Functional dyspepsia (FD) in female patients can present with abnormal urinalysis results, which may differ from those of urinary tract infections (UTIs). This study is to analyze and compare the differences in urinalysis indicators between the two conditions. We retrospectively collected data from 120 female patients diagnosed with either FD or UTI, with 60 patients in each group. We analyzed and compared the levels of urinary abnormal indicators using the Mann-Whitney U test and Chi-square test. The predictive value of urinalysis abnormalities for diagnosing FD or UTI was evaluated using ROC curve analysis, sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), multivariate regression analysis, and a nomogram prediction model. Abnormal urinalysis in female FD patients differ from that in UTI patients. The best combined indicators for diagnosing FD or UTI were occult blood, urinary protein, and leukocyte esterase. A nomogram was created for visual prediction.

Background Subjective well-being (SWB) was subjective happiness, and it was also objective. Anxiety and depression are now gradually believed to be the causes of functional dyspepsia (FD). The influence of SWB was ignored in FD patients. To explore the influence of SWB on anxiety, depression, symptom severity and quality of life (QoL) in FD patients. Methods A total of 374 patients with FD were selected according to Roman IV criteria. Satisfaction with life scale and affect balance scale, Generalized anxiety disorders-7, Patient healthy questionnaire-9, Dyspepsia symptoms severity(DSS）and Nepean dyspepsia index(NDI） were used to assess SWB,anxiety, depression, symptoms severity and QoL, respectively. One-way variance analysis, t-test, Pearson’s correlation and multiple linear regression were used to analyze the results. Results Life satisfaction and emotional balance of FD patients were negatively correlated with DSS, anxiety, depression, and NDI for QoL（r=-0.148,-0.330,-0.325,-0.195， all P<0.01), (r=-0.205,-0.545,-0.550, -0.357, all P<0.001), respectively. Multiple linear regression showed that life satisfaction and emotional balance were influencing factors of anxiety（β= -0. 143, P=0.001）, (β= -0. 318, P<0.001)， and depression（β=-0. 122, P=0.003）, (β= -0. 287, P<0.001), respectively. After removing anxiety and depression, life satisfaction and emotional balance were influencing factors of patients' DSS （β= -0.105, P=0.049）, (β= -0.180, P=0.001), and QoL（β= -0.117, P=0.023）, (β= -0.329,P<0.001) ,respectively. Conclusions FD patients’ SWB negatively affects their disease severity, anxiety and depression, and positively affects their QoL. These results suggested that further strengthening SWB may help reduce symptom severity and improve the QoL of patients, which needs to be confirmed by future follow-up studies.

Subjective well-being (SWB) encompasses both subjective happiness and objective factors. Anxiety and depression are increasingly recognized as contributing causes of functional dyspepsia (FD), yet the role of SWB in FD patients has been largely overlooked. This study aims to investigate the influence of SWB on anxiety, depression, symptom severity, and quality of life (QoL) in individuals with FD. A total of 374 patients with FD were selected according to Roman IV criteria. Satisfaction with life scale and affect balance scale, Generalized anxiety disorders-7, Patient healthy questionnaire-9, Dyspepsia symptoms severity(DSS)and Nepean dyspepsia index (NDI) were used to assess SWB, anxiety, depression, symptoms severity and QoL, respectively. The results were analyzed using one-way analysis, t-test, Pearson’s correlation, and multiple linear regression. Life satisfaction and emotional balance of FD patients were negatively correlated with DSS, anxiety, depression, and NDI for QoL(r=-0.148,-0.330,-0.325,-0.195, all p < 0.01), (r=-0.205,-0.545, -0.550, -0.357, all p < 0.001), respectively. Multiple linear regression showed that life satisfaction and emotional balance were influencing factors of anxiety (β= -0. 143, p = 0.001), (β= -0. 318, P < 0.001), and depression (β=-0. 122, p = 0.003), (β= -0. 287, p < 0.001), respectively. After removing anxiety and depression, life satisfaction and emotional balance were influencing factors of patients’ DSS (β= -0.105, p = 0.049), (β= -0.180, p = 0.001), and QoL (β= -0.117, p = 0.023), (β= -0.329, p < 0.001), respectively. The SWB of FD patients is negatively associated with disease severity, anxiety, and depression, and positively associated with their quality of life. These results suggested that further strengthening SWB might help reduce symptom severity and improve the QoL of patients, which needs to be confirmed by future follow-up studies.

