Background: The accuracy of dynamic renal scintigraphy in evaluating the function of hydronephrotic kidneys is controversial. This study sought to investigate the effects of ureteral obstruction on renal function and the role of the protein load test (PLT) in evaluating hydronephrotic kidneys' function. Methods: A ureteral obstruction model was generated with New Zealand white rabbits. The baseline glomerular filtration rate (GFR) and the GFR during the PLT were measured by dynamic renal scintigraphy at weeks 6, 9, and 12 after obstruction and the renal reserve GFRs were calculated. The renal GFR differences between different time points and between the PLT and baseline status were compared. Results: (I) Both the baseline GFRs (t=11.287, P=0.000) and the GFRs during the PLTs (t=16.235, P=0.000) of the hydronephrotic kidneys were significantly lower than those of the contralateral kidneys. (II) The baseline GFRs of the obstructed kidneys were not significantly different 6, 9, and 12 weeks after obstruction (F=0.122, P=0.887), but their net reserve GFRs (F=8.419, P=0.004) and relative reserve GFRs (F=3.770, P=0.049) gradually decreased over time. (III) There was no significant correlation between the net reserve GFRs (r=-0.006, P=0.977) or the relative reserve functions (r=-0.022, P=0.920) of the obstructed kidneys and their baseline GFRs. However, there was a significant negative correlation between the net reserve GFRs (r=-0.590, P=0.002) or the relative reserve functions (r=-0.546, P=0.006) of the obstructed kidneys and the duration of obstruction. (IV) The reserve GFRs of the obstructed kidneys were not proportional to their baseline GFRs. Conclusions: The functional changes in hydronephrotic kidneys are not sensitively reflected by baseline GFRs. GFRs during the PLTs and the reserve GFRs play important roles in the early and accurate evaluation of the function of obstructed kidneys.

BackgroundIt is controversial to evaluate the function of hydronephrotic kidneys by renal dynamic imaging (RDI). Our aim was to study the features of renal dynamic imaging (RDI) at different stages after unilateral ureteral obstruction (UUO) and to investigate a method that could be reasonably used to evaluate renal function and predict renal functional recoverability.MethodsWe made UUO models using fifteen adult New Zealand white rabbits and systematically observed the changes in kidney morphology, blood flow, radiotracer distribution and function by RDI. We then compared the differences in terms of imaging features between different periods and analyzed the relationship between blood flow and function in obstructed kidneys.Results1) Obstructed kidneys gradually became larger than preoperative kidneys and contralateral kidneys (P<0.05) and reached their peak size between days 42 and 56, after which they gradually got smaller in size. 2)The correlation between the blood perfusion of the obstructed kidney and the obstruction duration (r = 0.125, P = 0.045) was very weak. In the initial period of obstruction, the perfusion of the obstructed kidney significantly decreased, followed by a sharp rebound in later days, and then the perfusion declined again. The peak in blood perfusion was on day 7. 3) The uptake rate of the obstructed kidney drastically decreased in the early stage and became lower than that of the contralateral kidney and the kidney before the operation (P<0.05), after which uptake increased gradually; the peak was on day 28. After that, uptake gradually decreased. 4) The grading of the radiotracer distribution in obstructed kidneys was positively correlated with the obstruction duration (r = 0.975, P = 0.000), and a uniform renal distribution was an early feature of obstruction. 5) The blood perfusion of the obstructed kidney and its functioning frequently increased or decreased simultaneously, but sometimes there was also a mismatch. The peak of renal blood perfusion recovery occurred prior to the peak of renal function recovery.ConclusionIn different periods of severe UUO, the imaged features of obstructed kidneys were different. These features are beneficial for determining the degree of hydronephrosis and renal function and predicting renal functional recoverability.

本文根据流行性传染病的特点,制定了新型冠状病毒肺炎期间的病案管理流程:将电子病历的打印时间延后,打印地点调整为病案科的清洁区域,对特殊纸质病历的保管和消毒流程进行了规范,以降低纸质病案的污染风险;线上办理病案复印和电子版病案复制件的运用,以消除传统病案复印环节人群聚集的感染风险;对特殊纸质病历和电子病历的三种归档方式进行比较后发现,无纸化病案管理流程是疫期阻断病案纸张的病原传播途径、降低医院感染风险的最佳方案.

