Urban streets exhibit a diverse range of characteristics, with some presenting significant challenges to ambulance passage, directly impacting the safety of residents. Thus, ensuring unimpeded passage for ambulances on streets is a key focus of urban renewal and street governance initiatives. However, the identification of bottlenecks for emergency vehicle passage on urban streets currently relies on labor-intensive and inefficient on-site manual audits. This study proposes a deep learning-based approach to achieve automatic identification of ambulance passage on urban streets. The Vision Transformer network is utilized to construct the classification model of Impassable Narrow Roads, Passable Narrow Roads, and Wide Roads based on street view images. To train and test the constructed models, a specialized dataset is established, consisting of street view images labeled by experienced ambulance drivers. Comparative experiments are conducted to confirm the optimal structure of the model and the necessity of semantic segmentation preprocessing for street view images. To confirm the superiority of the proposed approach, four commonly used deep learning methods, MobileNet, ShuffleNet, SuperViT and DualViT serve as the baseline tests. Experimental results reveal that the model with four-head and one sequential encoder achieves the highest evaluation accuracy at 75.65% among the proposed models on the original dataset, significantly outperforming benchmark models. Meanwhile, the segmentation of street view images improves accuracy to 77.42%, but it reduces computational efficiency from 0.01 to 3 seconds per image. Finally, the optimal model is applied to the area within the Second Ring Road of Beijing as an example to discuss how the deep learning-based approach proposed in this paper supports urban planning practice and emergency medical response. The proposed approach facilitates the rapid and large-scale identification of bottlenecks in urban streets for ambulances with very limited costs, making a significant contribution to the accurate identification of key areas for urban renewal and street governance efforts. The proposed method can further assist emergency vehicle dispatchers and drivers in identifying accessible routes with greater precision during operations, thereby enabling more timely transportation of patients to medical facilities.

BackgroundIrreparable rotator cuff tears (IRCT) are defined as defects that cannot be repaired due to tendon retraction, fat infiltration, or muscle atrophy. One surgical remedy for IRCT is superior capsular reconstruction (SCR), which fixes graft materials between the larger tuberosity and the superior glenoid.Patients and methodsThe Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) criteria were followed for conducting the systematic review and meta-analysis. From their inception until February 25, 2022, Pubmed, Embase, and Cochrane Library's electronic databases were searched. Studies using cadavers on SCR for IRCT were also included. The humeral head's superior translation and subacromial peak contact pressure were the primary outcomes. The humeral head's anteroposterior translation, the kind of graft material used, its size, and the deltoid load were the secondary outcomes.ResultsAfter eliminating duplicates from the search results, 1,443 unique articles remained, and 20 papers were finally included in the quantitative research. In 14 investigations, the enhanced superior translation of the humeral head was documented in IRCTs. In 13 studies, a considerable improvement following SCR was found, especially when using fascia lata (FL), which could achieve more translation restraints than human dermal allograft (HDA) and long head of bicep tendon (LHBT). Six investigations reported a subacromial peak contact pressure increase in IRCTs, which could be rectified by SCR, and these studies found a substantial increase in this pressure. The results of the reduction in subacromial peak contact pressure remained consistent regardless of the graft material utilized for SCR. While there was a statistically significant difference in the change of graft material length between FL and HDA, the change in graft material thickness between FL and HDA was not significant. The humeral head's anterior-posterior translation was rising in IRCTs and could be returned to its original state with SCR. In five investigations, IRCTs caused a significant increase in deltoid force. Furthermore, only one study showed that SCR significantly decreased deltoid force.ConclusionWith IRCT, SCR might significantly decrease the glenohumeral joint's superior and anterior-posterior stability. Despite the risks for donor-site morbidity and the longer recovery time, FL is still the best current option for SCR.

