Introduction:The emergence of the Omicron variant has seen changes in the clinical and radiological presentations of COVID-19 in pediatric patients. We sought to compare these features between patients infected in the early phase of the pandemic and those during the Omicron outbreak.Methods:A retrospective study was conducted on 68 pediatric COVID-19 patients, of which 31 were infected with the original SARS-CoV-2 strain (original group) and 37 with the Omicron variant (Omicron group). Clinical symptoms and chest CT scans were examined to assess clinical characteristics, and the extent and severity of lung involvement.Results:Pediatric COVID-19 patients predominantly had normal or mild chest CT findings. The Omicron group demonstrated a significantly reduced CT severity score than the original group. Ground-glass opacities were the prevalent radiological findings in both sets. The Omicron group presented with fewer symptoms, had milder clinical manifestations, and recovered faster than the original group.Discussion:The clinical and radiological characteristics of pediatric COVID-19 patients have evolved with the advent of the Omicron variant. For children displaying severe symptoms warranting CT examinations, it is crucial to weigh the implications of ionizing radiation and employ customized scanning protocols and protective measures. This research offers insights into the shifting disease spectrum, aiding in the effective diagnosis and treatment of pediatric COVID-19 patients.

目的 探讨磁共振成像(MRI)多模态技术在超声靶向微泡爆破技术(UTMD)联合量子点(QDs)加载多西紫杉醇抗肿瘤药物[简写为CA-(Q-D-lip)]精准示踪和靶向治疗大鼠C6胶质瘤的应用价值.方法 选择80只雄性成年健康SD大鼠,分为对照组及4个不同治疗组{QDs溶液+超声爆破治疗组(Q-D+UTMD组)、空白脂质体+超声爆破治疗组(Blank lip+UTMD组)、QDs脂质体+超声爆破治疗组(Q-D-lip+UTMD组)和纤连蛋白靶向肽修饰的QDs脂质体+超声爆破治疗组[CA-(Q-D-lip)+UTMD组]},每组16只.治疗组从大鼠接种C6胶质瘤细胞后第7天开始定期给药,28 d内共接受7次给药.每次给药后立即行UTMD治疗,各组给药后第7、14、21、28天进行胶质瘤MRI常规、动态增强扫描及多扩散敏感因子(b)值扩散加权成像及荧光成像.计算增强MRI后胶质瘤体积;依据时间-信号强度曲线(TIC)特征,计算早期相对信号强化率(ARSER);分析不同数学扩散模型的评价效能.荧光成像仪检测胶质瘤QDs的分布特点,胶质瘤中靶向肽脂质体的靶向性.分析各组C6胶质瘤在同一及不同时间内体积变化、TIC信号强度差值及ARSER比较、多b值扩散加权成像中的多参数差异分析.结果 各组ARSER>60％.CA-(Q-D-lip)+UTMD组治疗后体积缩小最明显,ARSER最小,效果优于其他4组;CA-(Q-D-lip)+UTMD组随时间增加,表观弥散系数(ADC)、D、Dapp值整体呈上升趋势,Kapp、D*及f值呈下降趋势;其余4组随时间增加,ADC、D、Dapp值呈下降趋势,Kapp、D*及f值呈上升趋势;这些参数综合比较,ADC值相对稳定可靠,诊断效能较高;CA-(Q-D-lip)+UTMD组QDs量分布最多(第7天).结论 MRI多模态成像可精确评价CA-(Q-D-lip)+UTMD治疗胶质瘤的疗效.

