Objective:To explore early effects and multifidus muscle injury in patients with lumbar disc herniation by minimally invasive tubler discectomy and percutaneous transforaminal endoscope interlaminar approach discectomy.Methods:Totally, 92 patients with lumbar disc herniation treated in our hospital were selected as the research objects during Jan. 2018.to-Dec. 2021. The patients were divided into the minimally invasive tubler discectomy group (56 patients) and the percutaneous transforaminal endoscope interlaminar approach discectomy group (36 patients) according to the surgical procedures, and the postoperative clinical effects and atrophy of multifidus of the two groups were compared.Results:The incision length in minimally invasive group was larger than that in transforaminal endoscope group [(2.37±0.12) cm vs. (26.71±2.69) cm, t=62.435, P<0.05]. The intraoperative blood loss in minimally invasive group was more than that in transforaminal endoscope group [(43.42±3.23) ml vs. (0.82±0.11) ml, t=25.803, P<0.05]. The operation time in minimally invasive group was longer than that in transforaminal endoscope group [(65.22±5.75) min vs. (50.43±4.82) min, t=12.804, P<0.05]. The time to walk in minimally invasive group was later than that in transforaminal endoscope group [(3.02±0.62) d vs. (2.00±0.63) d, t=7.653, P<0.05]. The postoperative hospital stay in minimally invasive group was longer than that in transforaminal endoscope group [(6.56±0.85) d vs. (4.81±0.71) d, t=10.260, P<0.05]. The Japanese Orthopaedic Association (JOA) score in minimally invasive group was lower than that in transforaminal endoscope group [(17.51±2.19) points vs. (19.62±2.07) points, t=4.607, P<0.05]. The oswestry disability index (ODI) in minimally invasive group was higher than that in transforaminal endoscope group at 1st month after operation [(30.21±1.29)% vs. (28.57±1.31)%, t=5.915, P<0.05]. The excellent and good rate was 92.9% (52/56) in minimally invasive group and 91.7% (33/36) in transforaminal endoscope group one month after operation, with no significant difference between the two groups ( P>0.05). The rate of multifidus muscle atrophy in minimally invasive group was higher than that in transforaminal endoscope group at 3rd month after operation [(35.45±6.57)% vs. (32.13±6.45)%, t=2.382, P<0.05]. There was no significant difference in the rate of multifidus atrophy between the two groups at 6th month after operation [(21.22±3.43)% vs. (20.89±3.75)%, t=0.434, P>0.05]. Conclusion:Percutaneous transforaminal endoscope interlaminar approach discectomy has more advantages in improving postoperative indicators, reducing multifidus muscle injury injuries than minimally invasive tubler discectomy.

Objective To explore the effects of two surgical methods on cervical sagittal plane balance, and to provide reference for clinical selection of surgical methods for odontoid fracture complicated with upper cervical instability and prognosis evaluation. Methods The data of 48 patients with odontoid fracture complicated with upper cervical instability who underwent surgical treatment in the First Affiliated Hospital of Zhengzhou University from January 2015 to January 2019 were retrospectively analyzed.There were 31 cases atlantoaxial fusion（AAF） group and 17 cases occipitocervical fusion（OCF） group.The imaging parameters of the two groups were compared before surgery, 3 days after surgery and at the last follow-up: O～C 2 Angle, O～EA Angle, C 1 ～C 2 Angle, C 2～7 SVA and C 2～7 Cobb Angle. The dO～C 2 Angle, dO～EA Angle, dC 1～2 Angle, dSVA and dCobb Angle are calculated. Results Postoperative C 2～7 Cobb angle were significantly decreased in both AAF and OCF groups, while the O～C 2 angle, O～EA angle and C 2～7 SVA were significantly increased in both groups. The absolute values of dSVA and dCobb angle in OCF group were significantly greater than those in AAF group. The differences were statistically significant（P＜0.05）. Pearson correlation coefficient analysis showed that there was a significant correlation between dO～C 2 angle and dCobb angle in OCF group（R=0.54, R~2=0.29,P＜0.05）, and there was also a significant correlation between dO～C 2 angle and dO～EA angle（R=0.55, R~2=0.30, P＜0.05）. Conclusion Both posterior approach AAF and OCF can result in degeneration of the lower cervical spine. Compared with AAF, posterior sagittal balance of the lower cervical vertebra was significantly reduced after OCF. Intraoperative monitoring of occipitocervical Angle（O～C 2 Angle） fixation is recommended during OCF. Excessive increase in the Angle may accelerate the degeneration of the lower cervical spine.