Objective:This study aimed to summarize the causes, staging, and treatment of aseptic necrosis of the lunate bone.Methods:The keywords “月骨” “缺血坏死” “临床分期” “治疗” “lunate bone” “avascular necrosis” “clinical stages” and “treatment” were searched in Chinese and English databases such as CNKI, Wanfang, PubMed, and SinoMed. A total of 1 004 articles on aseptic necrosis of the lunate bone published before January 2023 were retrieved. After excluding articles with repeated retrieval, low content correlation, an inability to obtain full text, low quality, and poor innovation, 61 articles were finally included to summarize and analyze the causes, clinical stages, and treatment methods of aseptic necrosis of the lunate bone.Results:Aseptic necrosis of the lunate bone is a common osteonecrosis, which can be induced by anatomical and non-anatomical factors. The anatomical factors include lunate blood supply, lunate bone morphology, lunate bone biomechanics, radial anatomical parameters, and ulna variation. The non-anatomical factors include fracture and genetic factors. The Lichtman staging system is the widely used staging system for aseptic necrosis of the lunate bone. The Schmitt MRI staging system and Bain arthroscopic staging system are also used for the classification of the disease. The new Lichtman classification can guide orthopedic surgeons to treat patients with aseptic necrosis of the lunate bone. Conservative treatment is the main treatment for children and elderly patients with aseptic necrosis of the lunate bone. Adult patients should be treated conservatively for 3 to 6 months before surgery. In the selection of surgical methods, lunate decompression should be considered for the lunate with an intact articular surface and good blood supply prognosis. If there is a partial articular surface injury of the lunate bone, then lunate bone reconstruction should be performed. If the lunate has collapsed and shown no potential for revascularization, then the lunate should be resected. In addition, limited wrist arthrodesis should be performed if the radiolunate articular surface or middle carpal articular surface is injured. If the radioscaphoid joint is also injured, then total wrist arthrodesis should be performed.Conclusion:The occurrence of aseptic necrosis of the lunate bone results from the interaction of various risk factors. Therefore, accurately determining the stage of the disease is the key to its treatment. The new Lichtman classification follows the principle of individualized treatment, which can be used to accurately stage the disease. The treatment of aseptic necrosis of the lunate bone can be divided into conservative treatment and surgical treatment, which should be determined in accordance with the stage of the patient and the degree of disease progression.

With population aging becoming increasingly prominent, it has been recognized as a critical issue for urban planners whether older adults can access fair, high-quality medical services. Yet, few studies have investigated urban medical accessibility at a departmental level for older adults. Taking Beijing as a case study, this study puts forth a novel framework augmented by multisource data to analyze subdistrict-scale accessibility to urban medical departments, with a particular emphasis on older adults' common diseases. Online registration data were collected to indicate the supply capacity of medical services, with the influence of department reputation taken into account when determining the facilities' service range. A hierarchical two-step floating catchment area method was employed to examine accessibility for older adults to the cardiovascular, orthopedic, endocrinology, respiratory, and neurology departments. Subsequently, Gini indices were calculated to evaluate medical accessibility equity across urban spaces. Additionally, multiple linear regression was used to explore the correlations between medical accessibility and potential influencing factors. Results showed that medical accessibility is typically higher in downtown areas and decreases from the urban center to the peripheral areas in Beijing. Cardiovascular, respiratory, and orthopedic patients face relatively greater difficulty in accessing appropriate medical resources. Furthermore, significant inequity in medical accessibility was observed among the subdistricts at different locations, with accessibility inequity in the ecological conservation area being particularly concerning. Additionally, seven factors were found to significantly affect accessibility, including distance to the urban center, density of arterial and collector roads, proportion of residential land use, proportion of public service land use, proportion of transportation land use, and proportion of vehicle ownership. The proposed framework could identify subdistricts with low accessibility for older adult patients to access different medical departments. Therefore, it could potentially support the policy-making process by offering guidelines to adjust the construction plan of the medical system in metropolises and optimize the direction for resource input.

腱鞘巨细胞瘤(GCTTS)是一类起源于关节、滑囊和腱鞘滑膜的增生性炎症性疾病,根据其生长方式分为局限型和弥漫型,通常表现为独立、无痛、生长缓慢的肿块.GCTTS首选治疗方法是手术切除,术后有较高的复发率.目前对GCTTS病因、治疗及术后复发危险因素仍存在争议.该文就GCTTS研究进展进行综述.

[This corrects the article DOI: 10.3389/fsurg.2022.939096.].

Background Adolescent idiopathic scoliosis (AIS) is a spinal deformity that affects adolescents and poses a challenging public health problem. Compared to the general population, adolescents with AIS have a higher prevalence of hip dysplasia. However, the mechanisms underlying the impact of hip dysplasia on the coronal balance of the spine remain poorly understood. We hypothesized that the combination of AIS with hip dysplasia would exacerbate coronal imbalance. Methods We retrospectively analyzed the medical records and radiographs of adolescents diagnosed with AIS between 2015 and 2020. Participants were divided into two groups: those with hip dysplasia and those without. We recorded parameters related to the coronal deformity of the spine, sacral and pelvic obliquity, and center edge angle (CEA). We investigated differences in these parameters in those with and without hip dysplasia and analyzed their relationships in those with combined AIS and hip dysplasia. Results A total of 103 adolescents were included, 36 with hip dysplasia and 67 without. Those with hip dysplasia had significantly higher sacroiliac discrepancy (SID) compared to those without ( t = − 2.438, P = 0.017). In adolescents with hip dysplasia, only iliac obliquity angle (IOA) was significantly correlated with SID ( r = − 0.803, P < 0.001), with a linear relationship between them ( r 2 = 0.645, P < 0.001). Conclusions The incidence of hip dysplasia is higher in the AIS population. In adolescents with combined AIS and hip dysplasia, pelvic obliquity is greater, potentially contributing to the increased prevalence of low back pain.