Objective:To investigate the CT and MRI features of meningiomas of the skull.Methods:A retrospective analysis was performed; the CT and MRI findings of 20 patients with meningiomas of the skull confirmed by pathology after surgery in our hospital from January 2008 to December 2020 were collected.Results:Fourteen patients had skull osteolytic destruction, 4 had osteogenic destruction, and 2 had mixed destruction. There were 12 patients with soft tissue masses and 11 with radial spicules. In 16 patients accepted CT examination, uniform density was noted in 10 and uneven density in 6; 8 had high density, 5 had equal density, and 3 had low density; 5 patients were with calcification. In 17 patients accepted MRI examination, 11 had uniform signal and 6 had un-uniform signal; T1WI had slightly low signal in 12 patients and equal signal in 5 patients; T2WI had slightly high signal in 12 patients and slightly low signal in 5 patients; diffusion weighted imaging (DWI) had high signal in 12 patients and slightly high signal in 5 patients. Totally, enhanced homogeneous enhancement was noted in 12 patients and inhomogeneous enhancement was noted in 8 patients; and there were 13 patients with "meningeal tail sign" and 11 with peritumoral edema.Conclusion:Bone in patients with meningiomas of the skull is characterized by osteolytic or osteogenic destruction with soft tissue masses and radial spicules; CT shows uniform or un-uniform tumor density, MRI shows uniform or un-uniform signals, and enhanced "meningeal tail sign" is characterized.

Purpose: By analyzing the CT manifestations and evolution of COVID in non-epidemic areas of southeast China, analyzing the developmental abnormalities and accompanying signs in the early and late stages of the disease, providing imaging evidence for clinical diagnosis and identification, and assisting in judging disease progression and monitoring prognosis. Methods: This retrospective and multicenter study included 1,648 chest CT examinations from 693 patients with laboratory-confirmed COVID-19 infection from 16 hospitals of southeast China between January 19 and March 27, 2020. Six trained radiologists analyzed and recorded the distribution and location of the lesions in the CT images of these patients. The accompanying signs include crazy-paving sign, bronchial wall thickening, microvascular thickening, bronchogram sign, fibrous lesions, halo and reverse-halo signs, nodules, atelectasis, and pleural effusion, and at the same time, they analyze the evolution of the abovementioned manifestations over time. Result: There were 1,500 positive findings in 1,648 CT examinations of 693 patients; the average age of the patients was 46 years, including 13 children; the proportion of women was 49%. Early CT manifestations are single or multiple nodular, patchy, or flaky ground-glass–like density shadows. The frequency of occurrence of ground-glass shadows (47.27%), fibrous lesions (42.60%), and microvascular thickening (40.60%) was significantly higher than that of other signs. Ground-glass shadows increase and expand 3–7 days after the onset of symptoms. The distribution and location of lesions were not significantly related to the appearance time. Ground-glass shadow is the most common lesion, with an average absorption time of 6.2 days, followed by consolidation, with an absorption time of about 6.3 days. It takes about 8 days for pure ground-glass lesions to absorb. Consolidation change into ground glass or pure ground glass takes 10–14 days. For ground-glass opacity to evolve into pure ground-glass lesions, it takes an average of 17 days. For ground-glass lesions to evolve into consolidation, it takes 7 days, pure ground-glass lesions need 8 days to evolve into ground-glass lesions. The average time for CT signs to improve is 10–15 days, and the first to improve is the crazy-paving sign and nodules; while the progression of the disease is 6–12 days, the earliest signs of progression are air bronchogram signs, bronchial wall thickening, and bronchiectasis. There is no severe patient in this study. Conclusion: This study depicts the CT manifestation and evolution of COVID in non-epidemic origin areas, and provides valuable first-hand information for clinical diagnosis and judgment of patient’s disease evolution and prediction.

This study aimed to clarify and provide clinical evidence for which computed tomography (CT) assessment method can more appropriately reflect lung lesion burden of the COVID-19 pneumonia. A total of 244 COVID-19 patients were recruited from three local hospitals. All the patients were assigned to mild, common and severe types. Semi-quantitative assessment methods, e.g., lobar-, segmental-based CT scores and opacity-weighted score, and quantitative assessment method, i.e., lesion volume quantification, were applied to quantify the lung lesions. All four assessment methods had high inter-rater agreements. At the group level, the lesion load in severe type patients was consistently observed to be significantly higher than that in common type in the applications of four assessment methods (all the p < 0.001). In discriminating severe from common patients at the individual level, results for lobe-based, segment-based and opacity-weighted assessments had high true positives while the quantitative lesion volume had high true negatives. In conclusion, both semi-quantitative and quantitative methods have excellent repeatability in measuring inflammatory lesions, and can well distinguish between common type and severe type patients. Lobe-based CT score is fast, readily clinically available, and has a high sensitivity in identifying severe type patients. It is suggested to be a prioritized method for assessing the burden of lung lesions in COVID-19 patients.