Background:To study the effect of restrictive blood transfusion on the safety of early rebleeding after endoscopic variceal ligation(EVL) in patients with liver cirrhosis.Methods:The patients with cirrhosis and esophageal varices who underwent endoscopic variceal ligation at the Affiliated Hospital of North Sichuan Medical College from September 2021 to March 2023 were collected. The clinical data such as serum albumin level, hemoglobin level, liver function classification and the incidence of early rebleeding were recorded. The patients were divided into restrictive red blood cell transfusion group and non transfusion group according to whether there was red blood cell transfusion during hospitalization. The influence of restrictive transfusion and non transfusion group on the postoperative safety of endoscopic variceal ligation was observed.Results:A total of 246 cirrhotic patients were included in the analysis. There were significant differences in hemoglobin level, liver function classification, early rebleeding rate, hospitalization days, and hospitalization expenses between the restrictive transfusion and the non transfusion groups. The early rebleeding rate was significantly different between the groups with different hemoglobin levels after operation. Multivariate logistic analysis showed that postoperative hemoglobin level(OR=0.964, 95%CI: 0.956–0.971;P<0.001) and preoperative albumin level(OR=0.910, 95%CI: 0.892–0.929;P<0.001) were independent influencing factors of early rebleeding.Conclusions:The higher the hemoglobin level of cirrhotic patients with esophageal varices after endoscopic variceal ligation, the lower the incidence of early rebleeding, and restrictive blood transfusion appeared to increase the risk of early rebleeding, which needs be further confirmed in future research.

Abstract Background To develop the modified 4-item version of Perceived Stress Scale (PSS) with a better reliability and validity than the 4-item version of PSS (PSS-4) in evaluating psychological stress in patients with functional dyspepsia (FD). The present study also aimed to explore the correlation between dyspepsia symptoms severity (DSS), anxiety, depression, somatization, quality of life (QoL), and psychological stress assessed by two approaches in FD. Methods A total of 389 FD patients who met the Roman IV criteria completed the 10-item version of the PSS (PSS-10), and 4/10 items were selected by five methods, such as Cronbach’s coefficient, exploratory factor analysis (EFA), correlation coefficient, discrete degree, and item analysis, to develop the modified PSS-4. The reliability and validity of the modified PSS-4 and the PSS-4 were compared by internal consistency, EFA, and confirmatory factor analysis (CFA). The correlation between psychological stress assessed by two approaches and DSS, anxiety, depression, somatization, and QoL was explored by Pearson’s correlation coefficient and multiple linear regression analysis. Results Cronbach’s α coefficient of the modified PSS-4 and the PSS-4 was 0.855 and 0.848, respectively, and a common factor was extracted. The cumulative contribution rate of one factor to the overall variance for the modified PSS-4 and the PSS-4 was 70.194% and 68.698%, respectively. The model used for the modified PSS-4 showed that the values of the goodness-of-fit index (GFI) and the adjusted GFI (AGFI) were 0.987 and 0.933, respectively, indicating that the model fitted well. Psychological stress was correlated to DSS, anxiety, depression, somatization, and QoL as assessed by the modified PSS-4 and PSS-4. Multiple linear regression analysis revealed that psychological stress was correlated to somatization, as assessed by the modified PSS-4 (β = 0.251, P < 0.001) and PSS-4 (β = 0.247, P < 0.001). Psychological stress, DSS, and somatization were correlated to QoL, as assessed by the modified PSS-4 (β = 0.173, P < 0.001) and the PSS-4 (β = 0.167, P < 0.001). Conclusions The modified PSS-4 showed better reliability and validity, and psychological stress had a greater effect on the somatization and QoL of FD patients assessed by the modified PSS-4 than PSS-4. These findings were helpful for further investigation of the clinical application of the modified PSS-4 in FD.