BackgroundThe kinematic alignment technique, as one of the alignment options for total knee arthroplasty, has attracted increasing attention from orthopedic surgeons and has been increasingly performed in the most populous countries in the world. The purpose of this study is to explore and compare the early clinical outcomes of total knee arthroplasty with KA using specific instruments vs. mechanical alignment in our nation.MethodsA retrospective analysis was performed on patients who underwent unilateral total knee arthroplasty for knee osteoarthritis with varus deformity. Depending on the alignment method, patients were divided into a kinematically aligned total knee arthroplasty (KA-TKA) group and a mechanically aligned total knee arthroplasty (MA-TKA) group. The hip-knee-ankle (HKA) angle before and after surgery, the knee joint clinical score (KS-C), the knee joint functional score (KS-F) and the forgotten joint score (FJS) at 3 months and 2 years after surgery were recorded and statistically analyzed.ResultsA total of 126 patients were enrolled, including 65 in the KA-TKA group and 61 in the MA-TKA group. The mean follow-up period was 30.8 months. The postoperative HKA angle was not significantly different at the 2-year follow-up between the two groups (P > 0.05). The KS-C, KS-F and FJS scores in the KA-TKA group were higher than those in the MA-TKA group at 3 months after surgery, and the difference was statistically significant (P < 0.05). At the 2-year follow-up, the KS-C, KS-F and FJS scores in the KA-TKA group were higher than those in the MA-TKA group, and the difference in the KS-C and FJS scores was statistically significant (P < 0.05).ConclusionPatients who underwent KA-TKA had a postoperative lower limb alignment similar to that of those who underwent MA-TKA. The clinical outcomes of KA-TKA were superior to those of MA-TKA in terms of clinical performance, knee function and subjective sensation up to 2 years after surgery.

Objective:This study aimed to explore the changes in lower-limb alignment imaging parameters before and after kinematic alignment(KA)-total knee replacement (TKA) and mechanical alignment(MA)-TKA, as well as to analyze the causes of postoperative residual varus.Methods:A retrospective cohort study was conducted on 36 patients who underwent TKA from June 2020 to January 2021 in the Department of Orthopedics, Beijing Chaoyang Hospital Affiliated to Capital Medical University. The patients included 17 males and 19 females aged 58-82 years old. During TKA, 18 patients subjected to KA technique were included in the KA group, and 18 patients subjected to MA technique were included in the MA group. The baseline data of the patients including age, gender, body mass index, operative time, and lateral ratio were compared between the two groups. Hip-knee-ankle angle(HKA), medial proximal tibial angle(MPTA), medial lateral distal femoral angle(mLDFA), and the degree of correction were compared between the two groups pre- and post-operatively. Correlation and regression analyses were conducted on HKA, MPTA, and mLDFA in each group.Results:No statistical significance was found in the comparison of baseline data between the two groups (all P values > 0.05). Preoperative HKA (172.2° ± 5.3° vs. 172.8° ± 4.6°), mLDFA (88.9° ± 2.7° vs. 90.4° ± 3.1°), MPTA (84.8° ± 1.7° vs. 84.4° ± 3.7°), and postoperative HKA (175.8° ± 2.6° vs. 176.3° ± 2.0°), and mLDFA (89.4° ± 2.7° vs. 90.9° ± 2.4°) in the KA and MA groups had no statistically significant difference ( t=0.35, 1.58, 0.37, 0.68, 1.76, all P values > 0.05). Postoperative HKA in both groups was higher than that before surgery, and postoperative MPTA in the MA group was higher than that before surgery; the differences were statistically significant (all P values < 0.05). MPTA in the KA group was lower than that in the MA group (85.3° ± 1.8° vs. 87.4° ± 2.1°), and the difference was statistically significant ( t=3.33, P = 0.002). MPTA correction degree in the MA group (4.3° ± 2.8°) was higher than that in the KA group (1.9° ± 1.5°), and the difference was statistically significant ( t=3.25, P = 0.003). Additionally, a high correlation existed between post- and pre-operative mLDFA in the KA group ( R2 = 0.79, P < 0.001). Conclusion:KA-TKA with traditional instruments can restore the preoperative anatomical morphology of the joint line of the distal femur and proximal tibia. The joint line of the proximal tibia is more inclined, and the joint line of the distal femur is more evaginated, thereby making the knee joint line more parallel to the ground than MA-TKA. MA-TKA femoral prosthesis placement is more prone to varus. Therefore, for TKA with mild residual varus after surgery, the reasons for the residual varus differed between KA-TKA and MA-TKA, and KA is not MA with residual varus.