Objective. To investigate the influence of early bladder imaging (EBI) in experimental rabbits on the quantitative calculation of glomerular filtration rate (GFR) by the Gates method. Methods. We retrospectively analyzed the data of dynamic renal scintigraphy (DRS) in experimental rabbits. We calculated renal uptake during minutes 1-2 and 2-3 by correcting bladder radioactivity and computed the split GFR by renal uptake. Then, the EBI and GFR between 1-2 min and 2-3 min were compared, respectively. Results. The EBI proportion (57.3%) at 2-3 min of DRS was higher than that (8.5%) at 1-2 min (P<0.05). The correlations between the 1-2 min and 2-3 min uptake rates of unobstructed kidneys after correction (r=0.952-0.979) were higher than those before correction (r=0.859-0.936). However, the correlation between the two in obstructed kidneys was not improved (r(before)=0.967 versus rafter=0.968). For unobstructed kidneys, the difference in GFR based on 2-3 min uptake between before and after correction was significant (P<0.05), but not in obstructed kidneys (P>0.05). For GFR based on 1-2 min uptake, the difference between before and after correction was not significant in obstructed or unobstructed kidneys (P>0.05). Before correction, the GFR of unobstructed kidneys of 10.5% of the rabbits in the protein load test was lower than that in the baseline status, but not so after correction. Conclusion. The 2-3 min EBI on DRS has a significant influence on the GFR calculated by the Gates method in experimental rabbits. Controlling water intake or calculating the GFR by 1-2 min renal uptake helps to avoid the influence of EBI on GFR.

Background: There is a lack of consensus concerning changes in renal function after unilateral ureteral obstruction. The aim of this study was to assess the influence of ureteral obstruction on renal morphology and function and to explore the effectiveness of dynamic renal scintigraphy in evaluating obstructive renal function. Methods: We established a model of right ureteral obstruction using New Zealand white rabbits. We measured the glomerular filtration rate (GFR) before the operation and from days 1 to 82 after obstruction, observed the changes in bilateral kidney sizes and the GFR, and then compared the differences between the left and right kidneys. Results: The difference between left and right kidney sizes was not significant before obstruction (t=-0.430, P=0.674); the right kidneys increased in size after obstruction and were larger than the left kidneys (P <= 0.001). Obstructed kidneys demonstrated a morphological process of decelerated expansion and retraction. The difference in GFR between the left and right kidneys was not significant before obstruction (t=1.77, P=0.098); during days 1-21 and 42-82 after obstruction, the GFR of the right kidneys decreased and was lower than that of the left kidneys (P<0.001); on day 28, the GFR difference between the left and right kidneys (t=1.62, P=0.130) and the difference in the right kidney GFR before and after obstruction (t=1.03, P=0.323) were not significant. The GFR of obstructed kidneys rapidly declined initially, experienced a tortuous process of repeated dormancies and multiple self-recoveries, and then gradually declined. Conclusions: The GFR in hydronephrotic kidneys is fluctuating. Thus, evaluating the true function of hydronephrotic kidneys using only baseline GFR is difficult; however, combining baseline GFR with renal morphology to assess obstructive renal function and its recoverability can provide more meaningful results.

目的 分析湖北省紧急医学救援实战演练暨考核模式(简称湖北模式)在多省军民融合紧急医学救援实战演练使用效果,为卫生应急技能演练提供参考方案.方法 收集参加多省军民融合紧急医学救援实战演练的7省12支队伍的成绩,并进行比较分析.结果 本次演练难度最大的是理论站点,难度系数为0.386,难度最小的是紧急集结,难度系数为0.931;湖北队在专业理论、急妇产、传染病、野外宿营、检伤分类、综合处置成绩上分别为49.00±2.71、86.00±8.49、85.00±1.41、29.00±1.41、139.25±1.77、77.00±7.07;与其他参演队伍比较有统计学差异(P<0.05).结论 本模式考核难度适宜,可考核性强,可在更大范围内推广应用.