食管静脉曲张破裂出血是肝硬化常见的并发症，具有起病急、发展迅速、死亡率高的特点，因此，对肝硬化食管静脉曲张破裂出血的预防及治疗至关重要。防治分为一级预防、紧急止血、二级预防，主要包括药物治疗、内镜治疗、介入治疗及其他的联合治疗等。本文通过对食管静脉曲张出血防治的现状及研究进展作一综述。

目的:探讨服药信念干预在服用抗抑郁药物的功能性消化不良(F D)患者中的应用效果.方法:本研究为自身前后对照研究,选取2017年1月—2022年3月于川北医学院附属医院消化内科门诊诊断为FD的服用抗抑郁药物的患者327例,针对患者对抗抑郁药的不良认知及消极态度给予为期1年的认知干预.最终共269例(82.3％)患者完成了为期1年的随访研究.在干预前及干预1年后用服药信念特异性问卷、尼平消化不良指数简表(N D I)、消化不良症状严重度量表(DSS)、广泛性焦虑障碍量表(GAD-7)、患者健康问卷抑郁症状群

背景:功能性消化不良(FD)患者伴有不同程度的心理压力,临床医师对患者心理压力的量化评估不足.目的:探讨4项条目的知觉压力量表(PSS-4)与10项条目的知觉压力量表(PSS-10)评估的心理压力对FD患者的消化不良症状、焦虑、抑郁、躯体化和生命质量的影响.方法:采集2021年3月—2022年3月于川北医学院附属医院就诊的符合罗马Ⅳ标准的357例FD患者,并行PSS-4、PSS-10、7项广泛性焦虑障碍量表(GAD-7)、9项患者健康问卷(PHQ-9)、躯体化症状群量表(改编的PHQ-15)、消化不良症状严重程度量表(DSS)、Nepean消化不良指数简表(NDI)评分.分析PSS-4、PSS-10对FD患者的消化不良症状、焦虑、抑郁、躯体化和生命质量的影响.结果:相关性分析结果显示PSS-4(r=0.152,P=0.004)、PSS-10(r=0.194,P=0.000)与DSS相关;PSS-4(r=0.341,P=0.000)、PSS-10(r=0.389,P= 0.000)与改编的PHQ-15相关;PSS-4(r=0.239,P=0.000)、PSS-10(r=0.327,P=0.000)与NDI相关;PSS-4与焦虑(r= 0.561,P=0.000)、抑郁(r=0.449,P=0.000)相关;PSS-10与焦虑(r=0.680,P=0.000)、抑郁(r=0.524,P=0.000)相关.多元线性回归结果显示,PSS-4评估的心理压力(β=0.180,P=0.000)、DSS(β=0.390,P=0.000)、FD分型(β=-0.116,P= 0.024)是FD患者NDI的影响因素.PSS-10评估的心理压力(β=0.268,P=0.000)、DSS(β=0.360,P=0.000)、FD分型(β=-0.116,P=0.021)是FD患者NDI的影响因素.结论:PSS-4、PSS-10评估的心理压力对FD患者焦虑、抑郁、躯体化、DSS和NDI均有影响,但PSS-4更简短,临床上可用PSS-4快速初步评估心理压力对FD患者的影响.

Objective To explore the effect of illness perception interventions based on Meleis’s transitions theory on the rehabilitation of patients with functional dyspepsia. Methods 120 patients with functional dyspepsia were selected by convenient sampling in the outpatient department of gastroenterology of a tertiary A hospital in Nanchong,Sichuan Province from July to October 2021. They were divided into a control group and an experimental group with 60 cases in each group by SPSS 22.0 random number table method,and 20 cases were taken as a group to establish a Wechat group respectively. On the basis of routine outpatient care,the experimental group received illness perception interventions based on Meleis’s transitions theory;the control group received routine outpatient care and received relevant health education information through WeChat group. The duration of the intervention was 8 weeks. Data were collected by the Brief Illness Perception Questionnaire,Dyspepsia Symptoms Severity,the Affect Balance Scale,Nepean Dyspepsia Index-Short Form and so on. The cognitive level of disease,dyspepsia symptom severity,emotional balance and health-related quality of life of the 2 groups were compared before and after intervention. Results In the control group,3 cases were lost to follow-up. The cognitive level of disease and health-related quality of life of intra-group comparison and post-intervention comparison between the 2 groups were higher than those before the intervention;the severity of symptoms was lower than that before the intervention;the emotional balance was better than that before the intervention. The difference was statistically significant（P＜0.05）. After the intervention,the cognitive level of disease and health-related quality of life in the experimental group were higher than those in the control group;the severity of symptoms was lower than that in the control group;the emotional balance was better than that in the control group. The difference was statistically significant（P＜0.001）. Conclusion The illness perception intervention based on Meleis’s transitions theory is helpful to improve the cognitive level of disease in patients with functional dyspepsia,to reduce symptoms and negative emotions,and to improve health-related quality of life.