目的 探讨精细护理在颈椎神经鞘瘤术后脑脊液漏患者护理中的应用效果.方法 纳入2020年4月至2022年4月于郑州大学第一附属医院接受手术治疗的颈椎神经鞘瘤术后脑脊液漏患者,将患者随机均分为研究组和对照组,每组30例.其中对照组接受常规护理干预,而研究组在对照组基础上实施精细护理.比较2组患者的治疗效果和不良反应发生情况.结果 术后12个月,研究组健康状态、心理状态、睡眠质量、功能恢复评分均优于对照组,差异均有统计学意义(t=12.966,P＜0.001;t=21.826,P＜0.001;t=19.945,P＜0.001;t=10.531,P＜0.001).研究组不良反应总发生率低于对照组,差异有统计学意义(x2=19.200,P＜0.001).结论 采用精细护理对颈椎神经鞘瘤术后并发脑脊液漏患者进行干预,能够改善患者健康状况和恢复情况,降低不良反应发生风险.

Rationale:Brown tumor (BT), an uncommon focal lytic bone tumor, is a non-neoplastic and reactive process caused by increased osteoclastic activity and fibroblastic proliferation in primary or secondary hyperparathyroidism. Vertebral tumor causing neural compression is relatively rare, especially in the cervical spine. Patient concerns:A 29-year-old man developed neck pain and arm radicular pain 4 months ago, with the level of serum calcium significantly higher than normal. Computed tomography scan of the cervical spine revealed an expansile lytic lesion occupying the C6 body, left pedicle, and left lamina of C5-6. Diagnoses:Osteoclastoma according to imaging and histopathological results. Interventions:A laminectomy of C5-6 was performed. Outcomes:One month later, he was re-hospitalized due to nausea and vomiting and the serum calcium, was still, kept at a high level. Additionally, the parathormone (PTH) was greatly higher than normal. BT with primary hyperparathyroidism due to the parathyroid tumor was considered. After the surgery of the right parathyroid gland was performed, serum calcium and PTH both decreased, and computed tomography showed good recovery. Lessons:BTs might be misdiagnosed as other giant cell tumors, thus when giant cell tumors are considered, serum calcium and PTH examination may be needed to exclude BTs.

目的:探讨颈椎曲度与脊髓型颈椎病的关系.方法:选取2018年1月至2020年1月在郑州大学第一附属医院接受颈椎X线检查的114例脊髓型颈椎病患者(脊髓型颈椎病组)和同期在医院进行颈椎X线检查的61例健康体检者(非颈椎病组)进行研究.采用Borden法在拍摄的侧位X线片上测量颈椎曲线深度(cervical curve depth,CCD),比较2组受试者的CCD和颈椎曲度异常率,采用受试者操作特征(receiver operating characteristic,ROC)曲线分析评价CCD诊断脊髓型颈椎病的价值.结果:脊髓型颈椎病组的CCD小于非颈椎病组[(3.14±5.51)mm,(8.87±2.43)mm,t=-7.715,P=0.000];脊髓型颈椎病组颈椎曲度正常12例、异常102例,非颈椎病组颈椎曲度正常56例、异常5例,脊髓型颈椎病组的颈椎曲度异常率高于非颈椎病组(χ2=110.488,P=0.000).ROC曲线分析结果显示,依据CCD诊断脊髓型颈椎病的灵敏度为83.3％、特异度为90.2％、约登指数为74.4％、曲线下面积为0.876、诊断界值为6.945 mm.结论:脊髓型颈椎病的发生与颈椎曲度减小有关,CCD小于6.945 mm时发生脊髓型颈椎病的可能性较大.

Following the publication of this paper, it was drawn to the Editors' attention by a concerned reader that various panels showing the data from flow cytometry experiments in Figs. 2D, 5D and 6D, and certain of the migration assay data shown in Fig. 7A, were strikingly similar to data appearing in different form in other articles by different authors. Owing to the fact that the contentious data in the above article were already under consideration for publication prior to its submission to International Journal of Oncology, the Editor has decided that this paper should be retracted from the Journal. The authors were asked for an explanation to account for these concerns, but the Editorial Office did not receive a reply. The Editor apologizes to the readership for any inconvenience caused. [International Journal of Oncology 54: 1809‑1820, 2019; DOI: 10.3892/ijo.2019.4735].