目的:研究4-羟基-2,2,6,6-四甲基哌啶基-N-氧化物(Tempol)对小鼠缺血再灌注急性肾损伤的保护作用及其机制.方法:将60只小鼠随机分为正常对照组、缺血/再灌注组(I/R)、缺血/再灌注组+Tempol组(I/R+Tempol).I/R+Tempol组灌胃Tempol,其他小鼠灌胃等量生理盐水.实验4周后,测血中Cr、BUN及肾组织中SOD、CAT、O2-含量,然后处死小鼠,检测肾脏组织Akt、P-Akt、及Nrf2蛋白及mRNA的表达.结果:经Tempol处理后的小鼠能够显著提高Akt、P-Akt、及Nrf2蛋白及mRNA表达,显著降低小鼠血清中Cr、BUN水平,提高肾组织中O2-、SOD、CAT含量.结论:Tempol对小鼠缺血/再灌注急性肾损伤有保护作用,通过清除自由基,激活PI3K/Akt/Nrf2信号通路,减少机体氧化应激损伤,提高抗氧化酶活性.此研究为临床治疗急性肾损伤提供理论基础,为以后开展患者的特异性治疗打下基础.

Objective:To explore the clinical characteristics and pathogenesis of acute non-traumatic chest pain in different gen-ders. Methods:525 cases of acute non-traumatic chest pain patients in this study,divided into two groups according to gender,male group of 281 cases,244 cases of female group,the basic data,clinical features and pathogenesis were compared in two groups. Results:There were significant differences in age, smoking history and drinking history between the two groups (P＜0. 05). There were no sig-nificant differences in high blood pressure,high cholesterol and the history of diabetes (P＞0. 05). Compared the pain incentives,the nature of pain,pain time and the complication,the differences were statistically significant (P＜0. 05). Compared the electrocardio-gram,echocardiography ST-T segment changes,left ventricular function and other indicators,the differences were not statistically signifi-cant (P＞0. 05). Two groups of patients with acute non-traumatic cardiac chest pain were mainly cardiogenic chest pain,men had a higher incidence of 31~82 years old,while women mainly occurred at 71~82 years old. Conclusion:Acute non-traumatic chest pain in patients with different sex-cardiac chest pain are the main pathogenesis of different ages vary,clinical diagnosis and treatment process should be accurate treatment plan based on the characteristics of the disease,so that high-risk patients can receive treatment timely.

Objective:To study the immune regulation effect of Lipoxin A4 (LXA4) on CD4+ T ceils and the protective effect on germ cells in testicular ischemia and reperfusion injury in rats.Methods:Forty rats were randomly divided into 4 groups:sham group(A);testicular torsion group(B);torsion/detorsion (T/D) group(C),T/D plus LXA4-pretreated group(D).Biochemical analysis (IFN-γ,IL-2,IL-4,IL-10,MDA,SOD and GPx in the testes),apoptosis assessment of germ cells,and morphologic evaluation were carried out after orchiectomies.Results:Compared with group A,the levels of proinflammatory cytokines (IFN-γ,IL-2) and MDA were significantly increased in the testes (P＜0.05),and the levels of SOD and GPx were decreased after testicular torsion.Compared with B and C,the levels of IL-4,IL-10 and tissue SOD/GPx were significantly increased (P＜0.05) in group D,while IFN-y,IL-2 and MDA levels were significantly decreased.In addition,the AI (apoptosis index) values of group D was significantly lower than group B and C (P＜0.05),whereas Johnsen score was significantly increased (P＜0.05).Furthermore,swollen mitochondria with degenerated cristae and enlarged intercellular spaces were observed under transmission electron microscopy in group D.Conclusion:LXA4 can regulate cytokine secretion of CD4+ T cells and reduce the inflammation injure to germ cells,thus protecting reproductive function in testieular ischemia-reperfusion in rats.

Objective To investigate the variations of glomerular function in rabbits with partial unilateral ureteral obstruction (PUUO). Methods Thirty healty adult Japanese White Rabbits were randomly divided into the control group (6 rabbits) and the obstruction group (24 rabbits). The right PUUO model was established according to Cheng′s method. According to the PUUO duration, they were eaqually divided into four subgroups:the 7 day PUUO group, the 14 d PUUO group, the 28 d PUUO group and the 56 d PUUO group. The dynamic renal imaging was performed on all rabbits, and the glomerular filtration rate (GFR) was also calculated. The correlation between the renal function and PUUO duration was analyzed , and functional variations in the healthy kidneys were observed. Results (1)To the control group, no significant difference in the renal function was found between the left and the right kidneys (t = -0.145, P = 0.894). However, to the PUUO group, the right renal GFRs were significantly lower than the left renal GFRs (P < 0.05). (2) To the right renal GFR, significant difference was observed between the 7 day PUUO group and the control group (t = 5.066, P = 0.001),but not among the 7 day PUUO group, the 14 day PUUO group, the 28 day and the 56 day PUUO group (P > 0.05), (3)No significant differences were found in the left renal GFRs among the five groups. Conclusions The function of PUUO kidneys is characterized by an obvious decrease in the early stage, followed with a steady state. The basic function of the opposite healthy kidney does not present the compensation phenomenon.