Objective:To explore and compare the early clinical results between kinematic alignment using special tools and mechanical alignment in total knee arthroplasty.Methods:A retrospective analysis was performed on patients who underwent unilateral total knee arthroplasty due to knee osteoarthritis with a follow-up time of more than three months and complete follow-up data.in Beijing Chaoyang Hospital, Capital Medical University from March 2019 to March 2021. The patients with inflammatory arthropathy such as rheumatoid arthritis, severe misalignment of patellofemoral joint, and previous knee collateral ligament or posterior cruciate ligament injury were excluded. According to alignment method, patients were divided into special tools kinematically aligned total knee arthroplasty (KA-TKA) group and mechanically aligned total knee arthroplasty (MA-TKA) group. The hip-knee-ankle (HKA) angle before and after the surgery, the knee joint clinical score (KS-C), the knee joint functional score (KS-F) before and three months after the surgery were recorded, as well as the postoperative forgotten joint score (FJS). Independent sample t test was used to compare the data.Results:A total of 162 patients were enrolled, including 82 in the KA-TKA group and 80 in the MA-TKA group. There was no statistically significant difference in the postoperative HKA angle between the two groups (P>0.05). Three months after the surgery, the KS-C score (t=2.259), KS-F score (t=1.994) and FJS score (t=2.945) in the KA-TKA group were higher than those in the MA-TKA group, the differences between the two groups were statistically significant (all P<0.05).Conclusion:KA-TKA has similar postoperative lower limb alignment, better clinical performance and higher knee function, and a higher FJS compared with MA-TKA.

To date, few studies have investigated the accessibilities to proper medical departments for elderly patients. This paper examined the accessibilities to medical resources for the older adults in the sub-district level in Beijing with particular focus on elderly common diseases. Unlike the previous studies which used inpatient bed number, the present study collected online registration number to indicate the supply capacity of medical service. Moreover, the reputation of medical departments was considered while determining their service range. On this basis, an improved two-step floating catchment area method was proposed to calculate the accessibilities to the medical departments of Cardiovascular, Orthopedics, Endocrinology, Respiratory, and Neurology. After that, the Gini indexes were computed to evaluate the accessibility equity across the urban space. Our results revealed that significant disparity and inequity in accessibility exist for different diseases, especially for the Cardiovascular patients, Respiratory patients, and Orthopedics patients living in the Ecological conservation area.

Chemodynamic therapy (CDT)-activated apoptosis is a potential anticancer strategy. However, CDT encounters a bottleneck in clinical translation due to its serious side effects and low efficacy. Here, we first reveal that surface engineering of ginsenoside Rg3 dramatically alters the organ distribution and tumor enrichment of systematically administered nanocatalysts using the orthotopic pancreatic tumor model while avoiding toxicity and increasing efficacy in vivo to address the key and universal toxicity problems encountered in nanomedicine. Compared with nanocatalysts alone, Rg3-sheltered dynamic nanocatalysts form hydrophilic nanoclusters, prolonging their circulation lifespan in the blood, protecting the internal nanocatalysts from leakage while allowing their specific release at the tumor site. Moreover, the nanoclusters provide a drug-loading platform for Rg3 so that more Rg3 reaches the tumor site to achieve obvious synergistic effect with nanocatalysts. Rg3-sheltered dynamic nanocatalysts can simultaneously activate ferroptosis and apoptosis to significantly improve anticancer efficacy. Systematic administration of ginsenoside Rg3-sheltered nanocatalysts inhibited 86.6% of tumor growth without toxicity and prolonged the survival time of mice. This study provides a promising approach of nanomedicine with high biosafety and a new outlook for catalytic ferroptosis-apoptosis combined antitumor therapies.

