。仪器为1.5T磁共振成像仪（Magneton Avanto,Siemens）配置32个接收通道和并行采集技术。其中24例患者接受彩色多普勒超声诊断仪检查。结果40例病例包括临床诊断或怀疑行CE-MRA中37例下肢动脉可见不同程度的狭窄及闭塞,阳性诊断率92.5%（37/40）。与手术结果的符合率为92.7%。而彩色多普勒超声诊断结果符合率为88%。结论3D CE-MRA对下肢动脉病变的显示具有独特的优势,是一种无创、安全、可靠、有应用价值的检查方法,甚至是首选的方法。

<正>患者,女,82岁。黑便四天入院。体检:腹平软,未见肠型及蠕动波,未闻及肠鸣音亢进。全腹无压痛、反跳痛、肌卫,肝、脾肋下未扪及,移

目的探讨99Tcm-MIBI乳腺显像与P糖蛋白(Pgp)、增殖细胞核抗原(PCNA)、胎盘型谷胱甘肽-S-转移酶(GST-π) 的关系.方法 39例乳腺癌患者手术前行99Tcm-MIBI乳腺显像,术后标本病理检查并测定Pgp、PCNA、GST-π水平,分析三者与肿瘤/正常组织(T/B)摄取比值和滞留分数(RI)的关系.结果 Pgp阳性组RI明显低于Pgp阴性组,PCNA、GST-π与T/B摄取比值和RI无明显关系.结论计算99Tcm-MIBI乳腺显像RI可以评估乳腺癌细胞的Pgp水平,进而估测其多药耐药性.

Objective To discuss the criteria for detecting breast cancer in 99 Tc m methoxyisobutylisonitrile (MIBI) scintimammography Methods One hundred patients with histopathologically confirmed breast tumors (50 with benign disease and 50 with breast cancer) underwent 99 Tc m MIBI scintimammography The ratio of tumor to contralateral uptake (T/N), tumor to heart uptake (T/H) and tumor to sternum uptake (T/S) were obtained The three ratios were analysed for differentiating the benign breast lesions from the malignant tumors The differences of the results between 10 and 30 min imaging were also observed Results To detect breast cancer, the sensitivity, specificity and accuracy of T/N were 84%, 90% and 87% But those of T/H were 70% ( P 0 05), 72% ( P 0 05), 71% ( P 0 01), and those of T/S were 58% ( P 0 01), 78% ( P 0 05), 68% ( P 0 01) The best cut off of the T/N was 1 1 to 1 2 There was no difference in results between 10 and 30 min imaging Conclusion The T/N is the best index in 99 Tc m MIBI scintimammography and the best cut off range of the T/N value is 1 1 to 1 2

目的观察99mTc-MIBI乳腺显像检测乳腺癌腋下淋巴结转移的临床价值.方法56例乳腺癌患者术前行乳腺核素显像,乳腺内或腋窝区出现异常放射性分布浓聚影为阳性,显像结论与术后病理结果对照.结果56例乳腺癌腋下淋巴结显像阳性有19例,与病理对照,诊断乳腺癌腋下淋巴结转移的灵敏度为65.52%,特异性为100%,准确率为82.14%,阴性预测值为72.98%,阳性预测值为100%.结论99mTc-MIBI乳腺显像诊断乳腺肿瘤腋下淋巴结有较高的临床价值.

目的:探讨肺癌核素显像99mTc-MIBI滞留分数与P糖蛋白(Pgp)、增殖细胞核抗原(PCNA)和胎盘型谷胱甘肽-S-转移酶(GST-π)的关系.方法:12例肺癌病人术前分别作肺部早期和延迟99mTc-MIBI断层显像,计算肿瘤部位99mTc-MIBI滞留分数,与手术后肿瘤标本测定的Pgp、PCNA、GST-π水平作相关分析.结果:99mTc-MIBI滞留分数与Pgp明显负相关(r=-0.771 P＜0.01),而与PCNA、GST-π无显著意义的相关关系.结论:99mTc-MIBI滞留分数可能较好预测Pgp的水平,对由Pgp介导的肺癌细胞多药耐药性评估有价值.

目的:探讨99mTc-MIBI心肌显像对心肌炎患儿心肌损害的检测及评估价值.方法:对22例疑似心肌炎和40例心肌炎患儿进行99mTc-MIBI心肌断层显像,采用节段记分法对结果进行分析.结果:疑似心肌炎组有5例共8个节段(4.0%)显像异常;心肌炎组中30例共67个节段(18.6%)显像异常(P＜0.001).心肌炎组中11例伴心律失常的患儿心肌显像全部异常(P＜0.001).结论:99mTc-MIBI心肌断层显像对心肌炎患儿心肌损害检测及轻重程度的评估有较好的实用价值.