Objectives: To investigate the effects of bed width on the quality of chest compressions during simulated in-hospital resuscitation.Methods: Each candidate performed two 2-minute cycles of compression-only cardiopulmonary resuscitation on an adult manikin placed on either an emergency stretcher (narrow bed) or a standard hospital bed (wide bed) in random order at 1 day intervals. We conducted subjective assessments of cardiopulmonary resuscitation quality and rescuer fatigue at the end of each session, using surveys.Results: There were no significant differences between narrow and wide bed sessions in either mean depth or the percentage of compressions with adequate depth (P = .56 and .58, respectively). The mean rate of compressions and the percentage of compressions with adequate rate were also similar between sessions (P = .24 and .27, respectively). However, the percentage of correct hand position and complete chest recoil was significantly higher in the narrow bed session than in the wide bed session (P = .02 and .02, respectively). In addition, survey results showed that rescuers felt more comfortable and less exhausted in the narrow bed session compared with the wide bed session (P < .001 and < .001).Conclusions: When rescuers performed chest compressions on an emergency stretcher, chest compression quality increased, and the fatigue of rescuers decreased compared with a standard hospital bed. Therefore, we propose a narrow bed for critically ill inpatients with high risk of cardiac arrest. (C) 2016 Elsevier Inc. All rights reserved.

Primary hyperplasia of parathyroid is uncommon and rarely documented in literatures. We report an 18-year-old female patient with hyperparathyroidism due to unifocal primary hyperplasia of parathyroid glands. Dual-phase Tc-MIBI imaging was performed for this patient. We found remarkably increased MIBI uptake in the hyperplastic lesion in early imaging and no extinction of the uptake in delayed imaging. These results suggest that the dual-phase Tc-MIBI imaging is useful in localizing the hyperfunctioning lesions of primary hyperplasia of parathyroid glands.

BACKGROUND:Kaempferol has been reported as beneficial for both acute and chronic inflammatory diseases. This study aims to investigate whether kaempferol affects systemic inflammation and oxidative stress in the heart, lung, and liver after hemorrhagic shock in mice. METHODS:Male C57/BL6 mice underwent hemorrhagic shock (mean arterial pressure of 35 mmHg for 90 min) and were arbitrarily divided into Sham, hemorrhagic shock (HS), and Kae groups (n = 10 in each group). Mice in the Kae groups received a kaempferol (10-mg/kg body weight) injection 12 h prior to (Group Kae PT) or 90 min after (Group Kae T) the initiation of hemorrhagic shock. Plasma proinflammatory cytokines (TNF-α and IL-6), organ myeloperoxidase (MPO) and superoxide dismutase (SOD) activities, and organ malondialdehyde (MDA) concentrations and heme oxygenase-1 (HO-1) expression levels were assessed by enzyme-linked immunosorbent assay (ELISA) or western blot assay. RESULTS:Compared with the HS group and the Kae T group, pretreatment with kaempferol significantly decreased proinflammatory cytokines TNF-α (P = 0.012 and 0.015, respectively) and IL-6 (P = 0.023 and 0.014, respectively) following hemorrhagic shock. Kae pretreatment reverted MPO, SOD, and MDA to basal levels in the heart, lung, and liver (Ps < 0.05), while the Kae T group showed no significant differences in these biomarkers compared with the HS group (Ps > 0.05). HO-1 expression was significantly increased in the Kae PT group compared with the other groups (P = 0.011 vs. HS group and P = 0.02 vs. Kae T group). CONCLUSIONS:Pretreatment of hemorrhagic shock mice with kaempferol significantly decreased plasma levels of TNF-α and IL-6; reverted MPO, SOD, and MDA in the heart, lung, and liver; and increased expression of HO-1 in the same organs.