目的 评价后交叉韧带保留型膝关节置换术(CR TKA)术中完整保留后交叉韧带(PCL)的临床疗效.方法 回顾性分析北京朝阳医院骨科2016年6月至2018年12月收治的386例符合纳入标准并行单侧C R T K A患者的临床资料,其中男124例,女262例.患者在术前均行影像学检查并排除关节外畸形.术中进行等量截骨及常规软组织松解技术,PCL的两个束支完整保留.选择术前,术后3个月、6个月以及12个月对患者进行临床评价,观察指标包括膝关节活动度、膝关节临床评分系统(包括临床评分以及功能评分)以及屈膝90°位时膝关节前后向最大位移距离,并记录患者术后并发症情况及影像学检查结果.采用单因素方差分析对手术前后指标进行统计学分析.结果 由于各种原因共失访患者98例,最终纳入研究合计288例,年龄53～86岁,平均(64.8±8.7)岁,随访时间持续14～31个月,平均(21.2±4.3)个月.患者术后3个月、6个月以及12个月的膝关节活动度、膝关节临床评分系统较术前均有较大提高,差异有统计学意义(P<0.01);而术后6个月与12个月观察点屈膝90°位时膝关节前后向最大位移距离变化不大,差异无统计学意义(P>0.05).4例患者术后切口持续渗出、1例患者出现切口裂开,均早期清创处理后治愈,未发现切口皮肤坏死、下肢深静脉血栓形成、术后感染等并发症,影像学检查未见假体松动、垫片过度磨损、脱位病例.结论 CR TKA术中完整保留PCL不会影像假体的放置及关节活动,反而会增加膝关节的稳定性,早期恢复关节功能.

目的 研究对膝关节不同部位进行局部浸润麻醉(local infiltration anesthesia,LIA),对全膝关节置换术(total knee arthroplasty,TKA)术后患者早期镇痛效果的影响.方法 入组2017年3月至2018年6月因膝关节骨关节炎在首都医科大学附属北京朝阳医院骨科行单侧初次全膝关节置换术的患者,共100人,采用随机数分组法随机分为两组:后侧方浸润麻醉组(A组)及前方浸润麻醉组(B组),每组50例.其中A组在术中于后侧方结构[腘动脉与后关节囊间隙(interspace between the popliteal artery and posterior capsule of the knee,IPACK)]及内外侧副韧带附着区分别注射镇痛药物,并于前方结构[髌上囊滑膜、股四头肌肌腱及切口周围]分别注射0.9％(质量分数)氯化钠注射液(以下简称生理盐水)20 mL;B组在术中于后侧方结构分别注射生理盐水,并于前方结构分别注射镇痛药物.如患者出现不能耐受的疼痛则临时应用曲马多100 mg口服作为治疗补充.分析2组患者基线资料、术前及术后第5天视觉模拟评分(Visual Analogue Scale,VAS)、美国膝关节协会评分(American Knee Society Score,KSS)、美国骨关节炎指数(The Western Ontario and McMaster Universities Osteoarthritis Index,WOMAC),并统计两组术后曲马多的用量.结果 两组患者基线资料及术前VAS评分差异均无统计学意义(P>0.05),术后第5天在静息状态下,A组VAS明显优于B组(P<0.05);而在功能锻炼状态下,两组术后VAS差异无统计学意义(P>0.05).两组患者的术前及术后KSS及WOMAC差异均无统计学意义(P>0.05).A组患者的曲马多用量小于B组患者,但差异无统计学意义(P>0.05).结论 膝关节后侧方LIA对TKA术后患者的镇痛效果,在静息条件下明显优于膝关节前方LIA,并可减少术后口服阿片类药物的用量.对于TKA术后患者,建议加强膝关节后侧方区域的浸润镇痛而非单纯伤口等前方镇痛,能够有效控制患者术后早期的静息痛.