目的 探讨MSCT动态增强在乏脂肪RAML与嫌色细胞肾癌的鉴别诊断价值.方法 选取经临床病理证实的并有完整临床和CT资料的21例乏脂肪RAML与14例嫌色细胞肾癌,回顾性分析其MSCT表现,测量病灶的各期CT值,并测量病灶相同层面皮质的CT值,并计算病灶CT值与其邻近皮质CT值的比值,统计分析各期CT值及其比值的统计学差异.结果 乏脂肪RAML 21例,嫌色细胞肾癌14例,乏脂肪RAML呈等高密度影16例,嫌色细胞肾癌呈等高密度10例;乏脂肪RAML与嫌色细胞肾癌在平扫、皮质期、髓质期及分泌期CT值以及平扫、髓质期病灶与相近皮质比值均差异有明显统计学意义(P＜0.05),皮质期及分泌期病灶与邻近皮质比值差异无统计学意义(P＞0.05),皮质期ROC曲线下面积最大(0.871),当皮质期CT值选择为106 HU时,鉴别RAML和ThRCC的敏感度为74％,特异性为91％,Youden指数为0.66.结论 MSCT动态增强在乏脂肪RAML与嫌色细胞肾癌鉴别中具有一定的价值,特别是皮质期的病灶CT值具有良好的鉴别诊断价值.

Giant hypertrophy of gastric mucosa is rare and lack of typical clinical manifestations. The main treatment measures were minimally invasive surgery and drug intervention. Clinicians should pay attention to it's imaging features, in order to make early diagnosis and treatment, and obtain a good prognosis. The authors introduce the results of gastro-enterography and computed tomography in a case with giant hypertrophy of gastric mucosa, and differentiate the imaging results from gastric cancer, lymphoma and gastric stromal tumor, so as to provide references for the clinical diagnosis of the disease.

The peer review history for this article is available at https://publons.com/publon/10.1111/dom.14194. The database used and analyzed in the present study is available from the corresponding author on reasonable request. Appendix S1: Supporting Information Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.

回顾性分析经手术、病理证实的成年人先天性胃重复畸形11例CT表现及相关的临床资料。11例患者均有间断性呕吐，其中6例患者上腹部反复疼痛，3例上腹部可扪及质软的包块；病程10～15个月，平均12个月；囊肿位于胃底6例，胃窦4例，胃体1例；囊肿最大径3.3～12.0 cm，平均(6.2±5.8)cm；囊肿型7例，管状型2例，不规则形2例；囊肿界限清，囊内无分隔，囊壁厚度均匀，囊壁紧贴胃壁，与胃腔不相通。CT增强检查提示重复畸形囊壁与胃壁呈一致性均匀强化，其中显著强化7例，中度强化4例。成年先天性胃重复畸形的CT表现具有一定特征性，对胃重复畸形的术前诊断具有重要的价值。