Previous studies have shown improved external chest compression (ECC) quality and delayed rescuer fatigue when the dominant hand (DH) was in contact with the sternum. However, many rescuers prefer placing the non-dominant hand (NH) in contact with the sternum during ECC. We aimed to investigate the effects of up-down hand position switch on the quality of ECC and the fatigue of rescuers during cardiopulmonary resuscitation (CPR). After completion of a review of the standard adult basic life support (BLS) course, every candidate performed 10 cycles of single adult CPR twice on an adult manikin with either a constant hand position (CH) or a switched hand position (SH) in random order at 7-day intervals. The rescuers' general characteristics, hand positions, physiological signs, fatigue appearance and ECC qualities were recorded. Our results showed no significant differences in chest compression quality for the DH position rescuers between the CH and SH sessions (p>0.05, resp.). And also no significant differences were found for Borg score (p = 0.437) or cycle number (p = 0.127) of fatigue appearance after chest compressions between the two sessions. However, for NH position rescuers, the appearance of fatigue was delayed (p = 0.046), with a lower Borg score in the SH session (12.67 ± 2.03) compared to the CH session (13.33 ± 1.95) (p = 0.011). Moreover, the compression depth was significantly greater in the SH session (39.3 ± 7.2 mm) compared to the CH session (36.3 ± 8.1 mm) (p = 0.015). Our data suggest that the up-down hand position switch during CPR may delay the fatigue of non-dominant hand position rescuers and improve the quality of chest compressions.

Objective To investigate the correlation between plasma von Willebrand factor(vWF) and the extent of coronary artery lesion in acute coronary syndrome (ACS).Methods One hundred and forty eight ACS patients (ACS group) who performed coronary angiography (CAG) were divided into single stenosis group (54 patients),double stenosis group (51 patients) and multitude stenosis group (43 patients) by the number of stenosis through CAG.They were divided into mild group (Gensini score ≤ 20 points,31 patients),midrange group (Gensini score 21-40 points,47 patients) and severe group (Gensini score ≥ 41 points,70 patients).Fifty patients with stable angina pectoris (SA) were randomly selected and classified as SA group,while 50 patients with healthy coronary were randomly selected as control group.Blood sample of 248 patients were collected to detect the level of vWF,and blood routine examination,blood clotting function,liver and renal function,high sensitivity C-reactive protein (hs-CRP),blood glucose,blood fat were detected.The correlation between vWF and the extent of coronary artery lesion were analyzed.Results The level of white blood cell count (WBC) and hs-CRP in ACS group were significantly higher than those in SA group and control group (P ＜ 0.05).But the level of WBC and hs-CRP between SA group and control group had no significant difference (P ＞ 0.05).The level of blood platelet count,prothrombin time,partial prothrombin time,fasting blood glucose,thrombin time,2 h postprandial glucose,triglyceride,total cholesterol had no significant difference among three groups (P ＞ 0.05).The level of vWF in ACS group was significantly higher than that in SA group and control group [(143.25 ± 20.42)％ vs.(102.77 ± 11.84)％,(97.63 ± 10.31)％] (P ＜0.05).The level of vWF in single stenosis group,double stenosis group and multitude stenosis group was (127.34 ± 9.35)％,(144.81 ± 12.02)％,(159.55 ± 18.62)％,and significantly higher than that in control group (P ＜ 0.01).The level of vWF in mild group,midrange group and severe group was (124.77 ± 14.31)％,(132.53 ± 16.38)％,(155.06 ± 18.53)％,and significantly higher than that in control group (P ＜ 0.01).The level of vWF had significantly positive correlation with the number of stenosis and Gensini score (r =0.698,0.683,P ＜ 0.01).Conclusion The level of vWF in peripheral blood is closely related with the severity of ACS and has important clinical significance in evaluating the condition and guiding therapy in patients with ACS.