[目的]比较寰枢椎融合与颈枕融合治疗后路齿状突游离小骨合并寰枢椎脱位的临床效果.[方法]回顾性分析2010年1月-2015年12月行后路融合术治疗的29例齿状突游离小骨合并寰枢椎脱位患者的临床资料.依据患者具体情况与术前医患沟通结果,22例行寰枢椎融合(寰枢组),7例行颈枕融合(颈枕组).比较两组患者围手术期、随访和影像资料.[结果]两组患者均顺利完成手术,术中均无严重并发症.寰枢融合组切口长度显著小于颈枕融合组(P＜0.05).两组患者术后随访均在6年以上,寰枢组恢复完全负重活动显著早于颈枕组(P＜0.05).与术前相比,术后两组颈椎前屈-后伸ROM和左右旋转ROM均显著减小(P＜0.05).术后相应时间点寰枢组颈椎前屈-后伸ROM均显著大于颈枕组(P＜0.05).随时间推移,两组的NDI评分显著下降(P＜0.05),而JOA评分显著增加(P＜0.05);相应时间点两组间NDI和JOA评分的差异均无统计学意义(P＞0.05).影像方面,与术前相比,术后两组的C0～2角显著增大(P＜0.05),而C2～7角和ADI显著减小(P＜0.05).术后寰枢组的ADI均小于颈枕组,其中,术后5年时两组间差异有统计学意义(P＜0.05).[结论]两种术式均安全有效,与颈枕融合相比,寰枢融合可减小手术创伤,更好复位寰枢椎,保留更多颈椎活动度,功能恢复更好.

目的 评价经颈前咽前路松解结合枕颈融合内固定术与单纯后路枕颈融合内固定术治疗难复性寰枢椎脱位并颅底凹陷的临床效果.方法 回顾性分析2015-01—2019-06郑州大学第一附属医院收治的32例难复性寰枢椎脱位并颅底凹陷患者的临床资料,按手术方式分为经颈前咽前路松解结合枕颈融合内固定术组(前后路联合组)和单纯后路枕颈融合内固定术组(单纯后路组),各16例.比较2组患者的基线资料、术中情况及术后临床指标.记录手术前后钱氏线(CL)、枕大孔线(ML)、寰齿间距(ADI)、斜坡椎管角(CCA)、脊髓活动空间(SAC)影像学参数.统计手术前后视觉模拟评分(VAS)、日本骨科协会评分(JOA).结果 2组患者的基线资料差异无统计学意义(P>0.05).前后路联合组的手术时间长于单纯后路组,术中出血量多于单纯后路组,并发症发生率高于单纯后路组,差异均有统计学意义(P<0.05).2组患者术后枕颈关节植骨均获良好融合,植骨融合时间差异无统计学意义(P>0.05).末次随访,2组患者的ADI、CL、ML、CCA、SAC均较术前显著改善,其中前后路联合组的CL、ML、CCA、SAC改善情况优于单纯后路组,差异有统计学意义(P<0.05);2组患者的ADI差异无统计学意义(P<0.05).末次随访2组患者的VAS、JOA评分均较术前明显改善,差异均有统计学意义(P<0.05);但组间差异无统计学意义(P>0.05).结论 单纯后路枕颈融合内固定术治疗难复性寰枢椎脱位并颅底凹陷,虽然影像学参数改善效果不如经颈前咽松解结合枕颈融合内固定术,但患者的体征及症状改善效果与之相仿,并能缩短手术时间、减少术中出血量和手术并发症,尤其适用于手术耐受性差的老年患者.