Abstract Background: To develop the modified 4-itemversion of the Perceived Stress Scale (PSS) as a better reliability and validity than the 4-item version of the PSS (PSS-4) in evaluating psychological stress in patients with functional dyspepsia (FD). Also, to explore the relationship between psychological stress assessed by two approaches and symptoms of FD. Methods: 389 FD patients who met the Roman IV criteria completed the 10-item version of the PSS (PSS-10) and 4/10 items were selected by five methods of Cronbach’s coefficient, exploratory factor analysis (EFA), correlation coefficient, discrete degree and item analysis to develop the modified PSS-4. Reliability and validity of the modified PSS-4 and the PSS-4 were compared by internal consistency, EFA and confirmatory factor analysis (CFA). The relationship between psychological stress assessed by two approaches and symptoms of FD were explored by Pearson’s correlation coefficient and multiple linear regression analysis. Results: The Cronbach’s α coeffcient of the modified PSS-4 and the PSS-4 was 0.855 and 0.848, respectively, and a common factor was extracted, respectively. The cumulative contribution rate of one factor to the overall variance for the modified PSS-4 and the PSS-4 was 70.194% and 68.698%, respectively. The model used for the modified PSS-4 showed that the values of the goodness of ft index (GFI) and the adjusted GFI (AGFI) were 0.987 and 0.933, respectively, which indicated that the model fitted well. Psychological stress assessed by the modified PSS-4 (r=0.302, P=0.000) and the PSS-4 (r=0.301, P=0.000) was found to be correlated to somatization. And psychological stress assessed by the modified PSS-4 (r=0.225, P=0.000) and the PSS-4 (r=0.220, P=0.002) was found to be correlated to quality of life (QoL). Multiple linear regression analysis unveiled that psychological stress (β=0.251, P=0.000), dyspepsia symptoms severity (DSS) (β=0.345, P=0.000) assessed by the modified PSS-4 were correlated to somatization. In addition, psychological stress (β=0.247, P=0.003), DSS (β=0.343, P=0.000) assessed by the PSS-4 were correlated to somatization. Psychological stress (β=0.173, P=0.000), DSS (β=0.283,P=0.000), somatization (β=0.216, P=0.000) assessed by the modified PSS-4 were correlated to QoL. In addition, psychological stress (β=0.167, P=0.000), DSS (β=0.281, P=0.000), somatization (β=0.219, P=0.000) assessed by the PSS-4 were correlated to QoL. Conclusions: The modified PSS-4 showed a better reliability and validity, and psychological stress assessed by the modified PSS-4 may has a greater effect on the somatization and QoL of FD patients as compared to the PSS-4. These findings were helpful for further research on the clinical application value of the modified PSS-4 in FD.

