目的 观察“菟丝子-枸杞子”药对对雷公藤多苷(GTW)诱导的生精障碍大鼠模型血睾屏障的影响,初步探讨其改善模型大鼠生殖功能的机理.方法 将56只SD大鼠随机分为空白对照组、模型对照组、阳性对照组和药对组.以GTW 40mg/(kg·d)灌胃4周构建SD大鼠生精障碍模型,成模后阳性对照组每日给予左卡尼汀悬液[0.2g/(kg· d)]灌胃,药对组每日给予菟丝子-枸杞子悬液[6g/(kg·d)]灌胃,治疗4周后检测各组大鼠的精子质量、生殖激素和抑制素B、附睾肉毒碱,观察支持细胞形态,并采用Western blot检测睾丸组织血睾屏障相关蛋白的表达,分析比较不同组间的差异.结果 药对组大鼠精子浓度[(39.17±13.75)×106/mL]高于模型对照组[(28.23±8.05)×106/mL],其差异具有统计学意义(P＜0.05).药对组[(29.92±5.25)％]和左卡尼汀组精子活动率[(29.31±6.33)％]均显著高于模型对照组大鼠[(20.13±6.63)％],其差异具有统计学意义(P＜0.01);药对组和左卡尼汀组大鼠卵泡生成素(FSH)、黄体生成素(LH)和泌乳素(PRL)与模型对照组相比均显著降低,附睾肉毒碱含量显著升高,其差异具有统计学意义(P＜0.05或P＜0.01).药对组与模型对照组比较,支持细胞结构和形态改善,生精小管结构、排列较为正常,生精细胞明显增多,形态改善;药对组Occludin、ZO-1和connexin 43的蛋白表达比模型对照组显著增多,其差异具有统计学意义(P＜0.05);β-catenin和N-cadherin的蛋白表达也有不同程度增高,虽然未见明显差异,但增高趋势明显.结论 “菟丝子-枸杞子”药对能够有效减轻GTW造成的生精功能障碍,其机制可能与修复血睾屏障损伤有关.

春季,伴随着万物的复苏,人们充满活力,“性”致仿佛也高昂起来.从中医上讲“春三月,此谓发陈,天地俱生,万物以荣”.春天人体的阳气开始葫发,而人的性欲与人体的阳气密切相关,阳气盛则性欲强,阳气弱则性欲下降,所以在阳气逐渐上升的春季,人的性欲也会不断上涨.

Professor Shi Hanzhang,chief physician,was the first batch of "inheriting the old TCM experts academic experience instructor" issued by the State Administration of Traditional Chinese Medicine.He was engaged in medical treatment for nearly 70 years,and saved thousands of lives during his whole lifetime.His surgical skills were profound.In the treatment of male diseases,he was skilled with unique experience.He advocated the clinical medication of external treatment for internal diseases by using traditional technique in new approach.He was accomplished in micro syndrome differentiation.He also combined traditional Chinese medicine with western medicine,with good curative effect.This paper summarized the clinical experience of Professor Shi Hanzhang to cherish the memory of him and spare no efforts to inherit and carry forward the application of his academic thinking.

Observation,Smell,Inquiry and Palpation are four diagnostic prescriptions of traditional Chinese medicine (TCM) that are diagnosis and treatment based.As the first diagnosis of four clinics,doctors get the patient's first-hand information through their own eyes.TCM syndrome differentiation is an indispensable part.Professor Li Haisong considers that part of the clinical manifestations of male disease has a certain characteristic.By observation,the patient's important information can be obtained.The author studied under the tutelage of Professor Li and tried to sum up the clinical experience of Professor Li in the use of observation.