Objective:To analyze the correlation between osteoporosis and the degree of cervical spine degeneration in middle-aged and elderly patients.Methods:From January 2019 to May 2022, 107 patients over 45 years old who underwent cervical spine CT examination in the Department of Orthopedics, the First Affiliated Hospital of Zhengzhou University, including 60 males and 47 females, were (55.65±5.26) years old. The CT values of the upper, middle and lower sections of the cancellous bone of each vertebral body of the cervical spine C2-C7 were measured. According to the CT values of the cervical spine, the patients were divided into the osteoporosis group and the normal bone mass group. The cervical facet joint degeneration was evaluated by Pathria′s CT grading standard to reflect the degree of cervical degeneration. Spearman correlation analysis was used to test the correlation between cervical osteoporosis and cervical degeneration.Results:The CT value of C2-C7 vertebral body of 107 patients was (307.91±64.66) HU, the CT value of C2-C7 vertebral body of osteoporosis group was (269.70±51.70) HU, and the CT value of normal bone mass group was (342.70±55.10) HU. There was no significant difference in the gender, age, height, weight, body mass index (BMI) and other general data between the osteoporosis group and the normal bone mass group ( P>0.05), the average score of degeneration in C2/3, C3/4, C4/5, C5/ 6 was negatively correlated with the mean value of CT in C2-C7 vertebrae, and the degree of C2/3 degeneration was most significantly correlated with the mean value of C2-C7 vertebral body CT ( r=-0.611, P<0.01). Conclusion:The more severe the osteoporosis in middle-aged and elderly patients, the lower the mean value of C2-C7 vertebrae, the higher the cervical facet joint degeneration score, and the more severe cervical spine degeneration. There is a positive correlation between osteoporosis and cervical spine degeneration in middle-aged and elderly patients.

目的 探讨前路颈椎间盘切除椎间融合(ACDF)术对术后椎旁肌肉的影响以及ACDF术后椎旁肌肉的改变是否会影响术后临床症状.方法 选取2018年6月至2020年6月于郑州大学第一附属医院骨科接受ACDF术的50例单节段脊髓型颈椎病(CSM)患者作为手术组,选取同期在医院体检中心接受颈椎磁共振成像(MRI)检查的80例健康体检者作为健康组,测量相应平面肌肉及脂肪T2加权像上的横截面并计算脂肪与肌肉面积之比.比较健康组和手术组患者脂肪与肌肉面积比,比较手术组患者术前和末次随访时的脂肪与肌肉面积比.使用视觉模拟评分法(VAS)评估患者疼痛程度,采用颈椎功能障碍指数(NDI)评估患者残疾程度,采用改良颈椎日本骨科协会评分(mJOA)评估患者神经功能损伤程度.采用Spearman相关性分析比较脂肪与肌肉面积比与VAS、NDI、mJOA评分的关系.结果 健康组人群脂肪与肌肉面积比中位数为0.44(0.33,0.66),手术组患者术前及末次随访时的脂肪与肌肉面积比中位数分别为0.66(0.56,1.21)和0.77(0.58,1.28).健康组和手术组脂肪与肌肉面积比比较,差异有统计学意义(P<0.05);手术组患者术前和末次随访时的脂肪与肌肉面积比比较,差异有统计学意义(P<0.05).对功能评分和影像学数据进行相关性分析,发现术前和末次随访时的NDI、VAS评分分别与术前和末次随访的脂肪与肌肉面积比呈正相关(P<0.05).未发现mJOA评分和脂肪与肌肉面积比具有相关性(P>0.05).结论 ACDF手术可能与单节段CSM患者术后颈部肌肉退变有关,患者术后疼痛程度与相应节段椎旁肌肉的退变程度呈正相关,椎旁肌肉加权像上的横截面越小,其颈部疼痛症状越重,但与术后神经功能的恢复无相关性.