目的 探讨广泛性焦虑障碍量表-2(Generalized Anxiety Disorder-2,GAD-2)评估功能性消化不良(functional dyspepsia,FD)患者伴焦虑状态对疾病严重度、躯体化和生命质量的影响.方法 收集符合罗马Ⅳ标准确诊的FD患者440例,完成GAD-7、GAD-2、消化不良症状严重度量表(DSS)、躯体化症状群量表(改编的PHQ-15)以及尼平消化不良指数简表(NDI),与GAD-7比较,分析GAD-2评估焦虑状态的发生率,并探讨其与DSS、躯体化、NDI的关系.采用t检验、χ2检验、Spearman相关系数、多元线性回归分析进行统计分析.结果 GAD-2和GAD-7评估FD患者伴焦虑状态发生率分别为26.6％和17.3％(χ2=11.157,P=0.001).相关分析显示,GAD-2(r=0.178,P=0.000)和GAD-7(r=0.146,P=0.000)与DSS相关;GAD-2(r=0.342,P=0.000)和GAD-7(r=0.322,P=0.000)与躯体化(改编的PHQ-15)均相关;GAD-2(r=0.391,P=0.000)和GAD-7(r=0.406,P=0.000)与NDI均相关.多元线性回归分析显示,GAD-2量表评估的焦虑(β=0.184,P=0.000)、抑郁(β=0.238,P=0.000)、躯体化(β=0.537,P=0.000)是NDI的影响因素;GAD-7量表评估的焦虑(β=0.259,P=0.000)、抑郁(β=0.176,P=0.002)、躯体化(β=0.528,P=0.000)是NDI的影响因素.结论 GAD-2定性诊断FD患者伴焦虑状态可能更敏感,GAD-2评估焦虑状态对躯体化、DSS的影响可能较GAD-7更明显,这些结果提示临床上可用GAD-2快速评估FD患者伴焦虑状态.

目的:研究功能性消化不良(FD)患者血浆降钙素基因相关肽(CGRP)、神经肽S受体-1(NPSR1)、白介素-6(IL-6)的水平变化及临床意义.方法:选取136例FD患者,其中餐后不适综合征(PDS)组77例,上腹痛综合征(EPS)组59例,健康对照组40例,采用酶联免疫吸附法检测血浆中NPSR1、IL-6、CGRP的浓度.结果:FD组、PDS组和EPS组NPSR1水平较对照组明显减低(P<0.01),PDS组NPSR1水平低于EPS组(P<0.01);FD组、PDS组和EPS组CGRP水平较对照组明显减低(P<0.01),PDS组CGRP浓度明显低于EPS组(P<0.01);FD组、PDS组和EPS组中IL-6水平明显高于对照组(P<0.01),但PDS组IL-6水平明显低于EPS组(P<0.01).FD组中,NPSR1水平与IL-6水平正相关(P<0.01);PDS组中,NPSR1水平与CGRP水平正相关(P<0.01),与IL-6水平存在正相关(P<0.01);CGRP水平与IL-6水平正相关(P<0.01).结论:NPSR1、CGRP、IL-6参与FD的发生,在FD的发病中起重要作用;NPSR1、CGRP与PDS关系更密切,IL-6与EPS更密切;炎性反应激活自身免疫在FD的发生中起重要作用;NPSR1、CGRP和IL-6为判定FD患者不同亚型提供客观依据,作为FD患者病情评估的指标之一,有利于FD的分型和指导治疗.

目的 探讨汉防己甲素对恶唑酮诱导的小鼠溃疡性结肠炎(UC)的影响及其机制.方法 按照体重将雌性BALB/c小鼠随机均分为4组:空白组、模型组、对照组和实验组,每组10只.除空白组外,其余3组均给予恶唑酮灌肠制备UC模型.空白组和模型组小鼠给予0.9％NaCl,对照组给予柳氮磺吡啶肠溶片(0.5 g·kg-1溶于0.9％NaCl)灌胃,实验组给予汉防己甲素(40 mg·kg-1溶于0.9％NaCl)灌胃.对各组小鼠结肠进行组织学损伤指数(HI)评分,用免疫组化染色检测小鼠结肠核因子kappa B(NF-κB)p65、肿瘤坏死因子-α(TNF-α)和紧密连接蛋白闭合蛋白(occludin)的表达(灰度值).结果 空白组、模型组、对照组和实验组的小鼠结肠HI评分分别为0.73±0.52,22.70±1.88,12.08±1.22和12.30±0.92;这4组的小鼠结肠NF-кB p65表达水平分别为175.80±2.82,149.82±0.58,164.92±0.99和163.65±2.02;这4组的TNF-α表达水平分别为156.79±1.53,110.15±2.40,141.84±1.30和143.34±1.47;这4组的occludin表达水平分别为101.73±2.14,138.49±1.59,126.37±2.03和127.61±1.70.上述指标:模型组与空白组比较,差异均有统计学意义(均P<0.05);实验组和对照组与模型组相比,均有统计学意义(均P<0.05),表明汉防己甲素的疗效与柳氮磺吡啶肠溶片相当.结论 汉防己甲素能够减轻UC的炎症反应,从而改善UC的肠道病变,提高UC的黏膜屏障功能.