Background Coronavirus disease 2019 (COVID-19) has widely spread worldwide and caused a pandemic. Chest CT has been found to play an important role in the diagnosis and management of COVID-19. However, quantitatively assessing temporal changes of COVID-19 pneumonia over time using CT has still not been fully elucidated. The purpose of this study was to perform a longitudinal study to quantitatively assess temporal changes of COVID-19 pneumonia. Methods This retrospective and multi-center study included patients with laboratory-confirmed COVID-19 infection from 16 hospitals between January 19 and March 27, 2020. Mass was used as an approach to quantitatively measure dynamic changes of pulmonary involvement in patients with COVID-19. Artificial intelligence (AI) was employed as image segmentation and analysis tool for calculating the mass of pulmonary involvement. Results A total of 581 confirmed patients with 1,309 chest CT examinations were included in this study. The median age was 46 years (IQR, 35–55; range, 4–87 years), and 311 (53.5%) patients were male. The mass of pulmonary involvement peaked on day 10 after the onset of initial symptoms. Furthermore, the mass of pulmonary involvement of older patients (>45 years) was significantly severer (P<0.001) and peaked later (day 11 vs. day 8) than that of younger patients (≤45 years). In addition, there were no significant differences in the peak time (day 10 vs. day 10) and median mass (P=0.679) of pulmonary involvement between male and female. Conclusions Pulmonary involvement peaked on day 10 after the onset of initial symptoms in patients with COVID-19. Further, pulmonary involvement of older patients was severer and peaked later than that of younger patients. These findings suggest that AI-based quantitative mass evaluation of COVID-19 pneumonia hold great potential for monitoring the disease progression.

目的 探讨卵泡膜细胞瘤的MRI表现特点,并与组织病理学表现进行对照分析.方法 回顾性分析经手术病理正实的22例卵巢卵泡膜纤维瘤患者的临床资料.在MRI上观察肿瘤的大小、形状、边缘、位置、信号及强化表现,并将MRI信号特征及强化强度与组织病理形态学表现进行对照分析.结果 肿瘤位于右侧12例,左侧10例;肿瘤形态呈卵圆形、类圆形18例,不规则分叶状4例;边界清楚18例,边界不清4例.MRI信号不均匀18例,信号均匀4例;T1WI均表现为等信号或稍低信号;病灶实体部分于T2WI表现为等信号18例,高信号4例;DWI高信号.增强肿瘤呈轻度强化,延迟强化程度略增加.结论 卵泡膜细胞瘤MRI表现具有一定特征,MRI在卵泡膜细胞瘤的诊断与鉴别诊断中具有重要价值.

目的 探讨血友病性假肿瘤MRI表现特征.方法 回顾性分析经临床、实验室确诊的10例A型血友病性假肿瘤患者的MRI影像表现,对假肿瘤的部位、大小、形态、信号、骨质破坏、强化程度及周围组织受压等进行分析.结果 病变位于骨内型8例,骨膜下型1例,肌间型1例.颅骨5例,髂骨3例,股骨2例.假肿瘤最大直径5.0～58.0 cm,平均(18.6±4.0)cm,其中＞10 cm 6例.MRI表现:骨质呈膨胀破坏6例,膨胀并溶骨性破坏2例,侵蚀性破坏1例,多囊状破坏1例.骨质破坏边缘硬化7例,骨皮质大部吸收消失7例,骨皮质部分吸收消失3例,破坏内残留粗大骨嵴2例,假Codman氏三角1例,软组织肿块10例.增强扫描5例,骨质破坏区和软组织肿块均未见强化.MRI信号表现:骨质破坏区和软组织肿块于T2WI、T1WI、液体衰减反转恢复(SPAIR)和扩散加权成像(DWI)均呈高、低混杂信号,其中病变区有多囊状改变2例,病变区有分隔2例.结论 血友病性假肿瘤影像表现具有一定特征性,影像表现结合临床和实验室可明确诊断.