目的:探讨合并后纵韧带退变(cervical posterior longitudinal ligament degeneration,CPLLD)的脊髓型颈椎病(cervical spon-dylotic myelopathy,CSM)的临床及影像特征.方法:选取2013年1月至2015年12月因CSM在郑州大学第一附属医院行手术治疗,且临床和影像资料完整患者的病例资料进行研究.从患者的病例资料中提取性别、年龄、身高、体质量、术前颈椎功能障碍指数(neck disability index,NDI)、术前日本骨科学会(Japanese Orthopedic Association,JOA)颈椎病评分、术前疼痛视觉模拟量表(vis-ual analogue scale,VAS)评分、有效椎管矢状径(space available for the cord,SAC)、椎管椎体矢状径比值(diameter of sagittal canal and vertebral body ratio,DSR)及合并CPLLD和颈脊髓内信号改变情况.结果:①临床数据分析结果.共纳入128例CSM患者,其中53例合并CPLLD(CPLLD组),其余75例未合并CPLLD(无CPLLD组).合并颈脊髓内信号改变者49例,其中CPLLD组29例、无CPLLD组20例,CPLLD组颈脊髓内信号改变发生率高于无CPLLD组(χ2=13.866,P=0.000).合并CPLLD的CSM患者中51～60岁患者所占比例最高,性别分布无明显差异;55个节段CPLLD呈中央型、47个节段呈偏侧型,好发部位为C 4～C6节段.术前CPLLD组患者的NDI高于无CPLLD组[(46.57±8.20)％,(36.60±7.01)％,t=1.783,P=0.000],JOA颈椎病评分低于无CPLLD组[(9.97±1.41)分,(12.60±1.25)分,t=-3.247,P=0.000];2组患者术前的疼痛VAS评分比较,差异无统计学意义[(5.47±2.12)分,(5.44±2.03)分,t=0.693,P=0.075].②影像数据分析结果.CPLLD组术前颈椎SAC和DSR均小于无CPLLD组[(4.17±1.30)mm,(5.32±1.34)mm,t=-1.327,P=0.000;0.70±0.21,0.82±0.23,t=-3.733,P=0.000].CPLLD组组内不同性别患者的术前颈椎SAC和DSR比较,差异均无统计学意义[(4.21±1.32)mm,(4.12±1.30)mm,t=0.149,P=0.795;0.67±0.15,0.75±0.19,t=0.328,P=0.602];无CPLLD组组内不同性别患者的术前颈椎SAC和DSR比较,差异均无统计学意义[(5.36±1.30)mm,(5.27±1.39)mm,t=0.187,P=0.753;0.81±0.22,0.83±0.23,t=0.739,P=0.072].③临床数据和影像数据的相关性分析结果.CPLLD和颈脊髓内信号改变呈正相关(r s=0.317,P=0.000);SAC、DSR均与JOA颈椎病评分呈正相关(r=0.321,P=0.000;r=0.795,P=0.000),均与NDI呈负相关(r=-0.309,P=0.000;r=-0.432,P=0.000).结论:CSM患者常合并CPLLD,其中以51～60岁者多见,好发于C 4～C6节段;合并CPLLD的CSM患者更容易发生颈脊髓变性、DSR和SAC更小、患者生活质量更差,建议早期手术干预.

Objective:To explore the clinical effect of 3D printing assisted the SRS-Schwab Ⅳ osteotomy for senile kyphosis.Methods:A retrospective analysis of 48 elderly patients with kyphosis who were hospitalized for surgery in the First Affiliated Hospital of Zhengzhou University from June 2018 to December 2019. According to the random number table method, they were divided into experimental group and control group with 24 cases each. The experimental group used 3D printing model to assist SRS-Schwab Ⅳ osteotomy and the control group underwent SRS-Schwab Ⅳ osteotomy based on preoperative imaging data. The operation time, C arm perspective time, intraoperative blood loss, kyphosis Cobb angle, Cobb angle correction rate, lumbar lordosis correction degree, lumbar lordosis correction loss rate. The pain visual analog scale (VAS) and Oswestry dysfunction index (ODI) were used to assess the degree of improvement in both methods. Chi-square test was used for comparison of counting data between the two groups. The comparison between different time points in the measurement data group adopts one-way analysis of variance, and independent-samples t test was used for comparison between two groups at the same time point. Results:All patients underwent surgery successfully. The operative time [(171.1±50.9) min]and the perspective of time [(9.2±1.9) s] and the intraoperative blood loss [(321.5±76.8) ml]in the 3D group were significantly reduced as compared with those in the control group [operative time (264.2±44.2) min, t=6.767, P<0.05, the perspective of time (13.6±4.0) s, t=4.856, P<0.05, the intraoperative blood loss (472.9±86.2) ml, t=6.422, P<0.05], and the difference was statistically significant. The correction rate of Cobb angle (73.7%), LL correction degree (34.4°) in the 3D group was significantly higher than that in the control group [Cobb angle correction rate (51.9%), χ2=10.382, P<0.05, LL correction degree (30.1°), t=4.949, P<0.05], and the difference was statistically significant. The LL correction loss rate (11.9%) in the 3D group was slightly lower than that in the control group (13.6%), but there was no statistically significant difference between the two groups during the last follow-up ( χ2=0.177, P>0.05). VAS score and ODI index showed similar improvement at each time point during postoperative follow-up in both groups. Conclusion:3D printing assisted SRS-Schwab Ⅳ osteotomy is feasible for the treatment of senile kyphosis, which can reduce the operation time, intraoperative blood loss and radiation exposure time, as well as the satisfactory clinical effect.