Background: To adapt insufficiencies of the Somatic Symptom Scale-8 (SSS-8) measuring somatization in functional dyspepsia (FD) to develop PHQ-8, of which reliability, validity and the effects of somatization evaluated by the developed PHQ-8 on quality of life (QoL) were further assessed. Methods: 612 FD patients completed a 25 items questionnaire. 8 items were selected from 25 items to constitute the PHQ-8 by discrete degree, correlation coefficient, factor analysis and Cronbach coefficient four methods. Reliability and validity for the PHQ-8 and the SSS-8 were compared by principal component and confirmatory factor analysis. The effects of somatization, depression and anxiety on the Nepean Dyspepsia Index (NDI) for QoL were explored by Pearson correlation coefficient and linear regression analysis. Results: Cronbach’s α coefficients for the PHQ-8 and the SSS-8 were 0.601, 0.553, and cumulative contribution rates of three extracted factors were 55.103%, 51.666%, respectively. Somatization evaluated by the PHQ-8(r=0.309, P<0.001) and the SSS-8 (r=0.281, P<0.001) were related to the NDI. The model for the PHQ-8 showed χ2=31.247, RMR=0.01, RMSEA=0.042, GFI=0.984. Linear regression analysis showed that somatization measured by the PHQ-8 (β=0.270, P<0.001), anxiety (β=0.163, P<0.001) and depression (β=0.136, P=0.003) were determinants of the NDI; somatization measured by the SSS-8 (β=0.250, P<0.001), anxiety (β=0.156, P<0.001) and depression (β=0.155, P =0.001) were determinants of the NDI. Conclusions: The developed PHQ-8 had a better reliability and validity, which assessing somatization appeared to have a greater impact on QoL than that of the SSS-8. These results suggested that the developed PHQ-8 might improve to study the effects of somatization on QoL instead of the SSS-8 in specific FD patients.

目的 探讨功能性消化不良(FD)患者外周血浆神经肽S受体-1(NPSR1)、降钙素基因相关肽(CGRP)、白介素6(IL-6)的水平变化与精神心理因素的关系.方法 选取136例FD患者,其中餐后不适综合征(PDS)组77例,上腹痛综合征(EPS)组59例,以同期40名健康人作为对照组,采用抑郁自评量表(SDS)、焦虑自评量表(SAS)对FD患者的焦虑、抑郁情况进行评估,采用ELISA法检测血浆中NPSR1、IL-6、CGRP的浓度,分析FD不同亚型NPSR1、IL-6、CGRP及其与焦虑、抑郁之间的相关性.结果 PDS组、EPS组的焦虑、抑郁评分均高于对照组(P＜0.01),PDS组焦虑评分高于EPS组(P＜0.01).PDS组中,SAS评分与SDS评分呈正相关(P＜0.05).FD组中,NPSR1水平与焦虑评分呈负相关(P＜0.01);PDS组中,NPSR1水平与焦虑评分呈负相关(P＜0.05).结论 FD患者存在明显焦虑、抑郁,精神心理因素与FD的发生密切相关,在PDS组患者中更明显,焦虑、抑郁对FD的发生起促进作用,它在FD不同亚型的发病中所起的作用存在差异.NPSR1参与调节FD患者的焦虑情绪,PDS组患者的焦虑情绪影响NPSR1的分泌,对焦虑或抑郁的FD患者进行药物治疗及心理治疗等综合治疗措施,能提高疗效,改善患者的生活质量.