目的 探讨底颅脊索瘤的CT和MRI影像表现特征.方法 回顾性分析经手术病理证实的颅底脊索瘤的18例CT和MRI表现,观察病变部位、生长方式、密度或信号特点、强化特点及与邻近组织关系.结果 病变起源于斜坡14例,其中伴脑干和基底动脉受压后移4例,蝶窦、后组筛窦受侵2例,单侧或双侧海绵窦受侵2例,颅底及鼻咽部受侵并推压脑干1例,岩尖骨受侵并推压延髓1例;起源于斜坡外4例,其中伴突入鞍上池2例,累及邻近岩骨、枕骨破坏1例,向下延伸延髓并脑干受压1例.CT检查(11例):11例骨质均呈溶骨性破坏伴软组织肿块,其中骨质破坏区边缘硬化3例,病变内见斑点状钙化或残存骨6例.MR检查(16例):MRI信号均显示不均匀,其中T1WI呈高低混杂信号7例,等低信号5例,低信号4例;T2WI呈高低混杂信号6例,高信号7例,稍高信号3例.增强检查(13例):均呈不均匀强化,其中轻度强化6例,中度强化7例.病变呈缓慢渐进性强化8例,强化显示“蜂房征”6例,边缘轻度环形强化2例.结论 CT和MRI可清楚显示颅底脊索瘤的部位、形态、大小、周围组织侵犯范围及与邻近组织关系,对明确诊断、手术方式及术后随访评估具有重要作用.

Objective To investigate CT features of primary renal malignant fibrous histiocytoma and to improve the knowledge of this disease. Methods CT finding of 7 cases with primary renal malignant fibrous histiocytoma proved clinically and pathologi-cally were retrospectively reviewed. The tumor growth pattern,size,density,degree of enhancement,invasion to the surrounding tissues,and metastatic characteristics were observed. Results Of those 7 patients,4 were male and 3 were female aged from 49 to 70 years old,with the median age of 60 years old. All the 7 patients had lumbar and abdominal pain,in whom 4 presented with mild fever,fatigue,and weight loss,and 3 with painless gross hematuria. 4 occurred in the left kidney and 3 in the right kidney. The tumor size ranged from 4.0 cm×4.0 cm to 10.5 cm×11.5 cm,with an average of 6.1 cm×6.6 cm. On the CT scan,the low density was seen in 3 cases,the equal density in 3 cases,and the slightly high density in 1 case. The boundary was not clear in 4 cases andthe boundaries was clear in 3 cases. The intratumoral cystic necrosis was found in 4 cases,the intratumoral calcifi-cation in 3 cases,the invasion of psoas major in 2 cases,the enlarged lymph nodes in the renal hilum and retroperitoneal site in 3 cases,the liver metastases in 1 case,the lung metastases in 1 case,and the renal vein tumor thrombus in 1 case. On the en-hanced CT,the homogeneous enhancement was found in 1 case at cortical phase and the parenchymal enhancement degree de-creased obviously,which exhibited the"fast into fast out"feature. The moderate homogeneous enhancement was found in 3 cases at cortical phase and continued to be strengthened at the parenchymal phase,which exhibited the"fast in slow out"feature. The mild homogeneous enhancement was found in 3 cases at cortical phase. The parenchymal phase continued to strengthen, which showed the"slow in slow out"feature. Irregular strip vessels inside the tumor were found in 3 of 7 tumors. Conclusion The clinical and CT manifestations of renal malignant fibrous histiocytoma are lack of characteristics. The final diagnosis depends on pathological examination.

Objective To evaluate the use of MRI for early detection of tumor response to Liposomal doxorubicin therapy in a rat C6 glioma model .Methods Twenty-four male SD rats with C6 tumor cells implanted into the striatum were examined by a 3.0 T MRI scanner, then the rats bearing tumors were divided into two groups , treatment group (n=16) and control group (n=9).Rats in the treatment group received liposome doxorubicin therapy through the tail vein every other day , while control group received normal saline instead .Conventional MRI examinations were acquired on 1, 2, 3 weeks after implantation with a 5-inch surface coil .All rats were sacrificed to perform the histopathological examination after MRI examination in the third week .Pre-treatment and post treatment tumor volumes were calculated .Rank sum test was employed for statistical analysis .Results On MRI, 24 rats demonstrated tumors on day 7 with a successful rate of 100%.On week 2, the tumor volumes of the control and treatment group were 87.92 and 109.90 mm3, with no significant difference ( Z =-0.14, P >0.05).On week 3, the tumor vol-umes of the controls and treatment group were 156.64 and 29.64 mm3 , and a significant difference was observed ( Z =-3.46, P<0.01).Conclusion Liposomal doxorubicin therapy in a rat C6 glioma model is effective.HE stained slices showed more prominent tumor necrosis and death of tumor cells in the treated rats than the controls .