Purpose. To investigate the protective effects of lipoxin A4 (LXA4) in rat testis injury following testicular torsion/detorsion. Methods. A rat testicular torsion model has been established as described. Rats were randomly divided into 6 groups: sham group, torsion group, torsion/detorsion (T/D) group, and T/D plus LXA4-pretreated groups (3 subgroups). Rats in LXA4-pretreated groups received LXA4 injection (0.1, 1.0, and 10 μg/kg body weight in LXA4-pretreated subgroups 1–3, resp.) at a single dose 1 h before detorsion. Biochemical analysis, apoptosis assessment, and morphologic evaluation were carried out after orchiectomies. Results. GPx and SOD levels significantly increased and MDA levels significantly reduced in LXA4-pretreated groups compared to T/D group. LXA4 also reverted IL-2 and TNF-α to basal levels and improved the expression of IL-4 and IL-10 in LXA4-pretreated groups. Moreover, the expression of NF-κB was downregulated in LXA4-pretreated groups. LXA4 treatment also showed an improved testicular morphology and decreased apoptosis in testes. Conclusion. Lipoxin A4 protects rats against testes injury after torsion/detorsion via modulation of cytokines, oxidative stress, and NF-κB activity.

Objective To investigate the effects of the unbalance of CD4+T cell subgroups on germ cell apoptosis during rat testicular torsion. Methods Male SD rats were randomly divided into three groups and there were 10 rats in each group. For rats in sham operation group, they served as the control;For rats in left unilateral testicular torsion group, their left testes were rotated 720 degree for 2 hours;For rats in left testicular torsion reset group, their testes were reseted after 2 hours testicular torsion. At 24 hours after operation, levels of serum cytokines IFN-γ, IL-12, IL-4 and IL-10 were measured by ELISA. Germ cell apoptosis index in left testes of the rats was determined by TUNEL. Results Compared with that of the sham operation group, the levels of Th1 type cytokines were significantly increased in torsion and detorsion groups(P<0.05). The levels of Th2 type cytokines such as IL-4, IL-10 were obviously lower in torsion and detorsion groups than that in sham operation group (P<0.05). CD4+T cell subgroups was unbalance during testicular torsion in rats. The apoptosis index of germ cells was significantly higher in torsion and detorsion groups than that of sham operation group. Conclusion CD4+T cell subgroups is unbalance in ischemia reperfusion injury in rat testis, which may be associated with germ cell apoptosis.

Objective To investigate a reproducible model of severe crush injury (CI) in rats.Methods A total of 50 clean grade male SD rats were randomly (random number) divided into 5 groups.Both hindlimbs of anesthetized rats were compressed by blocks weighing 3.5 kg,for 6 hours and followed by 3 hours of reperfusion on a specially notched device (group SP,n =10),ordinary compression (group NM,n =10) and simple control (group SHAM,n =10).Arterial tension,serum lactate,and potassium (K+),serum myoglobin (MB),aspartate transferase (AST) and alanine transferase (ALT),BUN and Cr were measured at 10 minutes after cannulaton,and 3 hours after release from compression.Muscles and kidneys were evaluated morphologically.Group D and E were treated in the same way and were observed for 72 h to get the survival rate of the NM group and the specially notched compression group.The SPSS 17.0 statistical software was used for statistical analysis,repeated-measures ANOVA analysis for the differences between groups,Kaplan Meier-estimator for survival analysis.Results The Specially notched compression produced a greater increase in serum lactate (F =39.626,P ＜ 0.05),AST (F =24.965,P ＜ 0.05),ALT (F =19.096,P＜0.05),BUN (F=7.938,P＜0.05),CR (F=14.787,P＜0.05) and MB (F=16.840,P ＜0.05) by the end of experiment than NM group and simple control group.The direct cellular damage and ischemia-reperfusion injury were found under microscope.In crush injury caused by specially notched compression there was acute tubular necrosis found at 24 hours after injury.Mortality rate in the NM group was 20％,whereas mortality rate reached 90％ in rats with specially notched compression (P ＜0.05).Conclusions It successfully developed a severe crush injury model in experimental rats,suggesting it is worthwhile to popularization.

目的比较分析地塞米松用于重度中暑的早期治疗效果研究。方法选择回顾性分析本院重度中暑的临床资料,随机选取65例为研究对象。其中,早期地塞米松治疗组31例,常规治疗组34例,比较分析两组疗效。结果常规治疗组呼吸频率为(29.3±3.54)次/min,高于地塞米松组;常规治疗组动脉血氧分压PaO2,HCO3-浓度依次为(77.20±11.35)mmHg,(16.98±4.91)mmol/L,均低于地塞米松组;常规组病死率为23.53%,高于地塞米松组6.45%。结论重度中暑早期地塞米松干预可更好改善患者体征,提高治疗效果。