目的 观察补肾疏肝汤治疗肝郁肾虚型阳痿的临床疗效.方法 将106例符合诊断标准的患者按随机数字表法平均分为2组各53例.对照组给予苁蓉益肾颗粒(内蒙古兰太药业有限责任公司生产)口服治疗,治疗组给予自拟补肾疏肝汤免煎颗粒治疗,疗程均为4周,采用国际勃起功能指数(IIEF-5)、抑郁症筛查量表(PHQ-9)和中医证候评分为评价指标.结果 治疗后2组IIEF-5、PHQ-9量表和中医证候评分较治疗前均有改善,差异均有统计学意义,治疗后治疗组在IIEF-5、PHQ-9量表和中医证候评分改善情况方面均优于对照组,差异有统计学意义.治疗组总有效率为72.5％,对照组总有效率为58.3％,2组比较有显著差异(P＜0.05).结论 补肾疏肝汤治疗肝郁肾虚型阳痿具有疗效,并且在改善患者抑郁状态方面有一定优势,优于对照组.

The male infertility is commonly manifested as dyspermia.Oligo-astheno-teratospermia is one of the common causative factors.In the treatment by Prof.Li Haisong,he emphasizes that the kidney is the congenital foundation,acting on storing essence and reproduction.The treatment is given in terms of the individual characteristics of oligospermia,asthenospermia and teratospermia.Oligospermia is differentiated as kidney deficiency and blood stagnation,asthenospermia as kidney qi insufficiency besides kidney deficiency and blood stagnation,and teratospermia as kidney deficiency together with heat and blood stagnation.In the treatment,for oligospermia,the treatment focuses on tonifying kidney and activating blood circulation,for as-thenospermia,tonifying qi should be enhanced additionally,and for teratospermia,the great attention should be paid to nourish kidney yin,activating blood circulation and clearing heat.

传统医学中的七情有两种含义,一指情志,即怒喜思悲恐忧惊;二指药物配伍,包括单行、相须、相使、相畏、相杀、相恶、相反,本文所指的即是后者[1].关于七情配伍的记载最早见于四大经典之一的《神农本草经》[2],详述药物阴阳配合之理,极大程度上影响并启发了后世医家.黄芪味甘,性温.归肺脾经,具有补气固表,利尿排毒,排脓敛疮生肌的功能.用于气虚乏力,食少便溏,中气下陷,久泻脱肛,便血崩漏,表虚自汗等[3].黄芪始载于《神农本草经》:"主痈疽,久败疮,补虚,小儿百病".

早泄作为一种男科的常见疾病,中医药对其治疗有着显著疗效.李海松教授常年致力于男科疾病的研究,在先前研究的基础上,结合自身临证经验提出早泄的治疗当从心肝脾肾论治,在治法上首次提出分清虚实、保证勃起、首剂见效、中西结合、保证疗效、内外合治、夫妻同治的治疗方法.

身为成功男士的你一定很懂车,但你不一定懂性.你是否还在追求身体这辆“车”在性的“道路”上称心平稳的行驶呢?不要担忧,让东直门医院男科主任李海松教授教你开好这辆“车”. 目标明确,有的放矢 性爱虽然是一场说走就走的“旅程”,但你要明确这次旅行的目的,是尽快到达目的地,还是欣赏一下沿途的风景?性爱一直伴随人类的繁衍生息,但它并不只是以排精生育为目的,我们更多的是利用性爱这一过程来进行情感上的交流,更多的是欣赏沿途的“风景”.所以不要着急到达目的地,重要的是享受一下这个过程.

随着夫妻双方年龄的增加,生育能力正逐渐下降.其中女性的生育能力可以通过月经的情况反映出来,而男性的生育能力最直观的体现就是精液常规检查.最近几个月来,东直门医院男科查精液常规的人比以往多了至少三倍,年纪大多在40 ～ 45岁.这也说明大家都有一定的备育意识和医学认识.面对一份精液常规的报告,精子质量的数据结果正常或不正常显而易见.而容易被大家忽略的也是最让人不明白的就是精液不液化的问题.

2016年3月28日某地新闻报道,早市市场上大量男性中老年在排队购买性保健品和一些违法的黄色光盘,先抛开法律这些问题,我们先来看看为什么会有这样的事情发生,为什么这些东西会有存在的市场,我想这里面有很大一部分原因是很大部分的男性中老年人的性健康问题没有的到合理的解决,然后才会让某些心机不正的人有机可乘.为什么这些情况会出现在中老年中呢?