Objective To investigate the characteristics and diagnostic value of multi-slice spiral computed tomography (MSCT) examination of gastrointestinal lipoma.Methods The cross-sectional study was adopted.The clinicopathological data of 96 patients with gastrointestinal lipoma including 32 from the Second Hospital Affiliated to Wenzhou Medical University,30 from the First Hospital Affiliated to Wenzhou Medical University,17 from the Ruian People's Hospital of Zhejiang,11 from the Yueqing People's Hospital,3 from the Wenzhou Central Hospital and 3 from the Wenzhou People's Hospital from December 2006 to September 2015 were collected.All patients were fasted for 8 hours prior to the examination,and partial patients underwent enhanced scan after the conventional CT scanning with breathless scanning and no abdominal pressure.Coronal and sagittal images of gastrointestinal tract including the tumor were administrated with multiple planar reconstruction (MPR)techniques of Reformat software.Based on MPR images,the curves along the gastrointestinal tract were drawn,voxel distributed along the curve track were reconstructed,and curved planar reconstruction (CPR) images were obtained.The patients received operation or follow-up according to individual characteristics after examinations.The patients undergoing operation were followed up for detecting tumor recurrence and metastasis by CT examination and patients receiving follow-up were observed by endoscopy for detecting changes of tumor size and morphology up to June 2015.The analysis indexes included tumor location and size,performance of MSCT examination (tumor shape,density,margin,intussusceptions,enhanced MSCT examination),intraoperative findings,results of pathological examination and results of follow-up.Measurement data with normal distribution were presented as i ± s.Results All the 96 patients received MSCT plain scan and the 42 received enhanced MSCT scan.The CPR images in 30 patients were collected.(1) Tumor location and size:3 tumors were located in the stomach,16 in the duodenal,27 in the jejunum,23 in the ileal,2 in the ileocecus,9 in the sigmoid colon,9 in the ascending colon,3 in the descending colon,3 in the transverse colon and 1 in the appendix.The diameter of tumor was (3.8 ± 2.3) cm.(2) Performance of MSCT examination:of the 96 patients,round or oval tumors were detected in 68 patients,tubular tumors in 15 patients and lobulated tumors in 13 patients.Tumors showed homogeneous density in 67 patients and inhomogeneous density in 29 patients.The CT value of tumors was-110--53 HU with a median value of-80 HU.Tumors of the 96 patients had clear boundaries and smooth margins.Twenty-four patients were complicated with intussusceptions with nested length of (28 ±4)cm,including 10 cases of "multiple concentric rings",7 cases of "double-target sign" and 7 cases of "banana sign".Enhanced MSCT scan showed that capsule around tumors in the 96 patients demonstrated slightly intensified,tumor body demonstrated no enhancement and that angiolipoma in 10 patients had cable strip like enhancement in the tumors.(3) Intraoperative findings:of the 96 patients,59 patients underwent surgical resection with single tumor,24 patients were concomitant with intussusceptions,9 patients showed aphtha in the center of tumors and 1 patient had partial lipoma in the prepyloric region dropped into the duodenal.Thirty-seven patients received endoscopic examination,showing submucous nodular protrusive lesions of 1.7-3.5 cm.(4) Results of pathological examination:of 59 patients undergoing surgical resection,submucosal,subserous and intramural tumors were detected in 45,9 and 5 patients,respectively,with complete capsule and pedunculated or non-pedunculated.Of the 59 patients,tumors showed round or oval shape in 41 patients,tubular shape in 10 patients and lobulated shape in 8 patients.The section of tumors showed yellowish-white.Specimens from endoscopic and surgical resections were observed under microscopy,the tumors were composed of mature-differentiated adipocytes,different quantities of fibrous connective tissues,blood vessels and mucus ingredients.Tumor cells were round shape with hypochromatic cytoplast and became polygeal and vacuolated after squeezing,nucleus was compressed to peripheral area and cytoplasm was full of lipid droplets.The results of immunohistochemistry stain showed Vimentin,CD34,D2-40,CD68 were positive and AE1/3 and Calretinin were negative.All tumors were diagnosed as benign lipomas.Fifty-nine patients who underwent surgical resection were followed up for 0.5-5.0 years and 37 patients of which specimens were obstained by endoscopic resection were followed up for 1.0-2.0 years after the pathological diagnosis with no significant change.Conclusion The MSCT finding of the gastrointestinal lipoma has characteristic appearance,and MSCT examination can clearly show lipoma location,size,shape and properties,with a widespread application value.