Nanozymes have limited applications in clinical practice due to issues relating to their safety, stability, biocompatibility, and relatively low catalytic activity in the tumor microenvironment (TME) in vivo. Herein, we report a synergistic enhancement strategy involving the conjugation of metal-based nanozymes (Fe@Fe3O4) with natural bioactive organic molecules (ginsenoside Rg3) to establish a new nanodrug. Importantly, this metal-organic nanocomposite drug ensured the stability and biosafety of the nanozyme cores and the cellular uptake efficiency of the whole nanodrug entity. This nanodrug is based on integrating the biological characteristics and intrinsic physicochemical properties of bionics. The glycoside chain of Rg3 forms a hydrophilic layer on the outermost layer of the nanodrug to improve the biocompatibility and pharmacokinetics. Additionally, Rg3 can activate apoptosis and optimize the activity and status of normal cells. Internal nanozymes enter the TME and release Fe3+ and Fe2+, and the central metal Fe(0) continuously generates highly active Fe2+ under the conditions of the TME and in the presence of Fe3+, maintaining the catalytic activity. Therefore, these nanozymes can effectively produce reactive oxygen species and oxygen in the TME, thereby promoting the apoptosis of cancer cells. Thus, we propose the use of a new type of metal-organic nanocomposite material as a synergistic strategy against cancer.

OBJECTIVE:To compare the effectiveness of partial versus intact posterior cruciate ligament (PCL)-retaining in total knee arthroplasty (TKA) with cruciate-retaining (CR) prosthesis. METHODS:A total of 200 patients with osteoarthritis, who met the selection criteria and proposed unilateral TKA with CR prosthesis, were included in the study and randomly assigned into two groups ( n=100). The patients were treated with intact retention of the double bundles of PCL in intact group and with partial resection of the anterior lateral bundle of PCL and the anterior bone island at the time of intraoperative tibial osteotomy in partial group. Patients with lost follow-up and re-fracture were excluded, and 84 cases in partial group and 88 cases in intact group were included in the final study. There was no significant difference between the two groups ( P>0.05) in terms of gender, age, body mass index, course and grade of osteoarthritis, preoperative varus deformity of knee joint, flexion contracture, range of motion, clinical and functional scores of Knee Society Score (KSS). The operation time, wound drainage volume during 24 hours after operation, visual analogue scale (VAS) score at 24 hours after operation, range of motion of knee joint, clinical and functional scores of KSS, and the anteroposterior displacement of knee joint at 30° and 90° flexion positions were compared between the two groups. RESULTS:There was no significant difference between the two groups in operation time, wound drainage volume during 24 hours after operation, and VAS score at 24 hours after operation ( P>0.05). Patients in both groups were followed up after operation. The follow-up time was 25-40 months (mean, 30.2 months) in intact group and 24-40 months (mean, 31.8 months) in partial group. There was no significant difference in the range of motion and clinical scores of KSS between the two groups at 6, 12, and 24 months after operation ( P>0.05). The functional scores of KSS were significantly higher in intact group than in partial group ( P<0.05). There was no significant difference between the two groups in the anteroposterior displacement of knee joints at 30° flexion position at 6, 12, and 24 months after operation ( P>0.05). When the knee was at 90° flexion position, there was no significant difference between the two groups at 6 and 12 months after operation ( P>0.05), but the intact group was significantly smaller than partial group at 24 months after operation ( P<0.05). Postoperative incision continued exudation in 4 patients (2 cases of partial group and 2 cases of intact group), and incision debridement in 2 patients (1 case of partial group and 1 case of intact group). No prosthesis loosening, excessive wear, or dislocation of gasket was found during follow-up. CONCLUSION:The double bundle of PCL plays an equally important role in maintaining the stability of the knee joint, and the integrity of PCL should be kept as much as possible when TKA is performed with CR prosthesis.

Chitosan and alginate hydrogels are attractive because they are highly biocompatible and suitable for developing nanomedicine microcapsules. Here we fabricated a polydimethylsiloxane-based droplet microfluidic reactor to synthesize nanomedicine hydrogel microcapsules using Au@CoFeB-Rg3 as a nanomedicine model and a mixture of sodium alginate and PEG-g-chitosan crosslinked by genipin as a hydrogel model. The release kinetics of nanomedicines from the hydrogel were evaluated by simulating the pH and temperature of the digestive tract during drug transport and those of the target pathological cell microenvironment. Their pH and temperature-dependent release kinetics were studied by measuring the mass loss of small pieces of thin films formed by the nanomedicine-encapsulating hydrogels in buffers of pH 1.2, 7.4, and 5.5, which replicate the pH of the stomach, gut and blood, and cancer microenvironment, respectively, at 20 °C and 37 °C, corresponding to the storage temperature of hydrogels before use and normal body temperature. Interestingly, nanomedicine-encapsulating hydrogels can undergo rapid decomposition at pH 5.5 and are relatively stable at pH 7.4 at 37 °C, which are desirable qualities for drug delivery, controlled release, and residue elimination after achieving target effects. These results indicate that the designed nanomedicine hydrogel microcapsule system is suitable for oral administration.