Objective:To compare the clinical and radiological outcomes in smoking patients after cervical disc replacement (CDR) with those of non-smoking patients.Methods:A retrospective analysis was performed on 119 patients with single-segmental or two-segmental cervical spondylosis treated by CDR between February 2015 and February 2017. Finally, 78 patients with complete data were included. All patients were divided into smoking(27 cases) and non-smoking(51 cases) groups based on whether they had smoked in the six months prior to surgery. The visual analogue scale (VAS), neck dysfunction index (NDI), Japanese orthopaedic association scale (JOA), Nurick scale, and Bazaz scores for dysphagia were compared and evaluated at different time points before and after operation. All patients were evaluated by these radiological parameters, such as range of motion (ROM) on the surgical segment, neutral cervical lordosis (C 2-7 Cobb), and the presence of heterotopic ossification (HO). Chi-square test was used for comparison of counting data between the two groups, and paired t test was used for comparison of measurement data within the group. Independent sample t test was used for evaluation of intergroup data. Results:A total of 78 patients were followed up for at least 3 years (mean follow-up period of 51.2 months). There were 51 cases in non-smoking group and 27 cases in smoking group. The age in the smoking group (42.3±9.6) was younger than in non-smoking group (50.4±11.1) ( t=-21.737, P<0.05). The percentage of males in the smoking group (92.6%) was significantly higher than in the non-smoking group (31.4%; χ2=9.625, P<0.05). There were no statistically significant differences between the two groups in operative segment distribution (single-segmental ratio %) (70.4, 62.7, χ2=0.761, P>0.05), intraoperative blood loss (ml) (22.7±10.5, 24.3±11.2, t=-0.716, P>0.05), operative time (min) (65.4±11.5, 63.9±12.1, t=0.832, P>0.05), and follow-up time (month) (52.5±12.7, 50.9±13.5, t=0.661, P>0.05). Both groups showed similar improvements in all clinical outcomes before and after CDR treatment. In the smoking group, ROM on the surgical segment after CDR [preoperative: (7.3±4.2)°; postoperative: (7.8±4.6)°] was preserved well ( t=0.639, P>0.05). However, in the non-smoking group, the ROM on the surgical segment was significantly reduced after CDR surgery [before surgery: (8.1±4.9)°; after surgery: (6.9±3.2)°, t=18.564, P<0.05]. The occurrence trend of HO in the non-smoking group was higher than that in the smoking group, but the difference was not statistically significant (37.0% vs. 33.3%, χ2=0.798, P>0.05). Other radiological assessments for patients in both groups yielded similar results. Conclusion:CDR can maintain good ROM in smoking group, which may be a reasonable choice for smoking patients with cervical spondylosis.

Several microRNAs (miRNAs or miRs) that regulate a variety of cancer‑related events are dysregulated in osteosarcoma (OS). An exploration of the specific roles of miRNAs in OS is crucial for the identification of suitable therapeutic targets. Previous studies have shown that miR‑873 plays tumor suppressive or oncogenic roles in different types of cancer. However, whether miR‑873 is implicated in OS carcinogenesis and cancer progression remains poorly understood. In the present study, we demonstrated that the miR‑873 levels were decreased in OS tissues and cell lines. The decreased expression of miR‑873 was related to tumor size, clinical stage and distant metastasis in patients with OS. The introduction of miR‑873 significantly inhibited tumor cell proliferation, migration and invasion in vitro, promoted apoptosis in vitro and restricted tumor growth in vivo. Furthermore, homeobox A9 (HOXA9) was validated as a direct target gene of miR‑873 in OS cells. HOXA9 was markedly expressed in OS tissues, and its upregulation inversely correlated with the miR‑873 levels. Moreover, HOXA9 silencing produced similar effects as observed with miR‑873 overexpression in OS cells. Consistently, the exogenous expression of HOXA9 partially reversed the suppression of the aggressive phenotype induced by miR‑873 overexpression in OS cells. Notably, miR‑873 was able to deactivate the Wnt/β‑catenin pathway in OS cells by regulating HOXA9, both in vitro and in vivo. On the whole, the present study demonstrates that miR‑873 suppresses the development of OS by directly targeting HOXA9 and inhibiting the Wnt/β‑catenin pathway, and suggests that miR‑873 may prove to be useful as a diagnostic biomarker of OS, as well as in the development of novel therapies.