Objective To investigate the clinical and CT features of the tuberous sclerosis complex (TSC) with multiple organ impairment.Methods Clinical presentation and CT imaging data of 10 clinically confirmed TSC patients with multiple organ impairment were retrospectively analyzed.The position, size, shape and distribution of lesions of these patients were observed .Results There were fibrous hemangioma and fibroma in skin in 8 of the 10 patients, with multiple pink and light brown translucent waxy skin rash of 0.3 -1.2 cm in diameter on the face , waist, back skin, scattered symmetrically in distribution , 3 of whom with fibroma in periungual fibromas underneath and around the nails of 0.5-3.0 cm in diameter.The sub-ependymal nodular sclerosis was found in 10 patients , and CT showed multiple calcification nodules of 0.3 -1.5 cm in diameter on both sides of the ventricles.The renal angiomyolipoma was found in 10 patients, and CT showed multiple circular hybrid density lesions of 0.3-20.0 cm in diameter in bilateral kidneys.There was pulmonary lymphangiomyomatosis in 8 patients, with CT showing scattered cystic lucency shadow in double lung , with thin walled, about 0.5-2.0 cm in diameter.The tuberous sclerosis was found in bones in 7 patients, and CT scan showed nodular opacities of 0.3-2.3 cm in diameter in thoracic , lumbar and sacral vertebrae , ribs, the parietal bone and the mandible , with clear boundary and homogeneous density involving symmetrical and irregular density in radix of the posterior arch of the vertebral body.The hepatic angiomyolipoma was found in 3 patients, and CT showed low density mass of 0.5-7.6 cm in diameter in liver , with uneven density.The heart angiomyolipoma was found in 1 patient , and CT showed streaked low density lesions with 2.5 cm ×1.2 cm in size and clear boundary in the right atrium and the right ventricular wall .Conclusions The CT performance of TSC with multiple system diseases has some certain specificity .The disease can be definitely diagnosed based on CT manifestations and clinical symptoms .

目的:探讨原发性骨淋巴瘤(Primary bone lymphoma,PBL)的影像表现特点.方法:回顾性分析经病理证实26例PBL患者的X线平片、CT和MRI表现.结果:26例中男14例,女12例,年龄20～73岁,平均(40.7±5.8)岁.26例中中位于颅骨7例,股骨5例,肱骨4例,脊柱4例,锁骨2例,髂骨2例,胫骨1例,腓骨1例.X线和CT表现:溶骨型21例,混合型3例,硬化型1例,囊状型1例..伴病理性骨折3例,轻度骨膜反映3例,有较明显的软组织肿块21例.MRI检查7例:信号均匀3例,信号小均匀4例;病灶于T1WI 上呈等、稍低信号,T2WI上呈稍高信号5例,呈等信号2例.增强扫描7例:肿瘤中度强化5例,显著强化1例,轻度强化1例.结论:PBL影像学有一定的特点,骨破坏多见于溶骨型,增强后以中度强化为主,常伴有明显的软组织肿块.