Objective To explore the effects of cognitive intervention on the quality of life in patients with functional dyspepsia（FD）.Methods From May 2013 to February2015,a total of 412 patients with FD were enrolled,cognition of the disease and the quality of life were assessed by disease cognitive simple questionnaire（B-IPQ）and Nepean dyspepsia index（NDI）.The patients also re-

目的 探讨功能性消化不良(FD)患者躯体化与抑郁的相关性.方法 对279例FD患者行健康问卷躯体症状群量表(PHQ-15)及汉密尔顿抑郁量表(HAMD17)调查,统计分析抑郁与躯体化的分布、关系及具体躯体化症状对抑郁的影响.结果 FD患者抑郁状态发生率为41.2％,躯体化症状发生率为54.8％;FD、上腹痛综合征(EPS)、餐后不适综合征(PDS)、重叠组躯体化与抑郁皆呈正相关(r =0.546,P=0.000;r =0.564,P=0.000;r=0.437,P=0.002;r =0.628,P=0.000);线性回归分析发现四肢或关节痛、头痛、胸痛、头晕、气促、恶心、胀气或消化不良、感到疲乏是影响抑郁较为明显的因素(β=0.226,P=0.032;β =0.285,P=0.011;β =0.011,P=0.000;β=0.280,P=0.024;β =0.563,P=0.000;β =0.453,P=0.001;β =0.322,P=0.002).结论 FD患者的躯体化症状及抑郁状态常见,二者之间具有显著相关性,临床工作中重视这些症状及抑郁对FD的影响对总体治疗有益.

目的:探讨功能性消化不良(FD)的临床特点及躯体化症状,为临床提供依据.方法:分析1088例FD患者的临床资料,采用焦虑/抑郁量表(SAS/SDS)、消化不良症状量表、躯体化量表评分,研究性别、年龄、体重指数(BMI)、文化程度、病程、病情严重程度、临床特点、躯体化、焦虑抑郁情况.结果:性别:FD患者中,女性明显多于男性(72.1％ vs27.9％)(p＜0.05);年龄:40～49岁和50～60岁(45.6％、41.2％),(p＜0.05);BMI:18～24之间(78.7％)(p＜0 05);学历:小学和初中为主(552例、328例)(50.7％、30.2％) (p＜0.05);SAS:PDS组50～60分408例(66.2％),EPS组SAS＜50分200例,50～60分248例(42.4％、52.5％)(p＜0.05);SDS:PDS组SDS＜50分136例,50～59分440例(22.1％、71.4％),EPS组SDS＜50分176例,50～59分272例(37.3％、57.6％)(p＜0.05);症状比较:消化不良864例(79.4％),疲乏848例(77.9％),腹痛816例(75.0％),餐后饱胀768例(70.6％),口干768例(70.6％),麻木688例(63.2％),健忘656例(60.3％),咽痛640例(58.8％).结论:FD发病年龄在40-60岁之间,以女性多见,小学或初中学历为主,与年龄、性别、文化程度、焦虑抑郁状况关系密切,以轻中度焦虑、抑郁为主,以消化不良、乏力、腹痛、餐后饱胀、口干、麻木、咽痛等症状为主,早诊断、早治疗有利于改善患者预后.

背景:焦虑、抑郁、躯体化是影响功能性消化不良(FD)患者生活质量的重要因素,但与FD各亚型之间的关系尚不完全清楚.目的:探索焦虑、抑郁和躯体化对FD各亚型患者的影响.方法:应用焦虑自评量表(GAD-7)、抑郁自评量表(PHQ-9)、躯体化症状自评量表(PHQ-15)、悉尼消化不良指数简表(NDI)和消化不良症状严重度量表(DSS)分别评估223例FD患者的焦虑、抑郁、躯体化、生活质量和消化不良严重度,并分析焦虑、抑郁、躯体化对FD各亚型生活质量和消化不良的影响.结果:EPS、PDS和EPS与PDS重叠组的GAD-7、PHQO、PHQ-15、NDI、DSS评分相比差异有统计学意义(P＜0.05).FD各亚型患者的生活质量与焦虑、抑郁和躯体化均相关(P＜0.05),而消化不良严重度仅与躯体化相关(P＜0.05).抑郁和躯体化是影响FD各亚型患者生活质量的因素(P＜0.05),躯体化是影响各亚型患者消化不良的因素(P＜0.05).结论:EPS与PDS症状重叠患者的焦虑、抑郁、躯体化较EPS、PDS患者严重,对生活质量和消化不良的影响亦更大.