目的:分析双侧经椎弓根入路椎体后凸成形(PKP)术治疗高龄胸腰椎压缩骨折患者的应用效果.方法:选取2016-12 ～2018-09沈丘县人民医院骨科收治的高龄胸腰椎压缩骨折患者64例为研究对象,依照手术方案不同分为观察组与对照组,每组各32,对照组行单侧经椎弓根入路PKP术,观察组行双侧经椎弓根入路PKP术.对比两组术后伤椎体前缘高度、伤椎体恢复高度、疼痛程度(VAS评分)及后凸Cobb's角.结果:术后观察组伤椎体前缘高度高于对照组,VAS评分小于对照组(P＜0.05);两组后凸Cobb's角、伤椎体右侧及左侧椎体恢复高度比较差异无统计学意义(P＞0.05).结论:高龄胸腰椎压缩骨折患者采用双侧经椎弓根入路PKP术治疗,可有效缓解术后疼痛,提高伤椎体前缘高度.

目的:探究经皮椎体成形术(PVP)治疗脊柱转移瘤的效果.方法:选取2017年8月至2018年5月郑州大学第一附属医院收治的脊柱转移瘤患者30例,根据患者的治疗方法分为对照组(15例)和观察组(15例),对照组给予立体放射治疗,观察组应用PVP治疗,比较两组患者脊柱情况以及疼痛程度.结果:观察组患者术前椎体前缘、中部高度与对照组比较,差异均无统计学意义(P＞0.05),术后1d以及两周内观察组两者情况明显优于对照组患者,差异具有统计学意义(P＜0.05);观察组患者术前、术后1d、术后1周疼痛评分明显低于于对照组,差异具有统计学意义(P＜0.05).结论:患者应用PVP治疗,不仅手术创伤小且止痛效果比较显著,明显改善患者的生活质量.

[目的]探究脊髓型颈椎病颈长肌退变特征.[方法]选取2016年6月～2017年2月在郑州大学第一附属医院骨科治疗的符合脊髓型颈椎病诊断的36例患者作为病变组,并选择同期正常人志愿者31例为对照组.收集两组的MRI影像资料,并应用PACS Version 5.0软件测量在C5/C6节段双侧颈长肌的横截面积、左右横径及前后径,并计算肌肉的形状比,对两组数据进行统计学分析.[结果]与对照组相比,脊髓型颈椎病患者双侧颈长肌的横截面积、前后径(APD)、左右横径(LD)都变小(P＜0.01),肌肉的形状比变大(P＜0.01),但是以上指标左右侧差异无统计学意义(P＞0.05);在对照组,女性双侧颈长肌横截面积比男性小(P＜0.01),病变组两者之间差异无明显统计学意义;在两组中女性患者双侧颈长肌的前后径均比男性小(P＜0.01);在病变组女性患者颈长肌的形状比比男性大(P＜0.01),在对照组两者差异无统计学意义(P＞0.05).[结论]脊髓型颈椎病患者出现双侧颈长肌对称性萎缩,肌肉形状在横向水平变薄;其中男性患者的颈长肌横截面积减少的多,而女性患者有较大的形状比,颈长肌更薄.

Aberrant nucleus pulposus cell proliferation is implicated in the development of intervertebral disk degeneration (IDD). Recent studies have suggested that long noncoding RNAs (lncRNAs) can modulate cell proliferation in several pathological conditions. Here, we indicate that expression of SNHG1 was upregulated in IDD tissues compared with control tissues and that higher SNHG1 expression was associated with disk degeneration grade. In addition, we show that ectopic expression of SNHG1 promoted nucleus pulposus (NP) cell proliferation and increased the PCNA and cyclin D1 expression in NP cells. Ectopic expression of SNHG1 inhibited miR-326 expression in nucleus pulposus cells and promoted CCND1 expression, which is a direct target gene of SNHG1. Moreover, we demonstrate that expression of miR-326 was downregulated in IDD tissues compared with control tissues and that lower SNHG1 expression was associated with disk degeneration grade. Expression of miR-326 was negatively associated with SNHG1 expression in disk degeneration tissues. Overexpression of miR-326 inhibited NP cell growth and inhibited PCNA and cyclin D1 expression in NP cells. Furthermore, we show that overexpression of SNHG1 promoted nucleus pulposus cell proliferation through inhibiting miR-326 expression. These data shed novel light on the role of SNHG1 in the pathogenesis of IDD.